Research Output

Abstract

Age-dependent changes in neurotransmission to the fibromuscular stroma of the guinea-pig prostate gland

Haynes, J. (ed.), Buljubasich, R., Burnstock, G., Rose'Meyer, R. (ed.) & Ventura, S., 2006, p. 15 - 15. 1 p.

Research output: Contribution to conferenceAbstract

Characterisation of 5-HT receptors in the mouse bladder

Haynes, J. (ed.), Chetty, N., Rose'Meyer, R. (ed.), Coupar, I. M., Chess-Williams, R. & Kerr, K. P., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

Spontaneous electrical waveforms in immature and older guinea-pig prostates

Haynes, J. (ed.), Dey, A., Rose'Meyer, R. (ed.), Nguyen, D-T., Lang, R. J. & Exintaris, B., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

Spontaneous electrical waveforms in the prostate gland

Haynes, J. (ed.), Exintaris, B., Rose'Meyer, R. (ed.), Nguyen, D-T., Dey, A. & Lang, R. J., 2006, p. -. 0 p.

Research output: Contribution to conferenceAbstract

Article
Open Access
17 Citations (Scopus)

[3H]‐GUANFACINE: A RADIOLIGAND THAT SELECTIVELY LABELS HIGH AFFINITY α2‐ADRENOCEPTOR SITES IN HOMOGENATES OF RAT BRAIN

JARROTT, BEVYN., LOUIS, WILLIAM. J. & SUMMERS, ROGER. J., 1 Jan 1982, In : British Journal of Pharmacology. 75, 2, p. 401-408 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

[3H]Prazosin and [3H]clonidine binding to α‐adrenoceptors in membranes prepared from regions of rat kidney

McPherson, G. A. & Summers, R. J., 1 Jan 1981, In : Journal of Pharmacy and Pharmacology. 33, 1, p. 189-191 3 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

[3H]‐rauwolscine binding to α2‐adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species

Neylon, C. B. & Summers, R. J., 1 Jan 1985, In : British Journal of Pharmacology. 85, 2, p. 349-359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

{A figure is presented}Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis

Cottrell, G., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J., Murphy, B., Caughey, G., Wolters, P., Coughlin, S., Peterson, A., Knecht, W., Pothoulakis, C., Bunnett, N. & Grady, E., 2007, In : Gastroenterology. 132, 7, p. 2422 - 2437 16 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G., Gatti, R., Basbaum, A., Bunnett, N., Julius, D. & Geppetti, P., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 33, p. 13519 - 13524 6 p.

Research output: Contribution to journalArticleResearchpeer-review

539 Citations (Scopus)

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

A1 Adenosine receptor modulation of electrically-evoked contractions in the bisected vas deferens and cauda epididymis of the guinea-pig.

Haynes, J. M., Alexander, S. P. H. & Hill, S. J., 1998, In : British Journal of Pharmacology. 124, p. 964-970

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.

Haynes, J. M., 1998, In : British Journal of Pharmacology. 125, p. 570-576

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

A1‐and A2‐PURINOCEPTORS IN THE GUINEA‐PIG UTERUS

Haynes, J. M. & Pennefather, J. N., 1 Jan 1993, In : Clinical and Experimental Pharmacology and Physiology. 20, 10, p. 609-617 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Absence of mitochondrial β-adrenoceptors in guinea pig myocardium: Evidence for tissue disparity

Russell, F. D., Molenaar, P. & Summers, R. J., 1 Jan 1992, In : General Pharmacology. 23, 5, p. 827-832 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Miao, Y., Goldfeld, D. A., Moo, E. V., Sexton, P. M., Christopoulos, A., McCammon, J. A. & Valant, C., 20 Sep 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. E5675-E5684 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
48 Citations (Scopus)

Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Walker, L. C., Berizzi, A. E., Chen, N. A., Rueda, P., Perreau, V. M., Huckstep, K., Srisontiyakul, J., Govitrapong, P., Xiaojian, J., Lindsley, C. W., Jones, C. K., Riddy, D. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 28 Feb 2020, (Accepted/In press) In : Biological Psychiatry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition

Roca-Lapirot, O., Fossat, P., Ma, S., Egron, K., Trigilio, G., López-González, M. J., Covita, J., Bouali-Benazzouz, R., Favereaux, A., Gundlach, A. L. & Landry, M., 1 Feb 2019, In : Pain. 160, 2, p. 345-357 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

Mellor, J. D., Brown, M., Irving, H. R., Zalcberg, J. R. & Dobrovic, A., 2013, In : Journal of Hematology & Oncology. 6, p. 1 - 10 10 p., 1.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
172 Citations (Scopus)

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G., Santini, D., Pasquinelli, G., Morselli-Labate, A., Grady, E., Bunnett, N., Collins, S. & Corinaldesi, R., 2004, In : Gastroenterology. 126, 3, p. 693 - 702 10 p.

Research output: Contribution to journalArticleResearchpeer-review

999 Citations (Scopus)

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hubner, H., Pardon, E., Valant, C., Sexton, P., Christopoulos, A., Felder, C. C., Gmeiner, P., Steyaert, J., Weis, W., Garcia, K. C., Wess, J. & Kobilka, B., 2013, In : Nature. 504, 7478, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

527 Citations (Scopus)

Activation of canonical BMP4-Smad7 signaling suppresses breast cancer metastasis

Eckhardt, B. L., Cao, Y., Redfern, A. D., Chi, L. H., Burrows, A. D., Roslan, S., Sloan, E. K., Parker, B. S., Loi, S., Ueno, N. T., Lau, P. K. H., Latham, B. & Anderson, R. L., 15 Mar 2020, In : Cancer Research. 80, 6, p. 1304-1315 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

Rajagopal, S., Kumar, D. P., Mahavadi, S., Bhattacharya, S., Zhou, R., Corvera, C. U., Bunnett, N. W., Grider, J. R. & Murthy, K. S., 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 5, p. G527 - G535 9 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

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28 Citations (Scopus)

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T. M., Garcia-Caraballo, S., Maddern, J., Schober, G., O'Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. W. & Brierley, S. M., 17 Oct 2019, In : JCI Insight. 4, 20, 42 p., e131712.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticleResearchpeer-review

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14 Citations (Scopus)

Active cathepsins B, L, and S in murine and human pancreatitis

Lyo, V., Cattaruzza, F., Kim, T. N., Walker, A. W., Paulick, M., Cox, D. N., Cloyd, J., Buxbaum, J. L., Ostroff, J., Bogyo, M., Grady, E. F., Bunnett, N. W. & Kirkwood, K. S., 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 8, p. G894 - G903 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 others, Selemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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18 Citations (Scopus)

Acute β-adrenoceptor mediated glucose clearance in brown adipose tissue; a distinct pathway independent of functional insulin signaling

Olsen, J. M., Åslund, A., Bokhari, M. H., Hutchinson, D. S. & Bengtsson, T., Dec 2019, In : Molecular Metabolism. 30, p. 240-249 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture

Grubman, A., Vandekolk, T. H., Schröder, J., Sun, G., Hatwell-Humble, J., Chan, J., Oksanen, M., Lehtonen, S., Hunt, C., Koistinaho, J. E., Nilsson, S. K., Haynes, J. M., Pouton, C. W. & Polo, J. M., 9 Jun 2020, In : Stem Cell Reports. 14, 6, p. 1018-1032 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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A cyclic nucleotide sensitive promoter reporter system suitable for bacteria and plant cells

Wheeler, J., Freihat, L. & Irving, H. R., 2013, In : BMC Biotechnology. 13, 97, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

Fuxe, K., Ferre, S., Canals, M., Torvinen, M., Terasmaa, A., Marcellino, D., Goldberg, S., Staines, W., Jacobsen, K., Lluis, C., Woods, A., Agnati, L. & Franco, R., 2005, In : Journal of Molecular Neuroscience. 26, 2-3, p. 209 - 219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

Torvinen, M., Marcellino, D., Canals, M., Agnati, L., Lluis, C., Franco, R. & Fuxe, K., 2005, In : Molecular Pharmacology. 67, 2, p. 400 - 407 8 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Adipocyte-specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice

Whitham, M., Pal, M., Petzold, T., Hjorth, M., Egan, C. L., Brunner, J. S., Estevez, E., Iliades, P., Zivanovic, B., Reibe, S., Hughes, W. E., Findeisen, M., Hidalgo, J. & Febbraio, M. A., 30 Sep 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 317, 4, p. E597-E604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research & Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Adrenomedullin and calcitonin gene related peptide in the rat isolated kidney and in the anaesthetised rat: in vitro and in vivo effects.

Cooper, M. E. & Haynes, J. M., 1995, In : European Journal of Pharmacology. 280, p. 91-94

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Advances in G protein-coupled receptor allostery: From function to structure

Christopoulos, A., 2014, In : Molecular Pharmacology. 86, 5, p. 463 - 478 16 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

A fresh shine on cystic fibrosis inhalation therapy: Antimicrobial synergy of polymyxin B in combination with silver nanoparticles

Jasim, R., Schneider, E. K., Han, M., Azad, M. A. K., Hussein, M., Nowell, C., Baker, M. A., Wang, J., Li, J. & Velkov, T., 1 Apr 2017, In : Journal of Biomedical Nanotechnology. 13, 4, p. 447-457 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Age related changes of catecholamines and their metabolites in central nervous system regions of spontaneously hypertensive (SHR) and normotensive wistar-Kyoto (wky) rats:

Howes, L. G., Rowe, P. R., Summers, R. J. & Louis, W. J., 1 Jan 1984, In : Clinical and Experimental Hypertension. 6, 12, p. 2263-2277 15 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Age related changes of noradrenaline content in brain regions of spontaneously hypertensive (SHR) and normotensive wistar-Kyoto (WK) rats

Howes, L. G., Rowe, P. R., Summers, R. J. & Louis, W. J., 1 Jan 1983, In : Clinical and Experimental Hypertension. A5, 6, p. 857-874 18 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)