Research Output

2014
59 Citations (Scopus)

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants

Cattaruzza, F., Amadesi, S., Carlsson, J. F., Murphy, J. E., Lyo, V., Kirkwood, K. S., Cottrell, G. S., Bogyo, M., Knecht, W. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 16, p. 3814 - 3826 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick

Gibbs, M. E. & Hertz, L., 2014, In : Frontiers in Pharmacology. 5, Article 54, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Signalling profiles of H3 relaxin, H2 relaxin and R3(B?23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

Kocan, M., Sarwar, M., Hossain, M. A., Wade, J. D. & Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 11, p. 2827 - 2841 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development

Skelton, R. J. P., Costa, M., Anderson, D. J., Bruveris, F., Finnin, B. W., Koutsis, K., Arasaratnam, D., White, A. J., Rafii, A., Ng, E. S-S., Elefanty, A. G., Stanley, E. G., Pouton, C. W., Haynes, J. M., Ardehali, R., Davis, R. P., Mummery, C. L. & Elliott, D. A., 2014, In : Stem Cell Research. 13, 1, p. 172 - 179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
38 Citations (Scopus)

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs

Dong, M., Koole, C. R., Wootten, D. L., Sexton, P. & Miller, L. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1085 - 1101 17 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1

Millard, C. J., Ludeman, J. P., Canals, M., Bridgford, J. L., Hinds, M. G., Clayton, D. J., Christopoulos, A., Payne, R. J. & Stone, M. J., 2014, In : Structure. 22, 11, p. 1571 - 1581 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

Wu, H., Wang, C., Gregory, K. J., Han, G. W., Cho, H. P., Xia, Y., Niswender, C. M., Katritch, V., Meiler, J., Cherezov, V., Conn, P. J. & Stevens, R. C., 2014, In : Science. 344, 6179, p. 58 - 64 7 p.

Research output: Contribution to journalArticleResearchpeer-review

340 Citations (Scopus)

Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease

Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C. & Bunnett, N. W., 2014, In : Physiological Reviews. 94, 1, p. 265 - 301 37 p.

Research output: Contribution to journalArticleResearchpeer-review

251 Citations (Scopus)

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice

Lieu, T. M., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M., McIntyre, P., Bron, R., Wilson, Y., Krappitz, M., Haerteis, S., Korbmacher, C., Steinhoff, M. S., Nassini, R., Materazzi, S., Geppetti, P., Corvera, C. U. & Bunnett, N. W., 2014, In : Gastroenterology. 147, 6, p. 1417 - 1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus

Miller, L. J., Sexton, P. M., Dong, M. & Harikumar, K. G., 2014, In : International Journal of Obesity. 4, p. S9-S13 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Themed issue of the British Journal of Pharmacology

Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1069 - 1072 4 p.

Research output: Contribution to journalLetterOther

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

Debono, A. J., Mistry, S. J., Xie, A., Muthiah, D., Phillips, J. R., Ventura, S., Callaghan, R., Pouton, C. W., Capuano, B. & Scammells, P. J., 2014, In : ChemMedChem. 9, 2, p. 399 - 410 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Grace, M., Lieu, T. M., Darby, B., Abogadie, F. C., Veldhuis, N. A., Bunnett, N. W. & McIntyre, P., 2014, In : British Journal of Pharmacology. 171, 16, p. 3881 - 3894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: Effects of varying pancreatin and calcium levels

Sassene, P. J., Kleberg, K., Williams, H. D., Bakala-N'Goma, J-C., Carriere, F., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Porter, C. J., Pouton, C. W. & Mullertz, A., 2014, In : The AAPS Journal. 16, 6, p. 1344-1357 14 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells

Hartley, B. J., Fabb, S. A., Finnin, B. A. L., Haynes, J. M. & Pouton, C. W., 2014, In : Journal of Visualized Experiments. 2014, 90, 7 p., e51764.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

Mellor, J. D., Brown, M., Irving, H. R., Zalcberg, J. R. & Dobrovic, A., 2013, In : Journal of Hematology & Oncology. 6, p. 1 - 10 10 p., 1.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
174 Citations (Scopus)

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hubner, H., Pardon, E., Valant, C., Sexton, P., Christopoulos, A., Felder, C. C., Gmeiner, P., Steyaert, J., Weis, W., Garcia, K. C., Wess, J. & Kobilka, B., 2013, In : Nature. 504, 7478, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

533 Citations (Scopus)

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

Rajagopal, S., Kumar, D. P., Mahavadi, S., Bhattacharya, S., Zhou, R., Corvera, C. U., Bunnett, N. W., Grider, J. R. & Murthy, K. S., 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 5, p. G527 - G535 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

A cyclic nucleotide sensitive promoter reporter system suitable for bacteria and plant cells

Wheeler, J., Freihat, L. & Irving, H. R., 2013, In : BMC Biotechnology. 13, 97, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

Age-related changes in the innervation of the prostate gland: implications for prostate cancer initiation and progression

White, C. W., Xie, J. H. & Ventura, S., Jul 2013, In : Organogenesis. 9, 3, p. 206-215 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Zhao, P., Canals, M., Murphy, J. E., Klingler, D., Eriksson, E. M., Pelayo, J-C., Hardt, M., Bunnett, N. W. & Poole, D. P., 2013, In : The Journal of Biological Chemistry. 288, 36, p. 25689 - 25700 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Allosteric approaches to GPCR drug discovery

Lane, J. R. & Ijzerman, A. P., 2013, In : Drug Discovery Today: Technologies. 10, 2

Research output: Contribution to journalEditorialOtherpeer-review

3 Citations (Scopus)

Allosteric modulation of a chemogenetically modified G protein-coupled receptor

Abdul Ridha, A., Lane, J. R. D., Sexton, P., Canals, M. & Christopoulos, A., 2013, In : Molecular Pharmacology. 83, 2, p. 521 - 530 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Altered brain uptake of therapeutics in a triple transgenic mouse model of alzheimer's disease

Mehta, D., Short, J. L. & Nicolazzo, J., 2013, In : Pharmaceutical Research. 30, 11, p. 2868 - 2879 12 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts

Butcher, A., Scammells, P. J., White, P. J., Devine, S. & Rose'Meyer, R. B., 2013, In : Pharmaceuticals. 6, 4, p. 546 - 556 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle

Hunt, L. C., Upadhyay, A., Jazayeri, J., Tudor, E. M. & White, J. D., 2013, In : Histochemistry and Cell Biology. 139, 1, p. 13 - 34 22 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom

Chaisakul, J., Isbister, G. K., Kuruppu, D. M. S., Konstantakopoulos, N. & Hodgson, W. C., 2013, In : Toxicology Letters. 221, 3, p. 205 - 211 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A novel androgen signalling pathway uses dihydrotestosterone, but not testosterone, to activate the EGF receptor signalling cascade in prostate stromal cells

Oliver, V. L., Poulios, K., Ventura, S. & Haynes, J. M., 2013, In : British Journal of Pharmacology. 170, 3, p. 592 - 601 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

Noetzel, M. J., Gregory, K. J., Vinson, P. N., Manka, J. T., Stauffer, S. R., Lindsley, C. W., Niswender, C. M., Xiang, Z. & Conn, P. J., Apr 2013, In : Molecular Pharmacology. 83, 4, p. 835-847 13 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Arresting inflammation: Contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Cattaruzza, F., Poole, D. P. & Bunnett, N. W., 2013, In : Biochemical Society Transactions. 41, 1, p. 137 - 143 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

Savage, E. E., Wootten, D. L., Christopoulos, A., Sexton, P. & Furness, S. G. B., 2013, In : BioTechniques. 54, 4, p. 217 - 221 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Bioluminescent orthotopic model of pancreatic cancer progression

Chai, M. G., Kim-Fuchs, C., Angst, E. & Sloan, E. K., 1 Jun 2013, In : Journal of Visualized Experiments. 2013, 76, e50395.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Bridging the gap: bitopic ligands of G-protein-coupled receptors

Lane, J. R. D., Sexton, P. M. & Christopoulos, A., 2013, In : Trends in Pharmacological Sciences. 34, 1, p. 59 - 66 8 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells

Avlani, V. A., Ma, W., Mun, H., Leach, K., Delbridge, L., Christopoulos, A. & Conigrave, A., 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 10, p. 1097 - 1104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

CGRP/adrenomedullin

Wootten, D. L., Tilakaratne, N., Christopoulos, A. & Sexton, P., 2013, Handbook of Biologically Active Peptides. Kastin, A. J. (ed.). Second Edition ed. San Diego CA USA: Elsevier, p. 744 - 751 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines

Niclis, J. C., Pinar, A., Haynes, J. M., Alsanie, W. F., Jenny, R. A., Dottori, M. & Cram, D. S., 2013, In : Frontiers in Cellular Neuroscience. 7, 37, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Chronic activation of the low affinity site of beta -adrenoceptors stimulates haemodynamics but exacerbated pressure-overload cardiac remodelling

Kiriazis, H., Tugiono, N., Xu, Q., Gao, X-M., Jennings, N., Ming, Z., Su, Y., Klenowski, P., Summers, R. J., Kaumann, A., Molenaar, P. & Du, X-J., 2013, In : British Journal of Pharmacology. 170, 2, p. 352 - 365 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Correction to: A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

Noetzel, M. J., Gregory, K. J., Vinson, P. N., Manka, J. T., Stauffer, S. R., Lindsley, C. W., Niswender, C. M., Xiang, Z. & Conn, P. J., Oct 2013, In : Molecular Pharmacology. 84, 4, p. 654 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Deleterious effects of soluble beta amyloid on cognition, antagonism by saline and noradrenaline, a role for microglia

Gibbs, M. E. & Gibbs, C. L., 2013, In : Neuroscience. 230, p. 62 - 71 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

Wootten, D. L., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P., 2013, In : Molecular Pharmacology. 83, 4, p. 822 - 834 13 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)
5 Citations (Scopus)