Research Output

Article

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

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25 Citations (Scopus)

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

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27 Citations (Scopus)

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

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62 Citations (Scopus)
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1 Citation (Scopus)

G protein coupling and ligand selectivity of the D2L and D 3 dopamine receptors

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 1, p. 319 - 330 12 p.

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41 Citations (Scopus)

Granulocyte-macrophage colony stimulating factor as an indirect mediator of nociceptor activation and pain

Tewari, D., Cook, A., Lee, M. C., Christensen, A. D., Croxford, A. L., Becher, B., Poole, D. P., Rajasekhar, P., Bunnett, N., Smith, J. E., Hamilton, J. A. & McMahon, S. B., 11 Mar 2020, In : Journal of Neuroscience. 40, 11, p. 2189-2199 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

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4 Citations (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

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4 Citations (Scopus)

Haemodynamic response to simulated haemorrhage in the rabbit: Interaction of i.V. Anaesthesia and hypoxia

Blake, D. W., Van Leeuwen, F., Petring, O. U., Ludbrook, J. & Ventura, S., 1 Jan 1995, In : British Journal of Anaesthesia. 75, 5, p. 610-615 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Haplotyping the human leukocyte antigen system from single chromosomes

Murphy, N. M., Burton, M., Powell, D. R., Rossello, F. J., Cooper, D., Chopra, A., Hsieh, M. J., Sayer, D. C., Gordon, L., Pertile, M. D., Tait, B. D., Irving, H. R. & Pouton, C. W., 27 Jul 2016, In : Scientific Reports. 6, 9 p., 30381.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Powell, K. L., Jones, N. C., Kennard, J. T., Ng, C., Urmaliya, V., Lau, S., Tran, A., Zheng, T., Ozturk, E., Dezsi, G., Megatia, I., Delbridge, L. M. D., Pinault, D., Reid, C. A., White, P. J. & O'Brien, T. J., 2014, In : Epilepsia. 55, 4, p. 609 - 620 12 p.

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20 Citations (Scopus)

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor

Hasdemir, B., Bunnett, N. & Cottrell, G., 2007, In : The Journal of Biological Chemistry. 282, 40, p. 29646 - 29657 12 p.

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58 Citations (Scopus)

Heterogeneity of α1‐adrenoceptors in the guinea‐pig uterus

Haynes, J. M. & Pennefather, J. N., 1993, In : Journal of Autonomic Pharmacology. 13, 5, p. 305-314 10 p.

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8 Citations (Scopus)

High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgenindependent prostate cancer cells

Xie, J., Mølck, C., Paquet-Fifield, S., Butler, L., Australian Prostate Cancer BioResource, Sloan, E., Ventura, S. & Hollande, F., 7 Jun 2016, In : Oncotarget. 7, 28, p. 44492-44504 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

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3 Citations (Scopus)

Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation

McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R. D. & Capuano, B., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1622 - 1634 13 p.

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34 Citations (Scopus)

How an activation signal is transmitted through an excitatory receptor

Gregory, K. J., 7 Feb 2019, In : Nature. 566, 7742, p. 42-43 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes

Murphy, N., Pouton, C. W. & Irving, H. R., 2014, In : Molecular Genetics and Genomic Medicine. 2, 3, p. 245 - 253 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

Watmuff, B., Hartley, B. J., Hunt, C. P. J., Fabb, S. A., Pouton, C. W. & Haynes, J. M., 31 Mar 2015, In : Frontiers in Cellular Neuroscience. 9, 15 p., 104.

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9 Citations (Scopus)

Hybrid ortho/allosteric ligands for the adenosine A1 receptor

Narlawar, R., Lane, J., Doddareddy, M., Lin, J., Brussee, J. & IJzerman, A. P., 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3028 - 3037 10 p.

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64 Citations (Scopus)

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Zhu, C., Schneider, E. K., Nikolaou, V., Klein, T., Li, J., Davis, T. P., Whittaker, M. R., Wilson, P., Kempe, K., Velkov, T. & Haddleton, D. M., 19 Jul 2017, In : Bioconjugate Chemistry. 28, 7, p. 1916-1924 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Duerrauer, L., Muratspahić, E., Gattringer, J., Keov, P., Mendel, H. C., Pfleger, K. D. G., Muttenthaler, M. & Gruber, C. W., 17 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 19295.

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2 Citations (Scopus)

Identification of global and ligand-specific calcium sensing receptor activation mechanisms S

Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor

Leach, K., Wen, C., Davey, A. E., Sexton, P. M., Conigrave, A. D. & Christopoulos, A., 2012, In : Endocrinology. 153, 9, p. 4304 - 4316 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., Jun 2020, In : Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 104-115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

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5 Citations (Scopus)

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

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19 Citations (Scopus)

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

Jalan-Sakrikar, N., Field, J. R., Klar, R., Mattmann, M. E., Gregory, K. J., Zamorano, R., Engers, D. W., Bollinger, S. R., Weaver, C. D., Days, E., Lewis, L. M., Utley, T. J., Hurtado, M. A., Rigault, D., Acher, F. C., Walker, A. G., Melancon, B. J., Wood, M. R., Lindsley, C. W., Conn, P. J. & 3 others, Xiang, Z., Hopkins, C. R. & Niswender, C. M., 2014, In : ACS Chemical Neuroscience. 5, 12, p. 1221 - 1237 17 p.

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36 Citations (Scopus)

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site

Gregory, K. J., Nguyen, E. D., Malosh, C. F., Mendenhall, J. L., Zic, J. Z., Bates, B. S., Noetzel, M. J., Squire, E. F., Turner, E. M., Rook, J. M., Emmitte, K. A., Stauffer, S. R., Lindsley, C. W., Meiler, J. & Conn, P. J., 2014, In : ACS Chemical Neuroscience. 5, 4, p. 282 - 295 14 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Imidazolidinone nitroxide-mediated polymerization

Chong, Y. K., Ercole, F., Moad, G., Rizzardo, E., Thang, S. H. & Anderson, A. G., 19 Oct 1999, In : Macromolecules. 32, 21, p. 6902-6903 2 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., Feelisch, M., O'Sullivan, A. G., Christopoulos, A., Sverdlov, A. L., Ngo, D., Dautov, R., James, P. E., Horowitz, J. D. & Frenneaux, M. P., 2013, In : British Journal of Pharmacology. 169, 3, p. 659 - 670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators

Leach, K., Wen, C., Cook, A. E., Sexton, P., Conigrave, A. & Christopoulos, A., 2013, In : Endocrinology. 154, 3, p. 1105 - 1116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Impact of species variability and "probe-dependence" on the detection and in vivo validation of allosteric modulation at the M(4) muscarinic acetylcholine receptor

Suratman, N. S., Leach, K., Sexton, P., Felder, C. C., Loiacono, R. & Christopoulos, A., 2011, In : British Journal of Pharmacology. 162, 7, p. 1659 - 1670 12 p.

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44 Citations (Scopus)

Impaired pain sensation in mice lacking prokineticin 2

Hu, W-P., Zhang, C., Li, J-D., Luo, Z., Amadesi, S., Bunnett, N. & Zhou, Q-Y., 2006, In : Molecular Pain. 2, 35, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis

Dubowitz, J. A., Sloan, E. K. & Riedel, B. J., Apr 2018, In : Clinical and Experimental Metastasis. 35, 4, p. 347-358 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Coudrat, T., Simms, J., Christopoulos, A., Wootten, D. & Sexton, P. M., 1 Nov 2017, In : PLoS Computational Biology. 13, 11, 40 p., e1005819.

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5 Citations (Scopus)

Increased cardiomyocyte alignment and intracellular calcium transients using micropatterned and drug-releasing poly(glycerol sebacate) elastomers

Zhu, C., Rodda, A. E., Truong, V. X., Shi, Y., Zhou, K., Haynes, J. M., Wang, B., Cook, W. D. & Forsythe, J. S., 2018, In : ACS Biomaterials Science & Engineering. 4, 7, p. 2494-2504 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Induced pluripotent stem cell-derived podocyte-like cells as models for assessing mechanisms underlying heritable disease phenotype: Initial studies using two alport syndrome patient lines indicate impaired potassium channel activity

Haynes, J. M., Selby, J. N., Vandekolk, T. H., Abad, I. P. L., Ho, J. K., Lieuw, W-L., Leach, K., Savige, J., Saini, S., Fisher, C. L. & Ricardo, S. D., 1 Nov 2018, In : Journal of Pharmacology and Experimental Therapeutics. 367, 2, p. 335-347 13 p.

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3 Citations (Scopus)

Inflammation and Inflammatory Agents Activate Protein Kinase C ε Translocation and Excite Guinea-Pig Submucosal Neurons

Poole, D. P., Matsuyama, H., Nguyen, T. V., Eriksson, E. M. Y., Fowler, C. J. & Furness, J. B., 1 Jan 2007, In : Gastroenterology. 133, 4, p. 1229-1239 11 p.

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15 Citations (Scopus)

Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

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9 Citations (Scopus)

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

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12 Citations (Scopus)

Inflammation without pain: Immune-derived opioids hold the key

Carbone, S. & Poole, D. P., 1 Feb 2020, In : Neurogastroenterology and Motility. 32, 2, 5 p., e13787.

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Inhibition by cAMP of the phosphoinositide response to α1-adrenoceptor stimulation in rat kidney

Neylon, C. B. & Summers, R. J., 13 Apr 1988, In : European Journal of Pharmacology. 148, 3, p. 441-444 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Inhibition of nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation

Vlahos, R., Stambas, J., Bozinovski, S., Broughton, B. RS., Drummond, G. R. & Selemidis, S., 2011, In : PLoS Pathogens. 7, 2, p. 1 - 12 12 p.

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143 Citations (Scopus)

Inhibition of phenylephrine-stimulated gluconeogenesis by chlorpromazine is mediated by α-adrenergic receptors

Tilley, L., Summers, R. J., Redgrave, T. G. & Kemp, B. E., 20 Apr 1981, In : FEBS Letters. 126, 2, p. 313-317 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosisin a large animal model

Organ, L., Bacci, B., Koumoundouros, E., Kimpton, W. G., Samuel, C. S., Nowell, C. J., Bradding, P., Roach, K. M., Westall, G., Jaffar, J. & Snibson, K. J., 1 Apr 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 539-550 13 p.

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13 Citations (Scopus)

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A. A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J-P., Fischer, C. & 33 others, Rigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, Z., Segura, I., Gueguen, G., Bordes, M-F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J-M., Katsuma, S., Schaeffer, P., Yayon, A., Van Schepdael, A., Schwalbe, H., Gervasio, F. L., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J-M. & Carmeliet, P., 2013, In : Cancer Cell. 23, 4, p. 477 - 488 12 p.

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95 Citations (Scopus)

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): Effect of pertussis toxin

Kompa, A. R., Samuel, C. S. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 137, 5, p. 710-718 9 p.

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58 Citations (Scopus)