Research Output 1969 2019

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Review Article
2019

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, 15 May 2019, In : Canadian Journal of Anesthesia. 66, 5, p. 546-561 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Elucidating the mechanisms of psychosocial influences on cancer using preclinical in vivo models

Sloan, E. K. & Walker, A. K., 1 Aug 2019, In : Current Opinion in Behavioral Sciences. 28, p. 129-135 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Interaction of neurotransmitters and neurochemicals with lymphocytes

Kerage, D., Sloan, E. K., Mattarollo, S. R. & McCombe, P. A., 15 Jul 2019, In : Journal of Neuroimmunology. 332, p. 99-111 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Metabolic control and sex: A focus on inflammatory-linked mediators

Henstridge, D. C., Abildgaard, J., Lindegaard, B. & Febbraio, M. A., 28 Feb 2019, (Accepted/In press) In : British Journal of Pharmacology. 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio, M. A., Reibe, S., Shalapour, S., Ooi, G. J., Watt, M. J. & Karin, M., 8 Jan 2019, In : Cell Metabolism. 29, 1, p. 18-26 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relieving ER stress to target NASH-driven hepatocellular carcinoma

Reibe, S. & Febbraio, M. A., 1 Feb 2019, In : Nature Reviews Endocrinology. 15, 2, p. 73-74 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File
2018

Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Pratt, G., Hiller, J., Gottumukkala, V., Sloan, E., Riedel, B. & Schier, R., 1 Jul 2018, In : British Journal of Anaesthesia. 121, 1, p. 45-57 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Perioperative events influence cancer recurrence risk after surgery

Hiller, J. G., Perry, N. J., Poulogiannis, G., Riedel, B. & Sloan, E. K., 1 Apr 2018, In : Nature Reviews Clinical Oncology. 15, 4, p. 205-218 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Peripheral modulation of the endocannabinoid system in metabolic disease

Shrestha, N., Cuffe, J. S. M., Hutchinson, D. S., Headrick, J. P., Perkins, A. V., McAinch, A. J. & Hryciw, D. H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 592-604 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Rules of Engagement: GPCRs and G Proteins

Glukhova, A., Draper-Joyce, C. J., Sunahara, R. K., Christopoulos, A., Wootten, D. L. & Sexton, P. M., 7 Sep 2018, In : ACS Pharmacology and Translational Sciences. 1, 2, p. 73-83 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Structural insights into G-protein-coupled receptor allostery

Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A., 5 Jul 2018, In : Nature. 559, 7712, p. 45-53 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeting adenosine receptor signaling in cancer immunotherapy

Sek, K., Mølck, C., Stewart, G. D., Kats, L., Darcy, P. K. & Beavis, P. A., 1 Dec 2018, In : International Journal of Molecular Sciences. 19, 12, 23 p., 3837.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
2017

Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File

Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Leach, K. & Gregory, K. J., 1 Feb 2017, In : Pharmacological Research. 116, p. 105-118 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury

Chin, K. Y., Qin, C., May, L., Ritchie, R. H. & Woodman, O. L., 1 Jan 2017, In : Current Drug Targets. 18, 15, p. 1689-1711 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeting adenosine receptors for the treatment of cardiac fibrosis

Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In : Frontiers in Pharmacology. 8, MAY, 7 p., 243.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

The actions of relaxin on the human cardiovascular system

Sarwar, M., Du, X. J., Dschietzig, T. B. & Summers, R. J., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 933-949 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Does cannabidiol have a role in the treatment of schizophrenia?

Gururajan, A. & Malone, D. T., Oct 2016, In : Schizophrenia Research. 176, 2-3, p. 281-290 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Long-term consequences of the acute neural-inflammatory stress response in the cancer surgical patient: new findings and perspectives

Riedel, B., Sloan, E. & Forget, P., 1 Nov 2016, In : International Anesthesiology Clinics. 54, 4, p. 58-71 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Pathophysiological roles of proteases in gastrointestinal disease

Edgington-Mitchell, L. E., 15 Feb 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 310, 4, p. G234-G239 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors

Lindsley, C. W., Emmitte, K. A., Hopkins, C. R., Bridges, T. M., Gregory, K. J., Niswender, C. M. & Conn, P. J., 8 Jun 2016, In : Chemical Reviews. 116, 11, p. 6707-6741 35 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts

See Hoe, L. E., May, L. T., Headrick, J. P. & Peart, J. N., Oct 2016, In : British Journal of Pharmacology. 173, 20, p. 2966-2991 26 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2014

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus

Miller, L. J., Sexton, P. M., Dong, M. & Harikumar, K. G., 2014, In : International Journal of Obesity. 4, p. S9-S13 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2013

Age-related changes in the innervation of the prostate gland: implications for prostate cancer initiation and progression

White, C. W., Xie, J. H. & Ventura, S., Jul 2013, In : Organogenesis. 9, 3, p. 206-215 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2011

The role of placental homeobox genes in human fetal growth restriction

Murthi, P., Rajaraman, G., Brennecke, S. P. & Kalionis, B., 2011, In : Journal of Pregnancy. 2011, 11 p., 548171.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
2009

Orthosteric/allosteric bitopic ligands going hybrid with GPCRs

Valant, C., Sexton, P. M. & Christopoulos, A., 1 Jun 2009, In : Molecular Interventions. 9, 3, p. 125-135 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2002

Relaxin 3, a novel member of the insulin/relaxin superfamily of peptide hormones.

Bathgate, R. A. D., Scott, D. J., Samuel, C. S., Burazin, T. CD., Layfield, S., Claasz, A. A., Dawson, N. F., Ma, S., Bond, C., Summers, R. J., Wade, J. D. & Tregear, G. W., 2002, In : Biology of Reproduction.

Research output: Contribution to journalReview ArticleResearchpeer-review

1997

β-adrenoceptor subtypes and their desensitization mechanisms

Summers, R. J., Kompa, A. & Roberts, S. J., 1 Jan 1997, In : Journal of Autonomic Pharmacology. 17, 6, p. 331-343 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1993

Adrenoceptors and Their Second Messenger Systems

Summers, R. J. & McMartin, L. R., 1 Jan 1993, In : Journal of Neurochemistry. 60, 1, p. 10-23 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1989

New views of human cardiac β-adrenoceptors

Jones, C. R., Molenaar, P. & Summers, R. J., 1 Jan 1989, In : Journal of Molecular and Cellular Cardiology. 21, 5, p. 519-535 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1987

Autoradiographic localization of receptors in the cardiovascular system

Summers, R. J., Molenaar, P. & Stephenson, J. A., 1 Jan 1987, In : Trends in Pharmacological Sciences. 8, 7, p. 272-276 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1984

Renal α adrenoceptors

Summers, R. J., 1 Dec 1984, In : Federation Proceedings. 43, 14, p. 2917-2922 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review