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1993

A cleavable biotinylated photoactivable derivative of alpha-MSH. Its application to the characterization and isolation of the alpha-MSH receptor: Ann N Y Acad Sci

Ahmed, A. R., Olivier, G. W., Branch, S. K., Moss, S. H., Notarianni, L. J. & Pouton, C. W., 1993, In : Annals of the New York Academy of Sciences. 680, p. 442-444 3 p.

Research output: Contribution to journalArticleResearchpeer-review

A Cleavable Biotinylated Photoactivable Derivative of α‐MSH: Its Application to the Characterization and Isolation of the α‐MSH Receptor

AHMED, A. R. H., OLIVIER, G. W. J., BRANCH, S. K., MOSS, S. H., NOTARIANNI, L. J. & POUTON, C. W., 1 Jan 1993, In : Annals of the New York Academy of Sciences. 680, 1, p. 442-444 3 p.

Research output: Contribution to journalArticleResearchpeer-review

A conformational study of two cyclic peptide analogues of alpha-MSH: Ann N Y Acad Sci

Forsyth, G., Branch, S., Moss, S., Notarianni, L., Osguthorpe, D. & Pouton, C., 1993, In : Annals of the New York Academy of Sciences. 680, p. 517-519 3 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A Conformational Study of Two Cyclic Peptide Analogues of α‐MSH

FORSYTH, GEORGE., BRANCH, SARAH., MOSS, STEPHEN., NOTARIANNI, LIDIA., OSGUTHORPE, DAVID. & POUTON, COLIN., 1 Jan 1993, In : Annals of the New York Academy of Sciences. 680, 1, p. 517-519 3 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

An in vivo assessment of the tobramycin/ticarcillin interaction in cystic fibrosis patients

ROBERTS, GREGORY. W., NATION, ROGER. L., JARVINEN, ARI. O. & MARTIN, A. JAMES., 1 Jan 1993, In : British Journal of Clinical Pharmacology. 36, 4, p. 372-375 4 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep

Milne, R. W., Sloan, P. A., McLean, C. F., Mather, L. E., Nation, R. L., Runciman, W. B., Rutten, A. J. & Somogyi, A. A., 1 Jan 1993, In : Drug Metabolism and Disposition. 21, 6, p. 1151-1156 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence for the internalization of [125I-Tyr2, Nle4, D-Phe7] alpha-MSH following binding to the MSH receptor of B16 murine melanoma cells: Ann N Y Acad Sci

Adams, G., Olivier, G. W., Branch, S. K., Moss, S. H., Notarianni, L. J. & Pouton, C. W., 1993, In : Annals of the New York Academy of Sciences. 680, p. 440-441 2 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Evidence for the Internalization of [125I‐TYR2, NLE4, D‐PHE7] α‐MSH following Binding to the MSH Receptor of B16 Murine Melanoma Cells

ADAMS, G., OLIVIER, G. W. J., BRANCH, S. K., MOSS, S. H., NOTARIANNI, L. J. & POUTON, C. W., 1 Jan 1993, In : Annals of the New York Academy of Sciences. 680, 1, p. 440-441 2 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Plasma Concentrations and Renal Clearance of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Cancer Patients Receiving Morphine

Somogyi, A. A., Nation, R. L., Olweny, C., Tsirgiotis, P., van Crugten, J., Milne, R. W., Cleary, J. F., Danz, C. & Bochner, F., 1 Jan 1993, In : Clinical Pharmacokinetics. 24, 5, p. 413-420 8 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis.

Hayball, PJ., Nation, RL., Bochner, F., Sansom, LN., Ahern, MJ. & Smith, MD., 1 Jan 1993, In : British Journal of Clinical Pharmacology. 36, 3, p. 185-193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment

Charman, S. A., McCrossin, L. E. & Charman, W. N., 1993, In : Pharmaceutical Research. 10, 10, p. 1471-1477 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
43 Citations (Scopus)

Chirality in New Drug Development: Clinical Pharmacokinetic Considerations

Nation, R. L., 1 Jan 1994, In : Clinical Pharmacokinetics. 27, 4, p. 249-255 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Effect of lyophilization on the physical characteristics of medium molecular mass hyaluronates

Doherty, M. M., Hughes, P. J., Kim, S. R., Mainwaring, D. E. & Charman, W. N., 27 Oct 1994, In : International Journal of Pharmaceutics. 111, 3, p. 205-211 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Influence of alpha-MSH terminal amino acids on binding affinity and biological activity in melanoma cells

Sahm, U. G., Olivier, G. W., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : Peptides. 15, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Influence of α-MSH terminal amino acids on binding affinity and biological activity in melanoma cells

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : Peptides. 15, 3, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Kinetics of rearrangement and hydrolysis of amino acid derivatives of prazosin

Pochopin, N. L., Charman, W. N. & Stella, V. J., 2 May 1994, In : International Journal of Pharmaceutics. 105, 2, p. 169-176 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Marked enantioselective protein binding in humans of ketorolac in vitro: Elucidation of enantiomer unbound fractions following facile synthesis and direct chiral hplc resolution of tritium‐labelled ketorolac

Hayball, P. J., Holman, J. W., Nation, R. L., Massy‐Westropp, R. A. & Hamon, D. P. G., 1 Jan 1994, In : Chirality. 6, 8, p. 642-648 7 p.

Research output: Contribution to journalArticleResearchpeer-review

P190 binding of natural and synthetic MSH peptides to MC1 and MC3 melanocortin receptors

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

P191 determination of the number of molecules of methotrexate required per cell to effect growth inhibition of melanoma

Whelan, L. J., Pouton, C. W. & Moss, S. H., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

P298 computer aided learning programs in pharmacy and pharmacology

Moss, S. H., Redfern, P. H., Pouton, C. W., Brown, K. N. & Gilbert, M., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of alpha-MSH analogues substituted with alanine

Sahm, U. G., Olivier, G. W., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : Peptides. 15, p. 1297-1302 6 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Synthesis and biological evaluation of α-MSH analogues substituted with alanine

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : Peptides. 15, 7, p. 1297-1302 6 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

The melanocortin (MC3) receptor from rat hypothalamus: Photoaffinity labelling and binding of alanine-substituted α-MSH analogues

Sahm, U. G., Qarawi, M. A., Olivier, G. W. J., Ahmed, A. R. H., Branch, S. K., Moss, S. H. & Pouton, C. W., 15 Aug 1994, In : FEBS Letters. 350, 1, p. 29-32 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The melanocortin (MC3) receptor from rat hypothalamus: photoaffinity labelling and binding of alanine-substituted alpha-MSH analogues: FEBS Lett

Sahm, U. G., Qarawi, M. A., Olivier, G. W., Ahmed, A. R., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : FEBS Letters. 350, p. 29-32 4 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate.

Hayball, PJ., Wrobel, J., Tamblyn, JG. & Nation, RL., 1 Jan 1994, In : British Journal of Clinical Pharmacology. 37, 1, p. 75-78 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The synthesis of novel soluble biodegradable peptide co-polymers based on PEG

Lowndes, G. J., Threadgill, M. D. & Pouton, C. W., 1 Jan 1994, In : Proceedings of the Controlled Release Society. 21, p. 262-263 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
51 Citations (Scopus)

Amino acid derivatives of dapsone as water-soluble prodrugs

Pochopin, N. L., Charman, W. N. & Stella, V. J., 25 Jul 1995, In : International Journal of Pharmaceutics. 121, 2, p. 157-167 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Comparative Activity of Dihydrocodeine and Its Metabolites in the Electrically Stimulated Guinea‐pig Isolated Ileum

KIRKWOOD, LYNETTE. C., VENNING, MICHAEL. G., NATION, ROGER. L., REYNOLDS, GEOFFREY. D., SOMOGYI, ANDREW. A. & SANSOM, LLOYD. N., 1 Jan 1995, In : Pharmacy and Pharmacology Communications. 1, 12, p. 573-575 3 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Comparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep: Importance of the kidney

Milne, R. W., MacLean, C. F., Mather, L. E., Nation, R. L., Runciman, W. B., Rutten, A. J. & Somogyi, A. A., 1 Jan 1995, In : Drug Metabolism and Disposition. 23, 3, p. 334-342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Effect of cyclophosphamide administration on the activity and relative content of hepatic p4502d1 in rat

Laslett, T. J., Alvarez, F., Nation, R. L., Evans, A. M., Scott, S. D. & Stupans, I., 1 Jan 1995, In : Xenobiotica. 25, 10, p. 1031-1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Influence of formulation factors on gene transfer mediated by cationic polypeptides

Lucas, P., Pouton, C. W. & Moss, S. H., 1 Jan 1995, In : Proceedings of the Controlled Release Society. 22, p. 468-469 2 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: Pharmacodynamic and pharmacokinetic studies in the rabbit

Doherty, M. M., Hughes, P. J., Korszniak, N. V. & Charman, W. N., 4 Apr 1995, In : Anesthesia and Analgesia. 80, 4, p. 740-746 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

Amperometric enzyme biosensors for the analysis of drugs and metabolites: Advanced Drug Delivery Reviews

Harwood, G. W. & Pouton, C. W., 1996, In : Advanced Drug Delivery Reviews. 18, p. 163-191 29 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine

Humberstone, A. J., Porter, C. J. H. & Charman, W. N., May 1996, In : Journal of Pharmaceutical Sciences. 85, 5, p. 525-529 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthetic polyhydroxyalkanoates and their potential in drug delivery: Advanced Drug Delivery Reviews

Pouton, C. W. & Akhtar, S., 1996, In : Advanced Drug Delivery Reviews. 18, p. 133-162 30 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Development of an oral formulation for oestrone 3-O-sulphamate, a potent sulphatase inhibitor

Sahm, U. G., Williams, G. J., Purohit, A., Hidalgo Aragones, M. I., Parish, D., Reed, M. J., Potter, B. V. L. & Pouton, C. W., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 1, p. 17-20 4 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver

Sallustio, B. C., Fairchild, B. A., Shanahan, K., Evans, A. M. & Nation, R. L., 1 Sep 1996, In : Drug Metabolism and Disposition. 24, 9, p. 984-989 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial cell biology and culture methods for drug transport studies: Advanced Drug Delivery Reviews

DeAngelis, E., Moss, S. H. & Pouton, C. W., 1996, In : Advanced Drug Delivery Reviews. 18, p. 193-218 26 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Inhibition of growth of B16 murine melanoma cells by novel spermine analogues

Carrington, S., Qarawi, M. A., Blagbrough, I. S., Moss, S. H. & Pouton, C. W., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 1, p. 25-27 3 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Macromolecular systems for chemotherapy and magnetic resonance imaging: Advanced Drug Delivery Reviews

Matthews, S. E., Pouton, C. W. & Threadgill, M. D., 1996, In : Advanced Drug Delivery Reviews. 18, p. 219-267 49 p.

Research output: Contribution to journalArticleResearchpeer-review

Melanocortin probes for the melanoma MC1 receptor: synthesis, receptor binding and biological activity: Melanoma Res

Erskine-Grout, M. E., Olivier, G. W., Lucas, P., Sahm, U. G., Branch, S. K., Moss, S. H., Notarianni, L. J. & Pouton, C. W., 1996, In : Melanoma Research. 6, p. 89-94 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular modelling of beta turns in a cyclic melanotropin: J Pharm Pharmacol

Chan, N. C., Branch, S. K., Moss, S. H. & Pouton, C. W., 1996, In : Journal of Pharmacy and Pharmacology. 48, p. 218-222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Molecular modelling of β turns in a cyclic melanotropin

Chan, N. C., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1996, In : Journal of Pharmacy and Pharmacology. 48, 2, p. 218-222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Oxidative metabolism of dihydrocodeine in Dark-Agouti and Sprague-Dawley rat liver microsomes

Kirkwood, L. C., Nation, R. L., Reynolds, G. D., Somogyi, A. A. & Sansom, L. N., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 6, p. 299-303 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of oestrone-3-O-sulphamate: Journal of Steroid Biochemistry and Molecular Biology

Aragones, M. I. H., Purohit, A., Parish, D., Sahm, U. G., Pouton, C. W., Potter, B. V. L. & Reed, M. J., 1996, In : Journal of Steroid Biochemistry and Molecular Biology. 58, p. 611-617 7 p.

Research output: Contribution to journalArticleResearchpeer-review