Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 518 Active
• 1140 Finished

Projects per year

Search results

• Active

  A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) versus Epoetin Alfa for the Treatment of Anemia due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naive Subjects who require Red Blood Cell Transfusions.

  Tiong, I. S. & Kennedy, N.

  15/07/19 → 31/12/24

  Project: Research

• Spinal Cord Research

  Davies, S., Davies, J. & O'Brien, T.

  StepAhead Australia

  13/07/19 → 30/06/22

  Project: Research

• Brain, cognition, mental health and functional outcomes in Type 1 diabetes – ~thirty year follow-up of the Royal Children’s Hospital Cohort

  Cameron, F., Srikanth, V., Moran, C., Beare, R. & Northam, E. A.

  10/07/19 → 30/04/21

  Project: Research

• A Phase 4, Open-Label, Randomized Study of Two Inotuzumab Ozogamicin Dose Levels in Adult Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic leukemia Eligible for Hematopoietic Stem Cell Transplantation and Who Have Risk Factor(s) for Veno-Occlusive Disease.

  Fleming, S. A. & Kennedy, N.

  9/07/19 → 31/12/25

  Project: Research

• A Phase 1 First-In-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 427 in Subjects with Relapsed/Refractory Acute Myeloid Leukemia.

  Wei, A. & Kennedy, N.

  9/07/19 → 31/12/24

  Project: Research

• A Phase 1, Dose Escalation Study of Flotetuzumab, a CD123 x CD3 DART Protein, Combined with MGA012, an Anti-PD-1 Antibody, in Patients with Relapsed or Refractory Acute Myeloid Leukemia.

  Wei, A. & Kennedy, N.

  9/07/19 → 31/12/24

  Project: Research

• Preclinical activity of Aplidin in multiple myeloma

  Spencer, A. & Plowman, C.

  8/07/19 → 31/12/24

  Project: Research

• A StuDy eVAluatiNg the Long-Term EffiCacy and Safety of RalinEpag in subjects with PAH via an Open-label EXTENSION.

  Williams, T.

  4/07/19 → 30/04/21

  Project: Research

• A StuDy eVAluatiNg the EffiCacy and Safety of RalinEpag To Improve Treatment OUTCOMES in PAH Patients.

  Williams, T.

  4/07/19 → 31/05/24

  Project: Research

• A Phase 3, Multicenter, randomized, double-blind Study of the Efficacy and Safety of Rezafungin for Injection versus Intravenous Caspofungin Followed by Optional Oral Fluconazole Step-down in the Treatment of Subjects with Candidemia and /or Invasive Candidiasis (The ReSTORE Study).

  Morrissey, O. & Roney, J.

  1/07/19 → 28/02/21

  Project: Research

• Active Participatory Health Monitoring in people with Multiple Sclerosis to improve treatment outcomes (Active-MS)

  Butzkueven, H., Van Der Walt, A., Darby, D., Stankovich, J., Jokubaitis, V., Skibina, O., Marriott, M., Butler, E. & Gresle, M.

  Department of Health (Australia)

  1/07/19 → 30/06/21

  Project: Research

• Tackling superbugs: an integrated antimicrobial resistance infection prevention genomics service

  Peleg, A.

  1/07/19 → 30/06/21

  Project: Research

• Be Your Best: an innovative, co-designed approach to frailty and care transitions from hospital to home, in people aged 65 years or more.

  Lowthian, J., Mills, A., Cyarto, L., Meyer, C., Dickins, M., Thurgood, L., Boyd, L., Walker, K., Rose, M., De Villiers Smit, P., Newnham, H. & Hutchinson, A. M.

  Department of Health (Australia)

  1/07/19 → 30/06/21

  Project: Research

• The Damian Project

  Kulkarni, J., Gurvich, C., De Castella, A. & Thomas, N.

  The Mohr Family

  1/07/19 → 30/06/28

  Project: Research

• Using smart technology to more effectively and efficiently monitor the quality of cancer care

  Zalcberg, J., Evans, S., Bain, C., Aleti, A., Mac Manus, C., Brown, W., Sievert, W., Evans, P., Davis, I., Evans, M., Holland, J. & Brand, M.

  Department of Health (Australia)

  1/07/19 → 30/06/21

  Project: Research

• Conducting efficacy and implementation trials to improve the evidence-base of stroke rehabilitation to improve participation outcomes

  Lannin, N.

  1/07/19 → 31/12/22

  Project: Research

• Precision Medicine for hypertension: Early detection of primary aldosteronism

  Yang, J., Fuller, P., Young, M., Stowasser, M., Russell, G., Bach, L., Gilfillan, C., Lu, Z. X., Reid, C., Chen, G. & Gwini, S.

  1/07/19 → 30/06/21

  Project: Research

• Klebsiella pneumoniae – a key driver in the global spread of antimicrobial resistance and a target for new approaches in diagnostics, surveillance and alternative therapeutics (KLEB-GAP).

  Sundsfjord, A., Hoyland Lohr, I., Samuelsen, O., Sunde, M., Lunestad, B. T., Brisse, S., Giske, C., Bengoechea, J., Holt, K. & Frantzen, C.

  30/06/19 → 31/12/23

  Project: Research

• Assessing diagnostic accuracy for melanoma with compared to without access to Melanoma Surveillance Photography in high-risk individuals

  Mar, V., Cust, A. E., Soyer, P., Morton, R., Wolfe, R., Guitera, P., White, P., Janda, M., Fishburn, P. & Kelly, J.

  Department of Health (Australia)

  30/06/19 → 29/10/22

  Project: Research

• CLADIN sub study. Effect of CLADribine on Innate Immune Response (CLADIN). MS Immunity Project.

  Monif, M., Butzkueven, H. & O'Brien, T.

  27/06/19 → 9/09/22

  Project: Research

• An Adaptive, Open-Label, Dose-Finding, Phase 1/2 Study Investigating the Safety, Pharmacokinetics, and Clinical Activity of PRN1008, an Oral BTK Inhibitor, in Patients with Relapsed Immune Thrombocytopenic Purpura

  Kaplan, Z.

  24/06/19 → 23/06/24

  Project: Research

• A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GS-4224 in Healthy Volunteers and Subjects with the Chronic Hepatitis B (CHB) Virus

  Roberts, S. & Jones, A.

  19/06/19 → 31/05/21

  Project: Research

• A Randomized Open-Label, Phase 1b Study of the Safety of Pirfenidone Solution for Inhalation (AP01) in Patients with Idiopathic Pulmonary Fibrosis (ATLAS Study)

  Glaspole, I. & Symons, K. M.

  7/06/19 → 1/06/22

  Project: Research

• A Phase 3, randomized, double-blind, parallel-group, placebo controlled multicenter study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis.

  Glaspole, I. & Symons, K. M.

  7/06/19 → 1/12/22

  Project: Research

• Improved monitoring of Multiple Sclerosis (MS) using patient-derived and MRI scan information.

  Butzkueven, H.

  6/06/19 → 27/02/23

  Project: Research

• An open-label, multicenter, extension study to evaluate the safety and efficacy of Padsevonil as adjunctive treatment of focal-onset seizures in adult subjects with drug-resistant epilepsy.

  O'Brien, T., Perucca, P., D'Souza, W. J., Berkovic, S. F., Wijayath, M., Carney, P., Seneviratne, U., Reutens, D. C., Zentner, C., Frasca, J. & Nikpour, A.

  4/06/19 → 31/12/21

  Project: Research

• A Prospective, Single-arm, Multicenter Study to Evaluate the Safety and Performance of the Instylla Hydrogel Embolic System (HES) For Patients Requiring Vascular Embolization Alone or in the Pre-operative Setting for Treatment of Malignant and Benign Hypervascular Tumors, and Select Non-Traumatic End-Organ Infarct.

  Goh, G., Clements, W., Koukounaras, J. & Kavnoudias, H.

  3/06/19 → 31/12/24

  Project: Research

• Bazedoxifene – A New Selective Estrogen Receptor Modulator Treatment for People with Schizophrenia

  Kulkarni, J., Gurvich, C., Thomas, N., Sundram, S., Hill, R. & Chu, S.

  1/06/19 → 31/05/22

  Project: Research

• Identification and Forecasting of Seizure from EEG data recorded from rodents in Laboratory settings using QA/QC and Machine Learning Algorithms Stage 2

  O'Brien, T., Casillas-Espinosa, P. & Knight, K.

  Monash University – Internal Faculty Contribution

  1/06/19 → 30/05/21

  Project: Research

• Transforming pulmonary rehabilitation to reduce hospital admissions in COPD

  Holland, A., McDonald, C. F., Mahal, A. S., Lannin, N., Cox, N., Hepworth, G. & OʼHalloran, P. D.

  Department of Health (Australia)

  1/06/19 → 31/08/22

  Project: Research

• Preferences and cost-effectiveness of case detection and management strategies for chlamydia control in Hong Kong

  Ong, J. & Wong, W. C. W.

  1/06/19 → 31/05/21

  Project: Research

• Minimal genomics lab for AMR surveillance and diagnostics in provincial low-income settings.

  Okeke, I. & Holt, K.

  27/05/19 → 15/04/21

  Project: Research

• A phase 1a/1b multicenter, open-label, dose escalation, dose expansion study evaluating the safety, pharmacokinetics and activity of GDC-9545 alone or in combination with palbociclib and/or LHRH agonist in patients with locally advanced or metastatic estrogen receptor-positive breast cancer [GO39932].

  Richardson, G. & Baker, E.

  24/05/19 → 31/12/24

  Project: Research

• A phase 1b, multi-arm, open-label, study of HDM201 in combination with MBG453 or venetoclax in adult subjects with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS).

  Wei, A. & Kennedy, N.

  23/05/19 → 23/05/24

  Project: Research

• ATLAS-OLE: An Open-label, Long-term Safety and Efficacy Study of Fitusiran in Patients with Hemophilia A or B, with or without Inhibitory Antibodies to Factor VIII or IX.

  Tran, H. & Kennedy, N.

  20/05/19 → 31/12/24

  Project: Research

• A Phase 3, Double-blind, Randomized, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Adults who Require Regular Red Blood Cell Transfusions Due to Beta -Thalassemia

  Kaplan, Z.

  20/05/19 → 19/05/24

  Project: Research

• A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Durvalumab Monotherapy or in Combination with Bevacizumab as Adjuvant Therapy in Patients with Hepatocellular Carcinoma who are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (EMERALD-2).

  Roberts, S.

  17/05/19 → 31/05/23

  Project: Research

• A Cognitive-Mobility Stress Test To Detect MCI and Risk of Conversion to Dementia

  Callisaya, M.

  Dementia Australia Research Foundation Ltd

  1/05/19 → 1/05/21

  Project: Research

• Transforming the treatment landscape in elderly Acute Myeloid Leukaemia (AML)

  Wei, A., Bohlander, S. K., Reynolds, J. & Levis, M.

  1/05/19 → 31/12/22

  Project: Research

• Establishing the current state of teaching and knowledge of Interventional Radiology amongst Australian Medical students

  Clements, W. & Goh, G.

  1/05/19 → …

  Project: Research

• A Randomized, Controlled, Open-Label, Rater-Blinded, Phase 3b Study of the Efficacy, Safety, and Tolerability of 6-Week Extended Interval Dosing of Natalizumab (BG00002) in Subjects With Relapsing-Remitting Multiple Sclerosis Switching from Treatment with 4-Week Natalizumab Standard Interval Dosing (SID) in Relation to Continued SID Treatment.

  Van Der Walt, A.

  16/04/19 → 31/12/24

  Project: Research

• A Double-Blind, Randomized, Placebo-Controlled, Safety and Efficacy Study of ANAVEX2-73 in patients with Rett Syndrome.

  O'Brien, T.

  5/04/19 → 31/12/22

  Project: Research

• A Phase 2, Open-label, Single-Arm Study of Pamiparib (BGB-290) for the Treatment of Patients with Metatstatic Castration-Resistant Prostate Cancer (mCRPC) with Homologous Recombination Deficiency (HRD).

  Voskoboynik, M. & Cross, N.

  3/04/19 → 30/04/24

  Project: Research

• Clinical Study No. M15-563, An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP).

  Bertram, K. & Burn, K.

  3/04/19 → 30/04/24

  Project: Research

• Evaluating the effectiveness and safety of sodium selenate as a disease modifying treatment for patients with behavioural variant Frontotemporal Dementia (bvFTD)

  O'Brien, T., Malpas, C., Velakoulis, D., Brodtmann, A., Piguet, O., Kalincik, T., Walterfang, M., Ahmed, R., Bush, A. I. & Darby, D. G.

  Department of Health (Australia)

  1/04/19 → 31/03/24

  Project: Research

• Novel Venetoclax Combinations To Improve Outcomes In Unfit Older Patients With Acute Myeloid Leukaemia

  Wei, A., Reynolds, J., Ritchie, D. S., Ananda-Rajah, M., Liew, D. & Ivey, A.

  1/04/19 → 31/03/24

  Project: Research

• Improving the health of older Australians at risk of dementia - The role of physical function and exercise

  Callisaya, M.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/04/19 → 30/09/21

  Project: Research

• EPO-TRAUMA: ErythroPOietin alfa to prevent mortality and reduce severe disability in critically ill TRAUMA patients: a multicentre, stratified, double blind, placebo randomised controlled trial. (The EPO-TRAUMA trial)

  French, C., Nichol, A., Bellomo, R., Cooper, J., Bailey, M., Higgins, L., McArthur, C., Hodgson, C., Gabbe, B., Duranteau, J., Presneill, J., Rosenfeld, J., Napolitano, L., Skrifvars, M., Reade, M. & Pettila, V.

  Department of Health (Australia)

  1/04/19 → 1/10/24

  Project: Research

• A global prospective open access study to assess and optimize the monitoring of Multiple Sclerosis using smartphones (floodlight open study)

  Butzkueven, H. & Gresle, M.

  31/03/19 → 31/03/24

  Project: Research

• Tisagenlecleucel versus blinatumomab or inotuzumab for adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: A randomized, open-label, multicenter, phase III trial (OBERON).

  Wei, A. & Kennedy, N.

  28/03/19 → 31/12/24

  Project: Research