Research Output 1969 2019

2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Adrenoceptors—New roles for old players

Michel, M. C., Bond, R. A. & Summers, R. J., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2339-2342 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

Circulating epinephrine is not required for chronic stress to enhance metastasis

Walker, A. K., Martelli, D., Ziegler, A. I., Lambert, G. W., Phillips, S. E., Hill, S. J., McAllen, R. M. & Sloan, E. K., 1 Jan 2019, In : Psychoneuroendocrinology. 99, p. 191-195 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia (Canadian Journal of Anesthesia/Journal canadien d'anesthésie, (2019), 66, 5, (546-561), 10.1007/s12630-019-01330-x)

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, 22 May 2019, (Accepted/In press) In : Canadian Journal of Anesthesia. 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Development of a shape-controlled H 2 S delivery system using epoxide-functional nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 23 Apr 2019, (Accepted/In press) In : Journal of Polymer Science, Part A: Polymer Chemistry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes

Li, T., Nowell, C. J., Cipolla, D., Rades, T. & Boyd, B. J., 1 Apr 2019, In : Molecular Pharmaceutics. 16, 4, p. 1775-1781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Erratum to: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (Nature Chemical Biology, (2018), 14, 11, (1059-1066), 10.1038/s41589-018-0145-x)

Masureel, M., Zou, Y., Picard, L. P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R. K., Weis, W. I., Zhang, C. & Kobilka, B. K., 1 Feb 2019, In : Nature Chemical Biology. 15, 2, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation, Purification, Generation, and Culture of Osteocytes

Gooi, J. H., Chia, L. Y., Vrahnas, C. & Sims, N. A., 1 Jan 2019, Bone Research Protocols. Idris, A. I. (ed.). 3 ed. New York NY USA: Humana Press, Vol. 1914. p. 39-51 13 p. (Methods in Molecular Biology; vol. 1914, no. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Metabolic control and sex: A focus on inflammatory-linked mediators

Henstridge, D. C., Abildgaard, J., Lindegaard, B. & Febbraio, M. A., 28 Feb 2019, (Accepted/In press) In : British Journal of Pharmacology. 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., 1 Mar 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives

Muthiah, D., Henshaw, G. K., DeBono, A. J., Capuano, B., Scammells, P. J. & Callaghan, R., 1 Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 164-172 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio, M. A., Reibe, S., Shalapour, S., Ooi, G. J., Watt, M. J. & Karin, M., 8 Jan 2019, In : Cell Metabolism. 29, 1, p. 18-26 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relieving ER stress to target NASH-driven hepatocellular carcinoma

Reibe, S. & Febbraio, M. A., 1 Feb 2019, In : Nature Reviews Endocrinology. 15, 2, p. 73-74 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D 2 receptor

Fyfe, T. J., Kellam, B., Mistry, S. N., Scammells, P. J., Lane, J. R. & Capuano, B., 15 Apr 2019, In : European Journal of Medicinal Chemistry. 168, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

McInerney, M. P., Pan, Y., Volitakis, I., Bush, A. I., Short, J. L. & Nicolazzo, J. A., Dec 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2247-2255 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Molecular Control of Calcitonin Receptor Signaling

dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C. G., Atanasio, S., Reynolds, C. A., Ramirez-Aportela, E., Carazo, J-M., Hick, C. A., Furness, S. G. B., Hay, D. L., Liang, Y-L., Miller, L. J., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 11 Jan 2019, In : ACS Pharmacology and Translational Sciences. 2, 1, p. 31-51 21 p.

Research output: Contribution to journalArticleResearchpeer-review

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

Baratchi, S., Keov, P., Darby, W., Lai, A., Khoshmanesh, K., Thurgood, P., Vahidi, P., Ejendal, K. & McIntyre, P., 23 Jan 2019, In : Frontiers in Pharmacology. 10, 12 p., 6.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 othersSelemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers

Stewart, G. D., Comps-Agrar, L., Nørskov-Lauritsen, L. B., Pin, J. P. & Kniazeff, J., 1 Jul 2018, In : Neuropharmacology. 136, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A Qualitative Study on the Perception of Australian and Malaysian Academic Teaching Staff in an Undergraduate B.Pharm Program on Case-based Learning

Jacob, S. A., Hui Dhing, O. & Malone, D., 2018, (Accepted/In press) In : American Journal of Pharmaceutical Education. 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A Structure-Activity Relationship Study of Bitopic N 6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

Aurelio, L., Baltos, J. A., Ford, L., Nguyen, A. T. N., Jörg, M., Devine, S. M., Valant, C., White, P. J., Christopoulos, A., May, L. T. & Scammells, P. J., 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2087-2103 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes S

Bradley, S. J., Molloy, C., Bundgaard, C., Mogg, A. J., Thompson, K. J., Dwomoh, L., Sanger, H. E., Crabtree, M. D., Brooke, S. M., Sexton, P. M., Felder, C. C., Christopoulos, A., Broad, L. M., Tobin, A. B. & Langmead, C. J., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 645-656 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, E., Just, R., Hick, C., Christopoulos, A., Sexton, P. M., Wootten, D. & Furness, S. G. B., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 111-129 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., May 2018, In : Brain, Behavior, and Immunity. 70, p. 36-47 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice (Archives of Toxicology, (2018), 92, 7, (2259-2271), 10.1007/s00204-018-2192-1)

Yun, B., Zhang, T., Azad, M. A. K., Wang, J., Nowell, C. J., Kalitsis, P., Velkov, T., Hudson, D. F. & Li, J., 1 Jul 2018, In : Archives of Toxicology. 92, 7, p. 2273-2274 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Liang, Y-L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., 27 Sep 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journalArticleResearchpeer-review

DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome

Marsh, A. P. L., Edwards, T. J., Galea, C., Cooper, H. M., Engle, E. C., Jamuar, S. S., Méneret, A., Moutard, M-L., Nava, C., Rastetter, A., Robinson, G., Rouleau, G., Roze, E., Spencer-Smith, M., Trouillard, O., Billette de Villemeur, T., Walsh, C. A., Yu, T. W., IRC5 Consortium, Heron, D. & 5 othersSherr, E. H., Richards, L. J., Depienne, C., Leventer, R. J. & Lockhart, P. J., 1 Jan 2018, In : Human Mutation. 39, 1, p. 23-39 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, P. R., Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery

Yadav, P., McLeod, V. M., Nowell, C. J., Selby, L. I., Johnston, A. P. R., Kaminskas, L. M. & Trevaskis, N. L., 28 Feb 2018, In : Journal of Controlled Release. 272, p. 17-28 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Pratt, G., Hiller, J., Gottumukkala, V., Sloan, E., Riedel, B. & Schier, R., 1 Jul 2018, In : British Journal of Anaesthesia. 121, 1, p. 45-57 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep

Hutchinson, D. S., Brew, N., Vu, T., Merlin, J., Hale, N., Walker, D. W. & Wong, F. Y., 1 Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Ticks from diverse genera encode chemokine-inhibitory evasin proteins (J. Biol. Chem. (2018) 292 (15670–15680) DOI: 10.1074/jbc.M117.807255)

Hayward, J., Sanchez, J., Perry, A., Huang, C., Valle, M. R., Canals, M., Payne, R. J. & Stone, M. J., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 41, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

Sanchez, J., Huma, Z. E., Lane, J. R., Liu, X., Bridgford, J. L., Payne, R. J., Canals, M. & Stone, M. J., 19 Dec 2018, (Accepted/In press) In : Journal of Biological Chemistry.

Research output: Contribution to journalArticleResearchpeer-review