Research Output 1969 2019

2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Adrenoceptors—New roles for old players

Michel, M. C., Bond, R. A. & Summers, R. J., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2339-2342 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, 15 May 2019, In : Canadian Journal of Anesthesia. 66, 5, p. 546-561 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages

Lamkin, D. M., Srivastava, S., Bradshaw, K. P., Betz, J. E., Muy, K. B., Wiese, A. M., Yee, S. K., Waggoner, R. M., Arevalo, J. M. G., Yoon, A. J., Faull, K. F., Sloan, E. K. & Cole, S. W., 24 May 2019, (Accepted/In press) In : Brain, Behavior, and Immunity. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Circulating epinephrine is not required for chronic stress to enhance metastasis

Walker, A. K., Martelli, D., Ziegler, A. I., Lambert, G. W., Phillips, S. E., Hill, S. J., McAllen, R. M. & Sloan, E. K., 1 Jan 2019, In : Psychoneuroendocrinology. 99, p. 191-195 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Complex Formation between VEGFR2 and the β2-Adrenoceptor

Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia (Canadian Journal of Anesthesia/Journal canadien d'anesthésie, (2019), 66, 5, (546-561), 10.1007/s12630-019-01330-x)

Yap, A., Lopez-Olivo, M. A., Dubowitz, J., Hiller, J., Riedel, B. & the Global Onco-Anesthesia Research Collaboration Group, Aug 2019, In : Canadian Journal of Anesthesia. 66, 8, p. 1007-1008 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Development of a shape-controlled H 2 S delivery system using epoxide-functional nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 23 Apr 2019, (Accepted/In press) In : Journal of Polymer Science, Part A: Polymer Chemistry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes

Li, T., Nowell, C. J., Cipolla, D., Rades, T. & Boyd, B. J., 1 Apr 2019, In : Molecular Pharmaceutics. 16, 4, p. 1775-1781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Elucidating the mechanisms of psychosocial influences on cancer using preclinical in vivo models

Sloan, E. K. & Walker, A. K., 1 Aug 2019, In : Current Opinion in Behavioral Sciences. 28, p. 129-135 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Erratum to: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (Nature Chemical Biology, (2018), 14, 11, (1059-1066), 10.1038/s41589-018-0145-x)

Masureel, M., Zou, Y., Picard, L. P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R. K., Weis, W. I., Zhang, C. & Kobilka, B. K., 1 Feb 2019, In : Nature Chemical Biology. 15, 2, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

Sanchez, J., Huma, Z. E., Lane, J. R., Liu, X., Bridgford, J. L., Payne, R. J., Canals, M. & Stone, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3464-3475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of neurotransmitters and neurochemicals with lymphocytes

Kerage, D., Sloan, E. K., Mattarollo, S. R. & McCombe, P. A., 15 Jul 2019, In : Journal of Neuroimmunology. 332, p. 99-111 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Isolation, Purification, Generation, and Culture of Osteocytes

Gooi, J. H., Chia, L. Y., Vrahnas, C. & Sims, N. A., 1 Jan 2019, Bone Research Protocols. Idris, A. I. (ed.). 3 ed. New York NY USA: Humana Press, Vol. 1914. p. 39-51 13 p. (Methods in Molecular Biology; vol. 1914, no. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Localised GPCR signalling as revealed by FRET biosensors

Halls, M. L., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 48-56 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Metabolic control and sex: A focus on inflammatory-linked mediators

Henstridge, D. C., Abildgaard, J., Lindegaard, B. & Febbraio, M. A., 28 Feb 2019, (Accepted/In press) In : British Journal of Pharmacology. 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration

Dong, Y. D., Tchung, E., Nowell, C., Kaga, S., Leong, N., Mehta, D., Kaminskas, L. M. & Boyd, B. J., 2019, In : Journal of Liposome Research. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., 1 Mar 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open-Note Chemistry Exams as Opportunities for Meaningful Learning and Assessment

Yuriev, E., Lazarus, M. & Malone, D., 2019. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives

Muthiah, D., Henshaw, G. K., DeBono, A. J., Capuano, B., Scammells, P. J. & Callaghan, R., 1 Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 164-172 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio, M. A., Reibe, S., Shalapour, S., Ooi, G. J., Watt, M. J. & Karin, M., 8 Jan 2019, In : Cell Metabolism. 29, 1, p. 18-26 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relieving ER stress to target NASH-driven hepatocellular carcinoma

Reibe, S. & Febbraio, M. A., 1 Feb 2019, In : Nature Reviews Endocrinology. 15, 2, p. 73-74 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Civciristov, S. & Halls, M. L., Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2382-2401 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Deora, G. S., Qin, C. X., Vecchio, E. A., Debono, A. J., Priebbenow, D. L., Brady, R. M., Beveridge, J., Teguh, S. C., Deo, M., May, L. T., Krippner, G., Ritchie, R. H. & Baell, J. B., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5242-5248 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D 2 receptor

Fyfe, T. J., Kellam, B., Mistry, S. N., Scammells, P. J., Lane, J. R. & Capuano, B., 15 Apr 2019, In : European Journal of Medicinal Chemistry. 168, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The adenosine A 2B G protein-coupled receptor: Recent advances and therapeutic implications

Vecchio, E. A., White, P. J. & May, L. T., 1 Jan 2019, In : Pharmacology and Therapeutics. 198, p. 20-33 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

McInerney, M. P., Pan, Y., Volitakis, I., Bush, A. I., Short, J. L. & Nicolazzo, J. A., Dec 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2247-2255 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Molecular Control of Calcitonin Receptor Signaling

dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C. G., Atanasio, S., Reynolds, C. A., Ramirez-Aportela, E., Carazo, J-M., Hick, C. A., Furness, S. G. B., Hay, D. L., Liang, Y-L., Miller, L. J., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 11 Jan 2019, In : ACS Pharmacology and Translational Sciences. 2, 1, p. 31-51 21 p.

Research output: Contribution to journalArticleResearchpeer-review

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

Baratchi, S., Keov, P., Darby, W., Lai, A., Khoshmanesh, K., Thurgood, P., Vahidi, P., Ejendal, K. & McIntyre, P., 23 Jan 2019, In : Frontiers in Pharmacology. 10, 12 p., 6.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 othersSelemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers

Stewart, G. D., Comps-Agrar, L., Nørskov-Lauritsen, L. B., Pin, J. P. & Kniazeff, J., 1 Jul 2018, In : Neuropharmacology. 136, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein for Direct Volumetric Imaging of Whole Organs Using CLARITY

Scott, D. J., Gunn, N. J., Yong, K. J., Wimmer, V. C., Veldhuis, N. A., Challis, L. M., Haidar, M., Petrou, S., Bathgate, R. A. D. & Griffin, M. D. W., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 667.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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