Research Output

FUNCTION, CHARACTERIZATION AND AUTORADIOGRAPHIC LOCALIZATION AND QUANTITATION OF β‐ADRENOCEPTORS IN CARDIAC TISSUES

Molenaar, P., Russell, F. D., Shimada, T. & Summers, R. J., 1 Jan 1989, In : Clinical and Experimental Pharmacology and Physiology. 16, 6, p. 529-533 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Functional analysis of desensitization of the β-adrenoceptor signalling pathway in rat cardiac tissues following chronic isoprenaline infusion

McMartin, L. & Summers, R. J., 6 Jul 1999, In : British Journal of Pharmacology. 127, 4, p. 1012-1020 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Functional and structural perspectives on allosteric modulation of GPCRs

Langmead, C. J. & Christopoulos, A., 2014, In : Current Opinion in Cell Biology. 27, 1, p. 94 - 101 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms

Ruder, T., Ali, S. A., Ormerod, K., Brust, A., Roymanchadi, M-L., Ventura, S., Undheim, E. A. B., Jackson, T. N. W., Mercier, A. J., King, G. F., Alewood, P. F. & Fry, B. G., 2013, In : Peptides. 47, p. 71 - 76 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

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14 Citations (Scopus)

G-CSF receptor blockade ameliorates arthritic pain and disease

Lee, M. C., McCubbin, J. A., Christensen, A. D., Poole, D. P., Rajasekhar, P., Lieu, T., Bunnett, N. W., Garcia-Caraballo, S., Erickson, A., Brierley, S. M., Saleh, R., Achuthan, A., Fleetwood, A. J., Anderson, R. L., Hamilton, J. A. & Cook, A. D., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3565-3575 11 p.

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14 Citations (Scopus)

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Halls, M. L. & Canals, M., 1 Feb 2018, In : Trends in Pharmacological Sciences. 39, 2, p. 148-157 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

Koole, C., Reynolds, C. A., Mobarec, J. C., Hick, C., Sexton, P. M. & Sakmar, T. P., 28 Apr 2017, In : The Journal of Biological Chemistry. 292, 17, p. 7131-7144 14 p.

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27 Citations (Scopus)

Genetic reporter cell lines: tools for stem cell biology and drug discovery

Hunt, C. P. J., Watmuff, B., Hartley, B. J., Pouton, C. W. & Haynes, J. M., 2015, Neural Stem Cell Assays. Kaur, N. & Vemuri, M. C. (eds.). Hoboken NJ USA: John Wiley & Sons, p. 251-260 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D. L., Pinon, D. I., Koole, C. R., Ball, A. M., Furness, S. GB., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607 - 18612 6 p.

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44 Citations (Scopus)

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandstrom, A. L., Pisani, D. F., Chambard, J-C., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., 2014, In : Journal of Cell Biology. 207, 3, p. 365 - 374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Glyceride lipid formulations: Molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients

Warren, D., King, D. T., Benameur, H., Pouton, C. W. & Chalmers, D. K., 2013, In : Pharmaceutical Research. 30, 12, p. 3238 - 3253 16 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

GPBA: A GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Lieu, T. M., Jayaweera, G. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 5, p. 1156 - 1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

Research output: Contribution to journalArticleOther

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27 Citations (Scopus)

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition & Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

G protein-coupled receptors as anabolic drug targets in osteoporosis

Diepenhorst, N., Rueda, P., Cook, A. E., Pastoureau, P., Sabatini, M. & Langmead, C. J., 1 Apr 2018, In : Pharmacology and Therapeutics. 184, p. 1-12 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)
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1 Citation (Scopus)

G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

7 Citations (Scopus)

G protein coupling and ligand selectivity of the D2L and D 3 dopamine receptors

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 1, p. 319 - 330 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Granulocyte-macrophage colony stimulating factor as an indirect mediator of nociceptor activation and pain

Tewari, D., Cook, A., Lee, M. C., Christensen, A. D., Croxford, A. L., Becher, B., Poole, D. P., Rajasekhar, P., Bunnett, N., Smith, J. E., Hamilton, J. A. & McMahon, S. B., 11 Mar 2020, In : Journal of Neuroscience. 40, 11, p. 2189-2199 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

Haemodynamic response to simulated haemorrhage in the rabbit: Interaction of i.V. Anaesthesia and hypoxia

Blake, D. W., Van Leeuwen, F., Petring, O. U., Ludbrook, J. & Ventura, S., 1 Jan 1995, In : British Journal of Anaesthesia. 75, 5, p. 610-615 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Haplotyping the human leukocyte antigen system from single chromosomes

Murphy, N. M., Burton, M., Powell, D. R., Rossello, F. J., Cooper, D., Chopra, A., Hsieh, M. J., Sayer, D. C., Gordon, L., Pertile, M. D., Tait, B. D., Irving, H. R. & Pouton, C. W., 27 Jul 2016, In : Scientific Reports. 6, 9 p., 30381.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Powell, K. L., Jones, N. C., Kennard, J. T., Ng, C., Urmaliya, V., Lau, S., Tran, A., Zheng, T., Ozturk, E., Dezsi, G., Megatia, I., Delbridge, L. M. D., Pinault, D., Reid, C. A., White, P. J. & O'Brien, T. J., 2014, In : Epilepsia. 55, 4, p. 609 - 620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor

Hasdemir, B., Bunnett, N. & Cottrell, G., 2007, In : The Journal of Biological Chemistry. 282, 40, p. 29646 - 29657 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Heterogeneity of α1‐adrenoceptors in the guinea‐pig uterus

Haynes, J. M. & Pennefather, J. N., 1993, In : Journal of Autonomic Pharmacology. 13, 5, p. 305-314 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgenindependent prostate cancer cells

Xie, J., Mølck, C., Paquet-Fifield, S., Butler, L., Australian Prostate Cancer BioResource, Sloan, E., Ventura, S. & Hollande, F., 7 Jun 2016, In : Oncotarget. 7, 28, p. 44492-44504 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

High molecular weight DNA enrichment with peptide nucleic acid probes

Murphy, N. M., Pouton, C. W. & Irving, H. R., 2017, Haplotyping: Methods and Protocols. Tiemann-Boege, I. & Betancourt, A. (eds.). New York NY USA: Humana Press, Vol. 1551. p. 73-85 13 p. (Methods in Molecular Biology; vol. 1551).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation

McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R. D. & Capuano, B., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1622 - 1634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

How an activation signal is transmitted through an excitatory receptor

Gregory, K. J., 7 Feb 2019, In : Nature. 566, 7742, p. 42-43 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes

Murphy, N., Pouton, C. W. & Irving, H. R., 2014, In : Molecular Genetics and Genomic Medicine. 2, 3, p. 245 - 253 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

Watmuff, B., Hartley, B. J., Hunt, C. P. J., Fabb, S. A., Pouton, C. W. & Haynes, J. M., 31 Mar 2015, In : Frontiers in Cellular Neuroscience. 9, 15 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

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9 Citations (Scopus)

Hybrid ortho/allosteric ligands for the adenosine A1 receptor

Narlawar, R., Lane, J., Doddareddy, M., Lin, J., Brussee, J. & IJzerman, A. P., 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3028 - 3037 10 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Zhu, C., Schneider, E. K., Nikolaou, V., Klein, T., Li, J., Davis, T. P., Whittaker, M. R., Wilson, P., Kempe, K., Velkov, T. & Haddleton, D. M., 19 Jul 2017, In : Bioconjugate Chemistry. 28, 7, p. 1916-1924 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Duerrauer, L., Muratspahić, E., Gattringer, J., Keov, P., Mendel, H. C., Pfleger, K. D. G., Muttenthaler, M. & Gruber, C. W., 17 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 19295.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Identification of global and ligand-specific calcium sensing receptor activation mechanisms S

Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor

Leach, K., Wen, C., Davey, A. E., Sexton, P. M., Conigrave, A. D. & Christopoulos, A., 2012, In : Endocrinology. 153, 9, p. 4304 - 4316 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., Jun 2020, In : Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 104-115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

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5 Citations (Scopus)

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

Jalan-Sakrikar, N., Field, J. R., Klar, R., Mattmann, M. E., Gregory, K. J., Zamorano, R., Engers, D. W., Bollinger, S. R., Weaver, C. D., Days, E., Lewis, L. M., Utley, T. J., Hurtado, M. A., Rigault, D., Acher, F. C., Walker, A. G., Melancon, B. J., Wood, M. R., Lindsley, C. W., Conn, P. J. & 3 others, Xiang, Z., Hopkins, C. R. & Niswender, C. M., 2014, In : ACS Chemical Neuroscience. 5, 12, p. 1221 - 1237 17 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site

Gregory, K. J., Nguyen, E. D., Malosh, C. F., Mendenhall, J. L., Zic, J. Z., Bates, B. S., Noetzel, M. J., Squire, E. F., Turner, E. M., Rook, J. M., Emmitte, K. A., Stauffer, S. R., Lindsley, C. W., Meiler, J. & Conn, P. J., 2014, In : ACS Chemical Neuroscience. 5, 4, p. 282 - 295 14 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)