Projects per year
Search results
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Active
Understanding how neural circuit activity is controlled by adenosine
Imlach, W. (Primary Chief Investigator (PCI)), Christopoulos, A. (Chief Investigator (CI)), De Koninck, Y. (Partner Investigator (PI)) & Spanswick, D. (Partner Investigator (PI))
Australian Research Council (ARC), Monash University – Internal Department Contribution
25/03/25 → 24/03/28
Project: Research
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Development of a P2X1 receptor antagonist for use as a male contraceptive
Bennetts, F. (Primary Chief Investigator (PCI)), Ventura, S. (Supervisor) & Thal, D. (Supervisor)
17/03/25 → 17/03/27
Project: Research
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Are lymphatics a regulator of skeletal muscle growth, metabolism & renewal?
Trevaskis, N. (Primary Chief Investigator (PCI)) & Turpin-Nolan, S. (Chief Investigator (CI))
1/02/25 → 31/01/28
Project: Research
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Development of Allosteric and Bitopic Ligands to Tune Receptor Signalling
Scammells, P. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))
Australian Research Council (ARC)
29/01/25 → 28/01/28
Project: Research
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Dynamics of calcitonin family receptor activation
Josephs, T. (Primary Chief Investigator (PCI)) & Sexton, P. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University – Internal School Contribution
14/01/25 → 13/01/28
Project: Research
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Adenosine A1 receptor negative allosteric modulators as novel pharmacological interventions for heart failure.
TN Nguyen, A. (Primary Chief Investigator (PCI)) & May, L. (Chief Investigator (CI))
10/01/25 → 31/12/25
Project: Research
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Leveraging cryo-EM and protein engineering to elucidate GPCR function
Cary, B. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University – Internal School Contribution
1/01/25 → 31/12/27
Project: Research
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G protein-coupled receptor Response Mechanisms to Environmental Pollutants
TN Nguyen, A. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University – Internal School Contribution
1/01/25 → 31/12/27
Project: Research
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Impact of biased agonism at the GLP-1R in the treatment of obesity and type 2 diabetes
Hutchinson, D. (Primary Chief Investigator (PCI)), Cary, B. (Chief Investigator (CI)), Wootten, D. (Associate Investigator (AI)), Kebede, M. (Associate Investigator (AI)) & Sexton, P. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Understanding structure, dynamics and function of receptor splice variants
Piper, S. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/27
Project: Research
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Understanding structure, dynamics and function of receptor splice variants
Piper, S. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/26
Project: Research
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How lipid binding proteins shape the activity of nuclear hormone receptors
Halls, M. (Primary Chief Investigator (PCI)) & Scanlon, M. (Chief Investigator (CI))
Australian Research Council (ARC)
31/12/24 → 30/12/27
Project: Research
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Automating quantitative analysis of goblet cells and mucus components
Rowe, M. (Primary Chief Investigator (PCI)) & Poole, D. (Chief Investigator (CI))
1/10/24 → 30/09/25
Project: Research
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Molecular insights into the allosteric regulation of opioid receptors
Batista Gondin, A. (Primary Chief Investigator (PCI))
Australian Research Council (ARC)
6/07/24 → 4/08/28
Project: Research
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Mechanistic understanding of biased agonism and dimerisation for co-targeting incretin receptors for metabolic diseases
Wootten, D. (Primary Chief Investigator (PCI))
1/01/24 → 31/12/28
Project: Research
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Structure determination of GPCR heteromers
Sexton, P., Wootten, D., Belousoff, M. & Shepard, R.
27/07/23 → 26/07/27
Project: Research
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Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure
Ritchie, R. (Primary Chief Investigator (PCI)), Figtree, G. A. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)), Taylor, A. (Chief Investigator (CI)), Yang, J. Y. H. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Schiattarella, G. (Chief Investigator (CI)), Pinto, A. (Chief Investigator (CI)), Drummond, G. (Chief Investigator (CI)), Horowitz, J. D. (Chief Investigator (CI)), Bubb, K. (Chief Investigator (CI)), Ng, H. H. (Chief Investigator (CI)), Vecchio, L. (Associate Investigator (AI)), Nelson, A. (Associate Investigator (AI)), Kirkpatrick, C. (Associate Investigator (AI)), McDonald, C. (Associate Investigator (AI)), Febbraio, M. (Associate Investigator (AI)), Vinh, A. (Associate Investigator (AI)), Odiba, J. (Associate Investigator (AI)), Brown, H. (Associate Investigator (AI)) & Stupple, P. (Chief Investigator (CI))
1/02/23 → 31/01/26
Project: Research
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Structure and dynamics of class B1 G protein coupled receptors
Wootten, D. (Primary Chief Investigator (PCI)), Belousoff, M. (Chief Investigator (CI)) & Josephs, T. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University – Internal School Contribution
2/01/23 → 1/01/26
Project: Research
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The physiological importance of GLP-1R and GIPR dimerisation
Wootten, D. (Primary Chief Investigator (PCI)) & Hutchinson, D. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University – Internal School Contribution
2/01/23 → 1/01/26
Project: Research
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Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction
Ritchie, R. (Primary Chief Investigator (PCI)), Stupple, P. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Vecchio, L. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Chong, J. J. H. (Chief Investigator (CI)), Charman, S. (Associate Investigator (AI)) & McDonald, C. (Associate Investigator (AI))
1/01/23 → 31/12/25
Project: Research
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Cryo-electron microscopy determination of G protein-coupled receptor states
Zhang, C. (Primary Chief Investigator (PCI))
1/01/23 → 29/12/26
Project: Research
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D. (Primary Chief Investigator (PCI)), Valant, C. (Chief Investigator (CI)), Carbone, S. (Chief Investigator (CI)), Mobbs, J. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)), King, S. K. (Associate Investigator (AI)), Imlach, W. (Associate Investigator (AI)), Hamilton, J. A. (Associate Investigator (AI)) & Veldhuis, N. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Mapping and defining inter-organ cross talk during exercise
Febbraio, M. (Primary Chief Investigator (PCI)) & Ramm, G. (Partner Investigator (PI))
29/06/22 → 28/06/25
Project: Research
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Towards new therapeutics for neurofibromatosis-linked cancers and tumour growth
Ellisdon, A. (Primary Chief Investigator (PCI)) & Halls, M. (Chief Investigator (CI))
1/06/22 → 1/06/26
Project: Research
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Novel GPR52 agonists for schizophrenia / Phrenix Therapeutics
Stewart, G. (Primary Chief Investigator (PCI)), Langmead, C. (Chief Investigator (CI)), Nithianantharajah, J. (Chief Investigator (CI)) & Baell, J. (Chief Investigator (CI))
1/06/22 → …
Project: Research
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Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P. (Primary Chief Investigator (PCI)), May, L. (Chief Investigator (CI)), Rollo, B. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Casillas-Espinosa, P. (Chief Investigator (CI)), Howden, S. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), Elliot, D. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Antonic-Baker, A. (Chief Investigator (CI)), Sumer, H. (Chief Investigator (CI)), Javaid, S. (Associate Investigator (AI)) & Gu, J. (Chief Investigator (CI))
1/06/22 → 31/05/27
Project: Research
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Addressing the poor medication adherence in prevention of cardiovascular mortality and morbidity in Australia: development of a clinical decision support tool
Talic, S. (Primary Chief Investigator (PCI)), Ademi Delaney, Z. (Chief Investigator (CI)), Liew, D. (Chief Investigator (CI)), Bell, S. (Chief Investigator (CI)), Reid, C. (Chief Investigator (CI)), Green, S. (Chief Investigator (CI)), Ilomaki, J. (Chief Investigator (CI)), Zomer, E. (Chief Investigator (CI)), Berkovic, D. (Chief Investigator (CI)), Lybrand , S. (Chief Investigator (CI)) & Stratton, G. (Chief Investigator (CI))
1/06/22 → 31/05/26
Project: Research
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Development of approaches for inactive, antagonist bound GPCR structures determination
Wootten, D. (Primary Chief Investigator (PCI)), Sexton, P. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Johnson, R. (Chief Investigator (CI)) & Han, S. (Chief Investigator (CI))
22/02/22 → 21/02/26
Project: Research
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ASHRA: Australian Stroke and Heart Research Accelerator (ASHRA)
Nicholls, S. (Primary Chief Investigator (PCI)), Kovacic, J. C. (Chief Investigator (CI)), Zoungas, S. (Chief Investigator (CI)), Neal, B. C. (Chief Investigator (CI)), Chow, C. K. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Campbell, B. C. V. (Chief Investigator (CI)), Maple-Brown, L. J. (Chief Investigator (CI)), Brown, A. D. H. (Chief Investigator (CI)), Hayward, C. S. (Chief Investigator (CI)), Hill, A. (Chief Investigator (CI)), Hool, L. C. (Chief Investigator (CI)), Currie, P. (Chief Investigator (CI)), Rodgers, A. (Chief Investigator (CI)), Arnott, C. (Chief Investigator (CI)), Wu, J. H. Y. (Chief Investigator (CI)), Kritharides, L. (Chief Investigator (CI)), Ugander, M. (Chief Investigator (CI)), Chiang, J. (Chief Investigator (CI)), Davis, S. M. (Chief Investigator (CI)), Donnan, G. A. (Chief Investigator (CI)), Yan, B. (Chief Investigator (CI)), Barr, E. L. M. (Chief Investigator (CI)), Breen, J. (Chief Investigator (CI)), Barclay, J. (Chief Investigator (CI)), Brown, H. (Chief Investigator (CI)), Correa, M. (Chief Investigator (CI)), Wu, C. (Chief Investigator (CI)), Butters, J. (Chief Investigator (CI)), Glass, P. (Chief Investigator (CI)), Ritchie, R. (Chief Investigator (CI)), Vandenburg, J. (Chief Investigator (CI)), Patel, A. (Chief Investigator (CI)), Semsarian, C. (Chief Investigator (CI)), Martino, M. (Chief Investigator (CI)), Laranjo, L. (Chief Investigator (CI)), Thiagalingam, A. (Chief Investigator (CI)), Sivagangabalan, G. (Chief Investigator (CI)), Fox, K. (Chief Investigator (CI)), Rice, H. (Chief Investigator (CI)), Ali, M. (Chief Investigator (CI)), Francisco, J. (Chief Investigator (CI)), Dawidowska, I. (Chief Investigator (CI)), Greenway, A. (Chief Investigator (CI)), Prowse, A. B. J. (Chief Investigator (CI)), Delbaere, K. (Chief Investigator (CI)), Gray, P. (Chief Investigator (CI)) & Hennock, J. (Chief Investigator (CI))
10/01/22 → 15/02/26
Project: Research
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A personalised pharmacogenomic approach to inform autosomal dominant hypocalcaemia treatment
1/01/22 → 31/12/26
Project: Research
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L. (Primary Chief Investigator (PCI)), Webb, G. (Chief Investigator (CI)), Carlsson, J. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Christopoulos, A. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), O'Brien, T. (Associate Investigator (AI)), Rollo, B. (Associate Investigator (AI)), Casillas-Espinosa, P. (Associate Investigator (AI)), Gregory, K. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)) & Nguyen, T. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Impact of membrane composition on cholecystokinin receptor structure and function
Miller, L. J. (Primary Chief Investigator (PCI)) & Sexton, P. (Chief Investigator (CI))
1/01/22 → 30/11/25
Project: Research
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alpha1-adrenoceptor protein structures and selective tools: towards novel treatments for heart failure and Alzheimer’s disease
Scott, D. J. (Primary Chief Investigator (PCI)), Abdul Ridha, A. (Chief Investigator (CI)), Chalmers, D. (Chief Investigator (CI)), Draper-Joyce, C. (Associate Investigator (AI)), Gooley, P. R. (Associate Investigator (AI)), Adlard, P. A. (Associate Investigator (AI)), Lankadeva, Y. R. (Associate Investigator (AI)), Betrie, A. H. (Associate Investigator (AI)), Graham, B. (Associate Investigator (AI)) & Thal, D. (Associate Investigator (AI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/22 → 31/12/25
Project: Research
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Targeting the brain and sympathetic nervous system to improve outcomes in cancer cachexia
Lockie, S. (Primary Chief Investigator (PCI)), Walton, K. (Associate Investigator (AI)), Andrews, Z. (Associate Investigator (AI)), Stark, R. (Associate Investigator (AI)), Oldfield, B. (Associate Investigator (AI)), Sloan, E. (Associate Investigator (AI)) & Gregorevic, P. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Cryo‐EM structure determination of G protein‐coupled receptors
Sexton, P. (Primary Chief Investigator (PCI)), Wootten, D. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Nar, H. (Partner Investigator (PI)), Weichert, D. (Supervisor), Ebenhoch, R. (Supervisor), Ou, Q. (Chief Investigator (CI)) & Lee, D. (Chief Investigator (CI))
21/09/21 → 21/09/25
Project: Research
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ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery
Sexton, P. (Primary Chief Investigator (PCI)), Rouiller, I. (Chief Investigator (CI)), Wootten, D. (Chief Investigator (CI)), van Oijen, A. (Chief Investigator (CI)), Parker, M. W. (Chief Investigator (CI)), Lucet, I. (Partner Investigator (PI)), Griffin, M. (Chief Investigator (CI)), Adams, D. J. (Chief Investigator (CI)), Czabotar, P. E. (Partner Investigator (PI)), Flocco, M. (Partner Investigator (PI)), Han, S. (Partner Investigator (PI)), Shepherd, R. (Partner Investigator (PI)), Ciferri, C. (Partner Investigator (PI)), Williams, P. A. (Partner Investigator (PI)), Brown, D. (Partner Investigator (PI)), Schreuder, H. (Partner Investigator (PI)), Reedtz-Runge, S. (Partner Investigator (PI)), Drinkwater, C. (Partner Investigator (PI)), Howard, B. L. (Partner Investigator (PI)), Betigeri, G. (Partner Investigator (PI)), Pryor, E. (Partner Investigator (PI)), How, J. (Project Manager) & Christopoulos, T. (Chief Investigator (CI))
Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)
23/03/21 → 23/03/27
Project: Research
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Development of novel therapies to treat obesity related metabolic diseases
1/01/21 → 31/12/25
Project: Research
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Using protein structure and dynamics to facilitate drug discovery
Thal, D. (Primary Chief Investigator (PCI))
1/01/21 → 31/12/25
Project: Research
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Understanding GPCR signalling networks
Halls, M. (Primary Chief Investigator (PCI))
30/11/20 → 30/11/25
Project: Research
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Formyl peptide receptor biased agonists as novel cardioprotective agents against myocardial infarction.
Vecchio, L. (Primary Chief Investigator (PCI))
25/08/20 → 31/12/28
Project: Research
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Understanding the impact of anaesthetic technique and neural-inflammatory signalling on cancer recurrence and metastasis.
Dubowitz, J. A. (Chief Investigator (CI)) & Sloan, E. (Chief Investigator (CI))
1/01/17 → …
Project: Other