Research Output

2007

Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area

Lessard, A., Grady, E., Bunnett, N. & Pickel, V., 2007, In : Neuroscience. 144, 4, p. 1393 - 1408 16 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1, G i2, and Gi3

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2007, In : Molecular Pharmacology. 71, 5, p. 1349 - 1359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Grant, A., Cottrell, G., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G., Bautista-Cruz, F., Barajas-Lopez, C., Joseph, E., Levine, J., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P. & Bunnett, N., 2007, In : The Journal of Physiology. 578, 3, p. 715 - 733 19 p.

Research output: Contribution to journalArticleResearchpeer-review

295 Citations (Scopus)

Protease-activated receptors: mechanisms by which proteases sensitize TRPV channels to induce neurogenic inflammation and pain

Grant, A., Amadesi, S. & Bunnett, N., 2007, TRP ion channel function in sensory transduction and cellular signaling cascades. Liedtke, W. B. & Heller, S. (eds.). United States: Taylor & Francis, p. 1 - 12 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Protease-activated receptors: novel PARtners in innate immunity

Shpacovitch, V., Feld, M., Bunnett, N. & Steinhoff, M., 2007, In : Trends in Immunology. 28, 12, p. 535 - 544 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N., Sharkey, K., Ferraz, J., Shaffer, E. & Vergnolle, N., 2007, In : Journal of Clinical Investigation. 117, 3, p. 636 - 647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
443 Citations (Scopus)

Roof and floor of the muscarinic binding pocket: Variations in the binding modes of orthosteric ligands

Goodwin, J. A., Hulme, E. C., Langmead, C. J. & Tehan, B. G., 1 Dec 2007, In : Molecular Pharmacology. 72, 6, p. 1484-1496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Screening for positive allosteric modulators: Assessment of modulator concentration-response curves as a screening paradigm

Langmead, C. J., 1 Aug 2007, In : Journal of Biomolecular Screening. 12, 5, p. 668-676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury

Gazzieri, D., Trevisani, M., Springer, J., Harrison, S., Cottrell, G., Andre, E., Nicoletti, P., Massi, D., Zecchi, S., Nosi, D., Santucci, M., Gerard, N., Lucattelli, M., Lungarella, G., Fischer, A., Grady, E., Bunnett, N. & Geppetti, P., 2007, In : Free Radical Biology and Medicine. 43, 4, p. 581 - 589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The alpha1b-adrenoceptor exists as a higher-order oligomer: Effective oligomerization is required for receptor maturation, surface delivery, and function

Lopez-Gimenez, J., Canals, M., Pediani, J. & Milligan, G., 2007, In : Molecular Pharmacology. 71, 4, p. 1015 - 1029 15 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

Knecht, W., Cottrell, G., Amadesi, S., Mohlin, J., Skaregarde, A., Geddal, K., Peterson, A., Chapman, K., Hollenberg, M., Vergnolle, N. & Bunnett, N., 2007, In : The Journal of Biological Chemistry. 282, 36, p. 26089 - 26100 12 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

Gimenez-Llort, L., Schiffmann, S., Shmidt, T., Canela, L., Camon, L., Wassholm, M., Canals, M., Terasmaa, A., Fernandez-Teruel, A., Tobena, A., Popova, E., Ferre, S., Agnati, L., Ciruela, F., Martinez, E., Kruger, J., Lluis, C., Franco, R., Fuxe, K. & Bader, M., 2007, In : Neurobiology of Learning and Memory. 87, 1, p. 42 - 56 15 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)
2008

Antibodies that identify only the active conformation of Gi family G protein alpha subunits

Lane, J., Henderson, D., Powney, B., Wise, A., Rees, S., Daniels, D., Plumpton, C., Kinghorn, I. & Milligan, G., 2008, In : The FASEB Journal. 22, 6, p. 1924 - 1932 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats

Choy, K. H. C. & van den Buuse, M., 1 Jan 2008, In : European Neuropsychopharmacology. 18, 1, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system:Differences between peripheral and central CGRP receptor distribut

Lennerz, J., Ruhle, V., Ceppa, E., Neuhuber, W., Bunnett, N., Grady, E. & Messlinger, K., 2008, In : The Journal of Comparative Neurology. 507, 3, p. 1277 - 1299 23 p.

Research output: Contribution to journalArticleResearchpeer-review

208 Citations (Scopus)

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents

Andre, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P., Poole, D., Bunnett, N., Geppetti, P. & Patacchini, R., 2008, In : Journal of Clinical Investigation. 118, 7, p. 2574 - 2582 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
307 Citations (Scopus)

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

Canals, M. & Milligan, G., 2008, In : The Journal of Biological Chemistry. 283, 17, p. 11424 - 11434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andre, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N., Patacchini, R. & Geppetti, P., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 12045 - 12050 6 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

Chua, B. Y., Eriksson, E. M., Poole, D. P., Zeng, W. & Jackson, D. C., 1 Jun 2008, In : Peptides. 29, 6, p. 881-890 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Endothelin-converting enzyme-1 degrades internalized somatostatin-14

Roosterman, D., Kempkes, C., Cottrell, G., Padilla, B., Bunnett, N., Turck, C. & Steinhoff, M., 2008, In : Endocrinology. 149, 5, p. 2200 - 2207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

G protein coupling and ligand selectivity of the D2L and D 3 dopamine receptors

Lane, J., Powney, B., Wise, A., Rees, S. & Milligan, G., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 1, p. 319 - 330 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Proteinase activated-receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP response element binding protein

Wang, H., Wen, S., Bunnett, N., Leduc, R., Hollenberg, M. & MacNaughton, W., 2008, In : The Journal of Biological Chemistry. 283, 2, p. 809 - 815 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Stimulation of the neurokinin 3 receptor activates protein kinase Cepsilon and protein kinase D in enteric neurons

Poole, D., Amadesi, S., Rozengurt, E., Thacker, M., Bunnett, N. & Furness, J., 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, p. 1245 - 1256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor

Moloney, G. P., Angus, J. A., Robertson, A. D., Stoermer, M. J., Robinson, M., Lay, L., Wright, C. E., McRae, K. & Christopoulos, A., 28 Jul 2008, In : Australian Journal of Chemistry. 61, 7, p. 484-499 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

Jaakola, V-P., Griffith, M., Hanson, M., Cherezov, V., Chien, E., Lane, J., IJzerman, A. P. & Stevens, R., 2008, In : Science. 322, 21, p. 1211 - 1217 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1455 Citations (Scopus)

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

Sipe, W., Brierley, S., Martin, C., Phillis, B., Bautista-Cruz, F., Grady, E., Liedtke, W., Cohen, D., Vanner, S., Blackshaw, L. & Bunnett, N., 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 5, p. 1288 - 1298 11 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)
2009

B-type natriuretic peptide: Endogenous regulator of myocardial structure, biomarker and therapeutic target

Ritchie, R. H., Rosenkranz, A. C. & Kaye, D. M., 1 Sep 2009, In : Current Molecular Medicine. 9, 7, p. 814-825 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Cannabinoid receptor type 1 protects against age- related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells

Idris, A., Sophocleous, A., Landao-Bassonga, E., Canals, M., Milligan, G., Baker, D., Hof, R. & Ralston, S., 2009, In : Cell Metabolism. 10, 2, p. 139 - 147 9 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)

Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

Canals, M., Lopez-Gimenez, J. & Milligan, G., 2009, In : Biochemical Journal. 417, 1, p. 161 - 172 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Current and emerging trends in cell-based assays

Jordan, R., Bielefield-Sevigny, M., Christopoulos, A., Eglen, R. M., Mark, D. F., Pfleger, K., Valler, M. J. & Zaman, G. J. R., Dec 2009, In : Drug Discovery World. 11, 1, p. 66-78 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3- methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor

Lu, J. Y. L., Yang, Y., Gnacadja, G., Christopoulos, A. & Reagan, J. D., 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 3, p. 775 - 786 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2

Hasdemir, B., Murphy, J., Cottrell, G. & Bunnett, N., 2009, In : The Journal of Biological Chemistry. 284, 41, p. 28453 - 28466 14 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Endosomal endothelin-converting enzyme-1: A regulator of beta-arrestin-dependent ERK signaling

Cottrell, G., Padilla, B., Amadesi, S., Poole, D., Murphy, J., Hardt, M., Roosterman, D., Steinhoff, M. & Bunnett, N., 2009, In : The Journal of Biological Chemistry. 284, 33, p. 22411 - 22425 15 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Endosomes: A legitimate platform for the signaling train

Murphy, J., Padilla, B., Hasdemir, B., Cottrell, G. & Bunnett, N., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17615 - 17622 8 p.

Research output: Contribution to journalArticleResearchpeer-review

243 Citations (Scopus)

Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation

Cattaruzza, F., Cottrell, G., Vaksman, N. & Bunnett, N., 2009, In : British Journal of Pharmacology. 156, 5, p. 730 - 739 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., 15 Dec 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Orthosteric/allosteric bitopic ligands going hybrid with GPCRs

Valant, C., Sexton, P. M. & Christopoulos, A., 1 Jun 2009, In : Molecular Interventions. 9, 3, p. 125-135 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

69 Citations (Scopus)

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2

Amadesi, S., Grant, A., Cottrell, G., Vaksman, N., Poole, D., Rozengurt, E. & Bunnett, N., 2009, In : The Journal of Comparative Neurology. 516, 2, p. 141 - 156 16 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Relaxin family peptides and receptors in mammalian brain

Ma, S., 2009, Annals of the New York Academy of Sciences.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Structure and activity in the relaxin family of peptides

Ma, S., 2009, Annals of the New York Academy of Sciences.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Furness, S. & Whelan, F., 2009, In : Pharmacology and Therapeutics. 124, 3, p. 336 - 353 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
49 Citations (Scopus)
2010

AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems

Willoughby, D., Masada, N., Wachten, S., Pagano, M., Halls, M., Everett, K., Ciruela, A. & Cooper, D., 2010, In : The Journal of Biological Chemistry. 285, 26, p. 20328 - 20342 15 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

Horst, E., Peironcely, J., IJzerman, A. P., Beukers, M., Lane, J., van Vlijmen, H., Emmerich, M., Okuno, Y. & Bender, A., 2010, In : BMC Bioinformatics. 11, 316, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

Vergnolle, N., Cenac, N., Altier, C., Cellars, L., Chapman, K., Zamponi, G., Materazzi, S., Nassini, R., Liedtke, W., Cattaruzza, F., Grady, E., Geppetti, P. & Bunnett, N., 2010, In : British Journal of Pharmacology. 159, 5, p. 1161 - 1173 13 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Characterization of [3H]LUF5834: a novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor

Lane, J., Klaasse, E., Lin, J., van Bruchem, J., Beukers, M. & IJzerman, A. P., 2010, In : Biochemical Pharmacology. 80, 8, p. 1180 - 1189 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology

Hammond, A., Rodriguez, A., Townsend, S., Niswender, C., Gregory, K., Lindsley, C. & Conn, P., 2010, In : ACS Chemical Neuroscience. 1, 10, p. 702 - 716 15 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats

Choy, K. H. C., Dean, O., Berk, M., Bush, A. I. & van den Buuse, M., Dec 2010, In : European Journal of Pharmacology. 649, 1-3, p. 224-228 5 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Hybrid ortho/allosteric ligands for the adenosine A1 receptor

Narlawar, R., Lane, J., Doddareddy, M., Lin, J., Brussee, J. & IJzerman, A. P., 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3028 - 3037 10 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Ligand binding and subtype selectivity of the human A2A adenosine receptor: Identification and characterization of essential amino acid residues

Jaakola, V-P., Lane, J., Lin, J., Katritch, V., IJzerman, A. P. & Stevens, R., 2010, In : The Journal of Biological Chemistry. 285, 17, p. 13032 - 13044 13 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Measurement of ligand-G protein-coupled receptor interactions

Leach, K., Valant, C., Sexton, P. M. & Christopoulos, A., 25 Jan 2010, G Protein-Coupled Receptors: Essential Methods. Poyner, D. R. & Wheatley, M. (eds.). Chichester UK: Wiley-Blackwell, p. 1-29 29 p. (Proteins & Macromolecules).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)