Research Output

2006

Proteinase-activated receptors, targets for kallikrein signaling

Oikonomopoulou, K., Hansen, K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G., Bunnett, N., Diamandis, E. & Hollenberg, M., 2006, In : The Journal of Biological Chemistry. 281, 43, p. 32095 - 32112 18 p.

Research output: Contribution to journalArticleResearchpeer-review

188 Citations (Scopus)

SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Scott, C., Langmead, C. J., Clarke, K. L., Wyman, P., Smith, P. W., Starr, K. R., Dawson, L. A., Price, G. W., Hagan, J. J. & Watson, J., 1 Jun 2006, In : Neuropharmacology. 50, 8, p. 984-990 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue

Scott, C., Soffin, E. M., Hill, M., Atkinson, P. J., Langmead, C. J., Wren, P. B., Faedo, S., Gordon, L. J., Price, G. W., Bromidge, S., Johnson, C. N., Hagan, J. J. & Watson, J., 24 Apr 2006, In : European Journal of Pharmacology. 536, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Spontaneous electrical waveforms in immature and older guinea-pig prostates

Haynes, J. (ed.), Dey, A., Rose'Meyer, R. (ed.), Nguyen, D-T., Lang, R. J. & Exintaris, B., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

Spontaneous electrical waveforms in the prostate gland

Haynes, J. (ed.), Exintaris, B., Rose'Meyer, R. (ed.), Nguyen, D-T., Dey, A. & Lang, R. J., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

The distribution of PKC isoforms in enteric neurons, muscle and interstitial cells of the human intestine

Furness, J. B., Hind, A. J., Ngui, K., Robbins, H. L., Clerc, N., Merrot, T., Tjandra, J. J. & Poole, D. P., 1 Nov 2006, In : Histochemistry and Cell Biology. 126, 5, p. 537-548 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis

Wick, E., Hoge, S., Grahn, S., Kim, E., Divino, L., Grady, E., Bunnett, N. & Kirkwood, K., 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 290, p. 959 - 969 11 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Ubiquitin-dependent down-regulation of the neurokinin-1 receptor

Cottrell, G., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Gehringer, D., Grady, E. & Bunnett, N., 2006, In : The Journal of Biological Chemistry. 281, 38, p. 27773 - 27783 11 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS

Canals, M., Jenkins, L., Kellett, E. & Milligan, G., 2006, In : The Journal of Biological Chemistry. 281, 24, p. 16757 - 16767 11 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2005

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

Fuxe, K., Ferre, S., Canals, M., Torvinen, M., Terasmaa, A., Marcellino, D., Goldberg, S., Staines, W., Jacobsen, K., Lluis, C., Woods, A., Agnati, L. & Franco, R., 2005, In : Journal of Molecular Neuroscience. 26, 2-3, p. 209 - 219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

Torvinen, M., Marcellino, D., Canals, M., Agnati, L., Lluis, C., Franco, R. & Fuxe, K., 2005, In : Molecular Pharmacology. 67, 2, p. 400 - 407 8 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

Jacob, C., Cottrell, G., Gehringer, D., Schmidlin, F., Grady, E. & Bunnett, N., 2005, In : The Journal of Biological Chemistry. 280, 16, p. 16076 - 16087 12 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons

Nguyen, T. V., Poole, D. P., Harvey, J. R., Stebbing, M. J. & Furness, J. B., 1 Feb 2005, In : European Journal of Neuroscience. 21, 4, p. 905-913 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat

Cottrell, G., Roosterman, D., Marvizon, J-C., Song, B., Wick, E., Pikios, S., Wong, H., Berthelier, C., Tang, Y., Sternini, C., Bunnett, N. & Grady, E., 2005, In : The Journal of Comparative Neurology. 490, 3, p. 239 - 255 17 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Mast cell tryptase controls paracellular permeability of the intestine: Role of protease-activated receptor 2 and beta-arrestins

Jacob, C., Yang, P-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G., Coelho, A-M., Singh, P., Grady, E., Perdue, M. & Bunnett, N., 2005, In : The Journal of Biological Chemistry. 280, 36, p. 31936 - 31948 13 p.

Research output: Contribution to journalArticleResearchpeer-review

235 Citations (Scopus)

Neurochemical changes in LPA1 receptor deficient mice - A putative model of schizophrenia

Roberts, C., Winter, P., Shilliam, C. S., Hughes, Z. A., Langmead, C., Maycox, P. R. & Dawson, L. A., 1 Mar 2005, In : Neurochemical Research. 30, 3, p. 371-377 7 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone

Hughes, Z. A., Starr, K. R., Langmead, C. J., Hill, M., Bartoszyk, G. D., Hagan, J. J., Middlemiss, D. N. & Dawson, L. A., 7 Mar 2005, In : European Journal of Pharmacology. 510, 1-2, p. 49-57 9 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Neutral endopeptidase determines the severity of pancreatitis-associated lung injury

Day, A., Wick, E., Jordan, T., Jaffray, C., Bunnett, N., Grady, E. & Kirkwood, K., 2005, In : Journal of Surgical Research. 128, 1, p. 21 - 27 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

New Relaxin Peptides: Structure and Biological Function

Tregear, G. W., Bathgate, R. A. D., Samuel, C. S., Layfield, S., Ferraro, T., Gundlach, A. L., Ma, S., Lin, F., WILKINSON, T., Summers, R. J., Rosengren, J., Craik, D. J. & Wade, J., 2005, Peptide science: proceedings of the Japanese Peptide Symposium.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

New relaxin peptides: Structure and function

Tregear, G. W., Bathgate, R. A. D., Samuel, C., Layfield, S., Ferraro, T., Gundlach, A. L., Burazin, T. CD., Ma, S., Lin, F., WILKINSON, T., Summers, R. J., Rosengren, J., Craik, D. J. & Wade, J., 2005, 1st Asia-Pacific International Peptide Symposium.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells

Dulon, S., Leduc, D., Cottrell, G., D'Alayer, J., Hansen, K., Bunnett, N., Hollenberg, M., Pidard, D. & Chignard, M., 2005, In : American Journal of Respiratory Cell and Molecular Biology. 32, p. 411 - 419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

The Chemistry and Biology of Human Relaxin‐3

Tregear, G. W., Bathgate, R., Layfield, S., Ferraro, T., Gundlach, A. L., Ma, S., Lin, F., Hanson, N. F., Summers, R., Rosengren, J., Craik, D. J. & Wade, J., 2005, Annals of the New York Academy of Sciences .

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

The relaxin gene-knockout mouse: a model of progressive fibrosis

Samuel, C., Zhao, C., Bathgate, R., Du, X-J., Summers, R., Amento, E., Walker, L., McBurnie, M., Zhao, L. & Tregear, G., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 173 - 181 9 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

The stressed gut: Contributions of intestinal stress peptides to inflammation and motility

Bunnett, N., 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 21, p. 7409 - 7410 2 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2004

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G., Santini, D., Pasquinelli, G., Morselli-Labate, A., Grady, E., Bunnett, N., Collins, S. & Corinaldesi, R., 2004, In : Gastroenterology. 126, 3, p. 693 - 702 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1004 Citations (Scopus)

A role for proteinase-activated receptor-1 in inflammatory bowel diseases

Vergnolle, N., Cellars, L., Mencarelli, A., Rizzo, G., Swaminathan, S., Beck, P., Steinhoff, M., Andrade-Gordon, P., Bunnett, N., Hollenberg, M., Wallace, J., Cirino, G. & Fiorucci, S., 2004, In : Journal of Clinical Investigation. 114, 10, p. 1444 - 1456 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterisation of the binding of [ 3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

Langmead, C. J., Jerman, J. C., Brough, S. J., Scott, C., Porter, R. A. & Herdon, H. J., 1 Jan 2004, In : British Journal of Pharmacology. 141, 2, p. 340-346 7 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage

Scholzen, T., Steinhoff, M., Sindrilaru, A., Schwarz, A., Bunnett, N., Luger, T., Armstrong, C. A. & Ansel, J. C., 2004, In : The FASEB Journal. 18, 9, p. 1 - 22 22 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Plasminogen fragmentation and increased production of extracellular matrix-degrading proteinases are associated with serous epithelial ovarian cancer progression

Murthi, P., Barker, G., Nowell, C. J., Rice, G. E., Baker, M. S., Kalionis, B. & Quinn, M. A., 1 Jan 2004, In : Gynecologic Oncology. 92, 1, p. 80-88 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia

Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G., Grady, E., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J., Ennes, H., Davis, J., Mayer, E. & Bunnett, N., 2004, In : Journal of Neuroscience. 24, 18, p. 4300 - 4312 13 p.

Research output: Contribution to journalArticleResearchpeer-review

335 Citations (Scopus)

Protease-activated receptors: contribution to physiology and disease

Ossovskaya, V. & Bunnett, N., 2004, In : Physiological Reviews. 84, p. 579 - 621 43 p.

Research output: Contribution to journalArticleResearchpeer-review

851 Citations (Scopus)

Protease-activated receptors: protease signaling in the gastrointestinal tract

Amadesi, S. & Bunnett, N., 2004, In : Current Opinion in Pharmacology. 4, 6, p. 551 - 556 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Protein kinases expressed by interstitial cells of Cajal

Poole, D. P., Van Nguyen, T., Kawai, M. & Furness, J. B., 1 Jan 2004, In : Histochemistry and Cell Biology. 121, 1, p. 21-30 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Recycling and resensitization of the neurokinin 1 receptor

Roosterman, D., Cottrell, G., Schmidlin, F., Steinhoff, M. & Bunnett, N., 2004, In : The Journal of Biological Chemistry. 279, 29, p. 30670 - 30679 10 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro

Jenkins, D. W., Langmead, C. J., Parsons, A. A. & Strijbos, P. J., 19 Aug 2004, In : Neuroscience Letters. 366, 3, p. 241-244 4 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Trypsin IV, a novel agonist of protease-activated receptors 2 and 4

Cottrell, G., Amadesi, S., Grady, E. & Bunnett, N., 2004, In : The Journal of Biological Chemistry. 279, 14, p. 13532 - 13539 8 p.

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)
2003

Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons

Chiocchetti, R., Poole, D. P., Kimura, H., Aimi, Y., Robbins, H. L., Castelucci, P. & Furness, J. B., 1 Jan 2003, In : Cell and Tissue Research. 311, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Protein kinase C isoforms in the enteric nervous system

Poole, D. P., Hunne, B., Robbins, H. L. & Furness, J. B., 1 Jul 2003, In : Histochemistry and Cell Biology. 120, 1, p. 51-61 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2002

Characterization of the β-adrenoceptor subtype involved in mediation of glucose transport in L6 cells

Nevzorova, J., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 137, 1, p. 9-18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): Effect of pertussis toxin

Kompa, A. R., Samuel, C. S. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 137, 5, p. 710-718 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

Introduction

Sexton, P. M., 1 Jan 2002, In : Receptors and Channels. 8, 3-4, p. 135-136 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)

Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 135, 8, p. 1903-1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline

Ramasamy, S., Hodgson, W. C. & Ventura, S., 11 Jan 2002, In : European Journal of Pharmacology. 434, 3, p. 151-161 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Relaxin 3, a novel member of the insulin/relaxin superfamily of peptide hormones.

Bathgate, R. A. D., Scott, D. J., Samuel, C. S., Burazin, T. CD., Layfield, S., Claasz, A. A., Dawson, N. F., Ma, S., Bond, C., Summers, R. J., Wade, J. D. & Tregear, G. W., 2002, In : Biology of Reproduction.

Research output: Contribution to journalReview ArticleResearchpeer-review

The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system

Poole, D. P., Castelucci, P., Robbins, H. L., Chiocchetti, R. & Furness, J. B., 31 Oct 2002, In : Autonomic Neuroscience: Basic and Clinical. 101, 1-2, p. 39-47 9 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

The distribution of purine P2x2 receptors in the guinea-pig enteric nervous system

Castelucci, P., Robbins, H. L., Poole, D. P. & Furness, J. B., 8 Jun 2002, In : Histochemistry and Cell Biology. 117, 5, p. 415-422 8 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)
2001

Enhancement of memory consolidation in chicks by β3-adrenoceptor agonists

Gibbs, M. E. & Summers, R. J., 16 Feb 2001, In : European Journal of Pharmacology. 413, 2-3, p. 235-240 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Erratum: The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria (European Journal of Pharmacology (2001) 416 (235-244) PII: S0014299901008275)

Lanzafame, A., Christopoulos, A. & Mitchelson, F., 29 Jun 2001, In : European Journal of Pharmacology. 423, 1, p. 93-94 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Monitoring the physiological parameters of SCI patients during rehabilitation

Brown, I., Lai, A. & Nunn, A., 2001, ANZIIS 2001 - Proceedings of the 7th Australian and New Zealand Intelligent Information Systems Conference. IEEE, Institute of Electrical and Electronics Engineers, p. 297-302 6 p. 974094

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Stimulation of α1-adrenoceptors inhibits memory consolidation in the chick

Gibbs, M. E. & Summers, R. J., 1 Dec 2001, In : European Journal of Neuroscience. 14, 8, p. 1369-1376 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)