Research Output

2001

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice

Heffernan, M., Summers, R. J., Thorburn, A., Ogru, E., Gianello, R., Jiang, W. J. & Ng, F. M., 1 Jan 2001, In : Endocrinology. 142, 12, p. 5182-5189 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

β1-adrenoceptors compensate for β3-adrenoceptors in ileum from β3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2001, In : British Journal of Pharmacology. 132, 2, p. 433-442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

β1- and β3-adrenoceptor mediated smooth muscle relaxation in hypothyroid rat ileum

Brown, K. J. & Summers, R. J., 16 Mar 2001, In : European Journal of Pharmacology. 415, 2-3, p. 257-263 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2000

Intracerebroventricular administration of the β3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus

Castillo-Meléndez, M., McKinley, M. J. & Summers, R. J., 1 Sep 2000, In : Neuroscience Letters. 290, 3, p. 161-164 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.

Zumpe, E. T., Tilakaratne, N., Fraser, NJ., Christopoulos, G., Foord, S. M. & Sexton, P., 7 Jan 2000, In : Biochemical and Biophysical Research Communications. 267, 1, p. 368-372

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

β3-adrenoceptor regulation and relaxation responses in mouse ileum

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2000, In : British Journal of Pharmacology. 129, 6, p. 1251-1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
1999

Alternative splicing generates two isoforms of the β3-adrenoceptor which are differentially expressed in mouse tissues

Evans, B. A., Papaioannou, M., Hamilton, S. & Summers, R. J., 10 Aug 1999, In : British Journal of Pharmacology. 127, 6, p. 1525-1531 7 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Bradykinin-stimulated protein synthesis by myocytes is dependent on the MAP kinase pathway and p70(S6K)

Ritchie, R. H., Marsh, J. D. & Schiebinger, R. J., 1 Apr 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 276, 4 45-4

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Characterization of β-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for β1-, β2- and β3-adrenoceptors in rat ileum

Roberts, S. J., Papaioannou, M., Evans, B. A. & Summers, R. J., 6 Jul 1999, In : British Journal of Pharmacology. 127, 4, p. 949-961 13 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Desensitization and resensitization of β1- and putative β4-adrenoceptor mediated responses occur in parallel in a rat model of cardiac failure

Kompa, A. R. & Summers, R. J., 1 Jan 1999, In : British Journal of Pharmacology. 128, 7, p. 1399-1406 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Desensitization of cardiac β-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins

Kompa, A. R., Gu, X. H., Evans, B. A. & Summers, R. J., 1 Jan 1999, In : Journal of Molecular and Cellular Cardiology. 31, 6, p. 1185-1201 17 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Functional analysis of desensitization of the β-adrenoceptor signalling pathway in rat cardiac tissues following chronic isoprenaline infusion

McMartin, L. & Summers, R. J., 6 Jul 1999, In : British Journal of Pharmacology. 127, 4, p. 1012-1020 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Imidazolidinone nitroxide-mediated polymerization

Chong, Y. K., Ercole, F., Moad, G., Rizzardo, E., Thang, S. H. & Anderson, A. G., 19 Oct 1999, In : Macromolecules. 32, 21, p. 6902-6903 2 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Investigation of 5-HT 4 agonist activities using molecular field analysis

Iskander, M., Coupar, I. & Winkler, D. A., 1999, In : Journal of the Chemical Society, Perkin Transactions 2. 2, p. 153-158 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Separate roles for β2- and β3-adrenoceptors in memory consolidation

Gibbs, M. E. & Summers, R. J., 1 Dec 1999, In : Neuroscience. 95, 3, p. 913-922 10 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Tailored polymers by free radical processes

Rizzardo, E., Chiefari, J., Chong, B. Y. K., Ercole, F., Krstina, J., Jeffrey, J., Le, T. P. T., Mayadunne, R. T. A., Meijs, G. F., Moad, C. L., Moad, G. & Thang, S. H., 1 Jan 1999, In : Macromolecular Symposia. 143, p. 291-307 17 p.

Research output: Contribution to journalArticleResearchpeer-review

192 Citations (Scopus)
1998

A1 Adenosine receptor modulation of electrically-evoked contractions in the bisected vas deferens and cauda epididymis of the guinea-pig.

Haynes, J. M., Alexander, S. P. H. & Hill, S. J., 1998, In : British Journal of Pharmacology. 124, p. 964-970

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.

Haynes, J. M., 1998, In : British Journal of Pharmacology. 125, p. 570-576

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Controlled-Growth Free-Radical Polymerization of Methacrylate Esters: Reversible Chain Transfer versus Reversible Termination

Moad, G., Anderson, A. G., Ercole, F., Johnson, C. H. J., Krstina, J., Moad, C. L., Rizzardo, E., Spurling, T. H. & Thang, S. H., 1 Dec 1998, In : ACS Symposium Series. 685, p. 332-360 29 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Differential regulation of β3-adrenoceptors in gut and adipose tissue of genetically obese (ob/ob) C57BL/6J-mice

Evans, B. A., Papaioannou, M., Anastasopoulos, F. & Summers, R. J., 26 Jun 1998, In : British Journal of Pharmacology. 124, 4, p. 763-771 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Living free-radical polymerization by reversible addition - Fragmentation chain transfer: The RAFT process

Chiefari, J., Chong, Y. K., Ercole, F., Krstina, J., Jeffery, J., Le, T. P. T., Mayadunne, R. T. A., Meijs, G. F., Moad, C. L., Moad, G., Rizzardo, E. & Thang, S. H., 11 Aug 1998, In : Macromolecules. 31, 16, p. 5559-5562 4 p.

Research output: Contribution to journalArticleResearchpeer-review

4134 Citations (Scopus)

Modulation of Δ9-tetrahydrocannabinol-induced hypothermia by fluoxetine in the rat

Malone, D. T. & Taylor, D. A., 15 Aug 1998, In : British Journal of Pharmacology. 124, 7, p. 1419-1424 6 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor

Christopoulos, A., Pierce, T. L., Sorman, J. L. & El-Fakahany, E. E., 1 Jun 1998, In : Molecular Pharmacology. 53, 6, p. 1120-1130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Regulation of β-adrenoceptors in a rat model of cardiac failure: Effect of perindopril

Gu, X. H., Kompa, A. R. & Summers, R. J., 1 Jul 1998, In : Journal of Cardiovascular Pharmacology. 32, 1, p. 66-74 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The effects of the β3-adrenoceptor agonist BRL 35135 on UCP isoform mRNA expression

Emilsson, V., Summers, R. J., Hamilton, S., Liu, Y. L. & Cawthorne, M. A., 18 Nov 1998, In : Biochemical and Biophysical Research Communications. 252, 2, p. 450-454 5 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

β3-Andrenoceptors: Differential regulation and novel subtypes

Summers, R. J., Hutchinson, D. S. & Evans, B. A., 1 Jan 1998, In : Pharmacy and Toxicology, Supplement. 83, 1, p. 37-39 3 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

Controlled growth free radical polymerization of methacrylate esters - Reversible chain transfer vs. reversible termination

Moad, G., Ercole, F., Krstina, J., Moad, C. L., Rizzardo, E. & Thang, S. H., 1 Apr 1997, In : Polymer Preprints. 38, 1, p. 744-745 2 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Erratum: Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an 'infinite dilution' procedure (Biochemical Pharmacology (1997) 53 (795-800))

Christopoulos, A., Lanzafame, A., Ziegler, A. & Mitchelson, F., 1 Jan 1997, In : Biochemical Pharmacology. 53, 12, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an 'infinite dilution' procedure

Christopoulos, A., Lanzafame, A., Ziegler, A. & Mitchelson, F., 21 Mar 1997, In : Biochemical Pharmacology. 53, 6, p. 795-800 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Neuropeptide Y (NPY) and peptide YY (PYY) effects in the epididymis of the guinea-pig: evidence of a pre-junctional PYY-selective receptor.

Haynes, J. M., Hill, S. J. & Selbie, L. A., 1997, In : British Journal of Pharmacology. 122, p. 1530-1537

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Rat amylin mediates a presser response in the anaesthetised rat: Implications for the association between hypertension and diabetes mellitus

Haynes, J. M., Hodgson, W. C. & Cooper, M. E., 11 Mar 1997, In : Diabetologia. 40, 3, p. 256-261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

β-adrenoceptor subtypes and their desensitization mechanisms

Summers, R. J., Kompa, A. & Roberts, S. J., 1 Jan 1997, In : Journal of Autonomic Pharmacology. 17, 6, p. 331-343 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)
1996

Inverse agonism: A developing concept of drug action

Christopoulos, A. & Mitchelson, F., 1 Aug 1996, In : Australian Journal of Pharmacy. 77, 917, p. 868-871 4 p.

Research output: Contribution to journalArticleResearch

1995

Adrenomedullin and calcitonin gene related peptide in the rat isolated kidney and in the anaesthetised rat: in vitro and in vivo effects.

Cooper, M. E. & Haynes, J. M., 1995, In : European Journal of Pharmacology. 280, p. 91-94

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Haemodynamic response to simulated haemorrhage in the rabbit: Interaction of i.V. Anaesthesia and hypoxia

Blake, D. W., Van Leeuwen, F., Petring, O. U., Ludbrook, J. & Ventura, S., 1 Jan 1995, In : British Journal of Anaesthesia. 75, 5, p. 610-615 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
1994

Amylin and calcitonin gene-related peptide in the rat kidney: functional and autoradiographic studies.

Haynes, J. M., Wookey, P. J., Tikellis, C., Du, H-C., Sexton, P. & Cooper, M. E., 1994, In : Canadian Journal of Physiology and Pharmacology. 72, p. 566

Research output: Contribution to journalArticleResearchpeer-review

Attenuated 5-hydroxytryptamine receptor-mediated responses in aortae from streptozotocin-induced diabetic rats.

James, G. M., Hodgson, WC., Davis, E. A. & Haynes, J. M., 1994, In : British Journal of Pharmacology. 111, p. 370-376

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
19 Citations (Scopus)

Effect of chemical sympathectomy on (−)‐isoprenaline‐induced changes in cardiac β‐adrenoceptor subtypes in the guinea‐pig and rat

Kompa, A. R., Molenaar, P. & Summers, R. J., 1 Jan 1994, In : Journal of Autonomic Pharmacology. 14, 6, p. 411-423 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Muscarinic receptors in rat uterus

Pennefather, J. N., Gillman, T. A. & Mitchelson, F., 12 Sep 1994, In : European Journal of Pharmacology. 262, 3, p. 297-300 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Regulation of ß-adrenoceptors in the guinea-pig sinoatrial node

Russell, F. D., Kompa, A. R., Molenaar, P. & Summers, R. J., 1 May 1994, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 349, 5, p. 463-472 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
6 Citations (Scopus)
1993

A1‐and A2‐PURINOCEPTORS IN THE GUINEA‐PIG UTERUS

Haynes, J. M. & Pennefather, J. N., 1 Jan 1993, In : Clinical and Experimental Pharmacology and Physiology. 20, 10, p. 609-617 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Adrenoceptors and Their Second Messenger Systems

Summers, R. J. & McMartin, L. R., 1 Jan 1993, In : Journal of Neurochemistry. 60, 1, p. 10-23 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

121 Citations (Scopus)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation

Charman, W. N., Charman, S. A., Monkhouse, D. C., Frisbee, S. E., Lockhart, E. A., Weisman, S. & Fitzgerald, G. A., 1993, In : British Journal of Clinical Pharmacology. 36, 5, p. 470-473 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Characterization of propranolol‐resistant (−)‐[125I]‐cyanopindolol binding sites in rat soleus muscle

Roberts, S. J., Molenaar, P. & Summers, R. J., 1 Jan 1993, In : British Journal of Pharmacology. 109, 2, p. 344-352 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Effects of 5-HT-receptor and α2-adrenoceptor ligands on the haemodynamic response to acute hypovolaemia in conscious rabbits.

Evans, RG., Haynes, J. M. & Ludbrook, J., 1993, In : British Journal of Pharmacology. 109, p. 37-47

Research output: Contribution to journalArticleResearchpeer-review

Heterogeneity of α1‐adrenoceptors in the guinea‐pig uterus

Haynes, J. M. & Pennefather, J. N., 1993, In : Journal of Autonomic Pharmacology. 13, 5, p. 305-314 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)