Research Output

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

Sheykhzade, M., Abdolalizadeh, B., Koole, C., Pickering, D. S., Dreisig, K., Johansson, S. E., Abboud, B. K., Dreier, R., Berg, J. O., Jeppesen, J. L., Sexton, P. M., Edvinsson, L., Wootten, D. & Sams, A., 15 Jun 2018, In : European Journal of Pharmacology. 829, p. 85-92 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

Alcobia, D. C., Ziegler, A. I., Kondrashov, A., Comeo, E., Mistry, S., Kellam, B., Chang, A., Woolard, J., Hill, S. J. & Sloan, E. K., 31 Aug 2018, In : iScience. 6, p. 280-288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 27-40 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)

β-Adrenergic signaling impairs antitumor CD8+ T-cell responses to B-cell lymphoma immunotherapy

Nissen, M. D., Sloan, E. K. & Mattarollo, S. R., 1 Jan 2018, In : Cancer Immunology Research. 6, 1, p. 98-109 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2017

Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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22 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A fresh shine on cystic fibrosis inhalation therapy: Antimicrobial synergy of polymyxin B in combination with silver nanoparticles

Jasim, R., Schneider, E. K., Han, M., Azad, M. A. K., Hussein, M., Nowell, C., Baker, M. A., Wang, J., Li, J. & Velkov, T., 1 Apr 2017, In : Journal of Biomedical Nanotechnology. 13, 4, p. 447-457 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate

Lee, S. N., Chakrabarty, B., Wittmer, B., Papargiris, M., Ryan, A., Frydenberg, M., Frydenberg, M., Lawrentschuk, N., Middendorff, R., Risbridger, G. P., Ellem, S. J. & Exintaris, B., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 10150.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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54 Citations (Scopus)

Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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20 Citations (Scopus)

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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7 Citations (Scopus)

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

Niclis, J. C., Gantner, C. W., Hunt, C. P. J., Kauhausen, J. A., Durnall, J. C., Haynes, J. M., Pouton, C. W., Parish, C. L. & Thompson, L. H., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 868-882 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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15 Citations (Scopus)

A retractable lid in lecithin: Cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

Manthei, K. A., Ahn, J., Glukhova, A., Yuan, W., Larkin, C., Manett, T. D., Chang, L., Shayman, J. A., Axley, M. J., Schwendeman, A. & Tesmer, J. J. G., 1 Jan 2017, In : The Journal of Biological Chemistry. 292, 49, p. 20313-20327 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites & Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

Assessing the impact of lithium chloride on the expression of P-glycoprotein at the blood-brain barrier

Newman, S. A., Pan, Y., Short, J. L. & Nicolazzo, J. A., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9, p. 2625–2631 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration

Sinha, S., Kuo, C. Y., Ho, J. K., White, P. J., Jazayeri, J. A. & Pouton, C. W., 2017, In : Vaccine. 35, 38, 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A three-dimensional lymphatic endothelial cell tube formation assay to identify novel kinases involved in lymphatic vessel remodeling

Gambino, T. J., Williams, S. P., Caesar, C., Resnick, D., Nowell, C., Farnsworth, R., Achen, M. G., Stacker, S. A. & Karnezis, T., 1 Jan 2017, In : Assay and Drug Development Technologies. 15, 1, p. 30-43 14 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery

Sengmany, K., Singh, J., Stewart, G. D., Conn, P. J., Christopoulos, A. & Gregory, K. J., 15 Mar 2017, In : Neuropharmacology. 115, p. 60-72 13 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
17 Citations (Scopus)

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

Hager, M. V., Clydesdale, L., Gellman, S. H., Sexton, P. M. & Wootten, D., 15 Jul 2017, In : Biochemical Pharmacology. 136, p. 99-108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Coding GPCR-G protein specificity

Furness, S. G. B. & Sexton, P. M., 1 Oct 2017, In : Cell Research. 27, 10, p. 1193-1194 2 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

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1 Citation (Scopus)

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Cyclic nucleotide monophosphates in plants and plant signaling

Marondedze, C., Wong, A., Thomas, L., Irving, H. & Gehring, C., 2017, Non-canonical Cyclic Nucleotides. Seifert, R. (ed.). Cham Switzerland: Springer, Vol. 238. p. 87-103 17 p. (Handbook of Experimental Pharmacology; vol. 238).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

14 Citations (Scopus)

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

McArthur, K., D'Cruz, A., Segal, D., Lackovic, K., Wilks, A. F., O'Donnell, J. A., Nowell, C. J., Gerlic, M., Huang, D. C. S., Burns, C. J. & Croker, B. A., 2017, In : Oncotarget. 8, 35, p. 57948-57963 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

Preston, S., Korhonen, P. K., Mouchiroud, L., Cornaglia, M., McGee, S. L., Young, N. D., Davis, R. A., Crawford, S., Nowell, C., Ansell, B. R. E., Fisher, G. M., Andrews, K. T., Chang, B. C. H., Gijs, M. A. M., Sternberg, P. W., Auwerx, J., Baell, J., Hofmann, A., Jabbar, A. & Gasser, R. B., 1 Oct 2017, In : The FASEB Journal. 31, 10, p. 4515-4532 18 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Gilabert-Oriol, R., Furness, S. G. B., Stringer, B. W., Weng, A., Fuchs, H., Day, B. W., Kourakis, A., Boyd, A. W., Hare, D. L., Thakur, M., Johns, T. G. & Wookey, P. J., 2017, In : Cancer Immunology Immunotherapy. 66, 9, p. 1217–1228 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation

Wang, M., Kakinen, A., Pilkington, E. H., Davis, T. P. & Ke, P-C., 1 Mar 2017, In : Biomaterials Science. 5, 3, p. 485-493 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Effects of protein corona on IAPP amyloid aggregation, fibril remodelling, and cytotoxicity

Pilkington, E. H., Xing, Y., Wang, B., Kakinen, A., Wang, M., Davis, T. P., Ding, F. & Ke, P-C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 2455.

Research output: Contribution to journalArticleResearchpeer-review

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17 Citations (Scopus)

Efficiently specified ventral midbrain dopamine neurons from human pluripotent stem cells under Xeno-free conditions restore motor deficits in Parkinsonian rodents

Niclis, J. C., Gantner, C. W., Alsanie, W. F., McDougall, S. J., Bye, C. R., Elefanty, A. G., Stanley, E. G., Haynes, J. M., Pouton, C. W., Thompson, L. H. & Parish, C. L., 1 Mar 2017, In : Stem Cells Translational Medicine. 6, 3, p. 937-948 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

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40 Citations (Scopus)

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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45 Citations (Scopus)

Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (Pflügers Archiv - European Journal of Physiology, (2015), 467, 4, (687-701), 10.1007/s00424-014-1539-6)

Sostegni, S., Diakov, A., McIntyre, P., Bunnett, N., Korbmacher, C. & Haerteis, S., 1 Jun 2017, In : Pflugers Archiv European Journal of Physiology. 469, 5-6, p. 845-846 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

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Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor

da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

Research output: Contribution to journalArticleResearchpeer-review

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14 Citations (Scopus)

G-CSF receptor blockade ameliorates arthritic pain and disease

Lee, M. C., McCubbin, J. A., Christensen, A. D., Poole, D. P., Rajasekhar, P., Lieu, T., Bunnett, N. W., Garcia-Caraballo, S., Erickson, A., Brierley, S. M., Saleh, R., Achuthan, A., Fleetwood, A. J., Anderson, R. L., Hamilton, J. A. & Cook, A. D., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3565-3575 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

Koole, C., Reynolds, C. A., Mobarec, J. C., Hick, C., Sexton, P. M. & Sakmar, T. P., 28 Apr 2017, In : The Journal of Biological Chemistry. 292, 17, p. 7131-7144 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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26 Citations (Scopus)

High molecular weight DNA enrichment with peptide nucleic acid probes

Murphy, N. M., Pouton, C. W. & Irving, H. R., 2017, Haplotyping: Methods and Protocols. Tiemann-Boege, I. & Betancourt, A. (eds.). New York NY USA: Humana Press, Vol. 1551. p. 73-85 13 p. (Methods in Molecular Biology; vol. 1551).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Zhu, C., Schneider, E. K., Nikolaou, V., Klein, T., Li, J., Davis, T. P., Whittaker, M. R., Wilson, P., Kempe, K., Velkov, T. & Haddleton, D. M., 19 Jul 2017, In : Bioconjugate Chemistry. 28, 7, p. 1916-1924 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Coudrat, T., Simms, J., Christopoulos, A., Wootten, D. & Sexton, P. M., 1 Nov 2017, In : PLoS Computational Biology. 13, 11, 40 p., e1005819.

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5 Citations (Scopus)

Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosisin a large animal model

Organ, L., Bacci, B., Koumoundouros, E., Kimpton, W. G., Samuel, C. S., Nowell, C. J., Bradding, P., Roach, K. M., Westall, G., Jaffar, J. & Snibson, K. J., 1 Apr 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 539-550 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)