Gastroenterology

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A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in People With Celiac Disease
Brown, G.
4/09/23 → 4/09/25
Project: Research
FAD-UC: Investigating the therapeutic potential of a diet low in sulphite- & carrageenan food additives for ulcerative colitis
Yao, C., Gibson, P., Biesiekierski, J., Halmos, E., Fitzpatrick, J. W. & Ardalan, Z.
1/09/23 → 30/11/24
Project: Research
An Open-Label Phase 1b Study Evaluating the Safety, Tolerability, Immunogenicity and Antiviral Activity of Multiple Doses of CLB-3000 in Subjects with Chronic Hepatitis B
Roberts, S. & McKenzie, J.
2/08/23 → 1/08/25
Project: Research
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase III Efficacy and Safety Study of Tezepelumab in Patients with Eosinophilic Esophagitis (CROSSING)
Burgell, R.
4/04/23 → 3/04/25
Project: Research
Dissecting the role of group 2 innate lymphoid cells in gastric cancer
Buchert, M., Eissman, M. F., Locksley, R., Ernst, M., Li, X., Boussioutas, A., Shi, W., Lee, J. & Pal, B.
1/01/23 → 31/12/26
Project: Research
ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)
Roberts, S.
11/10/22 → 10/10/27
Project: Research
A three-part, double-blind, placebo-controlled, Phase I/Ib study of the safety, tolerability and pharmacokinetics of single and multiple ascending doses of IMU-856 in healthy volunteers and patients with celiac disease.
Brown, G.
20/09/22 → 1/06/24
Project: Research
A Phase IIb/III Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Cotadutide in Participants with Noncirrhotic Non-alcoholic Steatohepatitis with Fibrosis (PROXYMO-ADVANCE)
Roberts, S.
1/06/22 → 31/08/27
Project: Research
HER2 testing in advanced gastric cancer – understanding and reducing variation in current practice to improve patient survival
Ioannou, L., Zalcberg, J., Boussioutas, A., Fox, S. B., Duong, C. P., Wong, R., Chen, R., Haydon, A., Graco, M., Saxon, S., Ananda, S. S., Tagkalidis, P., Lipton, L. R., Brown, S. B., Aga, A., Hair, C. S. & Tawfik, B.
4/04/22 → 7/04/25
Project: Research
TRANSFORM: A 52-week, Randomized, Placebo-controlled, Double-blind, Adaptive Phase 2b/3 Trial of Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness.
Roberts, S.
26/02/22 → 1/01/26
Project: Research
The role of a low emulsifier diet in treating Crohn's disease
Halmos, E. & Fitzpatrick, J. W.
1/02/22 → 23/01/24
Project: Research
A Phase 2a, Randomized, Blinded, Multicenter Study Investigating a Combination of AB-729 and VTP-300 in Virologically-Suppressed Chronic Hepatitis B Participants.
Roberts, S.
1/02/22 → 31/12/24
Project: Research
Efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-controlled trial
Roberts, S.
9/09/21 → 31/12/24
Project: Research
RESPONSE: A Placebo-controlled, Randomized, Phase 3 Study to Evaluate the Efficacy and Safety of Seladelpar in Patients With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)
Roberts, S.
16/07/21 → 31/12/24
Project: Research
A PHASE 3, MULTICENTER, MULTINATIONAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INDUCTION AND MAINTENANCE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CC-93538 IN ADULT AND ADOLESCENT SUBJECTS WITH EOSINOPHILIC ESOPHAGITIS
Burgell, R.
8/07/21 → 31/12/24
Project: Research
AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer
Leong, T., Smithers, B., Lordick, F., Simes, R. J., Darling, G. E., Gebski, V. J., Boussioutas, A., Haustermans, K. M. G., Zalcberg, J. & Michael, M. Z.
1/07/21 → 30/06/26
Project: Research
A Multicentre, Observational, Phase 4 Study to Evaluate the Safety and Tolerability of Lenvatinib in Patients with Advanced or Unresectable Hepatocellular Carcinoma (STELLAR)
Roberts, S. & Lewis, P.
28/05/21 → 31/12/27
Project: Research
Using dietary therapy to slow the progression of diabetic kidney disease
Snelson, M., Coughlan, M., Ekinci, E., Baqar, S., Muir, J. & Kellow, N.
3/05/21 → 31/12/24
Project: Research
A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Patients with Active Eosinophilic Esophagitis (EoE)
Burgell, R.
27/04/21 → 31/12/25
Project: Research
A Double-Blinded, randomized, Parallel-Group, PHASE 2 Study to investigate the Effect of RO7049665 on the time to relapse following steroid tapering in patients with Autoimmune Hepatitis
Roberts, S. & Jones, A.
1/03/21 → 31/12/24
Project: Research
The role of a low emulsifier diet to treat Crohn's disease
Halmos, E.
1/01/21 → 31/12/25
Project: Research
Fluticasone propionate Oral Dispersible Tablet Formulation in Eosinophilic Esophagitis: A Two-Part, Randomized, Double- blind, Placebo-Controlled Study of APT-1011, with an open-label extension, in Adult Subjects with Eosinophilic Esophagitis
Burgell, R.
1/11/20 → 31/12/24
Project: Research
A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN 74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC).
Roberts, S., Adams, L. A., George, J., Strasser, S. I., Thompson, A. J. V. & Lynch, K. D.
1/10/20 → 1/11/23
Project: Research
A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012).
Roberts, S. & Lewis, P.
5/06/20 → 31/12/23
Project: Research
Creating an evidence base for clinical care: A randomized controlled study examining the efficacy of the low FODMAP diet for the relief of gastrointestinal symptoms in endometriosis.
Muir, J., Burgell, R., Varney, J., Moore, J., Morrison, M. & Fisher, J.
1/06/20 → 31/05/25
Project: Research
A 46-week, Double-blind, Placebo-controlled, Phase 3 Study with a 6-week Randomized-withdrawal Period to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.
Burgell, R. & McKenzie, J.
26/03/20 → 31/12/25
Project: Research
The 4-SURE (4-Sulfide-Reducing) project: pioneering a new diet paradigm in the management of ulcerative colitis and pouchitis
Yao, C.
Crohn's and Colitis Australia
24/02/20 → 24/02/24
Project: Research
A Phase 2, Randomized, Double-blinded, Placebo-controlled, Multicenter, Dose-finding Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects with Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis
Roberts, S.
19/12/19 → 31/12/24
Project: Research
Centre for Research Excellence in Digestive Health
Talley, N., Holtmann, G. J., Walker, M. M., Jones, M., Morrison, M., Keely, S., Gibson, P., Chan, S., Tack, J. & Coombes, J. S.
1/11/19 → 31/10/24
Project: Research
A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients with Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation. Clinical study No. MGL-3196-11.
Roberts, S.
24/10/19 → 31/12/24
Project: Research
A 12-week, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.
Burgell, R. & Hogg, J.
9/09/19 → 31/12/24
Project: Research