Research Output 2017 2019

2019

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

Torpe, N., Gopal, S., Baltaci, O., Rella, L., Handley, A., Korswagen, H. C. & Pocock, R., 19 Mar 2019, In : Cell Reports. 26, 12, p. 3183-3190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Caenorhabditis elegans hub genes that respond to amyloid beta are homologs of genes involved in human Alzheimer’s disease

Godini, R., Pocock, R. & Fallahi, H., 10 Jul 2019, In : PLoS ONE. 14, 7, 28 p., e0219486.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Context-specific behavioural changes induced by exposure to an androgenic endocrine disruptor

Bertram, M. G., Martin, J. M., Saaristo, M., Ecker, T. E., Michelangeli, M., Deal, N. D. S., Lim, S. L., O'Bryan, M. K. & Wong, B. B. M., 10 May 2019, In : Science of the Total Environment. 664, p. 177-187 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

Skvortsova, K., Masle-Farquhar, E., Luu, P. L., Song, J. Z., Qu, W., Zotenko, E., Gould, C. M., Du, Q., Peters, T. J., Colino-Sanguino, Y., Pidsley, R., Nair, S. S., Khoury, A., Smith, G. C., Miosge, L. A., Reed, J. H., Kench, J. G., Rubin, M. A., Horvath, L., Bogdanovic, O. & 5 others, Lim, S. M., Polo, J. M., Goodnow, C. C., Stirzaker, C. & Clark, S. J., 11 Feb 2019, In : Cancer Cell. 35, 2, p. 297-314 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions

Tichy, A-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M. & Janovjak, H., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3046-3055 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Generation of mouse-induced pluripotent stem cells by lentiviral transduction

Liu, X., Chen, J., Firas, J., Paynter, J. M., Nefzger, C. M. & Polo, J. M., 2019, Mouse Cell Culture: Methods and Protocols. Bertoncello, I. (ed.). New York, NY: Humana Press, p. 63-76 14 p. (Methods in Molecular Biology; vol. 1940).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline

Bellin, A. R., Zhang, Y., Thai, K., Rosenblum, N. D., Cullen-McEwen, L. A., Bertram, J. F. & Gilbert, R. E., 1 May 2019, In : Physiological Reports. 7, 9, 11 p., e14044.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction

Snieckute, G., Baltaci, O., Liu, H., Li, L., Hu, Z. & Pocock, R., 1 Jul 2019, In : Molecular and Cellular Neuroscience. 98, p. 70-81 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Normal foetal kidney volume in offspring of women treated for gestational diabetes

Hokke, S., De Zoysa, N., Carr, B. L., Abruzzo, V., Coombs, P. R., Allan, C. A., East, C., Ingelfinger, J., Puelles, V. G., Black, M. J., Ryan, D., Armitage, J. A., Wallace, E. M., Bertram, J. F. & Cullen-McEwen, L. A., Oct 2019, In : Endocrinology, Diabetes & Metabolism. 2, 4, 9 p., e00091.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

Puelles, V. G., Fleck, D., Ortz, L., Papadouri, S., Strieder, T., Böhner, A. M. C., van der Wolde, J. W., Vogt, M., Saritas, T., Kuppe, C., Fuss, A., Menzel, S., Klinkhammer, B. M., Müller-Newen, G., Heymann, F., Decker, L., Braun, F., Kretz, O., Huber, T. B., Susaki, E. A. & 9 others, Ueda, H. R., Boor, P., Floege, J., Kramann, R., Kurts, C., Bertram, J. F., Spehr, M., Nikolic-Paterson, D. J. & Moeller, M. J., 15 Mar 2019, (Accepted/In press) In : Kidney International. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Production of high-titer lentiviral particles for stable genetic modification of mammalian cells

Larcombe, M. R., Manent, J., Chen, J., Mishra, K., Liu, X. & Nefzger, C. M., 1 Jan 2019, Mouse Cell Culture: Methods and Protocols. Bertoncello, I. (ed.). New York: Humana Press, p. 47-61 15 p. (Methods in Molecular Biology; vol. 1940).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Rac GTPases: domain-specific functions in neuronal development

Norgaard, S. & Pocock, R., Apr 2019, In : Neural Regeneration Research. 14, 8, p. 1367-1368 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing

Liao, J., Ng, S. H., Luk, A. C., Suen, H. C., Qian, Y., Lee, A. W. T., Tu, J., Fung, J. C. L., Tang, N. L. S., Feng, B., Chan, W. Y., Fouchet, P., Hobbs, R. M. & Lee, T. L., 27 Mar 2019, In : Development (Cambridge). 146, 6, 15 p., dev174953.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Seruggia, D., Oti, M., Tripathi, P., Canver, M. C., LeBlanc, L., Di Giammartino, D. C., Bullen, M. J., Nefzger, C. M., Sun, Y. B. Y., Farouni, R., Polo, J. M., Pinello, L., Apostolou, E., Kim, J., Orkin, S. H. & Das, P. P., 20 Jun 2019, In : Molecular Cell. 74, 6, p. 1148-1163 16 p.

Research output: Contribution to journalArticleResearchpeer-review

The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans

Cao, W., Deng, J. & Pocock, R., 2019, (Accepted/In press) In : Small GTPases. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Topconfects: A package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list

Harrison, P. F., Pattison, A. D., Powell, D. R. & Beilharz, T. H., 28 Mar 2019, In : Genome Biology. 20, 1, 12 p., 67.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour

Kumarasingha, R., Young, N. D., Yeo, T. C., Lim, DI. S. L., Tu, C. L., Palombo, E. A., Shaw, J. M., Gasser, R. B. & Boag, P. R., 25 Apr 2019, In : Parasites and Vectors. 12, 1, 9 p., 181.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice

Winship, A. L., Carpenter, M., Griffiths, M. & Hutt, K. J., 1 May 2019, In : Toxicological sciences : an official journal of the Society of Toxicology. 169, 1, p. 43-53 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
7 Citations (Scopus)

Alternative polyadenylation in the regulation and dysregulation of gene expression

Turner, R. E., Pattison, A. D. & Beilharz, T. H., Mar 2018, In : Seminars in Cell and Developmental Biology. 75, p. 61-69 9 p.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Koch, B., Barugahare, A. A., Lo, T. L., Huang, C., Schittenhelm, R. B., Powell, D. R., Beilharz, T. H. & Traven, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2244-2258 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Pflueger, C., Tan, D., Swain, T., Nguyen, T., Pflueger, J., Nefzger, C., Polo, J. M., Ford, E. & Lister, R., 1 Aug 2018, In : Genome Research. 28, 8, p. 1193-1206 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Kim, E. J. Y., Anko, M-L., Flensberg, C., Majewski, I. J., Geng, F-S., Firas, J., Huang, D. C. S., van Delft, M. F. & Heath, J. K., 13 Feb 2018, In : Stem Cell Reports. 10, 2, p. 331-338 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Behavioral assays to study oxygen and carbon dioxide sensing in Caenorhabditis elegans

Romanos, T. R., Ng, L. & Pocock, R., 5 Jan 2018, In : Bio-protocol. 8, 1, 14 p., e2679.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Brain energy and oxygen metabolism: Emerging role in normal function and disease

Watts, M. E., Pocock, R. & Claudianos, C., 22 Jun 2018, In : Frontiers in Molecular Neuroscience. 11, 13 p., 216.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance

Woodhouse, R. M., Buchmann, G., Hoe, M., Harney, D. J., Low, J. K. K., Larance, M., Boag, P. R. & Ashe, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2259-2272 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Distinct CED-10/Rac1 domains confer context-specific functions in development

Norgaard, S., Deng, S., Cao, W. & Pocock, R., 28 Sep 2018, In : PLoS Genetics. 14, 9, 24 p., e1007670.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Electrical-assisted microinjection for analysis of fertilization and cell division in mammalian oocytes and early embryos

FitzHarris, G., Carroll, J. & Swann, K., 1 Jan 2018, Mitosis and Meiosis Part A. Maiato, H. & Schuh, M. (eds.). Academic Press, p. 431-440 10 p. (Methods in Cell Biology; vol. 144).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Examination of the ovotoxicity of 5-fluorouracil in mice

Lambouras, M., Liew, S. H., Horvay, K., Abud, H. E., Stringer, J. M. & Hutt, K. J., Jun 2018, In : Journal of Assisted Reproduction and Genetics. 35, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling

Chen, J., Nefzger, C. M., Rossello, F., Sun, Y. B. Y., Lim, S. M., Liu, X., De Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., Polo, J. M. & Barberi, T., 1 Jun 2018, In : Stem Cells. 36, 6, p. 822-833 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

La, H. M., Chan, A-L., Legrand, J. M. D., Rossello, F. J., Gangemi, C. G., Papa, A., Cheng, Q., Morand, E. F. & Hobbs, R. M., 1 Sep 2018, In : Development. 145, 18, dev165324.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M. & Hutt, K. J., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 12 p., 633.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

miR-222 isoforms are differentially regulated by type-I interferon

Nejad, C., Pillman, K. A., Siddle, K. J., Pépin, G., Anko, M. L., McCoy, C. E., Beilharz, T. H., Quintana-Murci, L., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Mar 2018, In : RNA. 24, 3, p. 332-341 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Proteomic characterisation of Caenorhabditis elegans larval development

Xia, T., Horton, E. R., Salcini, A. E., Pocock, R., Cox, T. R. & Erler, J. R., Jan 2018, In : Proteomics. 18, 2, 16 p., 1700238.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

RNA processing in the male germline: Mechanisms and implications for fertility

Legrand, J. M. D. & Hobbs, R. M., Jul 2018, In : Seminars in Cell and Developmental Biology. 79, p. 80-91 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

9 Citations (Scopus)

Splicing factors as regulators of miRNA biogenesis – links to human disease

Ratnadiwakara, M., Mohenska, M. & Anko, M-L., 1 Jul 2018, In : Seminars in Cell and Developmental Biology. 79, p. 113-122 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

SRSF3 promotes pluripotency through nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L., 9 May 2018, In : eLife. 7, 28 p., e37419.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Grabow, S., Kueh, A. J., Ke, F., Vanyai, H. K., Sheikh, B. N., Dengler, M. A., Chiang, W., Eccles, S., Smyth, I. M., Jones, L. K., De Sauvage, F. J., Scott, M., Whitehead, L., Voss, A. K. & Strasser, A., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3285-3295 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor, W. A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T. J., Lukianchikov, A., Liu, X., Polo, J. M., Jacobsen, S. E. & Clark, A. T., 1 May 2018, In : Nature Cell Biology. 20, 5, p. 553-564 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans

Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

O’brien, L. L., Combes, A. N., Short, K. M., Lindström, N. O., Whitney, P. H., Cullen-McEwen, L. A., Ju, A., Abdelhalim, A., Michos, O., Bertram, J. F., Smyth, I. M., Little, M. H. & McMahon, A. P., 5 Dec 2018, In : eLife. 7, 25 p., e40392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
1 Citation (Scopus)

Automated three-dimensional reconstruction of the Caenorhabditis elegans germline

Gopal, S., Boag, P. & Pocock, R., 15 Dec 2017, In : Developmental Biology. 432, 2, p. 222-228 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Cell Type of Origin Dictates the Route to Pluripotency

Nefzger, C. M., Rossello, F. J., Chen, J., Liu, X., Knaupp, A. S., Firas, J., Paynter, J. M., Pflueger, J., Buckberry, S., Lim, S. M., Williams, B., Alaei, S., Faye-Chauhan, K., Petretto, E., Nilsson, S. K., Lister, R., Ramialison, M., Powell, D. R., Rackham, O. J. L. & Polo, J. M., 5 Dec 2017, In : Cell Reports. 21, 10, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X., Nefzger, C. M., Rossello, F. J., Chen, J., Knaupp, A. S., Firas, J., Ford, E., Pflueger, J., Paynter, J. M., Chy, H. S., O'Brien, C. M., Huang, C., Mishra, K., Hodgson-Garms, M., Jansz, N., Williams, S. M., Blewitt, M. E., Nilsson, S. K., Schittenhelm, R. B., Laslett, A. L. & 2 others, Lister, R. & Polo, J. M., 31 Oct 2017, In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II

Zhang, Q-H., Yuen, W. S., Adhikari, D., Flegg, J. A., FitzHarris, G., Conti, M., Sicinski, P., Nabti, I., Marangos, P. & Carroll, J., 17 Aug 2017, In : Journal of Cell Biology. 216, 10, p. 3133-3143 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Exploring potential Germline-Associated roles of the TRIM-NHL Protein NHL-2 through RNAi screening

Davis, G. M., Low, W. Y., Anderson, J. W. T. & Boag, P. R., 1 Oct 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3251-3256 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Expression patterns of HENMT1 and PIWIL1 in human testis: Implications for transposon expression

Hempfling, AL., Lim, SL., Adelson, DL., Evans, J., O'Connor, AE., Qu, ZP., Kliesch, S., Weidner, W., O'Bryan, MK. & Bergmann, M., 1 Oct 2017, In : Reproduction. 154, p. 363-374 12 p.

Research output: Contribution to journalArticleResearchpeer-review