Drug Discovery Biology

Engineering new tools to aid structure determination of membrane proteins

Thal, D., Veldhuis, N., Wang, H. & Scott, D. J.

9/10/19 → 9/10/22

Project: Research

Chemical-Biology Approaches to Pathway Selective Adenosine Receptor Ligands

Scammells, P. & Christopoulos, A.

1/07/19 → 30/06/22

Project: Research

NAFLD, NASH and Hepatocellular carcinoma: Mechanisms & Potential Treatments

Febbraio, M., Karin, M. & Shackel, N.

1/07/19 → 31/12/20

Project: Research

Discovering novel allosteric probes of muscarinic acetylcholine receptors

Valant, C., Scammells, P. & Christopoulos, A.

10/06/19 → 9/06/22

Project: Research

Understanding the impact of anaesthetic technique and neural-inflammatory signalling on cancer recurrence and metastasis

Dubowitz, J. & Sloan, E.

1/06/19 → 29/02/20

Project: Research

Professionalism, reflective-thinking and resilience links with occupational therapy, social work, pharmacy and education students’ fieldwork-performance success?: Informing curriculum and work-readiness

Brown, T., O'Donovan, R., Oliaro, L., Grieve, A., Malone, D., Furletti, S., Bevilacqua, M., Hewitt, A., Yu, M., Ross, B. & Cousland, R. C.

Monash University – Internal Faculty Contribution

1/04/19 → 31/03/20

Project: Research

Understanding the kinetics of nanomedicine clearance from healthy and diseased lungs

Kaminskas, L., Whittaker, M. & Whittaker, A. K.

1/04/19 → 31/03/22

Project: Research

Characterisation of novel ligands for diabetes

Hutchinson, D. & Summers, R.

Atrogi Pty Ltd

4/02/19 → 3/02/20

Project: Research

The designer cytokine IC7: a novel therapy for the treatment of type 2 Diabetes

Febbraio, M. & Rose-John, S.

1/02/19 → 31/12/22

Project: Research

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Febbraio, M.

1/02/19 → 31/12/21

Project: Research

Novel targeting of the glucagon family of G protein coupled receptors

Wootten, D.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

A structural understanding of calcitonin gene-related peptide and adrenomedullin function

Liang, L. & Hay, D.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

The physiological and pathophysiological relevance of glucagon-like-peptide-1 receptor biased agonism

Wootten, D. & Hutchinson, D.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/22

Project: Research

Translating membrane proteins into therapeutics; from bedside to bench

Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.

1/01/19 → 31/12/23

Project: Research

NHMRC Research Fellowship

Sexton, P.

1/01/19 → 31/12/23

Project: Research

The molecular basis for efficacy at G protein coupled receptors (GPCRs)

Furness, S.

Australian Research Council (ARC)

1/01/19 → 31/12/22

Project: Research

Prodrug Development of Biased N-Alkylpyridazinones for the Acute Intravenous Treatment of Myocardial Ischaemia-Reperfusion Injury

Baell, J., Ritchie, R. H., Kirkpatrick, C., Figtree, G., Deora, G. & Qin, H.

1/01/19 → 31/12/20

Project: Research

NHMRC Equipment Grant - Promethion High-Definition Multiplexed Respirometry System

Sexton, P., Christopoulos, A., Wootten, D. & Langmead, C.

Monash University – Internal Faculty Contribution, Monash University – Internal Department Contribution

1/01/19 → 31/12/19

Project: Research

ICON: ICON Collaboration-Tracing health impacts of natural and added nutrients in foods – approach for next-generation validation of the function of foods

Bennett, L., Bucking, M., Kotthoff, M., McCaffrey, T., Robinson, A. & Haynes, J.

1/08/18 → 1/08/21

Project: Research

Male contraception through pharmacological blockade of sperm transport

Ventura, S., Baell, J., Charman, S. & Sexton, P.

Male Contraceptive Initiative

1/08/18 → 31/05/20

Project: Research

Defining the functional pathology of Hirschsprung's Disease

Carbone, S.

Equity Trustees

5/06/18 → 31/12/19

Project: Research

Intracellular Drug Transport

Porter, C., Scanlon, M. & Halls, M.

26/04/18 → 26/04/20

Project: Research

G Protein-Coupled Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

May, L.

The Heart Foundation

1/01/18 → 1/08/24

Project: Research

Structural characterisation of the co-inhibitory complex formed by the tumour suppressor PTEN and the metastatic factor PREX2

Ellisdon, A., Elmlund, H. & Halls, M.

1/01/18 → 31/12/20

Project: Research

Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

Christopoulos, A., May, L., Imlach, W., Hill, S. & Scott, D.

1/01/18 → 31/12/22

Project: Research

Discovery and Characterisation of Tick Evasins - Inhibitors of Chemokine-mediated Inflammation

Stone, M., Payne, R., Rothenberg, M., Canals, M. & Wilce, M.

1/01/18 → 31/12/20

Project: Research

Chikungunya virus disease; the role of proteases and their receptors

Suhrbier, A., Bird, P., Prow, N. A. & Zhao, E.

1/01/18 → 23/12/20

Project: Research

Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors

Thal, D., Gooley, P. R. & Dror, R.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/21

Project: Research

Adenosine Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

May, L., White, P. & Kompa, A.

1/01/18 → 31/12/20

Project: Research

Towards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disorders

Leach, K., Gregory, K., Conigrave, A., Capuano, B., Kufareva, I., Thakker, R. & Hannan, F.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/20

Project: Research

Mechanisms of Ligand-Selective Signalling by Chemokine Receptors

Stone, M., Canals, M., Lane, R. & Schittenhelm, R.

1/01/18 → 31/12/20

Project: Research

IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Meinhardt, A., Loveland, K., Bhushan, S., Ellem, S. J., Hedger, M., O'Bryan, M., O'Donnell, L., Stanton, P., Risbridger, G., Baker, M. A., Hobbs, R., Loveland, B., Exintaris, B., Western, P., McLachlan, R., Whittaker, M., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.

1/10/17 → 31/03/22

Project: Research

Exploring metabotropic glutamate receptor 5 bias, allostery and heteromers

Gregory, K.

1/07/17 → 30/06/21

Project: Research

Molecular insight into allosteric modulation of G protein-coupled receptors

Thal, D.

Australian Research Council (ARC)

1/01/17 → 31/12/19

Project: Research

Designing Nanoparticles to Combat Cellular Dysfunction

Whittaker, M., Kaminskas, L., Quinn, J. & Sloan, E.

Australian Research Council (ARC), Monash University

1/01/17 → 31/12/19

Project: Research

Understanding bias and allostery at the calcium sensing receptor

Leach, K.

Australian Research Council (ARC), Monash University

1/01/17 → 2/12/22

Project: Research

Spatial and temporal dimensions of mu-opioid receptor signalling: implications for the development of tolerance

Halls, M., Canals, M. & Poole, D.

National Health & Medical Research Council (NHMRC)

1/01/17 → 30/06/20

Project: Research

The structural basis for biased agonism at the glucagon-like peptide-1 receptor

Wootten, D. & Miller, L.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/20

Project: Research

Alcohol and Striatal Adaptation

Lawrence, A., Langmead, C. & Spanswick, D.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/20

Project: Research

Stabilising biased allosteric G protein-coupled receptor conformations

Leach, K., Gregory, K., Capuano, B. & Kufareva, I.

Australian Research Council (ARC), Monash University, University of California

1/01/17 → 31/12/19

Project: Research

Investigating the impact of coincident modulation of adenosine and glutamate receptors on neuronal activity - implications for CNS drug discovery

Gregory, K., May, L. & Vernall, A.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/19

Project: Research

Defining the mechanisms of action for ozonide antimalarials

Creek, D., Charman, S. & Edgington-Mitchell, L.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/19

Project: Research

Structural and functional characterisation of the oncogene P-Rex1

Ellisdon, A., Whisstock, J., Elmlund, H. & Halls, M.

1/01/17 → 31/12/19

Project: Research

Understanding the impact of anaesthetic technique and neural-inflammatory signalling on cancer recurrence and metastasis.

Dubowitz, J. A. & Sloan, E.

1/01/17 → …

Project: Other

A structural understanding of class B G protein-coupled receptor function

Sexton, P., Kobilka, B., Skiniotis, G. & Furness, S.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/21

Project: Research

Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical Efficacy

Christopoulos, A., Sexton, P. & Tobin, A. B.

1/11/16 → 31/10/21

Project: Research

The Importance of Receptor Trafficking for Signalling of Pain and Inflammation

Halls, M., Bunnett, N., Canals, M., Davis, T. & Porter, C.

National Health & Medical Research Council (NHMRC)

1/01/15 → 31/12/19

Project: Research

Understanding the Cellular Pathways of Nuclear Receptor Activation

Porter, C., Bunnett, N., Halls, M. & Scanlon, M.

Australian Research Council (ARC), Monash University

1/01/15 → 1/12/19

Project: Research

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Davis, T., Boyd, B., Bunnett, N., Caruso, F., Corrie, S. R., Crampin, E., Gooding, J., Johnston, A., Kavallaris, M., Kearnes, M., Kent, S., McGhee, J., Nann, T., Parton, R., Porter, C., Thordarson, P., Thurecht, K., Voelcker, N. H., Whittaker, A., Abbott, N., Alexander, C., Dawson, K., Greguric, I., Haddleton, D., Hawker, C., Lee, D. S., Lewis, J., McLean, K., Stevens, M., Jones-Jayasinghe, N., Thierry, B. & Prestidge, C. A.

Australian Research Council (ARC), Memorial Sloan Kettering Cancer Center, The University of Nottingham (UK), University College Dublin, University of California , University of Warwick, University of Wisconsin-Madison, SungKyunKwan University, Monash University, The University of Melbourne, The University of New South Wales, The University of Queensland , University of South Australia, Australian Nuclear Science and Technology Organisation , CSIRO Materials Science and Engineering (CMSE), Imperial College London

30/06/14 → 29/06/21

Project: Research

Signalosomes and compartmentalisation in cellular homeostasis and disease

Halls, M.

National Health & Medical Research Council (NHMRC)

1/01/14 → 31/10/19

Project: Research