Research Output 1969 2020

2020

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

Gregory, K., Giraldo, J., Diao, J., Christopoulos, A. & Leach, K., 2020, In : Molecular Pharmacology. 97, 1, p. 35-45 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition

Roca-Lapirot, O., Fossat, P., Ma, S., Egron, K., Trigilio, G., López-González, M. J., Covita, J., Bouali-Benazzouz, R., Favereaux, A., Gundlach, A. L. & Landry, M., 1 Feb 2019, In : Pain. 160, 2, p. 345-357 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O’Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. & Brierley, S. M., 19 Sep 2019, In : JCI Insight. 4, 18, 42 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Adipocyte-specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice

Whitham, M., Pal, M., Petzold, T., Hjorth, M., Egan, C. L., Brunner, J. S., Estevez, E., Iliades, P., Zivanovic, B., Reibe, S., Hughes, W. E., Findeisen, M., Hidalgo, J. & Febbraio, M. A., 30 Sep 2019, In : American journal of physiology. Endocrinology and metabolism. 317, 4, p. E597-E604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Adrenoceptors in white, brown, and brite adipocytes

Evans, B. A., Merlin, J., Bengtsson, T. & Hutchinson, D. S., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2416-2432 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Adrenoceptors—New roles for old players

Michel, M. C., Bond, R. A. & Summers, R. J., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2339-2342 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, 15 May 2019, In : Canadian Journal of Anesthesia. 66, 5, p. 546-561 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Ramirez Garcia, P. D., Retamal, J. S., Shenoy, P., Imlach, W., Sykes, M., Truong, N., Constandil, L., Pelissier, T., Nowell, C. J., Khor, S. Y., Layani, L. M., Lumb, C., Poole, D. P., Lieu, T., Stewart, G. D., Mai, Q. N., Jensen, D. D., Latorre, R., Scheff, N. N., Schmidt, B. L. & 5 others, Quinn, J. F., Whittaker, M. R., Veldhuis, N. A., Davis, T. P. & Bunnett, N. W., Dec 2019, In : Nature Nanotechnology. 14, p. 1150-1159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Anderson, B., Poole, D. P., Aurelio, L., Ng, G. Z., Fleischmann, M., Kasperkiewicz, P., Morissette, C., Drag, M., van Driel, I. R., Schmidt, B. L., Vanner, S. J., Bunnett, N. & Edgington-Mitchell, L., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 13295.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages

Lamkin, D. M., Srivastava, S., Bradshaw, K. P., Betz, J. E., Muy, K. B., Wiese, A. M., Yee, S. K., Waggoner, R. M., Arevalo, J. M. G., Yoon, A. J., Faull, K. F., Sloan, E. K. & Cole, S. W., 2019, In : Brain, Behavior, and Immunity. 80, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Can microbes increase exercise performance in athletes?

Turpin-Nolan, S. M., Joyner, M. J. & Febbraio, M. A., 1 Nov 2019, In : Nature Reviews Endocrinology. 15, 11, p. 629-630 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Carboxylated Cy5-Labeled Comb Polymers Passively Diffuse the Cell Membrane and Target Mitochondria

Mahmoud, A. M., De Jongh, P. A. J. M., Briere, S., Chen, M., Nowell, C. J., Johnston, A. P. R., Davis, T. P., Haddleton, D. M. & Kempe, K., 28 Aug 2019, In : ACS Applied Materials and Interfaces. 11, 34, p. 31302-31310 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance

Atkins, R. J., Stylli, S. S., Kurganovs, N., Mangiola, S., Nowell, C. J., Ware, T. M., Corcoran, N. M., Brown, D. V., Kaye, A. H., Morokoff, A., Luwor, R. B., Hovens, C. M. & Mantamadiotis, T., 15 Jan 2019, In : Experimental Cell Research. 374, 2, p. 353-364 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons

Albert-Gasco, H., Sanchez-Sarasua, S., Ma, S., García-Díaz, C., Gundlach, A. L., Sanchez-Perez, A. M. & Olucha-Bordonau, F. E., 15 Jan 2019, In : Brain Structure and Function. 224, 1, p. 453-469 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Characterisation and 3D structure of melanomacrophage centers in shorthorn sculpins (Myoxocephalus scorpius)

Dang, M., Nowell, C., Nguyen, T., Bach, L., Sonne, C., Nørregaard, R., Stride, M. & Nowak, B., 1 Apr 2019, In : Tissue and Cell. 57, p. 34-41 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Circulating epinephrine is not required for chronic stress to enhance metastasis

Walker, A. K., Martelli, D., Ziegler, A. I., Lambert, G. W., Phillips, S. E., Hill, S. J., McAllen, R. M. & Sloan, E. K., 1 Jan 2019, In : Psychoneuroendocrinology. 99, p. 191-195 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Complex Formation between VEGFR2 and the β2-Adrenoceptor

Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

Draper-Joyce, C. & Furness, S. G. B., 26 Jul 2019, In : ACS Pharmacology and Translational Sciences. 2, 4, p. 285-290 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Controlling the size and shape of liposomal ciprofloxacin nanocrystals by varying the lipid bilayer composition and drug to lipid ratio

Li, T., Clulow, A. J., Nowell, C. J., Hawley, A., Cipolla, D., Rades, T. & Boyd, B. J., 1 Nov 2019, In : Journal of Colloid and Interface Science. 555, p. 361-372 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia (Canadian Journal of Anesthesia/Journal canadien d'anesthésie, (2019), 66, 5, (546-561), 10.1007/s12630-019-01330-x)

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, Aug 2019, In : Canadian Journal of Anesthesia. 66, 8, p. 1007-1008 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., Felder, C. C., Christopoulos, A. & Dror, R. O., 1 Dec 2019, In : Nature Communications. 10, 1, p. 1-9 9 p., 3289.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

Pham, V., Zhu, Y., Dal Maso, E., Reynolds, C. A., Deganutti, G., Atanasio, S., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Furness, S. G. B., Wang, M-W., Wootten, D. & Sexton, P. M., 18 Mar 2019, In : ACS Pharmacology and Translational Sciences. 2, 3, p. 183-197 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Development of a Shape-Controlled H2S Delivery System Using Epoxide-Functional Nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 2019, In : Journal of Polymer Science, Part A: Polymer Chemistry. 57, 18, p. 1982–1993 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes

Li, T., Nowell, C. J., Cipolla, D., Rades, T. & Boyd, B. J., 1 Apr 2019, In : Molecular Pharmaceutics. 16, 4, p. 1775-1781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Elucidating the mechanisms of psychosocial influences on cancer using preclinical in vivo models

Sloan, E. K. & Walker, A. K., 1 Aug 2019, In : Current Opinion in Behavioral Sciences. 28, p. 129-135 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Erratum to: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (Nature Chemical Biology, (2018), 14, 11, (1059-1066), 10.1038/s41589-018-0145-x)

Masureel, M., Zou, Y., Picard, L. P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R. K., Weis, W. I., Zhang, C. & Kobilka, B. K., 1 Feb 2019, In : Nature Chemical Biology. 15, 2, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

Sanchez, J., Huma, Z. E., Lane, J. R., Liu, X., Bridgford, J. L., Payne, R. J., Canals, M. & Stone, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3464-3475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

Benredjem, B., Gallion, J., Pelletier, D., Dallaire, P., Charbonneau, J., Cawkill, D., Nagi, K., Gosink, M., Lukasheva, V., Jenkinson, S., Ren, Y., Somps, C., Murat, B., Van Der Westhuizen, E., Le Gouill, C., Lichtarge, O., Schmidt, A., Bouvier, M. & Pineyro, G., 9 Sep 2019, In : Nature Communications. 10, 1, 15 p., 4075.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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How an activation signal is transmitted through an excitatory receptor

Gregory, K. J., 7 Feb 2019, In : Nature. 566, 7742, p. 42-43 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Interaction of neurotransmitters and neurochemicals with lymphocytes

Kerage, D., Sloan, E. K., Mattarollo, S. R. & McCombe, P. A., 15 Jul 2019, In : Journal of Neuroimmunology. 332, p. 99-111 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

Retamal Santibanez, J. S., Ramirez Garcia, P., Shenoy, P., Poole, D. P. & Veldhuis, N., 12 Nov 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-10 10 p., 273.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain

Sulistio, A., Mansfeld, F. M., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Birkett, S., Blencowe, A., Qiao, G. G., Little, C. B., Shu, C. C., Bendele, A. M., Valade, D., Donohue, A. C., Quinn, J. F., Whittaker, M. R., Davis, T. P. & Tait, R. J., 24 May 2019, In : ACS Applied Bio Materials. 2, 7, p. 2822-2832 11 p.

Research output: Contribution to journalArticleResearchpeer-review