Research Output 1975 2019

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2010
54 Citations (Scopus)

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

Johnstone, K. D., Karoli, T., Liu, L., Dredge, K., Copeman, E., Li, C. P., Davis, K., Hammond, E., Bytheway, I., Kostewicz, E. S., Chiu, F. C. K., Shackleford, D., Charman, S. A., Charman, W. N., Harenberg, J., Gonda, T. & Ferro, V., 2010, In : Journal of Medicinal Chemistry. 53, 4, p. 1686 - 1699 14 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

Trevaskis, N., Charman, W. & Porter, C., 2010, In : Molecular Pharmaceutics. 7, 6, p. 2297 - 2309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The buccal mucosa as an alternative route for the systemic delivery of risperidone

Heemstra, L. B., Finnin, B. C. & Nicolazzo, J., 2010, In : Journal of Pharmaceutical Sciences. 99, 11, p. 4584 - 4592 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L., Santo Tomas, J., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563 - 566 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The effect of sucrose and salts in combination on the drug release behaviour of an HPMC matrix

Williams, H., Ward, R., Hardy, I. & Melia, C., 2010, In : European Journal of Pharmaceutics and Biopharmaceutics. 76, 3, p. 433 - 436 4 p.

Research output: Contribution to journalArticleOther

26 Citations (Scopus)
28 Citations (Scopus)

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623)

Trevaskis, N., McEvoy, C. L., McIntosh, M. P., Edwards, G. A., Shanker, R., Charman, W. N. & Porter, C. J., 2010, In : Pharmaceutical Research. 27, p. 878 - 893 16 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

The structure - activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Santo Tomas, J., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J., 2010, In : Journal of Medicinal Chemistry. 53, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Transport of drugs across the blood-brain barrier in Alzheimer's disease

Nicolazzo, J. & Mehta, D., 2010, In : Therapeutic Delivery. 1, 4, p. 595 - 611 17 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Ultrasonic nebulization platforms for pulmonary drug delivery

Yeo, L., Friend, J., McIntosh, M. P., Meeusen, E. & Morton, D., 2010, In : Expert Opinion on Drug Delivery. 7, 6, p. 663 - 679 17 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Understanding lactose behaviour during storage by monitoring surface energy change using inverse gas chromatography

Das, S., Larson, I., Young, P. & Stewart, P., Mar 2010, In : Dairy Science Technologies. 90, 2-3, p. 271-285 15 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders

Zhou, Q., Armstrong, B., Larson, I., Stewart, P. & Morton, D., 2010, In : European Journal of Pharmaceutical Sciences. 40, 5, p. 412 - 421 10 p.

Research output: Contribution to journalArticleResearchpeer-review

187 Citations (Scopus)

Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility

Warren, D., Benameur, H., Porter, C. J. & Pouton, C. W., 2010, In : Journal of Drug Targeting. 18, 10, p. 704 - 731 28 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
64 Citations (Scopus)

Activities of colistin- and minocycline-based combinations against extensive drug resistant acinetobacter baumannii isolates from intensive care unit patients

Liang, W., Liu, X-F., Huang, J., Zhu, D., Li, J. & Zhang, J., 2011, In : BMC Infectious Diseases. 11, 109, p. e1 - e7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)
35 Citations (Scopus)

Adsorption of nonlamellar nanostructured liquid-crystalline particles to biorelevant surfaces for improved delivery of bioactive compounds.

Dong, Y., Larson, I., Barnes, T., Prestidge, C. & Boyd, B., 2011, In : ACS Applied Materials and Interfaces. 3, 5, p. 1771 - 1780 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses

Velkov, T., Thompson, P., El-Kabbani, O., Lindh, F., Stambas, J. & Rockman, S., 2011, In : Acta Virologica. 55, 2, p. 131 - 137 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

An approach to characterising the cohesive behaviour of powders using a flow titration aerosolisation based methodology

Behara, S., Larson, I., Kippax, P., Morton, D. & Stewart, P., 2011, In : Chemical Engineering Science. 66, 8, p. 1640 - 1648 9 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options

Wang, J., Wong, E., Whitley, J., Li, J., Stringer, J., Short, K., Renfree, M., Belov, K. & Cocks, B., 2011, In : PLoS ONE. 6, 8, 8 p., e24030.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
55 Citations (Scopus)

Antimalarial Pyrido[1,2-a]benzimidazoles

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 4581 - 4589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Applications of X-ray scattering in pharmaceutical science

Dong, C. & Boyd, B., 2011, In : International Journal of Pharmaceutics. 417, 1-2, p. 101 - 111 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
51 Citations (Scopus)

Capping methotrexate alpha-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers

Kaminskas, L., McLeod, V., Sberna, G., Boyd, B., Owen, D. & Porter, C., 2011, In : Molecular Pharmaceutics. 8, p. 338 - 349 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q. & 1 others, Charman, S., 2011, In : Malaria Journal. 10, 150, p. e1 - e11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
82 Citations (Scopus)

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker

Kaminskas, L., Kelly, B., McLeod, V., Sberna, G., Owen, D., Boyd, B. & Porter, C., 2011, In : Journal of Controlled Release. 152, p. 241 - 248 8 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach

Zhou, Q., Denman, J., Gengenbach, T., Das, S., Qu, L., Zhang, H., Larson, I., Stewart, P. & Morton, D., 2011, In : Journal of Pharmaceutical Sciences. 100, 8, p. 3421 - 3430 10 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)
79 Citations (Scopus)

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant peudomonas aeruginosa at multiple inocula

Bergen, P., Forrest, A., Bulitta, J., Tsuji, B., Sidjabat, H., Paterson, D., Li, J. & Nation, R., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5134 - 5142 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds

Lau, S., Graham, B., Boyd, B., Pouton, C. & White, P., 2011, In : Journal of Nucleic Acids. 2011, 154609, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

Converging layer-by-layer polyelectrolyte microcapsule and cubic lyotropic liquid crystalline nanoparticle approaches for molecular encapsulation

Driever, C. D., Mulet, X., Johnston, A., Waddington, L. J., Thissen, H., Caruso, F. & Drummond, C. J., 2011, In : Soft Matter. 7, 9, p. 4257 - 4266 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?"

Trevaskis, N. L., Charman, W. N. & Porter, C. J. H., 5 Dec 2011, In : Molecular Pharmaceutics. 8, 6, p. 2484 1 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Counter-intuitive enhancement in the dissolution of indomethacin with the incorporation of cohesive poorly water-soluble inorganic salt additives

Tay, T., Allahham, A., Morton, D. & Stewart, P., 2011, In : European Journal of Pharmaceutics and Biopharmaceutics. 79, p. 674 - 682 9 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties

Kaminskas, L., Boyd, B. & Porter, C., 2011, In : Nanomedicine. 6, 6, p. 1063 - 1084 22 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R. & Li, J., 2011, In : Analytical Biochemistry. 409, 2, p. 273 - 283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Determination of the polar and total surface energy distributions of particulates by inverse gas chromatography

Das, S., Larson, I., Morton, D. & Stewart, P., 2011, In : Langmuir: the ACS journal of surfaces and colloids. 27, 2, p. 521 - 523 3 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance

Kaminskas, L., McLeod, V., Porter, C. & Boyd, B., 2011, In : Journal of Pharmaceutical Sciences. 11, p. 5069 - 5077 9 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
Open Access
101 Citations (Scopus)

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Dosing of colistin - back to basic PK/PD

Bergen, P., Li, J. & Nation, R., 2011, In : Current Opinion in Pharmacology. 11, 5, p. 464 - 469 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
38 Citations (Scopus)

Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: A model cohesive pharmaceutical powder

Zhou, Q., Qu, L., Larson, I., Stewart, P. & Morton, D., 2011, In : Powder Technology. 207, 1-3, p. 414 - 421 8 p.

Research output: Contribution to journalArticleResearchpeer-review

131 Citations (Scopus)

Evaluating the link between self-assembled mesophase structure and drug release

Phan, S., Fong, W., Kirby, N., Hanley, T. & Boyd, B., 2011, In : International Journal of Pharmaceutics. 421, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Trevaskis, N., Nguyen, G., Scanlon, M. & Porter, C., 2011, In : Pharmaceutical Research. 28, 9, p. 2176 - 2190 15 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
Open Access
87 Citations (Scopus)
Open Access
36 Citations (Scopus)

Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach

Sou, T., Orlando, L., McIntosh, M. P., Kaminskas, L. & Morton, D., 2011, In : International Journal of Pharmaceutics. 421, 2, p. 220 - 229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties

Zhou, Q., Qu, L., Gegenbach, T., Denman, J., Larson, I., Stewart, P. & Morton, D., 2011, In : International Journal of Pharmaceutics. 413, p. 36 - 43 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Kinetics of emitted mass - a study with three dry powder inhaler devices

Behara, S., Kippax, P., Larson, I., Morton, D. & Stewart, P., 2011, In : Chemical Engineering Science. 66, p. 5284 - 5292 9 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Gujjar, R., El Mazouni, F., White, K., White, J., Creason, S., Shackleford, D., Deng, X., Charman, W., Bathurst, I., Burrows, J., Floyd, D., Matthews, D., Buckner, F., Charman, S., Phillips, M. & Rathod, P., 2011, In : Journal of Medicinal Chemistry. 54, p. 3935 - 3949 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid-based formulations: exploring the link between in vitro supersaturation and in vivo exposure

Porter, C. J. H., Anby, M. U., Warren, D. B., Williams, H. D., Benameur, H. & Pouton, C. W., 2011, Bull. Tech. Gattefosse, 104, p. 60-68 9 p.

Research output: Contribution to specialist publicationArticleOther