Research Output 1975 2019

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2019

Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications

Zhang, D. X., Yoshikawa, C., Welch, N. G., Pasic, P., Thissen, H. & Voelcker, N. H., 4 Feb 2019, In : Scientific Reports. 9, 1, 11 p., 1367.

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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Müllertz, A., Bauer-Brandl, A. & Jannin, V., 1 Sep 2019, In : European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

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Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles

Patrick, P. S., Bogart, L. K., Macdonald, T. J., Southern, P., Powell, M. J., Zaw-Thin, M., Voelcker, N. H., Parkin, I. P., Pankhurst, Q. A., Lythgoe, M. F., Kalber, T. L. & Bear, J. C., 9 Jan 2019, In : Chemical Science. 10, 9, p. 2592-2597 6 p.

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Synthesis and identification of novel pryidazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation

Bin Farrukh, S. U., Javed, I., Ather, A. Q., Emwas, A-H., Alazmi, M., Gao, X., Chotana, G. A., Davis, T. P., Ke, P. C. & Saleem, R. S. Z., Mar 2019, In : Bioorganic Chemistry. 84, p. 339-346 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

McInerney, M. P., Pan, Y., Volitakis, I., Bush, A. I., Short, J. L. & Nicolazzo, J. A., Dec 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2247-2255 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., Trevaskis, N. L. & 4 othersValentová, K., Vertzoni, M., Čepo, D. V. & Corsetti, M., 15 Jun 2019, In : European Journal of Pharmaceutical Sciences. 134, p. 31-59 29 p.

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Tuning the Structure, Stability, and Responsivity of Polymeric Arsenical Nanoparticles Using Polythiol Cross-Linkers

Tanaka, J., Moriceau, G., Cook, A., Kerr, A., Zhang, J., Peltier, R., Perrier, S., Davis, T. P. & Wilson, P., 12 Feb 2019, In : Macromolecules. 52, 3, p. 992-1003 12 p.

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Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y-W., Morton, D., Chan, H-K., Li, J. & Zhou, T. Q., 1 Jan 2019, In : Pharmaceutical Research. 36, 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the kinetic mixing between liquid crystalline nanoparticles and agrochemical actives

Bisset, N. B., Webster, G. R., Dong, Y. D. & Boyd, B. J., 1 Mar 2019, In : Colloids and Surfaces B: Biointerfaces. 175, p. 324-332 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., Hu, G., Pouton, C. W., Scammells, P. J., Porter, C. J. H. & Benameur, H., 29 May 2019, (Accepted/In press) In : Advanced Drug Delivery Reviews. 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Uptake, depuration and sublethal effects of the neonicotinoid, imidacloprid, exposure in Sydney rock oysters

Ewere, E. E., Powell, D., Rudd, D., Reichelt-Brushett, A., Mouatt, P., Voelcker, N. H. & Benkendorff, K., 1 Sep 2019, In : Chemosphere. 230, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Visible light-triggered cargo release from donor acceptor Stenhouse adduct (DASA)-doped lyotropic liquid crystalline nanoparticles

Jia, S., Tan, A., Hawley, A., Graham, B. & Boyd, B. J., 15 Jul 2019, In : Journal of Colloid and Interface Science. 548, p. 151-159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A closer look at the behaviour of milk lipids during digestion

Clulow, A. J., Salim, M., Hawley, A. & Boyd, B. J., 1 Mar 2018, In : Chemistry and Physics of Lipids. 211, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

Jasim, R., Baker, M. A., Zhu, Y., Han, M., Schneider-Futschik, E. K., Hussein, M., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, (Accepted/In press) In : ACS Infectious Diseases. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A complementary forensic ‘proteo-genomic’ approach for the direct identification of biological fluid traces under fingernails

Kamanna, S., Henry, J., Voelcker, N., Linacre, A. & Paul Kirkbride, K., 1 Sep 2018, In : Analytical and Bioanalytical Chemistry. 410, 24, p. 6165-6175 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 othersSelemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A label-free optical biosensor based on nanoporous anodic alumina for tumour necrosis factor-alpha detection in chronic wounds

Rajeev, G., Xifre-Perez, E., Prieto Simon, B., Cowin, A. J., Marsal, L. F. & Voelcker, N. H., 1 Mar 2018, In : Sensors and Actuators B: Chemical. 257, p. 116-123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease

Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R. & Nicolazzo, J. A., 4 Sep 2018, In : Molecular Pharmaceutics. 15, 9, p. 4073-4083 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

Wang, S., Li, F., Qiao, R., Hu, X., Liao, H., Chen, L., Wu, J., Wu, H., Zhao, M., Liu, J., Chen, R., Ma, X., Kim, D., Sun, J., Davis, T. P., Chen, C., Tian, J., Hyeon, T. & Ling, D., 26 Dec 2018, In : ACS Nano. 12, 12, p. 12380-12392 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A tunable one-pot three-component synthesis of an 125I and Gd-labelled star polymer nanoparticle for hybrid imaging with MRI and nuclear medicine

Esser, L., Lengkeek, N. A., Moffat, B. A., Vu, M. N., Greguric, I., Quinn, J. F., Davis, T. P. & Whittaker, M. R., 7 Jul 2018, In : Polymer Chemistry. 9, 25, p. 3528-3535 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Bioconjugation and Fluorescence Labeling of Iron Oxide Nanoparticles Grafted with Bromomaleimide-Terminal Polymers

Qiao, R., Esser, L., Fu, C., Zhang, C., Hu, J., Ramírez-arcía, P., Li, Y., Quinn, J. F., Whittaker, M. R., Whittaker, A. K. & Davis, T. P., 12 Nov 2018, In : Biomacromolecules. 19, 11, p. 4423-4429 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure

Younus, M., Hawley, A., Boyd, B. J. & Rizwan, S. B., 1 Sep 2018, In : Colloids and Surfaces B: Biointerfaces. 169, p. 135-142 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Clickable Cubosomes for Antibody-Free Drug Targeting and Imaging Applications

Alcaraz, N., Liu, Q., Hanssen, E., Johnston, A. & Boyd, B. J., 17 Jan 2018, In : Bioconjugate Chemistry. 29, 1, p. 149-157 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., May 2018, In : Brain, Behavior, and Immunity. 70, p. 36-47 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling

Landersdorfer, C. B., Yadav, R., Rogers, K. E., Kim, T. H., Shin, B. S., Boyce, J. D., Nation, R. L. & Bulitta, J. B., 1 Apr 2018, In : Antimicrobial Agents and Chemotherapy. 62, 4, 8 p., e02053-17.

Research output: Contribution to journalArticleResearchpeer-review

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria

Huang, J., Zhu, Y., Han, M., Li, M., Song, J., Velkov, T., Li, C. & Li, J., 1 Apr 2018, In : International Journal of Antimicrobial Agents. 51, 4, p. 586-593 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of the composition and in vitro activity of polymyxin B products

Diep, J. K., Covelli, J., Sharma, R., Ruszaj, D. M., Kaye, K. S., Li, J., Straubinger, R. M. & Rao, G. G., 25 May 2018, (Accepted/In press) In : International Journal of Antimicrobial Agents. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution

Larnaudie, S. C., Sanchis, J., Nguyen, T. H., Peltier, R., Catrouillet, S., Brendel, J. C., Porter, C. J. H., Jolliffe, K. A. & Perrier, S., 1 Sep 2018, In : Biomaterials. 178, p. 570-582 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclic Peptide-Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes

Larnaudie, S. C., Brendel, J. C., Romero-Canelón, I., Sanchez-Cano, C., Catrouillet, S., Sanchis, J., Coverdale, J. P. C., Song, J. I., Habtemariam, A., Sadler, P. J., Jolliffe, K. A. & Perrier, S., 8 Jan 2018, In : Biomacromolecules. 19, 1, p. 239-247 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Tong, W. Y., Alnakhli, M., Bhardwaj, R., Apostolou, S., Sinha, S., Fraser, C., Kuchel, T., Kuss, B. & Voelcker, N. H., 13 Apr 2018, In : Journal of Nanobiotechnology. 16, 1, 17 p., 38.

Research output: Contribution to journalArticleResearchpeer-review

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Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli

Bergen, P. J., Bulitta, J. B., Sime, F. B., Lipman, J., McGregor, M. J., Millen, N., Paterson, D. L., Kirkpatrick, C. M. J., Roberts, J. A. & Landersdorfer, C. B., 1 May 2018, In : Diagnostic Microbiology and Infectious Disease. 91, 1, p. 69-76 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery

Yadav, P., McLeod, V. M., Nowell, C. J., Selby, L. I., Johnston, A. P. R., Kaminskas, L. M. & Trevaskis, N. L., 28 Feb 2018, In : Journal of Controlled Release. 272, p. 17-28 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats

Leong, N. J., Mehta, D., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Sep 2018, In : Journal of Pharmaceutical Sciences. 107, 9, p. 2509-2513 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 1 Mar 2018, In : Pharmaceutical Research. 35, 3, 12 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Efficient Binding, Protection, and Self-Release of dsRNA in Soil by Linear and Star Cationic Polymers

Whitfield, R., Anastasaki, A., Truong, N. P., Cook, A. B., Omedes-Pujol, M., Loczenski Rose, V., Nguyen, T. A. H., Burns, J. A., Perrier, S., Davis, T. P. & Haddleton, D. M., 21 Aug 2018, In : ACS Macro Letters. 7, 8, p. 909-915 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Electrochemical deposition of aminomalonitrile based films

Ball, V., Toh, R. J., Voelcker, N. H., Thissen, H. & Evans, R. A., 5 Sep 2018, In : Colloids and Surfaces A: Physicochemical and Engineering Aspects. 552, p. 124-129 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules

McInnes, S. J. P., Macdonald, T. J., Parkin, I. P., Nann, T. & Voelcker, N. H., 1 Apr 2018, In : Nanomaterials. 8, 4, 12 p., 205.

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Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization-Induced Self-Assembly

Khor, S. Y., Vu, M. N., Pilkington, E. H., Johnston, A. P. R., Whittaker, M. R., Quinn, J. F., Truong, N. P. & Davis, T. P., 23 Aug 2018, In : Small. 14, 34, 13 p., 1801702.

Research output: Contribution to journalArticleResearchpeer-review

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Chen, K., Onufrak, N. J., Wang, J., Turnidge, J. D., Howden, B. P., Forrest, A., Chan, H. K. & Li, J., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 9 p., e01790.

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Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model

Bilal, H., Peleg, A. Y., McIntosh, M. P., Styles, I. K., Hirsch, E. B., Landersdorfer, C. B. & Bergen, P. J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1570-1578 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

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Experimental study of the deformation and breakage of 3D printed agglomerates: Effects of packing density and inter-particle bond strength

Ge, R., Ghadiri, M., Bonakdar, T., Zhou, Z., Larson, I. & Hapgood, K., 1 Dec 2018, In : Powder Technology. 340, p. 299-310 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

Grace, J. L., Schneider-Futschik, E. K., Elliott, A. G., Amado, M., Truong, N. P., Cooper, M. A., Li, J., Davis, T. P., Quinn, J. F., Velkov, T. & Whittaker, M. R., 10 Dec 2018, In : Biomacromolecules. 19, 12, p. 4629-4640 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., Apr 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1185-1193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers

Jiao, Y., Kim, T. H., Tao, X., Kinzig, M., Landersdorfer, C. B., Drescher, S. K., Sutaria, D. S., Moya, B., Holzgrabe, U., Sörgel, F. & Bulitta, J. B., 15 Oct 2018, In : European Journal of Pharmaceutical Sciences. 123, p. 416-428 13 p.

Research output: Contribution to journalArticleResearchpeer-review