Research Output 1975 2019

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1993

An in vivo assessment of the tobramycin/ticarcillin interaction in cystic fibrosis patients

ROBERTS, GREGORY. W., NATION, ROGER. L., JARVINEN, ARI. O. & MARTIN, A. JAMES., 1 Jan 1993, In : British Journal of Clinical Pharmacology. 36, 4, p. 372-375 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep

Milne, R. W., Sloan, P. A., McLean, C. F., Mather, L. E., Nation, R. L., Runciman, W. B., Rutten, A. J. & Somogyi, A. A., 1 Jan 1993, In : Drug Metabolism and Disposition. 21, 6, p. 1151-1156 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence for the internalization of [125I-Tyr2, Nle4, D-Phe7] alpha-MSH following binding to the MSH receptor of B16 murine melanoma cells: Ann N Y Acad Sci

Adams, G., Olivier, G. W., Branch, S. K., Moss, S. H., Notarianni, L. J. & Pouton, C. W., 1993, In : Annals of the New York Academy of Sciences. 680, p. 440-441 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence for the Internalization of [125I‐TYR2, NLE4, D‐PHE7] α‐MSH following Binding to the MSH Receptor of B16 Murine Melanoma Cells

ADAMS, G., OLIVIER, G. W. J., BRANCH, S. K., MOSS, S. H., NOTARIANNI, L. J. & POUTON, C. W., 1 Jan 1993, In : Annals of the New York Academy of Sciences. 680, 1, p. 440-441 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Concentrations and Renal Clearance of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Cancer Patients Receiving Morphine

Somogyi, A. A., Nation, R. L., Olweny, C., Tsirgiotis, P., van Crugten, J., Milne, R. W., Cleary, J. F., Danz, C. & Bochner, F., 1 Jan 1993, In : Clinical Pharmacokinetics. 24, 5, p. 413-420 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis.

Hayball, PJ., Nation, RL., Bochner, F., Sansom, LN., Ahern, MJ. & Smith, MD., 1 Jan 1993, In : British Journal of Clinical Pharmacology. 36, 3, p. 185-193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1994

Chirality in New Drug Development: Clinical Pharmacokinetic Considerations

Nation, R. L., 1 Jan 1994, In : Clinical Pharmacokinetics. 27, 4, p. 249-255 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Influence of alpha-MSH terminal amino acids on binding affinity and biological activity in melanoma cells

Sahm, U. G., Olivier, G. W., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : Peptides. 15, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Influence of α-MSH terminal amino acids on binding affinity and biological activity in melanoma cells

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : Peptides. 15, 3, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Marked enantioselective protein binding in humans of ketorolac in vitro: Elucidation of enantiomer unbound fractions following facile synthesis and direct chiral hplc resolution of tritium‐labelled ketorolac

Hayball, P. J., Holman, J. W., Nation, R. L., Massy‐Westropp, R. A. & Hamon, D. P. G., 1 Jan 1994, In : Chirality. 6, 8, p. 642-648 7 p.

Research output: Contribution to journalArticleResearchpeer-review

P190 binding of natural and synthetic MSH peptides to MC1 and MC3 melanocortin receptors

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

P191 determination of the number of molecules of methotrexate required per cell to effect growth inhibition of melanoma

Whelan, L. J., Pouton, C. W. & Moss, S. H., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

P298 computer aided learning programs in pharmacy and pharmacology

Moss, S. H., Redfern, P. H., Pouton, C. W., Brown, K. N. & Gilbert, M., 1 Jan 1994, In : European Journal of Pharmaceutical Sciences. 2, 1-2, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of alpha-MSH analogues substituted with alanine

Sahm, U. G., Olivier, G. W., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : Peptides. 15, p. 1297-1302 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of α-MSH analogues substituted with alanine

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1994, In : Peptides. 15, 7, p. 1297-1302 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The melanocortin (MC3) receptor from rat hypothalamus: Photoaffinity labelling and binding of alanine-substituted α-MSH analogues

Sahm, U. G., Qarawi, M. A., Olivier, G. W. J., Ahmed, A. R. H., Branch, S. K., Moss, S. H. & Pouton, C. W., 15 Aug 1994, In : FEBS Letters. 350, 1, p. 29-32 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The melanocortin (MC3) receptor from rat hypothalamus: photoaffinity labelling and binding of alanine-substituted alpha-MSH analogues: FEBS Lett

Sahm, U. G., Qarawi, M. A., Olivier, G. W., Ahmed, A. R., Branch, S. K., Moss, S. H. & Pouton, C. W., 1994, In : FEBS Letters. 350, p. 29-32 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate.

Hayball, PJ., Wrobel, J., Tamblyn, JG. & Nation, RL., 1 Jan 1994, In : British Journal of Clinical Pharmacology. 37, 1, p. 75-78 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comparative Activity of Dihydrocodeine and Its Metabolites in the Electrically Stimulated Guinea‐pig Isolated Ileum

KIRKWOOD, LYNETTE. C., VENNING, MICHAEL. G., NATION, ROGER. L., REYNOLDS, GEOFFREY. D., SOMOGYI, ANDREW. A. & SANSOM, LLOYD. N., 1 Jan 1995, In : Pharmacy and Pharmacology Communications. 1, 12, p. 573-575 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep: Importance of the kidney

Milne, R. W., MacLean, C. F., Mather, L. E., Nation, R. L., Runciman, W. B., Rutten, A. J. & Somogyi, A. A., 1 Jan 1995, In : Drug Metabolism and Disposition. 23, 3, p. 334-342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of cyclophosphamide administration on the activity and relative content of hepatic p4502d1 in rat

Laslett, T. J., Alvarez, F., Nation, R. L., Evans, A. M., Scott, S. D. & Stupans, I., 1 Jan 1995, In : Xenobiotica. 25, 10, p. 1031-1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

Amperometric enzyme biosensors for the analysis of drugs and metabolites: Advanced Drug Delivery Reviews

Harwood, G. W. & Pouton, C. W., 1996, In : Advanced Drug Delivery Reviews. 18, p. 163-191 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthetic polyhydroxyalkanoates and their potential in drug delivery: Advanced Drug Delivery Reviews

Pouton, C. W. & Akhtar, S., 1996, In : Advanced Drug Delivery Reviews. 18, p. 133-162 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of an oral formulation for oestrone 3-O-sulphamate, a potent sulphatase inhibitor

Sahm, U. G., Williams, G. J., Purohit, A., Hidalgo Aragones, M. I., Parish, D., Reed, M. J., Potter, B. V. L. & Pouton, C. W., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 1, p. 17-20 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver

Sallustio, B. C., Fairchild, B. A., Shanahan, K., Evans, A. M. & Nation, R. L., 1 Sep 1996, In : Drug Metabolism and Disposition. 24, 9, p. 984-989 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial cell biology and culture methods for drug transport studies: Advanced Drug Delivery Reviews

DeAngelis, E., Moss, S. H. & Pouton, C. W., 1996, In : Advanced Drug Delivery Reviews. 18, p. 193-218 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of growth of B16 murine melanoma cells by novel spermine analogues

Carrington, S., Qarawi, M. A., Blagbrough, I. S., Moss, S. H. & Pouton, C. W., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 1, p. 25-27 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Macromolecular systems for chemotherapy and magnetic resonance imaging: Advanced Drug Delivery Reviews

Matthews, S. E., Pouton, C. W. & Threadgill, M. D., 1996, In : Advanced Drug Delivery Reviews. 18, p. 219-267 49 p.

Research output: Contribution to journalArticleResearchpeer-review

Melanocortin probes for the melanoma MC1 receptor: synthesis, receptor binding and biological activity: Melanoma Res

Erskine-Grout, M. E., Olivier, G. W., Lucas, P., Sahm, U. G., Branch, S. K., Moss, S. H., Notarianni, L. J. & Pouton, C. W., 1996, In : Melanoma Research. 6, p. 89-94 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular modelling of beta turns in a cyclic melanotropin: J Pharm Pharmacol

Chan, N. C., Branch, S. K., Moss, S. H. & Pouton, C. W., 1996, In : Journal of Pharmacy and Pharmacology. 48, p. 218-222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular modelling of β turns in a cyclic melanotropin

Chan, N. C., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1996, In : Journal of Pharmacy and Pharmacology. 48, 2, p. 218-222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative metabolism of dihydrocodeine in Dark-Agouti and Sprague-Dawley rat liver microsomes

Kirkwood, L. C., Nation, R. L., Reynolds, G. D., Somogyi, A. A. & Sansom, L. N., 1 Dec 1996, In : Pharmaceutical Sciences. 2, 6, p. 299-303 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of oestrone-3-O-sulphamate: Journal of Steroid Biochemistry and Molecular Biology

Aragones, M. I. H., Purohit, A., Parish, D., Sahm, U. G., Pouton, C. W., Potter, B. V. L. & Reed, M. J., 1996, In : Journal of Steroid Biochemistry and Molecular Biology. 58, p. 611-617 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of oestrone-3-Ο-sulphamate

Hidalgo Aragones, M. I., Purohit, A., Parish, D., Sahm, U. G., Pouton, C. W., Potter, B. V. L. & Reed, M. J., 1 Jan 1996, In : Journal of Steroid Biochemistry and Molecular Biology. 58, 5-6, p. 611-617 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor binding affinities and biological activities of linear and cyclic melanocortins in B16 murine melanoma cells expressing the native MC1 receptor: J Pharm Pharmacol

Sahm, U. G., Olivier, G. W., Branch, S. K., Moss, S. H. & Pouton, C. W., 1996, In : Journal of Pharmacy and Pharmacology. 48, p. 197-200 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor binding affinities and biological activities of linear and cyclic melanocortins in B16 murine melanoma cells expressing the native MC1 receptor

Sahm, U. G., Olivier, G. W. J., Branch, S. K., Moss, S. H. & Pouton, C. W., 1 Jan 1996, In : Journal of Pharmacy and Pharmacology. 48, 2, p. 197-200 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The disposition of morphine and morphine-3-glucuronide in the isolated perfused rat liver: Effects of altered perfusate flow rate

O'Brien, J. A., Nation, R. L. & Evans, A. M., 1 Jan 1996, In : Journal of Pharmacy and Pharmacology. 48, 5, p. 498-504 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation: Recent Prog Horm Res

Cone, R. D., Lu, D., Koppula, S., Vage, D. I., Klungland, H., Boston, B., Chen, W., Orth, D. N., Pouton, C. & Kesterson, R. A., 1996, In : Recent Progress in Hormone Research. 51, p. 287-317; discussion 318

Research output: Contribution to journalArticleResearchpeer-review

1997

Accuracy of volume measurement using helical CT

Nawaratne, S., Fabiny, R., Brien, J-A. E., Zalcberg, J. R., Cosolo, W., Whan, A. & Morgan, D. J., 1997, In : Journal of Computer Assisted Tomography. p. 481 - 486 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

Kirkwood, L. C., Nation, R. L. & Somogyi, A. A., 16 Dec 1997, In : British Journal of Clinical Pharmacology. 44, 6, p. 549-555 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of the disposition of hepatically-generated morphine-3-glucuronide and morphine-6-glucuronide in isolated perfused liver from the guinea pig

Milne, R. W., Jensen, R. H., Larsen, C., Evans, A. M. & Nation, R. L., 15 Sep 1997, In : Pharmaceutical Research. 14, 8, p. 1014-1018 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Concentration-effect relationships of morphine and morphine-6β- glucuronide in the rat

Van Crugten, J. T., Somogyi, A. A., Nation, R. L. & Reynolds, G., 9 Jun 1997, In : Clinical and Experimental Pharmacology and Physiology. 24, 5, p. 359-364 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Determination of the dihydrocodeine metabolites, dihydromorphine and nordihydrocodeine, in hepatic microsomal incubations by high-performance liquid chromatography

Kirkwood, L. C., Nation, R. L. & Somogyi, A. A., 7 Nov 1997, In : Journal of Chromatography B: Biomedical Applications. 701, 1, p. 129-134 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Disposition of morphine in the rat isolated perfused kidney: Concentration ranging studies

Shanahan, K. M., Evans, A. M. & Nation, R. L., 1 Sep 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 3, p. 1518-1525 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug delivery to the lymphatic system

Porter, C. J., 1997, In : Critical Reviews in Therapeutic Drug Carrier Systems. p. 333 - 393 61 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug disposition in mother and foetus

Morgan, D. J., 1997, In : Clinical and Experimental Pharmacology and Physiology. p. 869 - 873 5 p.

Research output: Contribution to journalArticleResearchpeer-review