Research Output

2020

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Jelinic, M., Kahlberg, N., Leo, C. H., Ng, H. H., Rosli, S., Deo, M., Li, M., Finlayson, S., Walsh, J., Parry, L. J., Ritchie, R. H. & Qin, C. X., 1 Apr 2020, In : British Journal of Pharmacology. 177, 7, p. 1677-1691 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Reutens, A. T., Jandeleit-Dahm, K., Thomas, M., Salim, A., De Livera, A. M., Bach, L. A., Colman, P. G., Davis, T. M. E., Ekinci, E. I., Fulcher, G., Hamblin, P. S., Kotowicz, M. A., MacIsaac, R. J., Morbey, C., Simmons, D., Soldatos, G., Wittert, G., Wu, T., Cooper, M. E. & Shaw, J. E., Mar 2020, In : Contemporary Clinical Trials. 90, 8 p., 105892.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

A Renal Clinician's Guide to the Gut Microbiota

Snelson, M., Biruete, A., McFarlane, C. & Campbell, K., 1 Jan 2020, (Accepted/In press) In : Journal of Renal Nutrition. 12 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Cardiovascular and kidney outcomes of linagliptin treatment in older people with type 2 diabetes and established cardiovascular disease and/or kidney disease: A prespecified subgroup analysis of the randomized, placebo-controlled CARMELINA® trial

Cooper, M. E., Rosenstock, J., Kadowaki, T., Seino, Y., Wanner, C., Schnaidt, S., Clark, D., Johansen, O. E. & on behalf of the CARMELINA investigators, 1 Feb 2020, (Accepted/In press) In : Diabetes, Obesity and Metabolism. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Chinese Famine and the diabetes mellitus epidemic

Zimmet, P., Shi, Z., El-Osta, A. & Ji, L., Feb 2020, In : Nature Reviews Endocrinology. 16, 2, p. 123-123 1 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access
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1 Citation (Scopus)

Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility

Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T. V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D. A., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, A., Meikle, P. J., Wilson, S. G., Forbes, J. M. & 4 others, Cooper, M. E., Ekinci, E. I., Woodruff, T. M. & Coughlan, M. T., 1 Jan 2020, In : Diabetes. 69, 1, p. 83-98 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart (Cardiovascular Drugs and Therapy, (2019), 33, 6, (669-674), 10.1007/s10557-019-06914-9)

Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T. & Ritchie, R. H., 1 Apr 2020, In : Cardiovascular Drugs and Therapy. 34, 2, p. 223 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
1 Citation (Scopus)

Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, Spector, T. D., Valdes, A. M., Mackay, C. R. & Marques, F. Z., 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Defining the Progression of Diabetic Cardiomyopathy in a Mouse Model of Type 1 Diabetes

De Blasio, M. J., Huynh, N., Deo, M., Dubrana, L. E., Walsh, J., Willis, A., Prakoso, D., Kiriazis, H., Donner, D. G., Chatham, J. C. & Ritchie, R. H., 20 Feb 2020, In : Frontiers in Physiology. 11, 16 p., 124.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Lindblom, R. S. J., Higgins, G. C., Nguyen, T. V., Arnstein, M., Henstridge, D. C., Granata, C., Snelson, M., Thallas-Bonke, V., Cooper, M. E., Forbes, J. M. & Coughlan, M. T., 29 Jan 2020, In : Clinical Science. 134, 2, p. 239-259 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Dicarbonyl-mediated AGEing and diabetic kidney disease

Dimitropoulos, A., Rosado, C. J. & Thomas, M. C., 13 Mar 2020, (Accepted/In press) In : Journal of Nephrology. 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure

Bain, C., Ziemann, M., Kaspi, A., Khan, A. W., Taylor, R., Trahair, H., Khurana, I., Kaipananickal, H., Wallace, S., El-Osta, A., Myles, P. S. & Bozaoglu, K., 2 Jul 2020, (Accepted/In press) In : ESC Heart Failure. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes

Gueguen, C., Burke, S. L., Barzel, B., Eikelis, N., Watson, A. M. D., Jha, J. C., Jackson, K. L., Sata, Y., Lim, K., Lambert, G. W., Jandeleit-Dahm, K. A. M., Cooper, M. E., Thomas, M. C. & Head, G. A., Jul 2020, In : Diabetologia. 63, 7, p. 1424–1434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Open Access

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

Snelson, M., Tan, S. M., Higgins, G. C., Lindblom, R. S. J. & Coughlan, M. T., 1 Mar 2020, In : American Journal of Physiology-Renal Physiology. 318, 3, p. F835-F842 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle

Granata, C., Oliveira, R. S. F., Little, J. P. & Bishop, D. J., 1 Feb 2020, In : American Journal of Physiology - Endocrinology and Metabolism. 318, 2, p. E224-E236 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes

Prakoso, D., De Blasio, M. J., Tate, M., Kiriazis, H., Donner, D. G., Qian, H., Nash, D., Deo, M., Weeks, K. L., Parry, L. J., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., Apr 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H840-H852 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2

Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L. & Li, Z., 1 Aug 2020, In : Cellular and Molecular Life Sciences. 77, 16, p. 3265-3277 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose and Blood Pressure-Dependent Pathways-The Progression of Diabetic Kidney Disease

Patel, D. M., Bose, M. & Cooper, M. E., 23 Mar 2020, In : International Journal of Molecular Sciences. 21, 6, 32 p., 2218.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg, M., Royce, S. G., Tikellis, C., Shallue, C., Batu, D., Velkoska, E., Burrell, L. M., Patel, S. K., Beswick, L., Jackson, A., Britto, K., Lukies, M., Sluka, P., Wardan, H., Hirokawa, Y., Tan, C. W., Faux, M., Burgess, A. W., Hosking, P., Monagle, S. & 3 others, Thomas, M., Gibson, P. R. & Lubel, J., 1 May 2020, In : Gut. 69, 5, p. 841-851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Davey, J. R., Estevez, E., Thomson, R. E., Whitham, M., Watt, K. I., Hagg, A., Qian, H., Henstridge, D. C., Ludlow, H., Hedger, M. P., McGee, S. L., Coughlan, M. T., Febbraio, M. A. & Gregorevic, P., Apr 2020, In : The FASEB Journal. 34, 4, p. 5697-5714 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Linagliptin and cardiorenal outcomes in Asians with type 2 diabetes mellitus and established cardiovascular and/or kidney disease: subgroup analysis of the randomized CARMELINA® trial

Inagaki, N., Yang, W., Watada, H., Ji, L., Schnaidt, S., Pfarr, E., Okamura, T., Johansen, O. E., George, J. T., von Eynatten, M., Rosenstock, J., Perkovic, V., Wanner, C., Cooper, M. E., Alexander, J. H., Komuro, I. & Nangaku, M., 1 Apr 2020, In : Diabetology International. 11, 2, p. 129-141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

New-Onset Diabetes in Covid-19

Rubino, F., Rubino, F., Zimmet, P., Alberti, K. G. M. M., Bornstein, S., Bornstein, S., Mingrone, G., Boehm, B. O., Cooper, M. E., Chai, Z-L., Prato, S. D., Ji, L., Hopkins, D. L., Herman, W. H., Khunti, K., Mbanya, J. C. N. & Renard, E., 12 Jun 2020, (Accepted/In press) In : The New England Journal of Medicine. 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In : Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Nitroxyl: A Novel Strategy to Circumvent Diabetes Associated Impairments in Nitric Oxide Signaling

Velagic, A., Qin, C., Woodman, O. L., Horowitz, J. D., Ritchie, R. H. & Kemp-Harper, B. K., 19 May 2020, In : Frontiers in Pharmacology. 11, 18 p., 727.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Deliyanti, D., Alrashdi, S. F., Touyz, R. M., Kennedy, C. R., Jha, J. C., Cooper, M. E., Jandeleit-Dahm, K. A. & Wilkinson-Berka, J. L., 1 Apr 2020, In : Hypertension. 75, 4, p. 1091-1101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract

Das, S. J., Wishart, T. F. L., Jandeleit-Dahm, K. & Lovicu, F. J., Mar 2020, In : Experimental Eye Research. 192, 15 p., 107918.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights

Leo, C. H., Ng, H. H., Marshall, S. A., Jelinic, M., Rupasinghe, T., Qin, C., Roessner, U., Ritchie, R. H., Tare, M. & Parry, L. J., Jan 2020, In : British Journal of Pharmacology. 177, 1, p. 217-233 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Renal protection: What have we learnt from ADVANCE about kidney disease in type 2 diabetes?

Knudsen, S. T. & Cooper, M. E., 1 Apr 2020, In : Diabetes, Obesity and Metabolism. 22, S2, p. 12-18 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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1 Citation (Scopus)

Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease

Østergaard, J. A., Cooper, M. E. & Jandeleit-Dahm, K. A. M., 23 May 2020, (Accepted/In press) In : Journal of Nephrology. 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome

Kaipananickal, H., Khan, A. W., Okabe, J., Corcoran, S. J., Esler, M. D. & El-Osta, A., 10 Apr 2020, In : Circulation Research. 126, 8, p. 1058-1060 3 p.

Research output: Contribution to journalArticleResearchpeer-review

The Devil's in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science

Snelson, M. & Coughlan, M., Jul 2020, In : Journal of Renal Nutrition. 30, 4, p. 274-275 2 p.

Research output: Contribution to journalLetterOtherpeer-review

The Heart Failure with Preserved Ejection Fraction Conundrum—Redefining the Problem and Finding Common Ground?

Iyngkaran, P., Thomas, M. C., Neil, C., Jelinek, M., Cooper, M., Horowitz, J. D., Hare, D. L. & Kaye, D. M., 1 Apr 2020, In : Current Heart Failure Reports. 17, 2, p. 34-42 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The Long-Term Incidence of Hospitalization for Ketoacidosis in Adults with Established T1D-A Prospective Cohort Study

Thomas, M., Harjutsalo, V., Feodoroff, M., Forsblom, C., Gordin, D., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2020, In : The Journal of Clinical Endocrinology and Metabolism. 105, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Therapeutic Potential of Lipoxin A4 in Chronic Inflammation: Focus on Cardiometabolic Disease

Fu, T., Mohan, M., Brennan, E. P., Woodman, O. L., Godson, C., Kantharidis, P., Ritchie, R. H. & Qin, C., 17 Jan 2020, In : ACS Pharmacology & Translational Science. 3, 1, p. 43-55 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Keating, S. T., Groh, L., van der Heijden, C. D. C. C., Rodriguez, H., dos Santos, J. C., Fanucchi, S., Okabe, J., Kaipananickal, H., van Puffelen, J. H., Helder, L., Noz, M. P., Matzaraki, V., Li, Y., de Bree, L. C. J., Koeken, V. A. C. M., Moorlag, S. J. C. F. M., Mourits, V. P., Domínguez-Andrés, J., Oosting, M., Bulthuis, E. P. & 6 others, Koopman, W. J. H., Mhlanga, M., El-Osta, A., Joosten, L. A. B., Netea, M. G. & Riksen, N. P., 21 Apr 2020, In : Cell Reports. 31, 3, 22 p., 107548.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

Flynn, M. C., Kraakman, M. J., Tikellis, C., Lee, M. K., Hanssen, N. M., Kammoun, H. L., Pickering, R., Dragoljevic, D., Al-Sharea, A., Barrett, T. J., Hortle, F., Byrne, F. L., Olzomer, E., McCarthy, D. A., Schalkwijk, C. G., Forbes, J. M., Hoehn, K., Makowski, L., Lancaster, G. I., El-Osta, A. & 6 others, Fisher, E. A., Goldberg, I. J., Cooper, M. E., Nagareddy, P. R., Thomas, M. C. & Murphy, A. J., 22 Jun 2020, (Accepted/In press) In : Circulation Research. 23 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus

Ohkuma, T., Jun, M., Rodgers, A., Cooper, M. E., Glasziou, P., Hamet, P., Harrap, S., Mancia, G., Marre, M., Neal, B., Perkovic, V., Poulter, N., Williams, B., Zoungas, S., Chalmers, J., Woodward, M. & on behalf of the ADVANCE Collaborative Group, 1 Jan 2019, In : Hypertension. 73, 1, p. 84-91 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

A promising outlook for diabetic kidney disease

Cooper, M. & Warren, A. M., 1 Feb 2019, In : Nature Reviews Nephrology. 15, 2, p. 68-70 3 p.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

A Single-Center Experience of the Optimal Initial Immunosuppressive Strategy for Preventing Early Acute Cellular Rejection in Orthotopic Heart Transplantation Associated With Renal Dysfunction

Mundisugih, J., Fernando, H., Bergin, P., Hare, J., Kaye, D., Leet, A., McGiffin, D. & Taylor, A. J., 1 Dec 2019, In : Progress in Transplantation. 29, 4, p. 327-334 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Characterising an Alternative Murine Model of Diabetic Cardiomyopathy

Tate, M., Prakoso, D., Willis, A. M., Peng, C., Deo, M., Qin, C. X., Walsh, J. L., Nash, D. M., Cohen, C. D., Rofe, A. K., Sharma, A., Kiriazis, H., Donner, D. G., De Haan, J. B., Watson, A. M. D., De Blasio, M. J. & Ritchie, R. H., 14 Nov 2019, In : Frontiers in Physiology. 10, 15 p., 1395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes

Ohkuma, T., Jun, M., Chalmers, J., Cooper, M. E., Hamet, P., Harrap, S., Zoungas, S., Perkovic, V., Woodward, M. & on behalf of the ADVANCE Collaborative Group, 7 Jun 2019, In : Clinical Journal of the American Society of Nephrology. 14, 6, p. 862-872 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

CrossTalk opposing view: Exercise training volume is more important than training intensity to promote increases in mitochondrial content

Bishop, D. J., Botella, J. & Granata, C., Aug 2019, In : The Journal of Physiology. 597, 16, p. 4115-4118 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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4 Citations (Scopus)

Deficiency of Either Prebiotic Dietary Fibre or Prebiotic-Responsive Gut Microbiota Result in High Blood Pressure

Marques, F. Z., Shihata, W. A., Jama, H., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Phillips, S. E., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W., Mackay, C. & Kaye, D. M., Sep 2019, p. A059-A059. 1 p.

Research output: Contribution to conferenceAbstract

Open Access

Development of a novel peptide tracer for detection of cardiac fibrosis and atrial fibrillation using mouse models of cardiomyopathies

Niego, B., Alt, K., Noor, A., How, O. J., Du, X-J., Donnelly, P. S., McMullen, J. & Hagemeyer, C., 9 Jul 2019.

Research output: Contribution to conferenceAbstract

Diabetes and hypertension differentially affect renal catecholamines and renal reactive oxygen species

Watson, A. M. D., Gould, E. A. M., Penfold, S. A., Lambert, G. W., Pratama, P. R., Dai, A., Gray, S. P., Head, G. A. & Jandeleit-Dahm, K. A., Apr 2019, In : Frontiers in Physiology. 10, MAR, 16 p., 309.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

Warren, A. M., Knudsen, S. T. & Cooper, M. E., 3 Jul 2019, In : Expert Opinion on Therapeutic Targets. 23, 7, p. 579-591 13 p.

Research output: Contribution to journalArticleOtherpeer-review

12 Citations (Scopus)