Research Output

2008

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents

Andre, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P., Poole, D., Bunnett, N., Geppetti, P. & Patacchini, R., 2008, In : Journal of Clinical Investigation. 118, 7, p. 2574 - 2582 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
307 Citations (Scopus)

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

Canals, M. & Milligan, G., 2008, In : The Journal of Biological Chemistry. 283, 17, p. 11424 - 11434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andre, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N., Patacchini, R. & Geppetti, P., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 12045 - 12050 6 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

Chua, B. Y., Eriksson, E. M., Poole, D. P., Zeng, W. & Jackson, D. C., 1 Jun 2008, In : Peptides. 29, 6, p. 881-890 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Endothelin-converting enzyme-1 degrades internalized somatostatin-14

Roosterman, D., Kempkes, C., Cottrell, G., Padilla, B., Bunnett, N., Turck, C. & Steinhoff, M., 2008, In : Endocrinology. 149, 5, p. 2200 - 2207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

G protein coupling and ligand selectivity of the D2L and D 3 dopamine receptors

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 1, p. 319 - 330 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Proteinase activated-receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP response element binding protein

Wang, H., Wen, S., Bunnett, N., Leduc, R., Hollenberg, M. & MacNaughton, W., 2008, In : The Journal of Biological Chemistry. 283, 2, p. 809 - 815 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Stimulation of the neurokinin 3 receptor activates protein kinase Cepsilon and protein kinase D in enteric neurons

Poole, D., Amadesi, S., Rozengurt, E., Thacker, M., Bunnett, N. & Furness, J., 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, p. 1245 - 1256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor

Moloney, G. P., Angus, J. A., Robertson, A. D., Stoermer, M. J., Robinson, M., Lay, L., Wright, C. E., McRae, K. & Christopoulos, A., 28 Jul 2008, In : Australian Journal of Chemistry. 61, 7, p. 484-499 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

Jaakola, V-P., Griffith, M., Hanson, M., Cherezov, V., Chien, E., Lane, J., IJzerman, A. P. & Stevens, R., 2008, In : Science. 322, 21, p. 1211 - 1217 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1455 Citations (Scopus)

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

Sipe, W., Brierley, S., Martin, C., Phillis, B., Bautista-Cruz, F., Grady, E., Liedtke, W., Cohen, D., Vanner, S., Blackshaw, L. & Bunnett, N., 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 5, p. 1288 - 1298 11 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)
2007

{A figure is presented}Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis

Cottrell, G., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J., Murphy, B., Caughey, G., Wolters, P., Coughlin, S., Peterson, A., Knecht, W., Pothoulakis, C., Bunnett, N. & Grady, E., 2007, In : Gastroenterology. 132, 7, p. 2422 - 2437 16 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G., Gatti, R., Basbaum, A., Bunnett, N., Julius, D. & Geppetti, P., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 33, p. 13519 - 13524 6 p.

Research output: Contribution to journalArticleResearchpeer-review

544 Citations (Scopus)

Agonist-induced endocytosis of rat somatostatin receptor 1

Roosterman, D., Kreuzer, O., Brune, N., Cottrell, G., Bunnett, N., Meyerhof, W. & Steinhoff, M., 2007, In : Endocrinology. 148, 3, p. 1050 - 1058 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder

Kirkland, J., Cottrell, G., Bunnett, N. & Corvera, C., 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, p. 335 - 346 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: Localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors

Marvizon, J. C. G., Perez, O. A., Song, B., Chen, W., Bunnett, N., Grady, E. & Todd, A., 2007, In : Neuroscience. 148, 1, p. 250 - 265 16 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling

Roosterman, D., Cottrell, G., Padilla, B., Muller, L., Eckman, C., Bunnett, N. & Steinhoff, M., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 28, p. 11838 - 11843 6 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins

Padilla, B., Cottrell, G., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M. & Bunnett, N., 2007, In : Journal of Cell Biology. 179, 5, p. 981 - 997 17 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat

Josephs, T., Waugh, H., Kokay, I., Grattan, D. & Thompson, M., 1 Aug 2007, In : Journal of Endocrinology. 194, 2, p. 305-312 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor

Hasdemir, B., Bunnett, N. & Cottrell, G., 2007, In : The Journal of Biological Chemistry. 282, 40, p. 29646 - 29657 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Inflammation and Inflammatory Agents Activate Protein Kinase C ε Translocation and Excite Guinea-Pig Submucosal Neurons

Poole, D. P., Matsuyama, H., Nguyen, T. V., Eriksson, E. M. Y., Fowler, C. J. & Furness, J. B., 1 Jan 2007, In : Gastroenterology. 133, 4, p. 1229-1239 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome

Barbara, G., Wang, B., Stanghellini, V., De Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., Bunnett, N., Grundy, D. & Corinaldesi, R., 2007, In : Gastroenterology. 132, 1, p. 26 - 37 12 p.

Research output: Contribution to journalArticleResearchpeer-review

526 Citations (Scopus)

Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon

Kayssi, A., Amadesi, S., Bautista, F., Bunnett, N. & Vanner, S., 2007, In : The Journal of Physiology. 580, 3, p. 977 - 991 15 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Neurochemical coding of the enteric nervous system in chagasic patients with megacolon

Da Silveira, A. B. M., D'Avila Reis, D., De Oliveira, E. C., Neto, S. G., Luquetti, A. O., Poole, D., Correa-Oliveira, R. & Furness, J. B., 1 Oct 2007, In : Digestive Diseases and Sciences. 52, 10, p. 2877-2883 7 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Novel pharmacological applications of G-protein-coupled receptor-G protein fusions

Milligan, G., Parenty, G., Stoddart, L. & Lane, J., 2007, In : Current Opinion in Pharmacology. 7, 5, p. 521 - 526 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

PKC δ-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle

Poole, D. P. & Furness, J. B., 1 Mar 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 3

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1

Cottrell, G., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Grady, E. & Bunnett, N., 2007, In : The Journal of Biological Chemistry. 282, 16, p. 12260 - 12271 12 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area

Lessard, A., Grady, E., Bunnett, N. & Pickel, V., 2007, In : Neuroscience. 144, 4, p. 1393 - 1408 16 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1, G i2, and Gi3

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2007, In : Molecular Pharmacology. 71, 5, p. 1349 - 1359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Grant, A., Cottrell, G., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G., Bautista-Cruz, F., Barajas-Lopez, C., Joseph, E., Levine, J., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P. & Bunnett, N., 2007, In : The Journal of Physiology. 578, 3, p. 715 - 733 19 p.

Research output: Contribution to journalArticleResearchpeer-review

295 Citations (Scopus)

Protease-activated receptors: mechanisms by which proteases sensitize TRPV channels to induce neurogenic inflammation and pain

Grant, A., Amadesi, S. & Bunnett, N., 2007, TRP ion channel function in sensory transduction and cellular signaling cascades. Liedtke, W. B. & Heller, S. (eds.). United States: Taylor & Francis, p. 1 - 12 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Protease-activated receptors: novel PARtners in innate immunity

Shpacovitch, V., Feld, M., Bunnett, N. & Steinhoff, M., 2007, In : Trends in Immunology. 28, 12, p. 535 - 544 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N., Sharkey, K., Ferraz, J., Shaffer, E. & Vergnolle, N., 2007, In : Journal of Clinical Investigation. 117, 3, p. 636 - 647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
443 Citations (Scopus)

Roof and floor of the muscarinic binding pocket: Variations in the binding modes of orthosteric ligands

Goodwin, J. A., Hulme, E. C., Langmead, C. J. & Tehan, B. G., 1 Dec 2007, In : Molecular Pharmacology. 72, 6, p. 1484-1496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Screening for positive allosteric modulators: Assessment of modulator concentration-response curves as a screening paradigm

Langmead, C. J., 1 Aug 2007, In : Journal of Biomolecular Screening. 12, 5, p. 668-676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury

Gazzieri, D., Trevisani, M., Springer, J., Harrison, S., Cottrell, G., Andre, E., Nicoletti, P., Massi, D., Zecchi, S., Nosi, D., Santucci, M., Gerard, N., Lucattelli, M., Lungarella, G., Fischer, A., Grady, E., Bunnett, N. & Geppetti, P., 2007, In : Free Radical Biology and Medicine. 43, 4, p. 581 - 589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The alpha1b-adrenoceptor exists as a higher-order oligomer: Effective oligomerization is required for receptor maturation, surface delivery, and function

Lopez-Gimenez, J., Canals, M., Pediani, J. & Milligan, G., 2007, In : Molecular Pharmacology. 71, 4, p. 1015 - 1029 15 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

Knecht, W., Cottrell, G., Amadesi, S., Mohlin, J., Skaregarde, A., Geddal, K., Peterson, A., Chapman, K., Hollenberg, M., Vergnolle, N. & Bunnett, N., 2007, In : The Journal of Biological Chemistry. 282, 36, p. 26089 - 26100 12 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

Gimenez-Llort, L., Schiffmann, S., Shmidt, T., Canela, L., Camon, L., Wassholm, M., Canals, M., Terasmaa, A., Fernandez-Teruel, A., Tobena, A., Popova, E., Ferre, S., Agnati, L., Ciruela, F., Martinez, E., Kruger, J., Lluis, C., Franco, R., Fuxe, K. & Bader, M., 2007, In : Neurobiology of Learning and Memory. 87, 1, p. 42 - 56 15 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)
2006

Age-dependent changes in neurotransmission to the fibromuscular stroma of the guinea-pig prostate gland

Haynes, J. (ed.), Buljubasich, R., Burnstock, G., Rose'Meyer, R. (ed.) & Ventura, S., 2006, p. 15 - 15. 1 p.

Research output: Contribution to conferenceAbstract

Asymmetric reduction of alpha, beta-unsaturated ketone to (R) allylic alcohol by Candida chilensis

Pollard, D. J., Telari, K., Lane, J., Humphrey, G., McWilliams, C., Nidositko, S., Salmon, P. & Moore, J., 2006, In : Biotechnology and Bioengineering. 93, 6, p. 674 - 686 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Calcitonin

Martin, T. J., Findlay, D. M. & Sexton, P., 2006, Endocrinology, Volume 2. DeGroot, L. J. & Jameson, J. L. (eds.). Fifth ed. USA: Elsevier, p. 1419 - 1433 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Characterisation of 5-HT receptors in the mouse bladder

Haynes, J. (ed.), Chetty, N., Rose'Meyer, R. (ed.), Coupar, I. M., Chess-Williams, R. & Kerr, K. P., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

Expression of the neurokinin type 1 receptor in the human colon

Boutaghou-Cherid, H., Porcher, C., Liberge, M., Jule, Y., Bunnett, N. & Christen, M-O., 2006, In : Autonomic Neuroscience: Basic and Clinical. 124, 1, p. 9 - 17 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Impaired pain sensation in mice lacking prokineticin 2

Hu, W-P., Zhang, C., Li, J-D., Luo, Z., Amadesi, S., Bunnett, N. & Zhou, Q-Y., 2006, In : Molecular Pain. 2, 35, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Neuronal control of skin function: The skin as a neuroimmunoendocrine organ

Roosterman, D., Goerge, T., Schneider, S., Bunnett, N. & Steinhoff, M., 2006, In : Physiological Reviews. 86, 4, p. 1309 - 1379 71 p.

Research output: Contribution to journalArticleResearchpeer-review

358 Citations (Scopus)

Oligomeric structure of the alpha1b-adrenoceptor: Comparisons with rhodopsin

Milligan, G., Pediani, J., Canals, M. & Lopez-Gimenez, J., 2006, In : Vision Research. 46, 27, p. 4434 - 4441 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function

Ellis, J., Pediani, J., Canals, M., Milasta, S. & Milligan, G., 2006, In : The Journal of Biological Chemistry. 281, 50, p. 38812 - 38824 13 p.

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Ciruela, F., Casado, V., Rodrigues, R., Lujan, R., Burgueno, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S., Mallol, J., Cortes, A., Canela, E., Lopez-Gimenez, J., Milligan, G., Lluis, C., Cunha, R., Ferre, S. & Franco, R., 2006, In : Journal of Neuroscience. 26, 7, p. 2080 - 2087 8 p.

Research output: Contribution to journalArticleResearchpeer-review

426 Citations (Scopus)

Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice

Amadesi, S., Cottrell, G., Divino, L., Chapman, K., Grady, E., Bautista, F., Karanjia, R., Barajas-Lopez, C., Vanner, S., Vergnolle, N. & Bunnett, N., 2006, In : The Journal of Physiology. 575, 2, p. 555 - 571 17 p.

Research output: Contribution to journalArticleResearchpeer-review

205 Citations (Scopus)