Drug Discovery Biology

Active

Understanding how neural circuit activity is controlled by adenosine

Imlach, W. (Primary Chief Investigator (PCI)), Christopoulos, A. (Chief Investigator (CI)), De Koninck, Y. (Partner Investigator (PI)) & Spanswick, D. (Partner Investigator (PI))

Australian Research Council (ARC), Monash University – Internal Department Contribution

25/03/25 → 24/03/28

Project: Research

Development of a P2X1 receptor antagonist for use as a male contraceptive

Bennetts, F. (Primary Chief Investigator (PCI)), Ventura, S. (Supervisor) & Thal, D. (Supervisor)

17/03/25 → 17/03/27

Project: Research

Are lymphatics a regulator of skeletal muscle growth, metabolism & renewal?

Trevaskis, N. (Primary Chief Investigator (PCI)) & Turpin-Nolan, S. (Chief Investigator (CI))

1/02/25 → 31/01/28

Project: Research

Development of Allosteric and Bitopic Ligands to Tune Receptor Signalling

Scammells, P. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))

Australian Research Council (ARC)

29/01/25 → 28/01/28

Project: Research

Dynamics of calcitonin family receptor activation

Josephs, T. (Primary Chief Investigator (PCI)) & Sexton, P. (Chief Investigator (CI))

Australian Research Council (ARC), Monash University – Internal School Contribution

14/01/25 → 13/01/28

Project: Research

Adenosine A1 receptor negative allosteric modulators as novel pharmacological interventions for heart failure.

TN Nguyen, A. (Primary Chief Investigator (PCI)) & May, L. (Chief Investigator (CI))

10/01/25 → 31/12/25

Project: Research

Leveraging cryo-EM and protein engineering to elucidate GPCR function

Cary, B. (Primary Chief Investigator (PCI))

Australian Research Council (ARC), Monash University – Internal School Contribution

1/01/25 → 31/12/27

Project: Research

G protein-coupled receptor Response Mechanisms to Environmental Pollutants

TN Nguyen, A. (Primary Chief Investigator (PCI))

Australian Research Council (ARC), Monash University – Internal School Contribution

1/01/25 → 31/12/27

Project: Research

Impact of biased agonism at the GLP-1R in the treatment of obesity and type 2 diabetes

Hutchinson, D. (Primary Chief Investigator (PCI)), Cary, B. (Chief Investigator (CI)), Wootten, D. (Associate Investigator (AI)), Kebede, M. (Associate Investigator (AI)) & Sexton, P. (Associate Investigator (AI))

1/01/25 → 31/12/28

Project: Research

Understanding structure, dynamics and function of receptor splice variants

Piper, S. (Primary Chief Investigator (PCI))

1/01/25 → 31/12/27

Project: Research

Understanding structure, dynamics and function of receptor splice variants

Piper, S. (Primary Chief Investigator (PCI))

1/01/25 → 31/12/26

Project: Research

How lipid binding proteins shape the activity of nuclear hormone receptors

Halls, M. (Primary Chief Investigator (PCI)) & Scanlon, M. (Chief Investigator (CI))

Australian Research Council (ARC)

31/12/24 → 30/12/27

Project: Research

Automating quantitative analysis of goblet cells and mucus components

Rowe, M. (Primary Chief Investigator (PCI)) & Poole, D. (Chief Investigator (CI))

Histochemical Society Inc

1/10/24 → 30/09/25

Project: Research

Molecular insights into the allosteric regulation of opioid receptors

Batista Gondin, A. (Primary Chief Investigator (PCI))

Australian Research Council (ARC)

6/07/24 → 4/08/28

Project: Research

Mechanistic understanding of biased agonism and dimerisation for co-targeting incretin receptors for metabolic diseases

Wootten, D. (Primary Chief Investigator (PCI))

1/01/24 → 31/12/28

Project: Research

Structure determination of GPCR heteromers

Sexton, P., Wootten, D., Belousoff, M. & Shepard, R.

27/07/23 → 26/07/27

Project: Research

Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure

Ritchie, R. (Primary Chief Investigator (PCI)), Figtree, G. A. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)), Taylor, A. (Chief Investigator (CI)), Yang, J. Y. H. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Schiattarella, G. (Chief Investigator (CI)), Pinto, A. (Chief Investigator (CI)), Drummond, G. (Chief Investigator (CI)), Horowitz, J. D. (Chief Investigator (CI)), Bubb, K. (Chief Investigator (CI)), Ng, H. H. (Chief Investigator (CI)), Vecchio, L. (Associate Investigator (AI)), Nelson, A. (Associate Investigator (AI)), Kirkpatrick, C. (Associate Investigator (AI)), McDonald, C. (Associate Investigator (AI)), Febbraio, M. (Associate Investigator (AI)), Vinh, A. (Associate Investigator (AI)), Odiba, J. (Associate Investigator (AI)), Brown, H. (Associate Investigator (AI)) & Stupple, P. (Chief Investigator (CI))

1/02/23 → 31/01/26

Project: Research

Structure and dynamics of class B1 G protein coupled receptors

Wootten, D. (Primary Chief Investigator (PCI)), Belousoff, M. (Chief Investigator (CI)) & Josephs, T. (Chief Investigator (CI))

Australian Research Council (ARC), Monash University – Internal School Contribution

2/01/23 → 1/01/26

Project: Research

The physiological importance of GLP-1R and GIPR dimerisation

Wootten, D. (Primary Chief Investigator (PCI)) & Hutchinson, D. (Chief Investigator (CI))

Australian Research Council (ARC), Monash University – Internal School Contribution

2/01/23 → 1/01/26

Project: Research

Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction

Ritchie, R. (Primary Chief Investigator (PCI)), Stupple, P. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Vecchio, L. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Chong, J. J. H. (Chief Investigator (CI)), Charman, S. (Associate Investigator (AI)) & McDonald, C. (Associate Investigator (AI))

1/01/23 → 31/12/25

Project: Research

Cryo-electron microscopy determination of G protein-coupled receptor states

Zhang, C. (Primary Chief Investigator (PCI))

1/01/23 → 29/12/26

Project: Research

Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain

Poole, D. (Primary Chief Investigator (PCI)), Valant, C. (Chief Investigator (CI)), Carbone, S. (Chief Investigator (CI)), Mobbs, J. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)), King, S. K. (Associate Investigator (AI)), Imlach, W. (Associate Investigator (AI)), Hamilton, J. A. (Associate Investigator (AI)) & Veldhuis, N. (Associate Investigator (AI))

1/01/23 → 31/12/26

Project: Research

Modulation of the M4 muscarinic receptor for the treatment of schizophrenia

Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))

1/01/23 → 31/12/26

Project: Research

Mapping and defining inter-organ cross talk during exercise

Febbraio, M. (Primary Chief Investigator (PCI)) & Ramm, G. (Partner Investigator (PI))

29/06/22 → 28/06/25

Project: Research

Towards new therapeutics for neurofibromatosis-linked cancers and tumour growth

Ellisdon, A. (Primary Chief Investigator (PCI)) & Halls, M. (Chief Investigator (CI))

1/06/22 → 1/06/26

Project: Research

Novel GPR52 agonists for schizophrenia / Phrenix Therapeutics

Stewart, G. (Primary Chief Investigator (PCI)), Langmead, C. (Chief Investigator (CI)), Nithianantharajah, J. (Chief Investigator (CI)) & Baell, J. (Chief Investigator (CI))

1/06/22 → …

Project: Research

Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy

Kwan, P. (Primary Chief Investigator (PCI)), May, L. (Chief Investigator (CI)), Rollo, B. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Casillas-Espinosa, P. (Chief Investigator (CI)), Howden, S. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), Elliot, D. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Antonic-Baker, A. (Chief Investigator (CI)), Sumer, H. (Chief Investigator (CI)), Javaid, S. (Associate Investigator (AI)) & Gu, J. (Chief Investigator (CI))

1/06/22 → 31/05/27

Project: Research

Addressing the poor medication adherence in prevention of cardiovascular mortality and morbidity in Australia: development of a clinical decision support tool

Talic, S. (Primary Chief Investigator (PCI)), Ademi Delaney, Z. (Chief Investigator (CI)), Liew, D. (Chief Investigator (CI)), Bell, S. (Chief Investigator (CI)), Reid, C. (Chief Investigator (CI)), Green, S. (Chief Investigator (CI)), Ilomaki, J. (Chief Investigator (CI)), Zomer, E. (Chief Investigator (CI)), Berkovic, D. (Chief Investigator (CI)), Lybrand , S. (Chief Investigator (CI)) & Stratton, G. (Chief Investigator (CI))

1/06/22 → 31/05/26

Project: Research

Development of approaches for inactive, antagonist bound GPCR structures determination

Wootten, D. (Primary Chief Investigator (PCI)), Sexton, P. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Johnson, R. (Chief Investigator (CI)) & Han, S. (Chief Investigator (CI))

22/02/22 → 21/02/26

Project: Research

ASHRA: Australian Stroke and Heart Research Accelerator (ASHRA)

Nicholls, S. (Primary Chief Investigator (PCI)), Kovacic, J. C. (Chief Investigator (CI)), Zoungas, S. (Chief Investigator (CI)), Neal, B. C. (Chief Investigator (CI)), Chow, C. K. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Campbell, B. C. V. (Chief Investigator (CI)), Maple-Brown, L. J. (Chief Investigator (CI)), Brown, A. D. H. (Chief Investigator (CI)), Hayward, C. S. (Chief Investigator (CI)), Hill, A. (Chief Investigator (CI)), Hool, L. C. (Chief Investigator (CI)), Currie, P. (Chief Investigator (CI)), Rodgers, A. (Chief Investigator (CI)), Arnott, C. (Chief Investigator (CI)), Wu, J. H. Y. (Chief Investigator (CI)), Kritharides, L. (Chief Investigator (CI)), Ugander, M. (Chief Investigator (CI)), Chiang, J. (Chief Investigator (CI)), Davis, S. M. (Chief Investigator (CI)), Donnan, G. A. (Chief Investigator (CI)), Yan, B. (Chief Investigator (CI)), Barr, E. L. M. (Chief Investigator (CI)), Breen, J. (Chief Investigator (CI)), Barclay, J. (Chief Investigator (CI)), Brown, H. (Chief Investigator (CI)), Correa, M. (Chief Investigator (CI)), Wu, C. (Chief Investigator (CI)), Butters, J. (Chief Investigator (CI)), Glass, P. (Chief Investigator (CI)), Ritchie, R. (Chief Investigator (CI)), Vandenburg, J. (Chief Investigator (CI)), Patel, A. (Chief Investigator (CI)), Semsarian, C. (Chief Investigator (CI)), Martino, M. (Chief Investigator (CI)), Laranjo, L. (Chief Investigator (CI)), Thiagalingam, A. (Chief Investigator (CI)), Sivagangabalan, G. (Chief Investigator (CI)), Fox, K. (Chief Investigator (CI)), Rice, H. (Chief Investigator (CI)), Ali, M. (Chief Investigator (CI)), Francisco, J. (Chief Investigator (CI)), Dawidowska, I. (Chief Investigator (CI)), Greenway, A. (Chief Investigator (CI)), Prowse, A. B. J. (Chief Investigator (CI)), Delbaere, K. (Chief Investigator (CI)), Gray, P. (Chief Investigator (CI)) & Hennock, J. (Chief Investigator (CI))

10/01/22 → 15/02/26

Project: Research

A personalised pharmacogenomic approach to inform autosomal dominant hypocalcaemia treatment

Josephs, T.

1/01/22 → 31/12/26

Project: Research

Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy

May, L. (Primary Chief Investigator (PCI)), Webb, G. (Chief Investigator (CI)), Carlsson, J. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Christopoulos, A. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), O'Brien, T. (Associate Investigator (AI)), Rollo, B. (Associate Investigator (AI)), Casillas-Espinosa, P. (Associate Investigator (AI)), Gregory, K. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)) & Nguyen, T. (Associate Investigator (AI))

1/01/22 → 31/12/25

Project: Research

Impact of membrane composition on cholecystokinin receptor structure and function

Miller, L. J. (Primary Chief Investigator (PCI)) & Sexton, P. (Chief Investigator (CI))

1/01/22 → 30/11/25

Project: Research

alpha1-adrenoceptor protein structures and selective tools: towards novel treatments for heart failure and Alzheimer’s disease

Scott, D. J. (Primary Chief Investigator (PCI)), Abdul Ridha, A. (Chief Investigator (CI)), Chalmers, D. (Chief Investigator (CI)), Draper-Joyce, C. (Associate Investigator (AI)), Gooley, P. R. (Associate Investigator (AI)), Adlard, P. A. (Associate Investigator (AI)), Lankadeva, Y. R. (Associate Investigator (AI)), Betrie, A. H. (Associate Investigator (AI)), Graham, B. (Associate Investigator (AI)) & Thal, D. (Associate Investigator (AI))

National Health and Medical Research Council (NHMRC) (Australia)

1/01/22 → 31/12/25

Project: Research

Targeting the brain and sympathetic nervous system to improve outcomes in cancer cachexia

Lockie, S. (Primary Chief Investigator (PCI)), Walton, K. (Associate Investigator (AI)), Andrews, Z. (Associate Investigator (AI)), Stark, R. (Associate Investigator (AI)), Oldfield, B. (Associate Investigator (AI)), Sloan, E. (Associate Investigator (AI)) & Gregorevic, P. (Associate Investigator (AI))

1/01/22 → 31/12/25

Project: Research

Cryo‐EM structure determination of G protein‐coupled receptors

Sexton, P. (Primary Chief Investigator (PCI)), Wootten, D. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Nar, H. (Partner Investigator (PI)), Weichert, D. (Supervisor), Ebenhoch, R. (Supervisor), Ou, Q. (Chief Investigator (CI)) & Lee, D. (Chief Investigator (CI))

21/09/21 → 21/09/25

Project: Research

ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery

Sexton, P. (Primary Chief Investigator (PCI)), Rouiller, I. (Chief Investigator (CI)), Wootten, D. (Chief Investigator (CI)), van Oijen, A. (Chief Investigator (CI)), Parker, M. W. (Chief Investigator (CI)), Lucet, I. (Partner Investigator (PI)), Griffin, M. (Chief Investigator (CI)), Adams, D. J. (Chief Investigator (CI)), Czabotar, P. E. (Partner Investigator (PI)), Flocco, M. (Partner Investigator (PI)), Han, S. (Partner Investigator (PI)), Shepherd, R. (Partner Investigator (PI)), Ciferri, C. (Partner Investigator (PI)), Williams, P. A. (Partner Investigator (PI)), Brown, D. (Partner Investigator (PI)), Schreuder, H. (Partner Investigator (PI)), Reedtz-Runge, S. (Partner Investigator (PI)), Drinkwater, C. (Partner Investigator (PI)), Howard, B. L. (Partner Investigator (PI)), Betigeri, G. (Partner Investigator (PI)), Pryor, E. (Partner Investigator (PI)), How, J. (Project Manager) & Christopoulos, T. (Chief Investigator (CI))

Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)

23/03/21 → 23/03/27

Project: Research