Gastroenterology

Projects

Projects per year 2013 2019 2020 2021 2027

• 4 Not started
• 31 Finished
• 32 Active

Projects per year

Search results

• Active

  A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in People With Celiac Disease

  Brown, G.

  4/09/23 → 4/09/25

  Project: Research

• FAD-UC: Investigating the therapeutic potential of a diet low in sulphite- & carrageenan food additives for ulcerative colitis

  Yao, C., Gibson, P., Biesiekierski, J., Halmos, E., Fitzpatrick, J. W. & Ardalan, Z.

  1/09/23 → 30/11/24

  Project: Research

• An Open-Label Phase 1b Study Evaluating the Safety, Tolerability, Immunogenicity and Antiviral Activity of Multiple Doses of CLB-3000 in Subjects with Chronic Hepatitis B

  Roberts, S. & McKenzie, J.

  2/08/23 → 1/08/25

  Project: Research

• A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase III Efficacy and Safety Study of Tezepelumab in Patients with Eosinophilic Esophagitis (CROSSING)

  Burgell, R.

  4/04/23 → 3/04/25

  Project: Research

• Dissecting the role of group 2 innate lymphoid cells in gastric cancer

  Buchert, M., Eissman, M. F., Locksley, R., Ernst, M., Li, X., Boussioutas, A., Shi, W., Lee, J. & Pal, B.

  1/01/23 → 31/12/26

  Project: Research

• ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)

  Roberts, S.

  11/10/22 → 10/10/27

  Project: Research

• A three-part, double-blind, placebo-controlled, Phase I/Ib study of the safety, tolerability and pharmacokinetics of single and multiple ascending doses of IMU-856 in healthy volunteers and patients with celiac disease.

  Brown, G.

  20/09/22 → 1/06/24

  Project: Research

• A Phase IIb/III Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Cotadutide in Participants with Noncirrhotic Non-alcoholic Steatohepatitis with Fibrosis (PROXYMO-ADVANCE)

  Roberts, S.

  1/06/22 → 31/08/27

  Project: Research

• HER2 testing in advanced gastric cancer – understanding and reducing variation in current practice to improve patient survival

  Ioannou, L., Zalcberg, J., Boussioutas, A., Fox, S. B., Duong, C. P., Wong, R., Chen, R., Haydon, A., Graco, M., Saxon, S., Ananda, S. S., Tagkalidis, P., Lipton, L. R., Brown, S. B., Aga, A., Hair, C. S. & Tawfik, B.

  4/04/22 → 7/04/25

  Project: Research

• TRANSFORM: A 52-week, Randomized, Placebo-controlled, Double-blind, Adaptive Phase 2b/3 Trial of Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness.

  Roberts, S.

  26/02/22 → 1/01/26

  Project: Research

• A Phase 2a, Randomized, Blinded, Multicenter Study Investigating a Combination of AB-729 and VTP-300 in Virologically-Suppressed Chronic Hepatitis B Participants.

  Roberts, S.

  1/02/22 → 31/12/24

  Project: Research

• The role of a low emulsifier diet in treating Crohn's disease

  Halmos, E. & Fitzpatrick, J. W.

  1/02/22 → 23/01/24

  Project: Research

• Efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-controlled trial

  Roberts, S.

  9/09/21 → 31/12/24

  Project: Research

• RESPONSE: A Placebo-controlled, Randomized, Phase 3 Study to Evaluate the Efficacy and Safety of Seladelpar in Patients With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)

  Roberts, S.

  16/07/21 → 31/12/24

  Project: Research

• A PHASE 3, MULTICENTER, MULTINATIONAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INDUCTION AND MAINTENANCE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CC-93538 IN ADULT AND ADOLESCENT SUBJECTS WITH EOSINOPHILIC ESOPHAGITIS

  Burgell, R.

  8/07/21 → 31/12/24

  Project: Research

• AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer

  Leong, T., Smithers, B., Lordick, F., Simes, R. J., Darling, G. E., Gebski, V. J., Boussioutas, A., Haustermans, K. M. G., Zalcberg, J. & Michael, M. Z.

  1/07/21 → 30/06/26

  Project: Research

• A Multicentre, Observational, Phase 4 Study to Evaluate the Safety and Tolerability of Lenvatinib in Patients with Advanced or Unresectable Hepatocellular Carcinoma (STELLAR)

  Roberts, S. & Lewis, P.

  28/05/21 → 31/12/27

  Project: Research

• Using dietary therapy to slow the progression of diabetic kidney disease

  Snelson, M., Coughlan, M., Ekinci, E., Baqar, S., Muir, J. & Kellow, N.

  3/05/21 → 31/12/24

  Project: Research

• A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Patients with Active Eosinophilic Esophagitis (EoE)

  Burgell, R.

  27/04/21 → 31/12/25

  Project: Research

• A Double-Blinded, randomized, Parallel-Group, PHASE 2 Study to investigate the Effect of RO7049665 on the time to relapse following steroid tapering in patients with Autoimmune Hepatitis

  Roberts, S. & Jones, A.

  1/03/21 → 31/12/24

  Project: Research

• The role of a low emulsifier diet to treat Crohn's disease

  Halmos, E.

  1/01/21 → 31/12/25

  Project: Research

• Fluticasone propionate Oral Dispersible Tablet Formulation in Eosinophilic Esophagitis: A Two-Part, Randomized, Double- blind, Placebo-Controlled Study of APT-1011, with an open-label extension, in Adult Subjects with Eosinophilic Esophagitis

  Burgell, R.

  1/11/20 → 31/12/24

  Project: Research

• A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN 74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC).

  Roberts, S., Adams, L. A., George, J., Strasser, S. I., Thompson, A. J. V. & Lynch, K. D.

  1/10/20 → 1/11/23

  Project: Research

• A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012).

  Roberts, S. & Lewis, P.

  5/06/20 → 31/12/23

  Project: Research

• Creating an evidence base for clinical care: A randomized controlled study examining the efficacy of the low FODMAP diet for the relief of gastrointestinal symptoms in endometriosis.

  Muir, J., Burgell, R., Varney, J., Moore, J., Morrison, M. & Fisher, J.

  1/06/20 → 31/05/25

  Project: Research

• A 46-week, Double-blind, Placebo-controlled, Phase 3 Study with a 6-week Randomized-withdrawal Period to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.

  Burgell, R. & McKenzie, J.

  26/03/20 → 31/12/25

  Project: Research

• The 4-SURE (4-Sulfide-Reducing) project: pioneering a new diet paradigm in the management of ulcerative colitis and pouchitis

  Yao, C.

  Crohn's and Colitis Australia

  24/02/20 → 24/02/24

  Project: Research

• A Phase 2, Randomized, Double-blinded, Placebo-controlled, Multicenter, Dose-finding Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects with Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis

  Roberts, S.

  19/12/19 → 31/12/24

  Project: Research

• Centre for Research Excellence in Digestive Health

  Talley, N., Holtmann, G. J., Walker, M. M., Jones, M., Morrison, M., Keely, S., Gibson, P., Chan, S., Tack, J. & Coombes, J. S.

  1/11/19 → 31/10/24

  Project: Research

• A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients with Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation. Clinical study No. MGL-3196-11.

  Roberts, S.

  24/10/19 → 31/12/24

  Project: Research

• A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination with Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants with Advanced Hepatocellular Carcinoma.

  Roberts, S., Lewis, P., George, J., Zekry, A., O'Beirne, J., Tse, E., McLachlan, S. A., Eastgate, M., Ananda, S. S. & Davison, S.

  24/09/19 → 30/09/23

  Project: Research

• A 12-week, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.

  Burgell, R. & Hogg, J.

  9/09/19 → 31/12/24

  Project: Research

• Not started

  A Phase 1/2a - Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of BJT-778 in Healthy Volunteers and in Subjects With Chronic Hepatitis B Infection, Including Subjects With Chronic Hepatitis D Infection

  Roberts, S.

  Project: Research

• A Randomized Phase 2 Trial of Atezolizumab and Bevacizumab in Combination With SRF388 or Placebo in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma.

  Roberts, S., Lewis, P., Matos, M., Zekry, A. & Haridy, J.

  Project: Research

• A PHASE 3, MULTICENTER, MULTINATIONAL, OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY OF CC-93538 IN ADULT AND ADOLESCENT SUBJECTS WITH EOSINOPHILIC ESOPHAGITIS.

  Burgell, R. & Charitra, R.

  Project: Research

• Discovery and validation of biomarkers for nonalcoholic steatohepatitis and liver fibrosis

  Watt, M., Montgomery, M., Burton, P., Brown, W., Roberts, S., Kemp, W. & Earnest, A.

  Project: Research

• Finished

  Atmo bar : Development of Atmo Cereal bars

  Gibson, P., Muir, J., Yao, C. & So, D.

  18/10/21 → 17/10/22

  Project: Research

• A Randomized Phase 2a, Multicenter, Open-Label, Multiple-Cohort Study Evaluating Regimens Containing Vebicorvir in Subjects with Chronic Hepatitis B Virus Infection

  Roberts, S., Matthews, G. V., Sasadeusz, J., Chen, F., Valaydon, Z. S., George, J., MacQuillan, G., Thompson, A. J. V. & Davison, S.

  12/05/21 → 31/12/22

  Project: Research

• The new face of dietary therapy in pouchitis: targeting pathogenic factors from the pouch microbiota

  Gibson, P., Yao, C. & Ardalan, Z. S. M.

  25/01/21 → 31/12/21

  Project: Research

• Randomized, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of EP547 in Healthy Subjects with Cholestatic or Uremic Pruritis.

  Roberts, S. & Kerr, P.

  1/12/20 → 31/12/22

  Project: Research

• A Phase 2a, Multicenter, Single-Blind, Placebo-Controlled, Multiple Cohort Study Evaluating ABI-H2158-Containing Regimens in Chronic Hepatitis B Infection.

  Roberts, S. & Mitchell, J. L.

  15/08/20 → 15/08/22

  Project: Research

• Evaluation of Efficacy, Safety and Tolerability of NGM282 (aldafermin) in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Subjects with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (ALPINE4)

  Roberts, S. & Jones, A.

  14/02/20 → 31/12/22

  Project: Research

• Prevalence of sucrase-isomaltase genetic hypomorphic variants in patients with irritable bowel syndrome in Australia

  Mitchell, H., Garg, M., Porter, J., Gibson, P. & Barrett, J.

  1/01/20 → 31/12/20

  Project: Research

• RECIPE: Randomised controlled trial (RCT) of ROTEM-guided blood component administration versus standard of care in patients with cirrhosis and coagulopathy undergoing invasive procedures.

  Majeed, A., Janko, N. E., Roberts, S., Kemp, W., Nandurkar, H. & Gow, P. J.

  5/12/19 → 31/08/21

  Project: Research

• Comparison of Regional Transit Measurement for the Atmo Capsule with those of a Gold Standard (Smart Pill)

  Gibson, P., Halmos, E. & Yao, C.

  Atmo Biosciences

  1/12/19 → 1/08/21

  Project: Research

• A Phase 2, Randomized, Double-Blind, Placebo-Controlled Multiple Center Study to Evaluate the Safety, Tolerability, and Efficacy of Seladelpar Administered for 24 Weeks in Adult Patients with Primary Sclerosing Cholangitis (PSC)

  Roberts, S.

  22/11/19 → 31/12/21

  Project: Research

• A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation

  Roberts, S. & Lewis, P.

  8/11/19 → 30/06/23

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Subjects with Primary Sclerosing Cholangitis

  Roberts, S. & Lewis, P.

  30/10/19 → 31/12/21

  Project: Research

• A prospective, cross-sectional, multi-centre study to evaluate the clinical performance of the ColoSTAT In Vitro Diagnostic for the detection and evaluation of Biomarkers associated with the occurrence of colorectal cancer.

  Brown, G.

  21/06/19 → 31/07/20

  Project: Research

• A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GS-4224 in Healthy Volunteers and Subjects with the Chronic Hepatitis B (CHB) Virus

  Roberts, S. & Jones, A.

  19/06/19 → 31/05/21

  Project: Research