Research Output 2017 2019

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2019

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

Torpe, N., Gopal, S., Baltaci, O., Rella, L., Handley, A., Korswagen, H. C. & Pocock, R., 19 Mar 2019, In : Cell Reports. 26, 12, p. 3183-3190 8 p.

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Caenorhabditis elegans hub genes that respond to amyloid beta are homologs of genes involved in human Alzheimer’s disease

Godini, R., Pocock, R. & Fallahi, H., 10 Jul 2019, In : PLoS ONE. 14, 7, 28 p., e0219486.

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Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Context-specific behavioural changes induced by exposure to an androgenic endocrine disruptor

Bertram, M. G., Martin, J. M., Saaristo, M., Ecker, T. E., Michelangeli, M., Deal, N. D. S., Lim, S. L., O'Bryan, M. K. & Wong, B. B. M., 10 May 2019, In : Science of the Total Environment. 664, p. 177-187 11 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

Skvortsova, K., Masle-Farquhar, E., Luu, P. L., Song, J. Z., Qu, W., Zotenko, E., Gould, C. M., Du, Q., Peters, T. J., Colino-Sanguino, Y., Pidsley, R., Nair, S. S., Khoury, A., Smith, G. C., Miosge, L. A., Reed, J. H., Kench, J. G., Rubin, M. A., Horvath, L., Bogdanovic, O. & 5 others, Lim, S. M., Polo, J. M., Goodnow, C. C., Stirzaker, C. & Clark, S. J., 11 Feb 2019, In : Cancer Cell. 35, 2, p. 297-314 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions

Tichy, A-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M. & Janovjak, H., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3046-3055 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline

Bellin, A. R., Zhang, Y., Thai, K., Rosenblum, N. D., Cullen-McEwen, L. A., Bertram, J. F. & Gilbert, R. E., 1 May 2019, In : Physiological Reports. 7, 9, 11 p., e14044.

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mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction

Snieckute, G., Baltaci, O., Liu, H., Li, L., Hu, Z. & Pocock, R., 1 Jul 2019, In : Molecular and Cellular Neuroscience. 98, p. 70-81 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

Puelles, V. G., Fleck, D., Ortz, L., Papadouri, S., Strieder, T., Böhner, A. M. C., van der Wolde, J. W., Vogt, M., Saritas, T., Kuppe, C., Fuss, A., Menzel, S., Klinkhammer, B. M., Müller-Newen, G., Heymann, F., Decker, L., Braun, F., Kretz, O., Huber, T. B., Susaki, E. A. & 9 others, Ueda, H. R., Boor, P., Floege, J., Kramann, R., Kurts, C., Bertram, J. F., Spehr, M., Nikolic-Paterson, D. J. & Moeller, M. J., 15 Mar 2019, (Accepted/In press) In : Kidney International. 12 p.

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Rac GTPases: domain-specific functions in neuronal development

Norgaard, S. & Pocock, R., Apr 2019, In : Neural Regeneration Research. 14, 8, p. 1367-1368 2 p.

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Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing

Liao, J., Ng, S. H., Luk, A. C., Suen, H. C., Qian, Y., Lee, A. W. T., Tu, J., Fung, J. C. L., Tang, N. L. S., Feng, B., Chan, W. Y., Fouchet, P., Hobbs, R. M. & Lee, T. L., 27 Mar 2019, In : Development (Cambridge). 146, 6, 15 p., dev174953.

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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Seruggia, D., Oti, M., Tripathi, P., Canver, M. C., LeBlanc, L., Di Giammartino, D. C., Bullen, M. J., Nefzger, C. M., Sun, Y. B. Y., Farouni, R., Polo, J. M., Pinello, L., Apostolou, E., Kim, J., Orkin, S. H. & Das, P. P., 20 Jun 2019, In : Molecular Cell. 74, 6, p. 1148-1163 16 p.

Research output: Contribution to journalArticleResearchpeer-review

The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans

Cao, W., Deng, J. & Pocock, R., 2019, (Accepted/In press) In : Small GTPases. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Topconfects: A package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list

Harrison, P. F., Pattison, A. D., Powell, D. R. & Beilharz, T. H., 28 Mar 2019, In : Genome Biology. 20, 1, 12 p., 67.

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Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour

Kumarasingha, R., Young, N. D., Yeo, T. C., Lim, DI. S. L., Tu, C. L., Palombo, E. A., Shaw, J. M., Gasser, R. B. & Boag, P. R., 25 Apr 2019, In : Parasites and Vectors. 12, 1, 9 p., 181.

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Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice

Winship, A. L., Carpenter, M., Griffiths, M. & Hutt, K. J., 1 May 2019, In : Toxicological sciences : an official journal of the Society of Toxicology. 169, 1, p. 43-53 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Alternative polyadenylation in the regulation and dysregulation of gene expression

Turner, R. E., Pattison, A. D. & Beilharz, T. H., Mar 2018, In : Seminars in Cell and Developmental Biology. 75, p. 61-69 9 p.

Research output: Contribution to journalArticleOtherpeer-review

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Koch, B., Barugahare, A. A., Lo, T. L., Huang, C., Schittenhelm, R. B., Powell, D. R., Beilharz, T. H. & Traven, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2244-2258 15 p.

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A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Pflueger, C., Tan, D., Swain, T., Nguyen, T., Pflueger, J., Nefzger, C., Polo, J. M., Ford, E. & Lister, R., 1 Aug 2018, In : Genome Research. 28, 8, p. 1193-1206 14 p.

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BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Kim, E. J. Y., Anko, M-L., Flensberg, C., Majewski, I. J., Geng, F-S., Firas, J., Huang, D. C. S., van Delft, M. F. & Heath, J. K., 13 Feb 2018, In : Stem Cell Reports. 10, 2, p. 331-338 8 p.

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Behavioral assays to study oxygen and carbon dioxide sensing in Caenorhabditis elegans

Romanos, T. R., Ng, L. & Pocock, R., 5 Jan 2018, In : Bio-protocol. 8, 1, 14 p., e2679.

Research output: Contribution to journalArticleOtherpeer-review

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance

Woodhouse, R. M., Buchmann, G., Hoe, M., Harney, D. J., Low, J. K. K., Larance, M., Boag, P. R. & Ashe, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2259-2272 14 p.

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Distinct CED-10/Rac1 domains confer context-specific functions in development

Norgaard, S., Deng, S., Cao, W. & Pocock, R., 28 Sep 2018, In : PLoS Genetics. 14, 9, 24 p., e1007670.

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Examination of the ovotoxicity of 5-fluorouracil in mice

Lambouras, M., Liew, S. H., Horvay, K., Abud, H. E., Stringer, J. M. & Hutt, K. J., Jun 2018, In : Journal of Assisted Reproduction and Genetics. 35, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling

Chen, J., Nefzger, C. M., Rossello, F., Sun, Y. B. Y., Lim, S. M., Liu, X., De Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., Polo, J. M. & Barberi, T., 1 Jun 2018, In : Stem Cells. 36, 6, p. 822-833 12 p.

Research output: Contribution to journalArticleResearchpeer-review

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

La, H. M., Chan, A-L., Legrand, J. M. D., Rossello, F. J., Gangemi, C. G., Papa, A., Cheng, Q., Morand, E. F. & Hobbs, R. M., 1 Sep 2018, In : Development. 145, 18, dev165324.

Research output: Contribution to journalArticleResearchpeer-review

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.

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Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M. & Hutt, K. J., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 12 p., 633.

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miR-222 isoforms are differentially regulated by type-I interferon

Nejad, C., Pillman, K. A., Siddle, K. J., Pépin, G., Anko, M. L., McCoy, C. E., Beilharz, T. H., Quintana-Murci, L., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Mar 2018, In : RNA. 24, 3, p. 332-341 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic characterisation of Caenorhabditis elegans larval development

Xia, T., Horton, E. R., Salcini, A. E., Pocock, R., Cox, T. R. & Erler, J. R., Jan 2018, In : Proteomics. 18, 2, 16 p., 1700238.

Research output: Contribution to journalArticleResearchpeer-review

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

SRSF3 promotes pluripotency through nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L., 9 May 2018, In : eLife. 7, 28 p., e37419.

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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Grabow, S., Kueh, A. J., Ke, F., Vanyai, H. K., Sheikh, B. N., Dengler, M. A., Chiang, W., Eccles, S., Smyth, I. M., Jones, L. K., De Sauvage, F. J., Scott, M., Whitehead, L., Voss, A. K. & Strasser, A., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3285-3295 11 p.

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TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor, W. A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T. J., Lukianchikov, A., Liu, X., Polo, J. M., Jacobsen, S. E. & Clark, A. T., 1 May 2018, In : Nature Cell Biology. 20, 5, p. 553-564 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans

Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.

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Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

O’brien, L. L., Combes, A. N., Short, K. M., Lindström, N. O., Whitney, P. H., Cullen-McEwen, L. A., Ju, A., Abdelhalim, A., Michos, O., Bertram, J. F., Smyth, I. M., Little, M. H. & McMahon, A. P., 5 Dec 2018, In : eLife. 7, 25 p., e40392.

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2017

Automated three-dimensional reconstruction of the Caenorhabditis elegans germline

Gopal, S., Boag, P. & Pocock, R., 15 Dec 2017, In : Developmental Biology. 432, 2, p. 222-228 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell Type of Origin Dictates the Route to Pluripotency

Nefzger, C. M., Rossello, F. J., Chen, J., Liu, X., Knaupp, A. S., Firas, J., Paynter, J. M., Pflueger, J., Buckberry, S., Lim, S. M., Williams, B., Alaei, S., Faye-Chauhan, K., Petretto, E., Nilsson, S. K., Lister, R., Ramialison, M., Powell, D. R., Rackham, O. J. L. & Polo, J. M., 5 Dec 2017, In : Cell Reports. 21, 10, p. 2649-2660 12 p.

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Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X., Nefzger, C. M., Rossello, F. J., Chen, J., Knaupp, A. S., Firas, J., Ford, E., Pflueger, J., Paynter, J. M., Chy, H. S., O'Brien, C. M., Huang, C., Mishra, K., Hodgson-Garms, M., Jansz, N., Williams, S. M., Blewitt, M. E., Nilsson, S. K., Schittenhelm, R. B., Laslett, A. L. & 2 others, Lister, R. & Polo, J. M., 31 Oct 2017, In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II

Zhang, Q-H., Yuen, W. S., Adhikari, D., Flegg, J. A., FitzHarris, G., Conti, M., Sicinski, P., Nabti, I., Marangos, P. & Carroll, J., 17 Aug 2017, In : Journal of Cell Biology. 216, 10, p. 3133-3143 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploring potential Germline-Associated roles of the TRIM-NHL Protein NHL-2 through RNAi screening

Davis, G. M., Low, W. Y., Anderson, J. W. T. & Boag, P. R., 1 Oct 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3251-3256 6 p.

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Expression patterns of HENMT1 and PIWIL1 in human testis: Implications for transposon expression

Hempfling, AL., Lim, SL., Adelson, DL., Evans, J., O'Connor, AE., Qu, ZP., Kliesch, S., Weidner, W., O'Bryan, MK. & Bergmann, M., 1 Oct 2017, In : Reproduction. 154, p. 363-374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Chan, A. L., La, H. M., Legrand, J. M. D., Mäkelä, J. A., Eichenlaub, M., De Seram, M., Ramialison, M. & Hobbs, R. M., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 956-971 16 p.

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In vivo evidence that RBM5 is a tumour suppressor in the lung

Jamsai, D., Watkins, D. N., O'Connor, A. E., Merriner, D. J., Gursoy, S., Bird, A. D., Kumar, B., Miller, A., Cole, T. J., Jenkins, B. J. & O'Bryan, M. K., 1 Dec 2017, In : Scientific Reports. 7, 1, 8 p., 15874.

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Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

Dunleavy, J. E. M., Okuda, H., O’Connor, A. E., Merriner, D. J., O’Donnell, L., Jamsai, D., Bergmann, M. & O’Bryan, M. K., 14 Nov 2017, In : PLoS Genetics. 13, 11, 28 p., e1007078.

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LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

Romanos, T. R., Pladevall-Morera, D., Langebeck-Jensen, K., Hansen, S., Ng, L. & Pocock, R., 1 Dec 2017, In : Scientific Reports. 7, 1, 10 p., 7294.

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PiRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Dufourt, J., Bontonou, G., Chartier, A., Jahan, C., Meunier, A. C., Pierson, S., Harrison, P. F., Papin, C., Beilharz, T. H. & Simonelig, M., 1 Dec 2017, In : Nature Communications. 8, 1, 12 p., 1305.

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Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants

Sozo, F., Ishak, N., Bhatia, R., Davis, P. G. & Harding, R., 1 Nov 2017, In : Pediatric Research. 82, 5, p. 839-849 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Knaupp, A. S., Buckberry, S., Pflueger, J., Lim, S. M., Ford, E., Larcombe, M. R., Rossello, F. J., de Mendoza, A., Alaei, S., Firas, J., Holmes, M. L., Nair, S. S., Clark, S. J., Nefzger, C. M., Lister, R. & Polo, J. M., 7 Dec 2017, In : Cell Stem Cell. 21, 6, p. 834-845.e6 18 p.

Research output: Contribution to journalArticleResearchpeer-review