Research Output

1986

THE INFLUENCE OF AGE AND SEX ON CARDIAC, RENAL AND CAUDAL ARTERY CATECHOLAMINE CONTENT IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND WISTAR KYOTO (WKY) RATS

HOWES, L. G., SUMMERS, R. J. & LOUIS, W. J., 1 Jan 1986, In : Journal of Autonomic Pharmacology. 6, 3, p. 171-180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
1985

[3H]‐rauwolscine binding to α2‐adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species

Neylon, C. B. & Summers, R. J., 1 Jan 1985, In : British Journal of Pharmacology. 85, 2, p. 349-359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Autoradiographic localization of β‐adrenoceptor subtypes in guinea‐pig kidney

Lew, R. & Summers, R. J., 1 Jan 1985, In : British Journal of Pharmacology. 85, 2, p. 341-348 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Changes in brainstem and spinal adrenoceptor binding with ageing in spontaneously hypertensive and Wistar-Kyoto rats

Howes, L. G. & Summers, R. J., 24 Jun 1985, In : Neuroscience Letters. 57, 3, p. 247-250 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Light microscopic autoradiography of the distribution of [3H]rauwolscine binding to α2-adrenoceptors in rat kidney

Stephenson, J. A. & Summers, R. J., 22 Oct 1985, In : European Journal of Pharmacology. 116, 3, p. 271-278 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Localization of beta adrenoceptor subtypes in rat kidney by light microscopic autoradiography

Summers, R. J., Stephenson, J. A. & Kuhar, M. J., 1 Jan 1985, In : Journal of Pharmacology and Experimental Therapeutics. 232, 2, p. 561-569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Localization of β-adrenoceptors in the rabbit ear by light microscopic autoradiography

Johnston, H. G. & Summers, R. J., 10 Sep 1985, In : European Journal of Pharmacology. 115, 1, p. 97-101 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The measurement of central noradrenergic activity in spontaneously hypertensive rats: A comparison of free 3,4-dihydroxyphenylethyleneglycol levels with FLA-63 induced noradrenaline depletion

Howes, L. G., Summers, R. J., Rowe, P. R. & Louis, W. J., 1 Jan 1985, In : Journal of Hypertension. 3, 3, p. 237-242 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

α2-adrenoceptors in dog kidney: Autoradiographic localization and putative functions

Summers, R. J., Stephenson, J. A., Lipe, S. & Neylon, C. B., 1 Jan 1985, In : Clinical Science. 68, SUPPL. 10

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
1984

Age related changes of catecholamines and their metabolites in central nervous system regions of spontaneously hypertensive (SHR) and normotensive wistar-Kyoto (wky) rats:

Howes, L. G., Rowe, P. R., Summers, R. J. & Louis, W. J., 1 Jan 1984, In : Clinical and Experimental Hypertension. 6, 12, p. 2263-2277 15 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Assay of brain 3,4-dihydroxyphenylethyleneglycol (DHPG) levels by high-performance liquid chromatography with electrochemical detection. Factors affecting stability during sample preparation

Howes, L. G., Summers, R. J., Rowe, P. R. & Louis, W. J., 1 Jan 1984, In : Journal of Chromatography A. 287, C, p. 133-135 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Autoradiographic localization of adrenoceptors in peripheral tissues

Summers, R. J., 1 Jan 1984, In : Trends in Pharmacological Sciences. 5, C, p. 216-217 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Effects of Methyldopa Metabolites on Amine Transmitters and Adrenergic Receptors in Rat Brain

Louis, W. J., Conway, E., Summers, R., Beart, P. & Jarrott, B., 1 Jan 1984, In : Hypertension. 6, 5, p. 40-44 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Renal α adrenoceptors

Summers, R. J., 1 Dec 1984, In : Federation Proceedings. 43, 14, p. 2917-2922 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

69 Citations (Scopus)

The involvement of central alpha adrenoceptors in the antihypertensive actions of methyldopa and clonidine in the rat

Jarrott, B., Lewis, S., Conway, E. L., Summers, R. & Louis, W. J., 1 Jan 1984, In : Clinical and Experimental Hypertension. A6, 1-2, p. 387-400 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
1983

Age related changes of noradrenaline content in brain regions of spontaneously hypertensive (SHR) and normotensive wistar-Kyoto (WK) rats

Howes, L. G., Rowe, P. R., Summers, R. J. & Louis, W. J., 1 Jan 1983, In : Clinical and Experimental Hypertension. A5, 6, p. 857-874 18 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Autoradiographic localization of β-adrenoceptors in rat kidney

Summers, R. J. & Kuhar, M. J., 22 Jul 1983, In : European Journal of Pharmacology. 91, 2-3, p. 305-310 6 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Characterization of central α-adrenoceptors using 3H-clonidine and its derivatives

Jarrott, B., Louis, W. J. & Summers, R. J., 1 Jan 1983, In : Chest. 83, Suppl. 2, p. 339-340 2 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Characterization of postsynaptic α‐adrenoceptors in rat aortic strips and portal veins

Digges, K. G. & Summers, R. J., 1 Jan 1983, In : British Journal of Pharmacology. 79, 3, p. 655-665 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
80 Citations (Scopus)

Effects of yohimbine stereoisomers on contractions of rat aortic strips produced by agonists with different selectivity for α1-and α2-adrenoceptors

Digges, K. G. & Summers, R. J., 9 Dec 1983, In : European Journal of Pharmacology. 96, 1-2, p. 95-99 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Evidence from binding studies for α2-adrenoceptors directly associated with glomeruli from rat kidney

McPherson, G. A. & Summers, R. J., 17 Jun 1983, In : European Journal of Pharmacology. 90, 4, p. 333-341 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Evidence from binding studies for β1-adrenoceptors associated with glomeruli isolated from rat kidney

McPherson, G. A. & Summers, R. J., 4 Jul 1983, In : Life Sciences. 33, 1, p. 87-94 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The simultaneous determination of 3,4-dihydroxyphenylethylene glycol, 3,4-dihydroxyphenylacetic acid and catecholamines in brain tissue by high performance liquid chromatography with electrochemical detection

Howes, L. G., Summers, R. J., Rowe, P. R. & Loui, W. J., 8 Aug 1983, In : Neuroscience Letters. 38, 3, p. 327-332 6 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
1982

[3H]‐GUANFACINE: A RADIOLIGAND THAT SELECTIVELY LABELS HIGH AFFINITY α2‐ADRENOCEPTOR SITES IN HOMOGENATES OF RAT BRAIN

JARROTT, BEVYN., LOUIS, WILLIAM. J. & SUMMERS, ROGER. J., 1 Jan 1982, In : British Journal of Pharmacology. 75, 2, p. 401-408 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Anticonvulsant effects of clonidine mediated through central α2-adrenoceptors

Papanicolaou, J., Summers, R. J., Vajda, F. J. E. & Louis, W. J., 22 Jan 1982, In : European Journal of Pharmacology. 77, 2-3, p. 163-166 4 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Anticonvulsant effects of clonidine on pentylenetetrazol (PTZ)-induced convulsions in rats

Papanicolaou, J., Summers, R. J., Vajda, F. J. E. & Louis, W. J., 1 Jan 1982, In : Clinical and Experimental Pharmacology and Physiology. 9, 4, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

CHARACTERIZATION AND LOCALIZATION OF [3H]‐CLONIDINE BINDING IN MEMBRANES PREPARED FROM GUINEA‐PIG SPLEEN

McPherson, G. A. & Summers, R. J., 1 Jan 1982, In : Clinical and Experimental Pharmacology and Physiology. 9, 1, p. 77-87 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Comparison of α-adrenoreceptors in aortic strips and portal veins of the rat

Digges, K. G. & Summers, R. J., 1 Jan 1982, In : Clinical and Experimental Pharmacology and Physiology. 9, 4, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Correlation between [3H]-prazosin binding and α1-adrenoceptors controlling gluconeogenesis in the rat renal cortex

McPherson, G. A. & Summers, R. J., 1 Jan 1982, In : Clinical and Experimental Pharmacology and Physiology. 9, 4, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancement of pentylenetetrazol (PTZ) induced convulsions following clonidine withdrawal in rats

Summers, R. J., Papanicolaou, J., Vajda, F. J. E. & Louis, W. J., 1 Jan 1982, In : Neuroscience Letters. 27, Suppl. 8

Research output: Contribution to journalArticleResearchpeer-review

Localisation of [3H]clonidine binding to membranes from guinea pig renal tubules

McPherson, G. A. & Summers, R. J., 15 Feb 1982, In : Biochemical Pharmacology. 31, 4, p. 583-587 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

New developments in α-adrenoreceptor drugs for the treatment of hypertension

Louis, W. J., Summers, R. J., Dynon, M. & Jarrott, B., 1 Jan 1982, In : Journal of Cardiovascular Pharmacology. 4, p. S168-S171

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Radioligand studies of α-adrenoceptors in the kidney

Summers, R. J. & McPherson, G. A., 1 Jan 1982, In : Trends in Pharmacological Sciences. 3, C, p. 291-294 4 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Relationship between α-adrenoceptor selectivity and anticonvulsant activity after chronic clonidine-like drugs in rats

Louis, W. J., Papanicolaou, J., Summers, R. J. & Vajda, F. J. E., 1 Jan 1982, In : British Journal of Pharmacology. 76, Suppl.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Role of central α2 adrenoceptors in control of pentylenetetrazol (PTZ) induced convulsions in rats

Summers, R. J., Papanicolaou, J., Vajda, F. J. E. & Louis, W. J., 1 Jan 1982, In : Neuroscience Letters. 27, Suppl. 8

Research output: Contribution to journalArticleResearchpeer-review

ROLE OF CENTRAL β‐ADRENOCEPTORS IN THE CONTROL OF PENTYLENETETRAZOL‐INDUCED CONVULSIONS IN RATS

LOUIS, W. J., PAPANICOLAOU, JENNY., SUMMERS, R. J. & VAJDA, F. J. E., 1 Jan 1982, In : British Journal of Pharmacology. 75, 3, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

Role of β‐adrenoceptors in the anticonvulsant effect of propranolol on leptazol‐induced convulsions in rats

Papanicolaou, J., Vajda, F. J. E., Summers, R. J. & Louis, W. J., 1 Jan 1982, In : Journal of Pharmacy and Pharmacology. 34, 2, p. 124-125 2 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The relationship between α2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs

Summers, R. J., Papanicolaou, J., Vajda, F. J. E. & Louis, W. J., 1 Jan 1982, In : Clinical and Experimental Pharmacology and Physiology. 9, 4, p. 473-474 2 p.

Research output: Contribution to journalArticleResearchpeer-review

The relationship between α2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs

Papanicolaou, J., Summers, R. J., Vajda, F. J. E. & Louis, W. J., 10 Jun 1982, In : Brain Research. 241, 2, p. 393-397 5 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
1981

[3H]Prazosin and [3H]clonidine binding to α‐adrenoceptors in membranes prepared from regions of rat kidney

McPherson, G. A. & Summers, R. J., 1 Jan 1981, In : Journal of Pharmacy and Pharmacology. 33, 1, p. 189-191 3 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Alpha-adrenoceptors in rat kidney studied by 3H-clonidine and 3H-prazosin binding

Summers, R. J. & McPherson, G. A., 1 Jan 1981, In : Clinical and Experimental Pharmacology and Physiology. 8, 6

Research output: Contribution to journalArticleResearchpeer-review

Comparison of [3H]clonidine and [3H]guanfacine binding to α2 adrenoceptors in membranes from rat cerebral cortex

Summers, R. J., Jarrott, B. & Louis, W. J., 7 Aug 1981, In : Neuroscience Letters. 25, 1, p. 31-36 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inhibition of phenylephrine-stimulated gluconeogenesis by chlorpromazine is mediated by α-adrenergic receptors

Tilley, L., Summers, R. J., Redgrave, T. G. & Kemp, B. E., 20 Apr 1981, In : FEBS Letters. 126, 2, p. 313-317 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Labeling of α2-adrenoceptors in rat cerebral cortex with 3H-guanfacine

Summers, R. J., Jarrott, B. & Louis, W. J., 1 Jan 1981, In : Clinical and Experimental Pharmacology and Physiology. 8, 6

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PHARMACOLOGICAL INVESTIGATION OF α‐ADRENORECEPTORS IN GUINEA‐PIG SPLENIC CAPSULE

DIGGES, K. G., McPHERSON, G. A. & SUMMERS, R. J., 1 Jan 1981, In : Journal of Autonomic Pharmacology. 1, 4, p. 313-320 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
1980
Open Access
17 Citations (Scopus)

Are radioligand assays useful for identification and characterization of prejunctional receptors

Summers, R. J. & Jarrott, B., 1 Jan 1980, In : Clinical and Experimental Pharmacology and Physiology. 7, 6, p. 641-642 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A sensitive method for measurement of catecholamines and their metabolites in extracts of small brain areas

Rowe, P. R., Summers, R. J. & Beart, P. M., 1 Jan 1980, In : Clinical and Experimental Pharmacology and Physiology. 7, 6, p. 674-675 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)