Research Output

2019

Using a Multiplex Nucleic Acid in situ Hybridization Technique to Determine HCN4 mRNA Expression in the Adult Rodent Brain

Oyrer, J., Bleakley, L. E., Richards, K. L., Maljevic, S., Phillips, A. M., Petrou, S., Nowell, C. J. & Reid, C. A., 28 Aug 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-13 13 p., 211.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

β2-Adrenergic receptor expression is associated with biomarkers of tumor immunity and predicts poor prognosis in estrogen receptor-negative breast cancer

Kurozumi, S., Kaira, K., Matsumoto, H., Hirakata, T., Yokobori, T., Inoue, K., Horiguchi, J., Katayama, A., Koshi, H., Shimizu, A., Oyama, T., Sloan, E. K., Kurosumi, M., Fujii, T. & Shirabe, K., 1 Jan 2019, In : Breast Cancer Research and Treatment. 177, 3, p. 603–610 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 others, Selemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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18 Citations (Scopus)

Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers

Stewart, G. D., Comps-Agrar, L., Nørskov-Lauritsen, L. B., Pin, J. P. & Kniazeff, J., 1 Jul 2018, In : Neuropharmacology. 136, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Altered amygdala excitation and CB1 receptor modulation of aggressive behavior in the neuroligin-3R451C mouse model of autism

Hosie, S., Malone, D. T., Liu, S., Glass, M., Adlard, P. A., Hannan, A. J. & Hill-Yardin, E. L., 3 Aug 2018, In : Frontiers in Cellular Neuroscience. 12, 234.

Research output: Contribution to journalArticleResearchpeer-review

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11 Citations (Scopus)

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein for Direct Volumetric Imaging of Whole Organs Using CLARITY

Scott, D. J., Gunn, N. J., Yong, K. J., Wimmer, V. C., Veldhuis, N. A., Challis, L. M., Haidar, M., Petrou, S., Bathgate, R. A. D. & Griffin, M. D. W., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 667.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

A Qualitative Study on the Perception of Australian and Malaysian Academic Teaching Staff in an Undergraduate B.Pharm Program on Case-based Learning

Jacob, S. A., Hui Dhing, O. & Malone, D., 2018, (Accepted/In press) In : American Journal of Pharmaceutical Education. 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Trinh, P. N. H., May, L. T., Leach, K. & Gregory, K. J., 15 Nov 2018, In : Clinical Science. 132, 21, p. 2323-2338 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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7 Citations (Scopus)

Biologically active constituents of the secretome of human W8B2+ cardiac stem cells

Nie, S., Wang, X., Sivakumaran, P., Chong, M. M. W., Liu, X., Karnezis, T., Bandara, N., Takov, K., Nowell, C. J., Wilcox, S., Shambrook, M., Hill, A. F., Harris, N. C., Newcomb, A. E., Strappe, P., Shayan, R., Hernández, D., Clarke, J., Hanssen, E., Davidson, S. M. & 5 others, Dusting, G. J., Pébay, A., Ho, J. W. K., Williamson, N. & Lim, S. Y., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 1579.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes S

Bradley, S. J., Molloy, C., Bundgaard, C., Mogg, A. J., Thompson, K. J., Dwomoh, L., Sanger, H. E., Crabtree, M. D., Brooke, S. M., Sexton, P. M., Felder, C. C., Christopoulos, A., Broad, L. M., Tobin, A. B. & Langmead, C. J., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 645-656 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment

Dandrieux, J. R. S., Martinez Lopez, L. M., Stent, A., Jergens, A., Allenspach, K., Nowell, C. J., Firestone, S. M., Kimpton, W. & Mansfield, C. S., 1 Oct 2018, In : Innate Immunity. 24, 7, p. 400-410 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, E., Just, R., Hick, C., Christopoulos, A., Sexton, P. M., Wootten, D. & Furness, S. G. B., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 111-129 19 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Co-expression of μ and δ opioid receptors by mouse colonic nociceptors

Guerrero-Alba, R., Valdez-Morales, E. E., Jiménez-Vargas, N. N., Bron, R., Poole, D., Reed, D., Castro, J., Campaniello, M., Hughes, P. A., Brierley, S. M., Bunnett, N., Lomax, A. E. & Vanner, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2622-2634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., May 2018, In : Brain, Behavior, and Immunity. 70, p. 36-47 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice (Archives of Toxicology, (2018), 92, 7, (2259-2271), 10.1007/s00204-018-2192-1)

Yun, B., Zhang, T., Azad, M. A. K., Wang, J., Nowell, C. J., Kalitsis, P., Velkov, T., Hudson, D. F. & Li, J., 1 Jul 2018, In : Archives of Toxicology. 92, 7, p. 2273-2274 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

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1 Citation (Scopus)

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Liang, Y-L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., 27 Sep 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome

Marsh, A. P. L., Edwards, T. J., Galea, C., Cooper, H. M., Engle, E. C., Jamuar, S. S., Méneret, A., Moutard, M-L., Nava, C., Rastetter, A., Robinson, G., Rouleau, G., Roze, E., Spencer-Smith, M., Trouillard, O., Billette de Villemeur, T., Walsh, C. A., Yu, T. W., IRC5 Consortium, Heron, D. & 5 others, Sherr, E. H., Richards, L. J., Depienne, C., Leventer, R. J. & Lockhart, P. J., 1 Jan 2018, In : Human Mutation. 39, 1, p. 23-39 17 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Development of a self-report instrument for measuring in-class student engagement reveals that pretending to engage is a significant unrecognized problem

Fuller, K. A., Karunaratne, N. S., Naidu, S., Exintaris, B., Short, J. L., Wolcott, M. D., Singleton, S. & White, P. J., 1 Oct 2018, In : PLoS ONE. 13, 10, 22 p., e0205828.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, P. R., Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery

Yadav, P., McLeod, V. M., Nowell, C. J., Selby, L. I., Johnston, A. P. R., Kaminskas, L. M. & Trevaskis, N. L., 28 Feb 2018, In : Journal of Controlled Release. 272, p. 17-28 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

Diepenhorst, N. A., Leach, K., Keller, A. N., Rueda, P., Cook, A. E., Pierce, T. L., Nowell, C., Pastoureau, P., Sabatini, M., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4095-4108 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Dominant negative g proteins enhance formation and purification of agonist-gpcr-g protein complexes for structure determination

Liang, Y-L., Zhao, P., Draper-Joyce, C. J., Baltos, J-A., Glukhova, A., Truong, T. T., May, L. T., Christopoulos, A., Wootten, D., Sexton, P. & Furness, S., 14 Sep 2018, In : ACS Pharmacology & Translational Science. 1, 1, p. 12-20 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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11 Citations (Scopus)

Drugs to tune up glutamatergic systems: Modulators of glutamate metabotropic receptors

Sengmany, K. & Gregory, K. J., 1 Jan 2018, Biochemical Approaches for Glutamatergic Neurotransmission. Parrot, S. & Denoroy, L. (eds.). 1 ed. New York NY USA: Humana Press, p. 227-261 35 p. (Neuromethods; vol. 130).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Dual action calcium-sensing receptor modulator unmasks novel mode-switching mechanism

Gregory, K., Kufareva, I., Keller, A. N., Khajehali, E., Mun, H., Goolam, M. A., Mason, R. S., Capuano, B., Conigrave, A., Christopoulos, A. & Leach, K., 12 Sep 2018, In : ACS Pharmacology & Translational Science. 1, 2, p. 96-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Pratt, G., Hiller, J., Gottumukkala, V., Sloan, E., Riedel, B. & Schier, R., 1 Jul 2018, In : British Journal of Anaesthesia. 121, 1, p. 45-57 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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25 Citations (Scopus)

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

Nedi, T., White, P. J., Coupar, I. M. & Irving, H. R., 8 Jun 2018, In : BMC Research Notes. 11, 1, 6 p., 362.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep

Hutchinson, D. S., Brew, N., Vu, T., Merlin, J., Hale, N., Walker, D. W. & Wong, F. Y., 1 Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Ticks from diverse genera encode chemokine-inhibitory evasin proteins (J. Biol. Chem. (2018) 292 (15670–15680) DOI: 10.1074/jbc.M117.807255)

Hayward, J., Sanchez, J., Perry, A., Huang, C., Valle, M. R., Canals, M., Payne, R. J. & Stone, M. J., 1 Jan 2018, In : The Journal of Biological Chemistry. 293, 41, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Wang, M. W., Sexton, P. M., Furness, S. G. B. & Wootten, D., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 214-244 31 p.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Lam, R., Gondin, A. B., Canals, M., Kellam, B., Briddon, S. J., Graham, B. & Scammells, P. J., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1316-1329 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Halls, M. L. & Canals, M., 1 Feb 2018, In : Trends in Pharmacological Sciences. 39, 2, p. 148-157 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

G protein-coupled receptors as anabolic drug targets in osteoporosis

Diepenhorst, N., Rueda, P., Cook, A. E., Pastoureau, P., Sabatini, M. & Langmead, C. J., 1 Apr 2018, In : Pharmacology and Therapeutics. 184, p. 1-12 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)

Identification of global and ligand-specific calcium sensing receptor activation mechanisms S

Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis

Dubowitz, J. A., Sloan, E. K. & Riedel, B. J., Apr 2018, In : Clinical and Experimental Metastasis. 35, 4, p. 347-358 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Increased cardiomyocyte alignment and intracellular calcium transients using micropatterned and drug-releasing poly(glycerol sebacate) elastomers

Zhu, C., Rodda, A. E., Truong, V. X., Shi, Y., Zhou, K., Haynes, J. M., Wang, B., Cook, W. D. & Forsythe, J. S., 2018, In : ACS Biomaterials Science & Engineering. 4, 7, p. 2494-2504 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Induced pluripotent stem cell-derived podocyte-like cells as models for assessing mechanisms underlying heritable disease phenotype: Initial studies using two alport syndrome patient lines indicate impaired potassium channel activity

Haynes, J. M., Selby, J. N., Vandekolk, T. H., Abad, I. P. L., Ho, J. K., Lieuw, W-L., Leach, K., Savige, J., Saini, S., Fisher, C. L. & Ricardo, S. D., 1 Nov 2018, In : Journal of Pharmacology and Experimental Therapeutics. 367, 2, p. 335-347 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

Research output: Contribution to journalArticleResearchpeer-review

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8 Citations (Scopus)

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)