Research Output

2016

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research & Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 1 Mar 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

103 Citations (Scopus)

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Gingell, J. J., Simms, J., Barwell, J., Poyner, D., Watkins, H. A., Pioszak, A. A., Sexton, P. M. & Hay, D., 17 May 2016, In : Cell Discovery. 2, 14 p., 16012.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

Furness, S. G. B., Hare, D. L., Kourakis, A., Turnley, A. M. & Wookey, P. J., 12 Dec 2016, In : Cell Death Discovery. 2, 1, 9 p., 16062.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : The Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

22 Citations (Scopus)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Calcitonin

Ostrovskaya, A., Findlay, D., Sexton, P. & Furness, S., 1 Jan 2016, Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Calcitonin

Findlay, D. M., Sexton, P. M. & Martin, T. J., 2016, Endocrinology: Adult & Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, p. 1004 - 1017 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling

Kim, T-H., Gill, N. K., Nyberg, K. D., Nguyen, A. V., Hohlbauch, S. V., Geisse, N. A., Nowell, C., Sloan, E. & Rowat, A. C., 2016, In : Journal of Cell Science. 129, 24, p. 4563-4575 13 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Cases in teaching and assessment in pharmacy education: guidelines for assigning difficulty

Spark, M. J., Malone, D. T., Maynard, G. & Stupans, I., 2016, In : Currents in Pharmacy Teaching and Learning. 8, 5, p. 722–725 4 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., Renne, G., Gandini, S., Pouton, C. W., Ferrari, D., Möller, A., Stacker, S. A. & Sloan, E. K., 1 Mar 2016, In : Nature Communications. 7, 14 p., 10634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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95 Citations (Scopus)

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 others, Gray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Compartmentalization of GPCR signalling controls unique cellular responses

Ellisdon, A. M. & Halls, M. L., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 562-567 6 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation

Zhang, T., Paulson, J. R., Bakhrebah, M., Kim, J. H., Nowell, C., Kalitsis, P. & Hudson, D. F., 1 May 2016, In : Chromosome Research. 24, 2, p. 243-269 27 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Crossword puzzles for chemistry education: Learning goals beyond vocabulary

Yuriev, E., Capuano, B. & Short, J. L., 2016, In : Chemistry Education Research and Practice. 17, 3, p. 532-554 23 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Thal, D. M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C. C., Bures, M. G., Evans, D. A., Weis, W. I., Bachhawat, P., Kobilka, T. S., Sexton, P. M., Kobilka, B. K. & Christopoulos, A., 17 Mar 2016, In : Nature. 531, 7594, p. 335-340 6 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)

Delineating a new class of membrane-bound guanylate cyclases

Muleya, V. & Irving, H. R., 2016, In : Springer Science Reviews. 4, 1, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Detection of active caspases during apoptosis using fluorescent activity-based probes

Edgington-Mitchell, L. E. & Bogyo, M., 1 Apr 2016, Programmed Cell Death: Methods and Protocols. Puthalakath, H. & Hawkins, C. J. (eds.). New York NY USA: Springer, Vol. 1419. p. 27-39 13 p. (Methods in Molecular Biology; vol. 1419).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Developing a framework for objective structured clinical examinations using the nominal group technique

Hussainy, S., Crum, M. F., White, P., Larson, I., Malone, D., Manallack, D., Nicolazzo, J., McDowell, J., Lim, A. & Kirkpatrick, C., 2016, In : American Journal of Pharmaceutical Education. 80, 9, 10 p., 158.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Differences in the cellular composition of small versus large uterine fibroids

Holdsworth-Carson, S. J., Zhao, D., Cann, L., Bittinger, S., Nowell, C. & Rogers, P., 2016, In : Reproduction. 152, 5, p. 467-480 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

Lay, J., Carbone, S. E., Dicello, J. J., Bunnett, N., Canals, M. & Poole, D. P., 1 Aug 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 2, p. G252-G266 15 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Does cannabidiol have a role in the treatment of schizophrenia?

Gururajan, A. & Malone, D. T., Oct 2016, In : Schizophrenia Research. 176, 2-3, p. 281-290 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Effects of food components that activate TRPA1 receptors on mucosal ion transport in the Mouse intestine

Fothergill, L. J., Callaghan, B., Rivera, L. R., Lieu, T. M., Poole, D. P., Cho, H. J., Bravo, D. M. & Furness, J. B., 1 Oct 2016, In : Nutrients. 8, 10, 11 p., 623.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Engineering of a novel simplified human insulin-like peptide 5 agonist

Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
Open Access
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25 Citations (Scopus)

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

7 Citations (Scopus)

Haplotyping the human leukocyte antigen system from single chromosomes

Murphy, N. M., Burton, M., Powell, D. R., Rossello, F. J., Cooper, D., Chopra, A., Hsieh, M. J., Sayer, D. C., Gordon, L., Pertile, M. D., Tait, B. D., Irving, H. R. & Pouton, C. W., 27 Jul 2016, In : Scientific Reports. 6, 9 p., 30381.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgenindependent prostate cancer cells

Xie, J., Mølck, C., Paquet-Fifield, S., Butler, L., Australian Prostate Cancer BioResource, Sloan, E., Ventura, S. & Hollande, F., 7 Jun 2016, In : Oncotarget. 7, 28, p. 44492-44504 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Instructional design and assessment: a simulated learning environment for teaching medicine dispensing skills

McDowell, J., Styles, K., Sewell, K., Trinder, P., Marriott, J., Maher, S. & Naidu, S., 2016, In : American Journal of Pharmaceutical Education. 80, 1, 11 p., 11.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Investigating the efficacy of CuII(gtsm), a copper delivery agent for the treatment of Menkes disease

Mckenzie-Nickson, S., 2016.

Research output: Contribution to conferencePoster

In vivo formation of cubic phase in situ after oral administration of cubic phase precursor formulation provides long duration gastric retention and absorption for poorly water-soluble drugs

Pham, A., Hong, L., Montagnat, O., Nowell, C., Nguyen, T-H. & Boyd, B. J., 4 Jan 2016, In : Molecular Pharmaceutics. 13, 1, p. 280-286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Isoform-specific bias of histamine H3 receptor agonists

Riddy, D., Cook, A. E., Diepenhorst, N., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R., Charman, W., Sexton, P. M., Christopoulos, A. & Langmead, C., 2016.

Research output: Contribution to conferencePoster

22 Citations (Scopus)

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)
34 Citations (Scopus)

Long noncoding RNAs: novel links to inflammatory bowel disease?

Edgington-Mitchell, L., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G444-G445 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

5 Citations (Scopus)

Long-term consequences of the acute neural-inflammatory stress response in the cancer surgical patient: new findings and perspectives

Riedel, B., Sloan, E. & Forget, P., 1 Nov 2016, In : International Anesthesiology Clinics. 54, 4, p. 58-71 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)