Research Output 1975 2019

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2016

An "unlikely" pair: the antimicrobial synergy of polymyxin B in combination with the cystic fibrosis transmembrane conductance regulator drugs KALYDECO and ORKAMBI

Schneider, E. K., Azad, M. A. K., Han, M-L., Zhou, Q. T., Wang, J., Huang, J. X., Cooper, M. A., Doi, Y., Baker, M. A., Bergen, P. J., Li, J. & Velkov, T., 8 Jul 2016, In : ACS Infectious Diseases. 2, 7, p. 478-488 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Applying surface energy derived cohesive-adhesive balance model in predicting the mixing, flow and compaction behaviour of interactive mixtures

Mangal, S., Meiser, F., Tan, G., Gengenbach, T., Morton, D. A. V. & Larson, I., 1 Jul 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 104, p. 110-116 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aqueous Copper(II) Photoinduced Polymerization of Acrylates: Low Copper Concentration and the Importance of Sodium Halide Salts

Jones, G. R., Whitfield, R., Anastasaki, A. & Haddleton, D. M., 15 Jun 2016, In : Journal of the American Chemical Society. 138, 23, p. 7346-7352 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo

Teo, J., McCarroll, J. A., Boyer, C., Youkhana, J., Sagnella, S. M., Duong, H. T. T., Liu, J., Sharbeen, G., Goldstein, D., Davis, T. P., Kavallaris, M. & Phillips, P. A., 11 Jul 2016, In : Biomacromolecules. 17, 7, p. 2337-2351 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J. F., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 7 Dec 2016, In : Polymer Chemistry. 7, 45, p. 6875-6879 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., Renne, G., Gandini, S., Pouton, C. W., Ferrari, D., Möller, A., Stacker, S. A. & Sloan, E. K., 1 Mar 2016, In : Nature Communications. 7, 14 p., 10634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Colistin and polymyxin B dosage regimens against Acinetobacter baumannii: differences in activity and the emergence of resistance

Cheah, S-E., Li, J., Tsuji, B. T., Forrest, A., Bulitta, J. B. & Nation, R., 1 Jul 2016, In : Antimicrobial Agents and Chemotherapy. 60, 7, p. 3921-3933 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Colistin-induced apoptosis of neuroblastoma-2a cells involves the generation of reactive oxygen species, mitochondrial dysfunction, and autophagy

Dai, C., Tang, S., Velkov, T. & Xiao, X., 1 Sep 2016, In : Molecular Neurobiology. 53, 7, p. 4685-4700 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

Rao, G. G., Ly, N. S., Diep, J., Forrest, A., Bulitta, J. B., Holden, P. N., Nation, R. L., Li, J. & Tsuji, B., 1 Sep 2016, In : International Journal of Antimicrobial Agents. 48, 3, p. 331-336 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii

Lenhard, J. R., Gall, J. S., Bulitta, J. B., Thamlikitkul, V., Landersdorfer, C. B., Forrest, A., Nation, R. L., Li, J. & Tsuji, B. T., 1 Dec 2016, In : International Journal of Antimicrobial Agents. 48, 6, p. 719-724 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strains

Yang, T., Xie, S. C., Cao, P., Giannangelo, C., McCaw, J., Creek, D. J., Charman, S. A., Klonis, N. & Tilley, L., 1 Aug 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4501-4510 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Compound heterozygous FXN mutations and clinical outcome in Friedreich ataxia

Galea, C., Huq, A., Lockhart, P. J., Tai, G., Corben, L., Yiu, E. M., Gurrin, L. C., Lynch, D. R., Gelbard, S., Durr, A., Pousset, F., Parkinson, M., Labrum, R., Giunti, P., Perlman, S. L., Delatycki, M. & Evans-Galea, M. V., 2016, In : Annals of Neurology. 79, 3, p. 485-495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergstrom, C., Charman, W. N. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 6-21 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity

Chan, L., Ascher, D. B., Yadav, R., Bulitta, J., Williams, C. C., Porter, C., Landersdorfer, C. & Kaminskas, L., 2016, In : Molecular Pharmaceutics. 13, 4, p. 1229-1241 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled aqueous polymerization of acrylamides and acrylates and "in situ " depolymerization in the presence of dissolved CO2

Lloyd, D. J., Nikolaou, V., Collins, J. S., Waldron, C., Anastasaki, A., Bassett, S. P., Howdle, S. M., Blanazs, A., Wilson, P., Kempe, K. & Haddleton, D., 2016, In : Chemical Communications. 52, 39, p. 6533-6536 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlling integrin-based adhesion to a degradable electrospun fibre scaffold via SI-ATRP

Rodda, A. E., Ercole, F., Glattauer, V., Nisbet, D. R., Healy, K. E., Dove, A. P., Meagher, L. & Forsythe, J. S., 7 Dec 2016, In : Journal of Materials Chemistry B. 4, 45, p. 7314-7322 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclic peptide-polymer conjugates: Grafting-to vs grafting-from

Larnaudie, S. C., Brendel, J. C., Jolliffe, K. A. & Perrier, S., 1 Apr 2016, In : Journal of Polymer Science, Part A: Polymer Chemistry. 54, 7, p. 1003-1011 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility

Hetherington, L., Schneider, E. K., DeKretser, D., Muller, C. H., Hondermarck, H., Velkov, T. & Baker, M. A., 1 Dec 2016, In : Molecular & Cellular Proteomics. 15, 12, p. 3685-3693 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation

Sou, T., Forbes, R. T., Gray, J., Prankerd, R. J., Kaminskas, L. M., McIntosh, M. P. & Morton, D. A. V., 1 Jan 2016, In : Powder Technology. 287, p. 248-255 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Determining the size exclusion for nanoparticles in citrus leaves

Etxeberria, E., Gonzalez, P., Bhattacharya, P., Sharma, P. & Ke, P-C., 1 Jun 2016, In : HortScience. 51, 6, p. 732-737 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Discrete copper(II)-formate complexes as catalytic precursors for photo-induced reversible deactivation polymerization

Nikolaou, V., Anastasaki, A., Brandford-Adams, F., Whitfield, R., Jones, G. R., Nurumbetov, G. & Haddleton, D. M., 7 Jan 2016, In : Polymer Chemistry. 7, 1, p. 191-197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling

Bergen, P. J., Bulitta, J. B., Kirkpatrick, C. M. J., Rogers, K. E., McGregor, M. J., Wallis, S. C., Paterson, D. L., Lipman, J., Roberts, J. A. & Landersdorfer, C. B., 1 Sep 2016, In : Journal of Antimicrobial Chemotherapy. 71, 9, p. 2509-2520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures

Mangal, S., Lakio, S., Gengenbach, T., Larson, I. & Morton, D. A. V., 5 Dec 2016, In : International Journal of Pharmaceutics. 514, 2, p. 341-352 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of colistin on amino acid neurotransmitters and blood-brain barrier in the mouse brain

Wang, J., Yi, M., Chen, X., Muhammad, I., Liu, F., Li, R., Li, J. & Li, J., 1 May 2016, In : Neurotoxicology and Teratology. 55, p. 32-37 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin

Wang, W., Zhou, Q. T., Sun, S-P., Denman, J. A., Gengenbach, T. R., Barraud, N., Rice, S. A., Li, J., Yang, M. & Chan, H-K., 1 Mar 2016, In : The AAPS Journal. 18, 2, p. 372-384 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Efficient click-addition sequence for polymer-polymer couplings

Brendel, J. C., Gody, G. & Perrier, S., 21 Sep 2016, In : Polymer Chemistry. 7, 35, p. 5536-5543 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Emotion response and regulation to “happy” and “sad” music stimuli: Partial synchronization of subjective and physiological responses

White, E. L. & Rickard, N. S., 1 Mar 2016, In : Musicae Scientiae. 20, 1, p. 11-25 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Energy transfer in pendant perylene diimide copolymers

Davis, N. J. L. K., Macqueen, R. W., Roberts, D. A., Danos, A., Dehn, S., Perrier, S. & Schmidt, T. W., 2016, In : Journal of Materials Chemistry C. 4, 35, p. 8270-8275 6 p.

Research output: Contribution to journalArticleResearchpeer-review

External manipulation of nanostructure in photoresponsive lipid depot matrix to control and predict drug release in vivo

Fong, W-K., Hanley, T. L., Thierry, B., Hawley, A., Boyd, B. J. & Landersdorfer, C. B., 28 Apr 2016, In : Journal of Controlled Release. 228, p. 67-73 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile access to thermoresponsive filomicelles with tuneable cores

Truong Phuoc, N., Quinn, J. F., Anastasaki, A., Haddleton, D. M., Whittaker, M. R. & Davis, T. P., 2016, In : Chemical Communications. 52, 24, p. 4497-4500 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile one-pot/one-step synthesis of heterotelechelic: N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers

de Jongh, P. A. J. M., Bennett, M. R., Sulley, G. S., Wilson, P., Davis, T. P., Haddleton, D. M. & Kempe, K., 28 Nov 2016, In : Polymer Chemistry. 7, 44, p. 6703-6707 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

Truong Phuoc, N., Whittaker, M. R., Anastasaki, A., Haddleton, D. M., Quinn, J. F. & Davis, T. P., 14 Jan 2016, In : Polymer Chemistry. 7, 2, p. 430-440 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding protein 5 at the blood–brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function

Pan, Y., Short, J. L., Choy, K. H. C., Zeng, A. X., Marriott, P. J., Owada, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., 16 Nov 2016, In : Journal of Neuroscience. 36, 46, p. 11755-11767 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Formation of drug nanocrystals under nanoconfinement afforded by liposomes

Cipolla, D., Wu, H., Salentinig, S., Boyd, B., Rades, T., Vanhecke, D., Petri-Fink, A., Rothin-Rutishauser, B., Eastman, S., Redelmeier, T., Gonda, I. & Chan, H. K., 2016, In : RSC Advances. 6, 8, p. 6223-6233 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Gadolinium-functionalized nanoparticles for application as magnetic resonance imaging contrast agents: via polymerization-induced self-assembly

Esser, L., Truong, N. P., Karagoz, B., Moffat, B. A., Boyer, C., Quinn, J. F., Whittaker, M. R. & Davis, T. P., 21 Dec 2016, In : Polymer Chemistry. 7, 47, p. 7325-7337 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells

Nedumpully-Govindan, P., Gurzov, E., Chen, P., Pilkington, E. H., Stanley, W. J., Litwak, S. A., Davis, T. P., Ke, P. C. & Ding, F., 2016, In : Physical Chemistry Chemical Physics. 18, 1, p. 94-100 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Haplotyping the human leukocyte antigen system from single chromosomes

Murphy, N. M., Burton, M., Powell, D. R., Rossello, F. J., Cooper, D., Chopra, A., Hsieh, M. J., Sayer, D. C., Gordon, L., Pertile, M. D., Tait, B. D., Irving, H. R. & Pouton, C. W., 27 Jul 2016, In : Scientific Reports. 6, 9 p., 30381.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

HD Flow Cytometry: An Improved Way to Quantify Cellular Interactions with Nanoparticles

Selby, L. I., Kongkatigumjorn, N., Such, G. K. & Johnston, A. P. R., 21 Sep 2016, In : Advanced Healthcare Materials. 5, 18, p. 2333-2338 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Human immune cell targeting of protein nanoparticles - caveospheres

Glass, J. J., Yuen, D. M. T., Rae, J. A., Johnston, A., Parton, R. G., Kent, S. J. & De Rose, R., 2016, In : Nanoscale. 8, 15, p. 8255 - 8265 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

Lu, X., Chan, F. T., Xu, C., Zhu, L., Zhou, Q. T., Roberts, K. D., Chan, H. K., Li, J. & Zhou, F., 1 Feb 2016, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 403-412 10 p., dkv340.

Research output: Contribution to journalArticleResearchpeer-review

Hyaluronic acid molecular weight determines lung clearance and biodistribution after instillation

Kuehl, C., Zhang, T., Kaminskas, L. M., Porter, C. J. H., Davies, N. M., Forrest, L. & Berkland, C., 6 Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 1904-1914 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hyperbranched Polymers with High Degrees of Branching and Low Dispersity Values: Pushing the Limits of Thiol-Yne Chemistry

Cook, A. B., Barbey, R., Burns, J. A. & Perrier, S., 8 Mar 2016, In : Macromolecules. 49, 4, p. 1296-1304 9 p.

Research output: Contribution to journalArticleResearchpeer-review