Drug Delivery Disposition & Dynamics

Research Output 1975 2019

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2016
37 Citations (Scopus)

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

Tran, T. B., Velkov, T., Nation, R. L., Forrest, A., Tsuji, B. T., Bergen, P. J. & Li, J., 1 Dec 2016, In : International Journal of Antimicrobial Agents. 48, 6, p. 592-597 6 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Pharmacokinetics of levobupivacaine following infant spinal anesthesia

Frawley, G., Hallett, B., Velkov, T. & Bjorksten, A., 1 Jun 2016, In : Pediatric Anesthesia. 26, 6, p. 575-581 7 p.

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Poly(bromoethyl acrylate): A Reactive Precursor for the Synthesis of Functional RAFT Materials

Barlow, T. R., Brendel, J. C. & Perrier, S., 13 Sep 2016, In : Macromolecules. 49, 17, p. 6203-6212 10 p.

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Polymerisation of 2-acrylamido-2-methylpropane sulfonic acid sodium salt (NaAMPS) and acryloyl phosphatidylcholine (APC) via aqueous Cu(0)-mediated radical polymerisation

Nikolaou, V., Simula, A., Droesbeke, M., Risangud, N., Anastasaki, A., Kempe, K., Wilson, P. & Haddleton, D., 14 Apr 2016, In : Polymer Chemistry. 7, 14, p. 2452-2456 5 p.

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

Rao, G. G., Ly, N. S., Bulitta, J. B., Soon, R. L., San Roman, M. D., Holden, P. N., Landersdorfer, C. B., Nation, R. L., Li, J., Forrest, A. & Tsuji, B. T., 1 Nov 2016, In : Journal of Antimicrobial Chemotherapy. 71, 11, p. 3148-3156 9 p.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Polymyxin resistance in Acinetobacter baumannii: genetic mutations and transcriptomic changes in response to clinically relevant dosage regimens

Cheah, S-E., Johnson, M. D., Zhu, Y., Tsuji, B. T., Forrest, A., Bulitta, J., Boyce, J. D., Nation, R. L. & Li, J., 19 May 2016, In : Scientific Reports. 6, 11 p., 26233.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
5 Citations (Scopus)

Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria

Tchaparian, E., Sambol, N. C., Arinaitwe, E., McCormack, S. A., Bigira, V., Wanzira, H., Muhindo, M., Creek, D. J., Sukumar, N., Blessborn, D., Tappero, J. W., Kakuru, A., Bergqvist, Y., Aweeka, F. T. & Parikh, S., 15 Oct 2016, In : Journal of Infectious Diseases. 214, 8, p. 1243-1251 9 p.

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products

Joyce, P., Barnes, T. J., Boyd, B. J. & Prestidge, C. A., 2016, In : RSC Advances. 6, 82, p. 78385-78395 11 p.

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever

Wyber, R., Boyd, B. J., Colquhoun, S., Currie, B. J., Engel, M., Kado, J., Karthikeyan, G., Sullivan, M., Saxena, A., Sheel, M., Steer, A., Mucumbitsi, J., Zühlke, L. & Carapetis, J., 1 Oct 2016, In : Drug Delivery and Translational Research. 6, 5, p. 572-578 7 p.

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Preparation of Inert Polystyrene Latex Particles as MicroRNA Delivery Vectors by Surfactant-Free RAFT Emulsion Polymerization

Poon, C. K., Tang, O., Chen, X. M., Pham, B. T. T., Gody, G., Pollock, C. A., Hawkett, B. S. & Perrier, S., 14 Mar 2016, In : Biomacromolecules. 17, 3, p. 965-973 9 p.

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases

Jin, L., Zhou, Q. T., Chan, H-K., Larson, I. C., Pennington, M. W., Morales, R. A. V., Boyd, B. J., Norton, R. S. & Nicolazzo, J. A., 1 Feb 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 650-656 7 p.

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Quantifying nanoparticle internalization using a high throughput internalization assay

Mann, S. K., Czuba, E., Selby, L. I., Such, G. K. & Johnston, A. P. R., 1 Oct 2016, In : Pharmaceutical Research. 33, 10, p. 2421-2432 12 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Quantitation of polymyxin-lipopolysaccharide interactions using an image-based fluorescent probe

McInerney, M. P., Roberts, K. D., Thompson, P. E., Li, J., Nation, R. L., Velkov, T. & Nicolazzo, J. A., 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 1006-1010 5 p.

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Rapid Synthesis of Well-Defined Polyacrylamide by Aqueous Cu(0)-Mediated Reversible-Deactivation Radical Polymerization

Jones, G. R., Li, Z., Anastasaki, A., Lloyd, D. J., Wilson, P., Zhang, Q. & Haddleton, D. M., 26 Jan 2016, In : Macromolecules. 49, 2, p. 483-489 7 p.

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Relationship between the cohesion of guest particles on the flow behaviour of interactive mixtures

Mangal, S., Gengenbach, T., Millington-Smith, D., Armstrong, B., Morton, D. A. V. & Larson, I., 1 May 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 102, p. 168-177 10 p.

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa

Rees, V. E., Bulitta, J. B., Oliver, A., Tsuji, B. T., Rayner, C. R., Nation, R. L. & Landersdorfer, C. B., 1 Nov 2016, In : Journal of Antimicrobial Chemotherapy. 71, 11, p. 3157-3167 11 p.

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Selective sequence for the peptide-triggered phase transition of lyotropic liquid-crystalline structures

Liu, Q., Dong, Y-D. & Boyd, B. J., 24 May 2016, In : Langmuir: the ACS journal of surfaces and colloids. 32, 20, p. 5155-5161 7 p.

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

Isahak, N., Gody, G., Malins, L. R., Mitchell, N. J., Payne, R. J. & Perrier, S., 2016, In : Chemical Communications. 52, 88, p. 12952-12955 4 p.

Research output: Contribution to journal › Article › Other › peer-review

6 Citations (Scopus)

Single intravenous dose of novel flurbiprofen-loaded proniosome formulations provides prolonged systemic exposure and anti-inflammatory effect

Verma, P., Prajapati, S. K., Yadav, R., Senyschyn, D., Shea, P. R. & Trevaskis, N. L., 7 Nov 2016, In : Molecular Pharmaceutics. 13, 11, p. 3688-3699 12 p.

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier

Azhari, H., Strauss, M., Hook, S., Boyd, B. J. & Rizwan, S. B., 1 Jul 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 104, p. 148-155 8 p.

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Stability enhancing N-terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches

Collins, J., Kempe, K., Wilson, P., Blindauer, C. A., McIntosh, M. P., Davis, T. P., Whittaker, M. R. & Haddleton, D. M., 8 Aug 2016, In : Biomacromolecules. 17, 8, p. 2755-2766 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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42 Citations (Scopus)

Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition

Nedumpully-Govindan, P., Kakinen, A., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 2016, In : Scientific Reports. 6, p. 1-12 12 p., 19463.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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8 Citations (Scopus)

Strategies for extending metabolomics studies with stable isotope labelling and fluxomics

Srivastava, A., Kowalski, G. M., Callahan, D. L., Meikle, P. J. & Creek, D. J., 1 Dec 2016, In : Metabolites. 6, 4, 13 p., 32.

Research output: Contribution to journal › Article › Other › peer-review

5 Citations (Scopus)

Study of (cyclic peptide)–polymer conjugate assemblies by small-angle neutron scattering

Koh, M. L., FitzGerald, P. A., Warr, G. G., Jolliffe, K. A. & Perrier, S., 19 Dec 2016, In : Chemistry - A European Journal. 22, 51, p. 18419-18428 10 p.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

Madsen, C. M., Boyd, B., Rades, T. & Mullertz, A., 25 Aug 2016, In : European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Surface-initiated SET living radical polymerisation for the synthesis of silica-polymer core-shell nanoparticles

Tom, J., Ohno, K. & Perrier, S., 21 Oct 2016, In : Polymer Chemistry. 7, 39, p. 6075-6083 9 p.

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Synergistic combinations of polymyxins

Lenhard, J. R., Nation, R. L. & Tsuji, B. T., 1 Dec 2016, In : International Journal of Antimicrobial Agents. 48, 6, p. 607-613 7 p.

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol

Blin, T., Kakinen, A., Pilkington, E. H., Ivask, A., Ding, F., Quinn, J., Whittaker, M. R., Ke, P. C. & Davis, T. P., 2016, In : Polymer Chemistry. 7, 10, p. 1931-1944 14 p.

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Synthesis of mannosylated and PEGylated nanoparticles via RAFT emulsion polymerisation, and investigation of particle-lectin aggregation using turbidimetric and DLS techniques

Gurnani, P., Lunn, A. M. & Perrier, S., 5 Dec 2016, In : Polymer. 106, p. 229-237 9 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding

Isahak, N., Sanchez, J., Perrier, S., Stone, M. J. & Payne, R. J., 28 Jun 2016, In : Organic and Biomolecular Chemistry. 14, 24, p. 5652-5658 7 p.

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Synthesis of sequence-controlled multiblock single chain nanoparticles by a stepwise folding-chain extension-folding process

Zhang, J., Gody, G., Hartlieb, M., Catrouillet, S., Moffat, J. & Perrier, S., 13 Dec 2016, In : Macromolecules. 49, 23, p. 8933-8942 10 p.

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

The Hydrolysis of Diclofenac Esters: Synthetic Prodrug Building Blocks for Biodegradable Drug-Polymer Conjugates

Wang, F., Finnin, J., Tait, C., Quirk, S., Chekhtman, I., Donohue, A. C., Ng, S., D'Souza, A., Tait, R. & Prankerd, R., 1 Feb 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 773-785 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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11 Citations (Scopus)

The influence of lung surfactant liquid crystalline nanostructures on respiratory drug delivery

Das, S. C. & Stewart, P. J., 5 Dec 2016, In : International Journal of Pharmaceutics. 514, 2, p. 465-474 10 p.

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

The limits of precision monomer placement in chain growth polymerization

Gody, G., Zetterlund, P. B., Perrier, S. & Harrisson, S., 1 Feb 2016, In : Nature Communications. 7, 8 p., 10514.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
11 Citations (Scopus)

The pharmacokinetics and biodistribution of a 64 kDa PolyPEG star polymer after subcutaneous and pulmonary administration to rats

Khor, S. Y., Hu, J., McLeod, V., Quinn, J., Porter, C. J. H., Whittaker, M., Kaminskas, L. & Davis, T., 2016, In : Journal of Pharmaceutical Sciences. 105, 1, p. 293-300 8 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

The plasma protein binding proteome of ertapenem: a novel compound-centric proteomic approach for elucidating drug-plasma protein binding interactions

Baker, M. A., Schneider, E. K., X. Huang, J., Cooper, M. A., Li, J. & Velkov, T., 16 Dec 2016, In : ACS Chemical Biology. 11, 12, p. 3353-3364 12 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Tissue-specific calibration of real-time PCR facilitates absolute quantification of plasmid DNA in biodistribution studies

Ho, J. K., White, P. J. & Pouton, C. W., 4 Oct 2016, In : Molecular Therapy - Nucleic Acids. 5, 10, 9 p., e371.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
24 Citations (Scopus)

Tools for early prediction of drug loading in lipid-based formulations

Alskär, L. C., Porter, C. & Bergstrom, C., 4 Jan 2016, In : Molecular Pharmaceutics. 13, 1, p. 251-261 11 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus

Zhao, J., Cheah, S-E., Roberts, K. D., Nation, R. L., Thompson, P. E., Velkov, T., Du, Z., Johnson, M. D. & Li, J., 2016, In : mSphere. 1, 4, 13 p., e00119-16.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
21 Citations (Scopus)

Tunable length of cyclic peptide-polymer conjugate self-assemblies in water

Catrouillet, S., Brendel, J. C., Larnaudie, S., Barlow, T., Jolliffe, K. A. & Perrier, S., 18 Oct 2016, In : ACS Macro Letters. 5, 10, p. 1119-1123 5 p.

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Tuning the properties of pH responsive nanoparticles to control cellular interactions in vitro and ex vivo

Mann, S. K., Dufour, A., Glass, J. J., De Rose, R., Kent, S. J., Such, G. K. & Johnston, A. P. R., 14 Oct 2016, In : Polymer Chemistry. 7, 38, p. 6015-6024 10 p.

Research output: Contribution to journal › Article › Research › peer-review

74 Citations (Scopus)

Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perform?

Nation, R. L., Garonzik, S. M., Li, J., Thamlikitkul, V., Giamarellos-Bourboulis, E. J., Paterson, D. L., Turnidge, J. D., Forrest, A. & Silveira, F. P., 1 Mar 2016, In : Clinical Infectious Diseases. 62, 5, p. 552-558 7 p.

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Validation and characterization of a novel peptide that binds monomeric and aggregated β-amyloid and inhibits the formation of neurotoxic oligomers

Barr, R. K., Verdile, G., Wijaya, L. K., Morici, M., Taddei, K., Gupta, V. B., Pedrini, S., Jin, L., Nicolazzo, J. A., Knock, E., Fraser, P. E. & Martins, R. N., 8 Jan 2016, In : Journal of Biological Chemistry. 291, 2, p. 547-559 13 p.

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Well-defined PDMAEA stars via Cu(0)-mediated reversible deactivation radical polymerization

Whitfield, R., Anastasaki, A., Truong Phuoc, N., Wilson, P., Kempe, K., Burns, J. A., Davis, T. & Haddleton, D., 13 Dec 2016, In : Macromolecules. 49, 23, p. 8914-8924 11 p.

Research output: Contribution to journal › Article › Research › peer-review

2015
9 Citations (Scopus)

Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

Xu, X., Zhang, L., Assanhou, A. G., Wang, L., Zhang, Y., Li, W., Xue, L., Mo, R. & Zhang, C., 2015, In : RSC Advances. 5, 83, p. 67803-67808 6 p.

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Alphaxalone reformulated: a water-soluble intravenous anesthetic preparation in sulfobutyl-ether-(beta)-cyclodextrin

Goodchild, C. S., Serrao, J. M., Kolosov, A. & Boyd, B. J., 2015, In : Anesthesia and Analgesia. 120, 5, p. 1025 - 1031 7 p.

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Amine-functionalized CO2 responsive triblock copolymer micelles-a small-angle X-ray scattering study

Salentinig, S., Jackson, P. & Hawley, A., 2015, In : Macromolecules. 48, 7, p. 2283 - 2289 7 p.

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Analysis of protein thiol changes occurring during rat sperm epididymal maturation

Baker, M. A., Weinberg, A., Hetherington, L., Villaverde, A-I. S. B. & Velkov, T., 2015, In : Biology of Reproduction. 92, 1, p. 1-10 10 p., 11.

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

An attenuated total reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells

Kozicki, M., Creek, D. J., Sexton, A., Morahan, B. J., Weselucha-Birczynska, A. & Wood, B. R., 2015, In : The Analyst. 140, 7, p. 2236 - 2246 11 p.

Research output: Contribution to journal › Article › Research › peer-review

47 Citations (Scopus)

Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: last-line antibiotics against multidrug-resistant gram-negative bacteria

Roberts, K. D., Azad, M. A. K., Wang, J., Horne, A. S., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 2015, In : ACS Infectious Diseases. 1, 11, p. 568-575 8 p.

Research output: Contribution to journal › Article › Research › peer-review