Research Output

Article

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

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3 Citations (Scopus)

Instructional design and assessment: a simulated learning environment for teaching medicine dispensing skills

McDowell, J., Styles, K., Sewell, K., Trinder, P., Marriott, J., Maher, S. & Naidu, S., 2016, In : American Journal of Pharmaceutical Education. 80, 1, 11 p., 11.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Interaction of clonidine metabolites with an α-adreno receptor in rat brain membranes

Jarrott, B., Louis, W. J. & Summers, R. J., 1 Jan 1979, In : Clinical and Experimental Pharmacology and Physiology. 6, 6, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : The Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

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20 Citations (Scopus)

International union of basic and clinical pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands

Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R., Pin, J. P., Sexton, P., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J., 2014, In : Pharmacological Reviews. 66, 4, p. 918 - 947 30 p.

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120 Citations (Scopus)
77 Citations (Scopus)

Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain

Sulistio, A., Mansfeld, F. M., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Birkett, S., Blencowe, A., Qiao, G. G., Little, C. B., Shu, C. C., Bendele, A. M., Valade, D., Donohue, A. C., Quinn, J. F., Whittaker, M. R., Davis, T. P. & Tait, R. J., 24 May 2019, In : ACS Applied Bio Materials. 2, 7, p. 2822-2832 11 p.

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1 Citation (Scopus)

Intracerebroventricular administration of the β3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus

Castillo-Meléndez, M., McKinley, M. J. & Summers, R. J., 1 Sep 2000, In : Neuroscience Letters. 290, 3, p. 161-164 4 p.

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12 Citations (Scopus)

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Davey, J. R., Estevez, E., Thomson, R. E., Whitham, M., Watt, K. I., Hagg, A., Qian, H., Henstridge, D. C., Ludlow, H., Hedger, M. P., McGee, S. L., Coughlan, M. T., Febbraio, M. A. & Gregorevic, P., Apr 2020, In : The FASEB Journal. 34, 4, p. 5697-5714 18 p.

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1 Citation (Scopus)

Inverse agonism: A developing concept of drug action

Christopoulos, A. & Mitchelson, F., 1 Aug 1996, In : Australian Journal of Pharmacy. 77, 917, p. 868-871 4 p.

Research output: Contribution to journalArticleResearch

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: Enriching structure-function studies and structure-activity relationships

Gregory, K. J., Noetzel, M. J., Rook, J. M., Vinson, P. N., Stauffer, S. R., Rodriguez, A. L., Emmitte, K. A., Zhou, Y., Chun, A. C., Felts, A. S., Chauder, B. A., Lindsley, C. W., Niswender, C. M. & Conn, P. J., 2012, In : Molecular Pharmacology. 82, 5, p. 860 - 875 16 p.

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65 Citations (Scopus)

Investigation of 5-HT 4 agonist activities using molecular field analysis

Iskander, M., Coupar, I. & Winkler, D. A., 1999, In : Journal of the Chemical Society, Perkin Transactions 2. 2, p. 153-158 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons

Nguyen, T. V., Poole, D. P., Harvey, J. R., Stebbing, M. J. & Furness, J. B., 1 Feb 2005, In : European Journal of Neuroscience. 21, 4, p. 905-913 9 p.

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16 Citations (Scopus)
27 Citations (Scopus)

In vivo formation of cubic phase in situ after oral administration of cubic phase precursor formulation provides long duration gastric retention and absorption for poorly water-soluble drugs

Pham, A., Hong, L., Montagnat, O., Nowell, C., Nguyen, T-H. & Boyd, B. J., 4 Jan 2016, In : Molecular Pharmaceutics. 13, 1, p. 280-286 7 p.

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12 Citations (Scopus)

Involvement of rho-kinase signaling pathways in nerve evoked and spontaneous contractions of the guinea pig prostate

Lam, M., Kerr, K. P. & Exintaris, B., 2013, In : Journal of Urology. 189, 3, p. 1147 - 1154 8 p.

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5 Citations (Scopus)

Ionophore and Biometal Modulation of P-glycoprotein Expression and Function in Human Brain Microvascular Endothelial Cells

McInerney, M. P., Volitakis, I., Bush, A. I., Banks, W. A., Short, J. L. & Nicolazzo, J. A., 1 Apr 2018, In : Pharmaceutical Research. 35, 4, 12 p., 83.

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6 Citations (Scopus)

IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity

Freihat, L. A., Wheeler, J. I., Wong, A., Turek, I., Manallack, D. T. & Irving, H. R., Oct 2019, In : Scientific Reports. 9, 12 p., 15468.

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1 Citation (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

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12 Citations (Scopus)

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, 13 p., eaai8529.

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17 Citations (Scopus)
23 Citations (Scopus)

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

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8 Citations (Scopus)

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an 'infinite dilution' procedure

Christopoulos, A., Lanzafame, A., Ziegler, A. & Mitchelson, F., 21 Mar 1997, In : Biochemical Pharmacology. 53, 6, p. 795-800 6 p.

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23 Citations (Scopus)

Labeling of α2-adrenoceptors in rat cerebral cortex with 3H-guanfacine

Summers, R. J., Jarrott, B. & Louis, W. J., 1 Jan 1981, In : Clinical and Experimental Pharmacology and Physiology. 8, 6

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1 Citation (Scopus)

L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells

Mun, H. C., Leach, K. M. & Conigrave, A. D., 1 Jan 2019, In : Endocrinology. 160, 7, p. 1590-1599 10 p.

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1 Citation (Scopus)

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

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14 Citations (Scopus)

Lifting the lid on GPCRs: the role of extracellular loops

Wheatley, M., Wootten, D. L., Conner, M., Simms, J. W., Kendrick, R., Logan, R. T., Poyner, D. R. & Barwell, J., 2012, In : British Journal of Pharmacology. 165, 6, p. 1688 - 1703 16 p.

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149 Citations (Scopus)

Ligand binding and subtype selectivity of the human A2A adenosine receptor: Identification and characterization of essential amino acid residues

Jaakola, V-P., Lane, J., Lin, J., Katritch, V., IJzerman, A. P. & Stevens, R., 2010, In : The Journal of Biological Chemistry. 285, 17, p. 13032 - 13044 13 p.

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73 Citations (Scopus)

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

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64 Citations (Scopus)

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

Civciristov, S., Huang, C., Liu, B., Marquez, E. A., Gondin, A. B., Schittenhelm, R. B., Ellisdon, A. M., Canals, M. & Halls, M. L., 1 Nov 2019, In : The Journal of Biological Chemistry. 294, 44, p. 16198-16213 16 p.

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2 Citations (Scopus)

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

Stallaert, W., Christopoulos, A. & Bouvier, M., 2011, In : Expert Opinion on Drug Discovery. 6, 8, p. 811 - 825 15 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)
35 Citations (Scopus)

Light microscopic autoradiography of the distribution of [3H]rauwolscine binding to α2-adrenoceptors in rat kidney

Stephenson, J. A. & Summers, R. J., 22 Oct 1985, In : European Journal of Pharmacology. 116, 3, p. 271-278 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Yu, S. H., Patra, M., Ferrari, S., Ramirez Garcia, P., Veldhuis, N. A., Kaminskas, L. M., Graham, B., Quinn, J. F., Whittaker, M. R., Gasser, G. & Davis, T. P., 29 Oct 2018, In : Journal of Materials Chemistry B. 6, 47, p. 7805-7810 6 p.

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4 Citations (Scopus)

Lipid-based formulations and drug supersaturation: Harnessing the unique benefits of the lipid digestion/absorption pathway

Williams, H. D., Trevaskis, N., Yeap, Y. Y., Anby, M. U., Pouton, C. W. & Porter, C. J., 2013, In : Pharmaceutical Research. 30, 12, p. 2976 - 2992 17 p.

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68 Citations (Scopus)

Liver and biliary tract physiology/pathophysiology: Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice

Tarasco, E., Pellegrini, G., Whiting, L. & Lutz, T. A., 5 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G602-G617 16 p.

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3 Citations (Scopus)

Living free-radical polymerization by reversible addition - Fragmentation chain transfer: The RAFT process

Chiefari, J., Chong, Y. K., Ercole, F., Krstina, J., Jeffery, J., Le, T. P. T., Mayadunne, R. T. A., Meijs, G. F., Moad, C. L., Moad, G., Rizzardo, E. & Thang, S. H., 11 Aug 1998, In : Macromolecules. 31, 16, p. 5559-5562 4 p.

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4134 Citations (Scopus)

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

Zanker, D., Pang, K., Oveissi, S., Lu, C., Faou, P., Nowell, C., Mbogo, G. W., Carotta, S., Quillici, C., Karupiah, G., Hibbs, M. L., Nutt, S. L., Neeson, P., Puthalakath, H. & Chen, W., 1 Oct 2018, In : Immunology and Cell Biology. 96, 9, p. 981-993 13 p.

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3 Citations (Scopus)

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

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8 Citations (Scopus)

Localisation of [3H]-clonidine binding in guinea pig kidney

Jarrott, B. & Summers, R. J., 1 Jan 1978, In : British Journal of Pharmacology. 64, 3

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6 Citations (Scopus)

Localisation of [3H]clonidine binding to membranes from guinea pig renal tubules

McPherson, G. A. & Summers, R. J., 15 Feb 1982, In : Biochemical Pharmacology. 31, 4, p. 583-587 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Localization and characterization of two propranolol resistant (-) [125I]cyanopindolol binding sites in rat skeletal muscle

Molenaar, P., Roberts, S. J., Kim, Y. S., Pak, H. S., Sainz, R. D. & Summers, R. J., 17 Dec 1991, In : European Journal of Pharmacology. 209, 3, p. 257-262 6 p.

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34 Citations (Scopus)

Localization and function of components of the β-adrenergic system in human and blood vessels

Summers, R. J., 1 Jul 1990, In : European Journal of Pharmacology. 183, 1, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice

Poole, D., Pelayo, J-C., Scherrer, G., Evans, C., Kieffer, B. & Bunnett, N., 2011, In : Gastroenterology. 141, 3, p. 982 - 991 10 p.

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42 Citations (Scopus)

Localization of (-)-[125I]cyanopindolol binding in guinea-pig heart: characteristics of non-β-adrenoceptor related binding in cardiac pacemaker and conducting regions

Molenaar, P., Kompa, A. R., Roberts, S. J., Pak, H. S. & Summers, R. J., 17 Feb 1992, In : Neuroscience Letters. 136, 1, p. 118-122 5 p.

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6 Citations (Scopus)

Localization of [3H]clonidine binding sites in membranes prepared from guinea pig renal cortex

McPherson, G. & Summers, R. J., 1 Jan 1980, In : Clinical and Experimental Pharmacology and Physiology. 7, 6, p. 659-660 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Localization of beta adrenoceptor subtypes in rat kidney by light microscopic autoradiography

Summers, R. J., Stephenson, J. A. & Kuhar, M. J., 1 Jan 1985, In : Journal of Pharmacology and Experimental Therapeutics. 232, 2, p. 561-569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat

Cottrell, G., Roosterman, D., Marvizon, J-C., Song, B., Wick, E., Pikios, S., Wong, H., Berthelier, C., Tang, Y., Sternini, C., Bunnett, N. & Grady, E., 2005, In : The Journal of Comparative Neurology. 490, 3, p. 239 - 255 17 p.

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84 Citations (Scopus)