Research Output

2015

A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Fleming, C. L., Ashton, T., Nowell, C., Devlin, M., Natoli, A., Schreuders, J. & Pfeffer, F. M., 7 May 2015, In : Chemical Communications. 51, 37, p. 7827-7830 4 p.

Research output: Contribution to journalLetterResearchpeer-review

19 Citations (Scopus)

Allosteric modulation of chemokine receptors

Tschammer, N., Christopoulos, A. & Kenakin, T., 2015, Chemokines: Chemokines and Their Receptors in Drug Discovery. Tschammer, N. (ed.). Cham Switzerland: Springer, p. 87-117 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

3 Citations (Scopus)

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G., Kimpton, W., Nowell, C., Samuel, C. & Snibson, K., 2015, In : Experimental Lung Research. 41, 3, p. 115-134 20 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Antibodies: Friend or foe?

Bron, R. & Bunnett, N. W., 1 Nov 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 9, p. G717-G718 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)

A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model

Imlach, W. L., Bhola, R. F., May, L. T., Christopoulos, A. & Christie, M. J., 2015, In : Molecular Pharmacology. 88, 3, p. 460-468 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

Szabo, M., Huynh, T., Valant, C., Lane, J. R., Sexton, P. M., Christopoulos, A. & Capuano, B., 2015, In : MedChemComm. 6, 11, p. 1998-2003 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptors

Khajehali, E., Malone, D. T., Glass, M., Sexton, P., Christopoulos, A. & Leach, K., 2015, In : Molecular Pharmacology. 88, 2, p. 368-379 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Biased agonism of endogenous opioid peptides at the μ-opioid receptor

Thompson, G. L., Lane, J. R. D., Coudrat, T., Sexton, P., Christopoulos, A. & Canals, M., 2015, In : Molecular Pharmacology. 88, 2, p. 335-346 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P., Scammells, P. J., Conigrave, A., Christopoulos, A. & Leach, K., 2015, In : British Journal of Pharmacology. 172, 1, p. 185 - 200 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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46 Citations (Scopus)

Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents

Rook, J. M., Xiang, Z., Lv, X., Ghoshal, A., Dickerson, J. W., Bridges, T. M., Johnson, K. A., Foster, D. J., Gregory, K. J., Vinson, P. N., Thompson, A. D., Byun, N., Collier, R. L., Bubser, M., Nebelcovych, M. T., Gould, R. W., Stauffer, S. R., Daniels, J. S., Niswender, C. M., Lavreysen, H. & 10 others, Mackie, C., Conde-Ceide, S., Alcazar, J., Bartolome-Nebreda, J. M., Macdonald, G. J., Talpos, J. C., Steckler, T., Jones, C. K., Lindsley, C. W. & Conn, P. J., 2015, In : Neuron. 86, 4, p. 1029-1040 12 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

Jin, L., Boyd, B. J., White, P. J., Pennington, M. W., Norton, R. S. & Nicolazzo, J., 2015, In : Journal of Controlled Release. 199, p. 37 - 44 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Bunnett named editor of AJP–GI

Bunnett, N., 2015, The Physiologist Magazine, 58, 2, p. 92 1 p.

Research output: Contribution to specialist publicationEditorialOther

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Qin, C. H., Yang, Y. H., May, L. T., Gao, X-M., Stewart, A. G., Tu, Y., Woodman, O. L. & Ritchie, R. H., 2015, In : Pharmacology and Therapeutics. 148, p. 47 - 65 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

30 Citations (Scopus)

Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes

Yun, B., Azad, M. A. K., Nowell, C. J., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7489-7496 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)
2 Citations (Scopus)

Conserved functional motifs and homology modeling to predict hidden moonlighting functional sites

Wong, A., Gehring, C. & Irving, H. R., 2015, In : Frontiers in Bioengineering and Biotechnology. 3, p. 1-8 8 p., 82.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Corrigendum: CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

Xie, W., Fisher, J. T., Lynch, T. J., Luo, M., Evans, T. I. A., Neff, T. L., Zhou, W., Zhang, Y., Ou, Y., Bunnett, N. W., Russo, A. F., Goodheart, M. J., Parekh, K. R., Liu, X. & Engelhardt, J. F., 1 May 2015, In : Journal of Clinical Investigation. 125, 5, p. 2179 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

Edgington-Mitchell, L. E., Rautela, J., Duivenvoorden, H. M., Jayatilleke, K. M., van der Linden, W. A., Verdoes, M., Bogyo, M. & Parker, B. S., 2015, In : Oncotarget. 6, 29, p. 27008-27022 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
Open Access
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6 Citations (Scopus)

Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging

Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. & Canals, M., 2015, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols. Filizola, M. (ed.). 2 ed. New York NY USA: Springer, Vol. 1335. p. 131-161 31 p. (Methods in Molecular Biology; vol. 1335, no. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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14 Citations (Scopus)

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P., Haines, D. R. & Miller, L. J., 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Development of a P2X1-purinoceptor mediated contractile response in the aged mouse prostate gland through slowing down of ATP breakdown

White, C. W., Short, J. L., Evans, R. J. & Ventura, S., 2015, In : Neurourology and Urodynamics. 34, 3, p. 292-298 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
Open Access
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12 Citations (Scopus)

Differential use of autophagy by primary dendritic cells specialized in cross-presentation

Mintern, J. D., Macri, C., Chin, W. J., Panozza, S. E., Segura, E., Patterson, N. L., Zeller, P., Bourges, D., Bedoui, S., McMillan, P., Idris, A., Nowell, C. J., Brown, A., Radford, K. J., Johnston, A. & Villadangos, J. A., 2015, In : Autophagy. 11, 6, p. 906-917 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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42 Citations (Scopus)

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

Burford, N. T., Livingston, K. E., Canals, M., Ryan, M. R., Budenholzer, L. M. L., Han, Y., Shang, Y., Herbst, J. J., O'Connell, J., Banks, M., Zhang, L., Filizola, M., Bassoni, D. L., Wehrman, T. S., Christopoulos, A., Traynor, J. R., Gerritz, S. W. & Alt, A., 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4220-4229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties

Christopher, J. A., Aves, S. J., Brown, J., Errey, J. C., Klair, S. S., Langmead, C. J., Mace, O. J., Mould, R., Patel, J. C., Tehan, B. G., Zhukov, A., Marshall, F. H. & Congreve, M., 1 May 2015, In : MedChemComm. 6, 5, p. 947-955 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Distribution of 5-HT3, 5-HT4, and 5-HT7 receptors along the human colon

Yaakob, N. S., Chinkwo, K. A., Chetty, N., Coupar, I. M. & Irving, H. R., 2015, In : Journal of Neurogastroenterology and Motility. 21, 3, p. 361-369 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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61 Citations (Scopus)

Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights

Mehta, D., Short, J. L., Hilmer, S. N. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 3, p. 819 - 839 21 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Endogenous allosteric modulators of G protein-coupled receptors

Van Der Westhuizen, E. T., Valant, C., Sexton, P. & Christopoulos, A., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 2, p. 246 - 260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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66 Citations (Scopus)

Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging

Pham, A. C., Nguyen, T-H., Nowell, C. J., Graham, B. & Boyd, B. J., 2015, In : Drug Delivery and Translational Research. 5, 6, p. 566-574 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Facile one-step micropatterning using photodegradable gelatin hydrogels for improved cardiomyocyte organization and alignment

Tsang, K. M. C., Annabi, N., Ercole, F., Zhou, K., Karst, D. J., Li, F., Haynes, J. M., Evans, R. A., Thissen, H., Khademhosseini, A. & Forsythe, J. S., 2015, In : Advanced Functional Materials. 25, 6, p. 977 - 986 10 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : The Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Genetic reporter cell lines: tools for stem cell biology and drug discovery

Hunt, C. P. J., Watmuff, B., Hartley, B. J., Pouton, C. W. & Haynes, J. M., 2015, Neural Stem Cell Assays. Kaur, N. & Vemuri, M. C. (eds.). Hoboken NJ USA: John Wiley & Sons, p. 251-260 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

Research output: Contribution to journalArticleOther

Open Access
26 Citations (Scopus)

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

Watmuff, B., Hartley, B. J., Hunt, C. P. J., Fabb, S. A., Pouton, C. W. & Haynes, J. M., 31 Mar 2015, In : Frontiers in Cellular Neuroscience. 9, 15 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
74 Citations (Scopus)

In vitro differentiation of pluripotent stem cells towards either forebrain GABAergic or midbrain dopaminergic neurons

Hartley, B. J., Watmuff, B., Hunt, C. P. J., Haynes, J. M. & Pouton, C. W., 30 Jan 2015, Neural Stem Cell Assays. Kaur, N. & Vemuri, M. C. (eds.). Hoboken NJ USA: John Wiley & Sons, p. 91-99 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Mapping of the Australian Qualifications Framework standards onto an undergraduate Bachelor of Pharmacy course

Malone, D. T., Short, J. L., Naidu, S., White, P. J. & Kirkpatrick, C. M., 2015, In : Pharmacy Education. 15, 1, p. 261-269 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Mechanisms of chemotherapy-induced behavioral toxicities

Vichaya, E. G., Chiu, G. S., Krukowski, K., Lacourt, T. E., Kavelaars, A., Dantzer, R., Heijnen, C. J. & Walker, A. K., 2015, In : Frontiers in Neuroscience. 9, 17 p., 131.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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75 Citations (Scopus)

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 others, Fagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
364 Citations (Scopus)

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

Kaminskas, L. M., McLeod, V. M., Ascher, D. B., Ryan, G., Jones, S. A., Haynes, J. M., Trevaskis, N., Chan, L. J., Sloan, E. K., Finnin, B. A. L., Williamson, M. M., Velkov, T., Williams, E. D., Kelly, B., Owen, D. J. & Porter, C. J., 2015, In : Molecular Pharmaceutics. 12, 2, p. 432 - 443 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Molecular insights into metabotropic glutamate receptor allosteric modulations

Gregory, K. J. & Conn, P. J., 1 Jul 2015, In : Molecular Pharmacology. 88, 1, p. 188-202 15 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

31 Citations (Scopus)

Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)