Faculty of Pharmacy and Pharmaceutical Sciences

Research Output 1969 2019

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2019

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O’Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. & Brierley, S. M., 19 Sep 2019, In : JCI Insight. 4, 18, 42 p.

Research output: Contribution to journalArticleResearchpeer-review

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Adherence, Persistence, and Switching Among People Prescribed Sodium Glucose Co-transporter 2 Inhibitors: A Nationwide Retrospective Cohort Study

Ofori-Asenso, R., Liew, D., Lalic, S., Mazidi, M., Magliano, D. J., Ademi, Z., Bell, J. S. & Ilomaki, J., 3 Sep 2019, (Accepted/In press) In : Advances in Therapy. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A fluorogenic probe based on chelation-hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models

Zhang, G., Zhao, Y., Peng, B., Li, Z., Xu, C., Liu, Y., Zhang, C., Voelcker, N. H., Li, L. & Huang, W., 14 Apr 2019, In : Journal of Materials Chemistry B. 7, 14, p. 2252-2260 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

Sun, Y., Kakinen, A., Zhang, C., Yang, Y., Faridi, A., Davis, T. P., Cao, W., Ke, P. C. & Ding, F., 28 Jun 2019, In : Nanoscale. 11, 24, p. 11933-11945 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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A novel online platform promotes asynchronous class preparation and thought transparency

Shin, J., Gruenberg, K. & Brock, T., 1 Jan 2019, (Accepted/In press) In : Currents in Pharmacy Teaching and Learning. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M. S., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 Jan 2019, In : Oncogene. 38, 20, p. 3824-3842 19 p.

Research output: Contribution to journalArticleResearchpeer-review

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Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Anderson, B., Poole, D. P., Aurelio, L., Ng, G. Z., Fleischmann, M., Kasperkiewicz, P., Morissette, C., Drag, M., van Driel, I. R., Schmidt, B. L., Vanner, S. J., Bunnett, N. & Edgington-Mitchell, L., 16 Sep 2019, In : Scientific Reports. 9, 12 p., 13295.

Research output: Contribution to journalArticleResearchpeer-review

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Application of Low-Frequency Raman Scattering Spectroscopy to Probe in Situ Drug Solubilization in Milk during Digestion

Salim, M., Fraser-Miller, S. J., Sutton, J. J., Berzinš, K., Hawley, A., Clulow, A. J., Beilles, S., Gordon, K. C. & Boyd, B. J., 2 May 2019, In : Journal of Physical Chemistry Letters. 10, 9, p. 2258-2263 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics

Vithani, K., Goyanes, A., Jannin, V., Basit, A. W., Gaisford, S. & Boyd, B. J., 1 Jul 2019, In : Pharmaceutical Research. 36, 7, 13 p., 102.

Research output: Contribution to journalArticleResearchpeer-review

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., Sep 2019, (Accepted/In press) In : Journal of the American Society of Nephrology. 30, 9, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages

Lamkin, D. M., Srivastava, S., Bradshaw, K. P., Betz, J. E., Muy, K. B., Wiese, A. M., Yee, S. K., Waggoner, R. M., Arevalo, J. M. G., Yoon, A. J., Faull, K. F., Sloan, E. K. & Cole, S. W., 2019, In : Brain, Behavior, and Immunity. 80, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Rees, V. E., Deveson Lucas, D. S., López-Causapé, C., Huang, Y., Kotsimbos, T., Bulitta, J. B., Rees, M. C., Barugahare, A., Peleg, A. Y., Nation, R. L., Oliver, A., Boyce, J. D. & Landersdorfer, C. B., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02538-18.

Research output: Contribution to journalArticleResearchpeer-review

Choosing Wisely: Sedatives

Campbell, C., Page, A., Edwards, S., Moles, R., Lee, K., Pisano, A., Jackson, S. L. & Freeman, C. R., May 2019, Australian Pharmacist, 38, 4, p. 70-71 2 p.

Research output: Contribution to specialist publicationArticleOther

Choosing Wisely: Polypharmacy

Campbell, C., Page, A., Edwards, S., Moles, R., Lee, K., Pisano, A., Jackson, S. L. & Freeman, C., 2019, Australian Pharmacist, 38, 3, p. 76-78 3 p.

Research output: Contribution to specialist publicationArticleOther

Circulating epinephrine is not required for chronic stress to enhance metastasis

Walker, A. K., Martelli, D., Ziegler, A. I., Lambert, G. W., Phillips, S. E., Hill, S. J., McAllen, R. M. & Sloan, E. K., 1 Jan 2019, In : Psychoneuroendocrinology. 99, p. 191-195 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, M., Chin, Y. K. Y., Mas, C., Feathers, J. R., Paul, B., Datta, S., Chen, K. E., Jia, X., Yang, Z., Norwood, S. J., Mohanty, B., Bugarcic, A., Teasdale, R. D., Henne, W. M., Mobli, M. & Collins, B. M., 4 Apr 2019, In : Nature Communications. 10, 1, 14 p., 1528.

Research output: Contribution to journalArticleResearchpeer-review

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Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

Ledo, A. M., Sasso, M. S., Bronte, V., Marigo, I., Boyd, B. J., Garcia-Fuentes, M. & Alonso, M. J., 10 Feb 2019, In : Journal of Controlled Release. 295, p. 60-73 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

Vithani, K., Jannin, V., Pouton, C. W. & Boyd, B. J., 2019, In : Advanced Drug Delivery Reviews. 142, p. 16-34 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Comorbid tobacco and other substance use and symptoms of anxiety and depression among hospitalised orthopaedic trauma patients

McCrabb, S., Baker, A. L., Attia, J., Balogh, Z. J., Lott, N., Palazzi, K., Naylor, J., Harris, I. A., Doran, C. M., George, J., Wolfenden, L., Skelton, E. & Bonevski, B., 17 Jan 2019, In : BMC Psychiatry. 19, 1, 9 p., 28.

Research output: Contribution to journalArticleResearchpeer-review

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Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

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Complex Formation between VEGFR2 and the β2-Adrenoceptor

Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

Draper-Joyce, C. & Furness, S. G. B., 26 Jul 2019, In : ACS Pharmacology and Translational Sciences. 2, 4, p. 285-290 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Schneider-Futschik, E. K., Hoyer, D., Khromykh, A. A., Baell, J. B., Marsh, G. A., Baker, M. A., Li, J. & Velkov, T., 1 Nov 2019, In : ACS Infectious Diseases. 5, 1, p. 35-48 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled Construction of Cyclic d / l Peptide Nanorods

Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly

Khor, S. Y., Quinn, J. F., Whittaker, M. R., Truong, N. P. & Davis, T. P., Jan 2019, In : Macromolecular Rapid Communications. 40, 2, 22 p., 1800438.

Research output: Contribution to journalArticleResearchpeer-review

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

Pham, V., Zhu, Y., Dal Maso, E., Reynolds, C. A., Deganutti, G., Atanasio, S., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Furness, S. G. B., Wang, M-W., Wootten, D. & Sexton, P. M., 18 Mar 2019, In : ACS Pharmacology and Translational Sciences. 2, 3, p. 183-197 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Deposition of aminomalononitrile-based films: Kinetics, chemistry, and morphology

Toh, R. J., Evans, R., Thissen, H., Voelcker, N. H., D'ischia, M. & Ball, V., 30 Jul 2019, In : Langmuir. 35, 30, p. 9896-9903 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Deuterated phytantriol – A versatile compound for probing material distribution in liquid crystalline lipid phases using neutron scattering

Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., Boyd, B. J. & Darwish, T. A., 15 Jan 2019, In : Journal of Colloid and Interface Science. 534, p. 399-407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a Shape-Controlled H2S Delivery System Using Epoxide-Functional Nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 2019, In : Journal of Polymer Science, Part A: Polymer Chemistry. 57, 18, p. 1982–1993 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential functionalisation of the internal and external surfaces of carbon-stabilised nanoporous silicon

Alba, M., Robin, M., Menzies, D., Gengenbach, T. R., Prieto-Simon, B. & Voelcker, N. H., 15 Jun 2019, In : Chemical Communications. 55, 55, p. 8001-8004 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients

Rasi Ghaemi, S., Delalat, B., Cavallaro, A., Mierczynska-Vasilev, A., Vasilev, K. & Voelcker, N. H., 1 Sep 2019, In : Advanced Healthcare Materials. 8, 17, 11 p., 1900595.

Research output: Contribution to journalArticleResearchpeer-review

Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes

Li, T., Nowell, C. J., Cipolla, D., Rades, T. & Boyd, B. J., 1 Apr 2019, In : Molecular Pharmaceutics. 16, 4, p. 1775-1781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Dispensing Patterns of Blood Pressure Lowering Agents in Older Australians From 2006 to 2016

Si, S., Ofori-Asenso, R., Briffa, T., Ilomaki, J., Sanfilippo, F., Reid, C. M. & Liew, D., May 2019, In : Journal of Cardiovascular Pharmacology and Therapeutics. 24, 3, p. 242-250 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions

Xu, T., Ding, J., Ge, H., Xu, X., Scammells, P., Wang, B. & Ju, S., 1 Jun 2019, In : Journal of Biomedical Nanotechnology. 15, 6, p. 1325-1333 9 p.

Research output: Contribution to journalArticleResearchpeer-review