Research Output 1975 2019

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2018

Optimization of a meropenem-tobramycin combination dosage regimen against hypermutable and nonhypermutable pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model

Landersdorfer, C. B., Rees, V. E., Yadav, R., Rogers, K. E., Kim, T. H., Bergen, P. J., Cheah, S-E., Boyce, J. D., Peleg, A. Y., Oliver, A., Shin, B. S., Nation, R. L. & Bulitta, J. B., 1 Apr 2018, In : Antimicrobial Agents and Chemotherapy. 62, 4, 13 p., e02055-17.

Research output: Contribution to journalArticleResearchpeer-review

Optimization of binding B-lymphocytes in a microfluidic channel: Surface modification, stasis time and shear response

McCormick, S., Tong, Z., Ivask, A., Morozesk, M., Voelcker, N. H., Lombi, E. & Priest, C., 1 Jan 2018, In : Biofabrication. 10, 1, 10 p., 014101.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming Surfactant-Induced Morphology Instability of Noncrosslinked Diblock Copolymer Nano-Objects Obtained by RAFT Emulsion Polymerization

Truong, N. P., Zhang, C., Nguyen, T. A. H., Anastasaki, A., Schulze, M. W., Quinn, J. F., Whittaker, A. K., Hawker, C. J., Whittaker, M. R. & Davis, T. P., 20 Feb 2018, In : ACS Macro Letters. 7, 2, p. 159-165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K. & Caruso, F., 15 Nov 2018, In : Advanced Materials. 30, 46, 66 p., 1801362.

Research output: Contribution to journalArticleResearchpeer-review

Oxygen-permeable microwell device maintains islet mass and integrity during shipping

Rojas-Canales, D. M., Waibel, M., Forget, A., Penko, D., Nitschke, J., Harding, F. J., Delalat, B., Blencowe, A., Loudovaris, T., Grey, S. T., Thomas, H. E., Kay, T. W. H., Drogemuller, C. J., Voelcker, N. H. & Coates, P. T., 1 Mar 2018, In : Endocrine Connections. 7, 3, p. 490-503 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity

Giannangelo, C., Stingelin, L., Yang, T., Tilley, L., Charman, S. A. & Creek, D. J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01566-17.

Research output: Contribution to journalArticleResearchpeer-review

Performance optimisation of porous silicon rugate filter biosensor for the detection of insulin

Chhasatia, R., Sweetman, M. J., Prieto-Simon, B. & Voelcker, N. H., 10 Nov 2018, In : Sensors and Actuators B: Chemical. 273, p. 1313-1322 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Personalizing Polymyxin B dosing using an adaptive feedback control algorithm

Lakota, E. A., Landersdorfer, C. B., Nation, R. L., Li, J., Kaye, K. S., Rao, G. G. & Forrest, A., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 9 p., e00483-18.

Research output: Contribution to journalArticleResearchpeer-review

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Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

Landersdorfer, C. B., Wang, J., Wirth, V., Chen, K., Kaye, K. S., Tsuji, B., Li, J. & Nation, R. L., 1 Feb 2018, In : Journal of Antimicrobial Chemotherapy. 73, 2, p. 462-468 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Daniel, P. M., Filiz, G., Brown, D. V., Christie, M., Waring, P. M., Zhang, Y., Haynes, J. M., Pouton, C., Flanagan, D., Vincan, E., Johns, T. G., Montgomery, K., Phillips, W. A. & Mantamadiotis, T., 1 Jan 2018, In : Neuro-Oncology. 20, 10, p. 1344-1355 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymorphism rs1385129 Within Glut1 Gene SLC2A1 Is Linked To Poor CD4+ T cell Recovery In Antiretroviral-Treated HIV+ Individuals

Masson, J. J. R., Cherry, C. L., Murphy, N. M., Sada-Ovalle, I., Hussain, T., Billah, B., Crowe, S. M. & Palmer, C., 17 May 2018, In : Frontiers in Immunology. 9, 13 p., 00900.

Research output: Contribution to journalArticleResearchpeer-review

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Polymyxin B and fosfomycin thwart KPC-producing Klebsiella pneumoniae in the hollow-fibre infection model

Bulman, Z. P., Zhao, M., Satlin, M. J., Chen, L., Kreiswirth, B. N., Walsh, T. J., Nation, R. L., Li, J. & Tsuji, B. T., 1 Jul 2018, In : International Journal of Antimicrobial Agents. 52, 1, p. 114-118 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin B causes DNA damage in HK-2 cells and mice

Yun, B., Zhang, T., Azad, M. A. K., Wang, J., Nowell, C. J., Kalitsis, P., Velkov, T., Hudson, D. F. & Li, J., Jul 2018, In : Archives of Toxicology. 92, 7, p. 2259-2271 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance

Han, M-L., Velkov, T., Zhu, Y., Roberts, K. D., Le Brun, A. P., Chow, S. H., Gutu, A. D., Moskowitz, S. M., Shen, H-H. & Li, J., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 121-130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Population pharmacokinetic analyses for ertapenem in subjects with a wide range of body sizes

Lakota, E. A., Landersdorfer, C. B., Zhang, L., Nafziger, A. N., Bertino, J. S., Bhavnani, S. M. & Forrest, A., 1 Oct 2018, In : Antimicrobial Agents and Chemotherapy. 62, 10, 11 p., e00784.

Research output: Contribution to journalArticleResearchpeer-review

Porous silicon-poly(ε-caprolactone) film composites: evaluation of drug release and degradation behavior

Bodiford, N. K., McInnes, S. J. P., Voelcker, N. H. & Coffer, J. L., 1 Sep 2018, In : Biomedical Microdevices. 20, 3, 9 p., 71.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

Pilkington, E. H., Gustafsson, O. J. R., Xing, Y., Hernandez-Fernaud, J., Zampronio, C., Kakinen, A., Faridi, A., Ding, F., Wilson, P., Ke, P. C. & Davis, T. P., 26 Jun 2018, In : ACS Nano. 12, 6, p. 6066-6078 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Prolonged and continuous antibacterial and anti-biofilm activities of thin films embedded with gentamicin-loaded mesoporous silica nanoparticles

Tamanna, T., Landersdorfer, C. B., Ng, H. J., Bulitta, J., Wood, P. & Yu, A., 1 Aug 2018, In : Applied Nanoscience. 8, 6, p. 1471-1482 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Proof-of-principle study in a murine lung infection model of antipseudomonal activity of phage PEV20 in a dry-powder formulation

Chang, R. Y. K., Chen, K., Wang, J., Wallin, M., Britton, W., Morales, S., Kutter, E., Li, J. & Chan, H. K., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 8 p., e01714-17.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Quantifying cellular internalization with a fluorescent click sensor

Selby, L. I., Aurelio, L., Yuen, D., Graham, B. & Johnston, A. P. R., 22 Jun 2018, In : ACS Sensors. 3, 6, p. 1182-1189 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways

Dai, C., Ciccotosto, G. D., Cappai, R., Wang, Y., Tang, S., Hoyer, D., Schneider, E. K., Velkov, T. & Xiao, X., 18 Apr 2018, In : ACS Chemical Neuroscience. 9, 4, p. 824-837 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker

Mehta, D., Leong, N., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2018, In : Molecular Pharmaceutics. 15, 10, p. 4568-4576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Repurposing existing medications as cancer therapy: Design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation

Knight, J. M., Kerswill, S. A., Hari, P., Cole, S. W., Logan, B. R., D'Souza, A., Shah, N. N., Horowitz, M. M., Stolley, M. R., Sloan, E. K., Giles, K. E., Costanzo, E. S., Hamadani, M., Chhabra, S., Dhakal, B. & Rizzo, J. D., 24 May 2018, In : BMC Cancer. 18, 1, 12 p., 593.

Research output: Contribution to journalArticleResearchpeer-review

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Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells

Brendel, J. C., Sanchis, J., Catrouillet, S., Czuba, E., Chen, M. Z., Long, B. M., Nowell, C., Johnston, A., Jolliffe, K. A. & Perrier, S., 17 Dec 2018, In : Angewandte Chemie - International Edition. 57, 51, p. 16678-16682 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution

Ho, J. K., White, P. J. & Pouton, C. W., 7 Sep 2018, In : Molecular Therapy - Nucleic Acids. 12, p. 504-517 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein

Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., Sep 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 9, p. 1803-1809 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS

Vithani, K., Hawley, A., Jannin, V., Pouton, C. & Boyd, B. J., 1 Sep 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 130, p. 236-246 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Spontaneous zwitterionic copolymerisation: An undervalued and efficacious technique for the synthesis of functional degradable oligomers and polymers

de Jongh, P. A. J. M., Haddleton, D. M. & Kempe, K., 1 Jan 2018, (Accepted/In press) In : Progress in Polymer Science. 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation

von Halling Laier, C., Gibson, B., van de Weert, M., Boyd, B. J., Rades, T., Boisen, A., Hook, S. & Nielsen, L. H., 25 Oct 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 35-44 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Schneider-Futschik, E. K., Paulin, O. K. A., Hoyer, D., Roberts, K. D., Ziogas, J., Baker, M. A., Karas, J., Li, J. & Velkov, T., 11 May 2018, In : ACS Infectious Diseases. 4, 5, p. 646-655 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Stable White Light-Emitting Biocomposite Films

Gotta, J., Shalom, T. B., Aslanoglou, S., Cifuentes-Rius, A., Voelcker, N. H., Elnathan, R., Shoseyov, O. & Richter, S., 13 Jun 2018, In : Advanced Functional Materials. 28, 24, 9 p., 1706967.

Research output: Contribution to journalArticleResearchpeer-review

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 othersOwen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic killing of polymyxin B in combination with the antineoplastic drug mitotane against polymyxin-susceptible and -resistant Acinetobacter baumannii: A metabolomic study

Tran, T. B., Bergen, P. J., Creek, D. J., Velkov, T. & Li, J., 16 Apr 2018, In : Frontiers in Pharmacology. 9, 14 p., 359.

Research output: Contribution to journalArticleResearchpeer-review

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Synthesis, aggregation and responsivity of block copolymers containing organic arsenicals

Tanaka, J., Tani, S., Peltier, R., Pilkington, E. H., Kerr, A., Davis, T. P. & Wilson, P., 7 Apr 2018, In : Polymer Chemistry. 9, 13, p. 1551-1556 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

Devine, S. M., Yong, C., Amenuvegbe, D., Aurelio, L., Muthiah, D., Pouton, C., Callaghan, R., Capuano, B. & Scammells, P. J., 27 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8444-8456 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of Sub-100 nm Glycosylated Nanoparticles via a One Step, Free Radical, and Surfactant Free Emulsion Polymerization

Lunn, A. M. & Perrier, S., 2018, (Accepted/In press) In : Macromolecular Rapid Communications. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The Curious Case of the OZ439 Mesylate Salt: An Amphiphilic Antimalarial Drug with Diverse Solution and Solid State Structures

Clulow, A. J., Salim, M., Hawley, A., Gilbert, E. P. & Boyd, B. J., 7 May 2018, In : Molecular Pharmaceutics. 15, 5, p. 2027-2035 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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The Essential Elements of a Risk Governance Framework for Current and Future Nanotechnologies

Stone, V., Führ, M., Feindt, P. H., Bouwmeester, H., Linkov, I., Sabella, S., Murphy, F., Bizer, K., Tran, L., Ågerstrand, M., Fito, C., Andersen, T., Anderson, D., Bergamaschi, E., Cherrie, J. W., Cowan, S., Dalemcourt, J. F., Faure, M., Gabbert, S., Gajewicz, A. & 17 othersFernandes, T. F., Hristozov, D., Johnston, H. J., Lansdown, T. C., Linder, S., Marvin, H. J. P., Mullins, M., Purnhagen, K., Puzyn, T., Sanchez Jimenez, A., Scott-Fordsmand, J. J., Streftaris, G., van Tongeren, M., Voelcker, N. H., Voyiatzis, G., Yannopoulos, S. N. & Poortvliet, P. M., 1 Jul 2018, In : Risk Analysis. 38, 7, p. 1321-1331 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia

Clarkson, A. N., Boothman-Burrell, L., Dósa, Z., Nagaraja, R. Y., Jin, L., Parker, K., van Nieuwenhuijzen, P. S., Neumann, S., Gowing, E. K., Gavande, N., Ahring, P. K., Holm, M. M., Hanrahan, J. R., Nicolazzo, J. A., Jensen, K. & Chebib, M., 29 Jan 2018, In : Journal of Cerebral Blood Flow and Metabolism. 39, 7, p. 1266-1282 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs

Boyd, B. J., Salim, M., Clulow, A. J., Ramirez, G., Pham, A. C. & Hawley, A., 28 Dec 2018, In : Journal of Controlled Release. 292, p. 13-17 5 p.

Research output: Contribution to journalArticleResearchpeer-review

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The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models

Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q. T., Li, J., Chan, H. K. & Zhou, F., 30 Mar 2018, In : European Journal of Pharmaceutical Sciences. 115, p. 132-143 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Schneider, E. K., McQuade, R. M., Carbone, V. C., Reyes-Ortega, F., Wilson, J. W., Button, B., Saito, A., Poole, D. P., Hoyer, D. & Li, J., 1 Jan 2018, In : ERJ Open Research. 4, 1, 10 p., 00127-2017.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The role of algal organic matter in the separation of algae and cyanobacteria using the novel “Posi” - Dissolved air flotation process

Rao, N. R. H., Yap, R., Whittaker, M., Stuetz, R. M., Jefferson, B., Peirson, W. L., Granville, A. M. & Henderson, R. K., 1 Mar 2018, In : Water Research. 130, p. 20-30 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Thinking about critical thinking: An industry perspective

Pearl, A. O., Rayner, G. M., Larson, I. & Orlando, L., 2 Sep 2018, (Accepted/In press) In : Industry and Higher Education. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Williams, H. D., Ford, L., Lim, S., Han, S., Baumann, J., Sullivan, H., Vodak, D., Igonin, A., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 203–216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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