Research Output

2020

New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery

Park, J., Langmead, C. & Riddy, D., 20 Jan 2020, In : ACS Pharmacology & Translational Science. 3, 1, p. 88-106 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In : Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Nitroxyl: A Novel Strategy to Circumvent Diabetes Associated Impairments in Nitric Oxide Signaling

Velagic, A., Qin, C., Woodman, O. L., Horowitz, J. D., Ritchie, R. H. & Kemp-Harper, B. K., 19 May 2020, In : Frontiers in Pharmacology. 11, 18 p., 727.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Opioid pharmacology under the microscope

Jullié, D., Gondin, AB., von Zastrow, M. & Canals, M., 20 Mar 2020, (Accepted/In press) In : Molecular Pharmacology. 21 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access

Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors

Yuliantie, E., Darbalaei, S., Dai, A., Zhao, P., Yang, D., Sexton, P. M., Wang, M-W. & Wootten, D., Jul 2020, In : Biochemical Pharmacology. 177, 13 p., 114001.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Polymers with Dithiobenzoate End Groups Constitutively Release Hydrogen Sulfide upon Exposure to Cysteine and Homocysteine

Urquhart, M. C., Dao, N. V., Ercole, F., Boyd, B. J., Davis, T. P., Whittaker, M. R. & Quinn, J. F., 21 Apr 2020, In : ACS Macro Letters. 9, 4, p. 553-557 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Preface

Langmead, C. J., 2020, Advances in Pharmacology. Langmead, C. J. (ed.). Apple Academic Press, Inc., p. xiii-xvii 5 p.

Research output: Chapter in Book/Report/Conference proceedingForeword / PostscriptOtherpeer-review

1 Citation (Scopus)

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, Weller, E., Lewis, N. E., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Qualitative evaluation of how a virtual dementia experience impacts medical and pharmacy students’ self-reported knowledge and attitudes towards people with dementia

Gilmartin-Thomas, J. F-M., McNeil, J., Powell, A., Malone, D. T., Larson, I. C., O’Reilly, C. L., Kirkpatrick, C. M., Kipen, E., Petrovich, T., Ryan-Atwood, T. E. & Bell, J. S., Feb 2020, In : Dementia. 19, 2, p. 205-220 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Rational development of a high-affinity secretin receptor antagonist

Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In : Biochemical Pharmacology. 177, 13 p., 113929.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Roadmap for the Emerging Field of Cancer Neuroscience

Monje, M., Borniger, J. C., D'Silva, N. J., Deneen, B., Dirks, P. B., Fattahi, F., Frenette, P. S., Garzia, L., Gutmann, D. H., Hanahan, D., Hervey-Jumper, S. L., Hondermarck, H., Hurov, J. B., Kepecs, A., Knox, S. M., Lloyd, A. C., Magnon, C., Saloman, J. L., Segal, R. A., Sloan, E. K. & 8 others, Sun, X., Taylor, M. D., Tracey, K. J., Trotman, L. C., Tuveson, D. A., Wang, T. C., White, R. A. & Winkler, F., 16 Apr 2020, In : Cell. 181, 2, p. 219-222 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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4 Citations (Scopus)

Sex-specific adipose tissue imprinting of regulatory T cells

Vasanthakumar, A., Chisanga, D., Blume, J., Gloury, R., Britt, K., Henstridge, D. C., Zhan, Y., Torres, S. V., Liene, S., Collins, N., Cao, E., Sidwell, T., Li, C., Spallanzani, R. G., Liao, Y., Beavis, P. A., Gebhardt, T., Trevaskis, N., Nutt, S. L., Zajac, J. D. & 5 others, Davey, R. A., Febbraio, M. A., Mathis, D., Shi, W. & Kallies, A., 26 Mar 2020, In : Nature. 579, 7800, p. 581–585+ 29 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Structural basis for allosteric modulation of class b g protein-coupled receptors

Wootten, D. & Miller, L. J., 6 Jan 2020, In : Annual Review of Pharmacology and Toxicology. 60, p. 89-107 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Structural basis of Gs and Gi recognition by the human glucagon receptor

Qiao, A., Han, S., Li, X., Li, Z., Zhao, P., Dai, A., Chang, R., Tai, L., Tan, Q., Chu, X., Ma, L., Thorsen, T. S., Reedtz-Runge, S., Yang, D., Wang, M-W., Sexton, P. M., Wootten, D., Sun, F., Zhao, Q. & Wu, B., 20 Mar 2020, In : Science. 367, 6484, p. 1346-1352 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Sulfoxide-Containing Polymer-Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation

Qiao, R., Fu, C., Li, Y., Qi, X., Ni, D., Nandakumar, A., Siddiqui, G., Wang, H., Zhang, Z., Wu, T., Zhong, J., Tang, S-Y., Pan, S., Zhang, C., Whittaker, M. R., Engle, J. W., Creek, D. J., Caruso, F., Ke, P. C., Cai, W. & 2 others, Whittaker, A. K. & Davis, T. P., May 2020, In : Advanced Science. 7, 13, 13 p., 2000406.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Targeting longevity genes in the battle against diabetic heart disease – is there a gene delivery fountain of youth?

Ritchie, R., Galougahi, K. K. & Figtree, G. A., 1 Jul 2020, (Accepted/In press) In : European Journal of Heart Failure. 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

The novel small-molecule annexin-a1 mimetic, compound 17b, elicits vasoprotective actions in streptozotocin-induced diabetic mice

Marshall, S. A., Qin, C. X., Jelinic, M., O’sullivan, K., Deo, M., Walsh, J., Li, M., Parry, L. J., Ritchie, R. H. & Leo, C. H., 2 Feb 2020, In : International Journal of Molecular Sciences. 21, 4, 21 p., 1384.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Therapeutic Potential of Lipoxin A4 in Chronic Inflammation: Focus on Cardiometabolic Disease

Fu, T., Mohan, M., Brennan, E. P., Woodman, O. L., Godson, C., Kantharidis, P., Ritchie, R. H. & Qin, C., 17 Jan 2020, In : ACS Pharmacology & Translational Science. 3, 1, p. 43-55 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The role of ceramides in metabolic disorders: when size and localization matters

Turpin-Nolan, S. M. & Brüning, J. C., 1 Apr 2020, In : Nature Reviews Endocrinology. 16, 4, p. 224-233 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Peng, S., Grace, M., Gondin, AB., Retamal, J. S., Dill, L., Darby, W. G., Bunnett, N., Abogadie, F. C., Carbone, S., Tigani, T., Davis, T. P., Poole, D. P., Veldhuis, N. & McIntyre, P., 2 Apr 2020, (Accepted/In press) In : Laboratory Investigation. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Three-dimensional differentiation of human pluripotent stem cell-derived neural precursor cells using tailored porous polymer scaffolds

Murphy, A. R., Haynes, J. M., Laslett, A. L., Cameron, N. R. & O'Brien, C. M., 1 Jan 2020, In : Acta Biomaterialia. 101, p. 102-116 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In : Molecular Cell. 77, 3, p. 656-668.e5 18 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)