Faculty of Pharmacy and Pharmaceutical Sciences

Research Output 1969 2020

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2020

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

Gregory, K., Giraldo, J., Diao, J., Christopoulos, A. & Leach, K., 2020, In : Molecular Pharmacology. 97, 1, p. 35-45 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2019

(S)-(−)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines

Al Amin, M., Camerino, M. A., Mountford, S. J., Ma, X., Manallack, D. T., Chalmers, D. K., Wills, M. & Thompson, P. E., 1 Jan 2019, In : Tetrahedron. 75, 43, p. 1-7 7 p., 130591.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition

Roca-Lapirot, O., Fossat, P., Ma, S., Egron, K., Trigilio, G., López-González, M. J., Covita, J., Bouali-Benazzouz, R., Favereaux, A., Gundlach, A. L. & Landry, M., 1 Feb 2019, In : Pain. 160, 2, p. 345-357 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O’Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. & Brierley, S. M., 19 Sep 2019, In : JCI Insight. 4, 18, 42 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Acute β-adrenoceptor mediated glucose clearance in brown adipose tissue; a distinct pathway independent of functional insulin signaling

Olsen, J. M., Åslund, A., Bokhari, M. H., Hutchinson, D. S. & Bengtsson, T., Dec 2019, In : Molecular Metabolism. 30, p. 240-249 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Adherence, Persistence, and Switching Among People Prescribed Sodium Glucose Co-transporter 2 Inhibitors: A Nationwide Retrospective Cohort Study

Ofori-Asenso, R., Liew, D., Lalic, S., Mazidi, M., Magliano, D. J., Ademi, Z., Bell, J. S. & Ilomaki, J., 3 Sep 2019, (Accepted/In press) In : Advances in Therapy. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Adipocyte-specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice

Whitham, M., Pal, M., Petzold, T., Hjorth, M., Egan, C. L., Brunner, J. S., Estevez, E., Iliades, P., Zivanovic, B., Reibe, S., Hughes, W. E., Findeisen, M., Hidalgo, J. & Febbraio, M. A., 30 Sep 2019, In : American journal of physiology. Endocrinology and metabolism. 317, 4, p. E597-E604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

A fluorogenic probe based on chelation-hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models

Zhang, G., Zhao, Y., Peng, B., Li, Z., Xu, C., Liu, Y., Zhang, C., Voelcker, N. H., Li, L. & Huang, W., 14 Apr 2019, In : Journal of Materials Chemistry B. 7, 14, p. 2252-2260 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

Sun, Y., Kakinen, A., Zhang, C., Yang, Y., Faridi, A., Davis, T. P., Cao, W., Ke, P. C. & Ding, F., 28 Jun 2019, In : Nanoscale. 11, 24, p. 11933-11945 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2 Citations (Scopus)

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

Yang, L., Uboldi, A. D., Seizova, S., Wilde, M. L., Coffey, M. J., Katris, N. J., Yamaryo-Botté, Y., Kocan, M., Bathgate, R. A. D., Stewart, R. J., McConville, M. J., Thompson, P. E., Botté, C. Y. & Tonkin, C. J., 31 May 2019, In : Journal of Biological Chemistry. 294, 22, p. 8959-8972 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

Grace, J. L., Amado, M., Reid, J. C., Elliott, A. G., Landersdorfer, C. B., Truong, N. P., Kempe, K., Cooper, M. A., Davis, T. P., Montembault, V., Pascual, S., Fontaine, L., Velkov, T., Quinn, J. F. & Whittaker, M. R., 21 Nov 2019, In : Journal of Materials Chemistry B. 7, 43, p. 6796-6809 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

Yong, C., Devine, S. M., Gao, X., Yan, A., Callaghan, R., Capuano, B. & Scammells, P. J., 1 Jan 2019, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticleResearchpeer-review

A novel online platform promotes asynchronous class preparation and thought transparency

Shin, J., Gruenberg, K. & Brock, T., 1 Jan 2019, (Accepted/In press) In : Currents in Pharmacy Teaching and Learning. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M. S., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 Jan 2019, In : Oncogene. 38, 20, p. 3824-3842 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

Rodriguez, A., Pedersen, M., Villegas, E., Rivas-Santiago, B., Villegas-Moreno, J., Amero, C., Norton, R. S. & Corzo, G., 1 Jan 2019, (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journalArticleResearchpeer-review

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Ramirez Garcia, P. D., Retamal, J. S., Shenoy, P., Imlach, W., Sykes, M., Truong, N., Constandil, L., Pelissier, T., Nowell, C. J., Khor, S. Y., Layani, L. M., Lumb, C., Poole, D. P., Lieu, T., Stewart, G. D., Mai, Q. N., Jensen, D. D., Latorre, R., Scheff, N. N., Schmidt, B. L. & 5 others, Quinn, J. F., Whittaker, M. R., Veldhuis, N. A., Davis, T. P. & Bunnett, N. W., Dec 2019, In : Nature Nanotechnology. 14, p. 1150-1159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Anderson, B., Poole, D. P., Aurelio, L., Ng, G. Z., Fleischmann, M., Kasperkiewicz, P., Morissette, C., Drag, M., van Driel, I. R., Schmidt, B. L., Vanner, S. J., Bunnett, N. & Edgington-Mitchell, L., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 13295.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Application of Low-Frequency Raman Scattering Spectroscopy to Probe in Situ Drug Solubilization in Milk during Digestion

Salim, M., Fraser-Miller, S. J., Sutton, J. J., Berzinš, K., Hawley, A., Clulow, A. J., Beilles, S., Gordon, K. C. & Boyd, B. J., 2 May 2019, In : Journal of Physical Chemistry Letters. 10, 9, p. 2258-2263 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics

Vithani, K., Goyanes, A., Jannin, V., Basit, A. W., Gaisford, S. & Boyd, B. J., 1 Jul 2019, In : Pharmaceutical Research. 36, 7, 13 p., 102.

Research output: Contribution to journalArticleResearchpeer-review

A sequential native chemical ligation-thiol-Michael addition strategy for polymer-polymer ligation

Rajakanthan, A., Jongh, P. A. J. M. D., Town, J. S., Wilson, P. & Kempe, K., 14 Oct 2019, In : Polymer Chemistry. 10, 38, p. 5242-5250 9 p.

Research output: Contribution to journalArticleResearchpeer-review

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages

Lamkin, D. M., Srivastava, S., Bradshaw, K. P., Betz, J. E., Muy, K. B., Wiese, A. M., Yee, S. K., Waggoner, R. M., Arevalo, J. M. G., Yoon, A. J., Faull, K. F., Sloan, E. K. & Cole, S. W., 2019, In : Brain, Behavior, and Immunity. 80, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Carboxylated Cy5-Labeled Comb Polymers Passively Diffuse the Cell Membrane and Target Mitochondria

Mahmoud, A. M., De Jongh, P. A. J. M., Briere, S., Chen, M., Nowell, C. J., Johnston, A. P. R., Davis, T. P., Haddleton, D. M. & Kempe, K., 28 Aug 2019, In : ACS Applied Materials and Interfaces. 11, 34, p. 31302-31310 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance

Atkins, R. J., Stylli, S. S., Kurganovs, N., Mangiola, S., Nowell, C. J., Ware, T. M., Corcoran, N. M., Brown, D. V., Kaye, A. H., Morokoff, A., Luwor, R. B., Hovens, C. M. & Mantamadiotis, T., 15 Jan 2019, In : Experimental Cell Research. 374, 2, p. 353-364 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Cellular Deformations Induced by Conical Silicon Nanowire Arrays Facilitate Gene Delivery

Chen, Y., Aslanoglou, S., Gervinskas, G., Abdelmaksoud, H., Voelcker, N. H. & Elnathan, R., 10 Oct 2019, (Accepted/In press) In : Small. 1904819.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons

Albert-Gasco, H., Sanchez-Sarasua, S., Ma, S., García-Díaz, C., Gundlach, A. L., Sanchez-Perez, A. M. & Olucha-Bordonau, F. E., 15 Jan 2019, In : Brain Structure and Function. 224, 1, p. 453-469 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Characterisation and 3D structure of melanomacrophage centers in shorthorn sculpins (Myoxocephalus scorpius)

Dang, M., Nowell, C., Nguyen, T., Bach, L., Sonne, C., Nørregaard, R., Stride, M. & Nowak, B., 1 Apr 2019, In : Tissue and Cell. 57, p. 34-41 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Rees, V. E., Deveson Lucas, D. S., López-Causapé, C., Huang, Y., Kotsimbos, T., Bulitta, J. B., Rees, M. C., Barugahare, A., Peleg, A. Y., Nation, R. L., Oliver, A., Boyce, J. D. & Landersdorfer, C. B., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02538-18.

Research output: Contribution to journalArticleResearchpeer-review

Choosing Wisely: Sedatives

Campbell, C., Page, A., Edwards, S., Moles, R., Lee, K., Pisano, A., Jackson, S. L. & Freeman, C. R., May 2019, Australian Pharmacist, 38, 4, p. 70-71 2 p.

Research output: Contribution to specialist publicationArticleOther

Choosing Wisely: Polypharmacy

Campbell, C., Page, A., Edwards, S., Moles, R., Lee, K., Pisano, A., Jackson, S. L. & Freeman, C., 2019, Australian Pharmacist, 38, 3, p. 76-78 3 p.

Research output: Contribution to specialist publicationArticleOther

4 Citations (Scopus)

Circulating epinephrine is not required for chronic stress to enhance metastasis

Walker, A. K., Martelli, D., Ziegler, A. I., Lambert, G. W., Phillips, S. E., Hill, S. J., McAllen, R. M. & Sloan, E. K., 1 Jan 2019, In : Psychoneuroendocrinology. 99, p. 191-195 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, M., Chin, Y. K. Y., Mas, C., Feathers, J. R., Paul, B., Datta, S., Chen, K. E., Jia, X., Yang, Z., Norwood, S. J., Mohanty, B., Bugarcic, A., Teasdale, R. D., Henne, W. M., Mobli, M. & Collins, B. M., 4 Apr 2019, In : Nature Communications. 10, 1, 14 p., 1528.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

Ledo, A. M., Sasso, M. S., Bronte, V., Marigo, I., Boyd, B. J., Garcia-Fuentes, M. & Alonso, M. J., 10 Feb 2019, In : Journal of Controlled Release. 295, p. 60-73 14 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

Vithani, K., Jannin, V., Pouton, C. W. & Boyd, B. J., 2019, In : Advanced Drug Delivery Reviews. 142, p. 16-34 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Comorbid tobacco and other substance use and symptoms of anxiety and depression among hospitalised orthopaedic trauma patients

McCrabb, S., Baker, A. L., Attia, J., Balogh, Z. J., Lott, N., Palazzi, K., Naylor, J., Harris, I. A., Doran, C. M., George, J., Wolfenden, L., Skelton, E. & Bonevski, B., 17 Jan 2019, In : BMC Psychiatry. 19, 1, 9 p., 28.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

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Comparative metabolomics reveals key pathways associated with the synergistic killing of colistin and sulbactam combination against multidrug-resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Creek, D. J., Barlow, C. K., Yu, H. H., Zhou, Z., Zhang, J. & Li, J., 4 Jul 2019, In : Frontiers in Pharmacology. 10, 11 p., 754.

Research output: Contribution to journalArticleResearchpeer-review

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