Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 518 Active
• 1140 Finished

Projects per year

Search results

• Active

  A randomised controlled trial of Focal Electrically Administered Seizure Therapy (FEAST) in patients with severe depression

  Loo, C., Martin, D., Fitzgerald, P., Dokos, S., Hadzi-Pavlovic, D., George, M., Bai, S. & Boonstra, T.

  1/01/19 → 31/12/23

  Project: Research

• A translational research approach to study mild traumatic brain injury

  Shultz, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/22

  Project: Research

• A statistical framework to exploit routine pathogen genomics data for public health

  Holt, K. & Duchene, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/21

  Project: Research

• The role of NOX4 in antioxidant defence and mitochondrial biogenesis in muscle

  Tiganis, T., McLean, C., Bennett, A. M., Lee-Young, R., Mitchell, C. & Hawley, J.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/21

  Project: Research

• Halting the atopic march: harnessing the skin microbiome in early life to prevent allergies

  Marsland, B.

  1/01/19 → 31/12/21

  Project: Research

• Harnessing the microbiome to protect against chronic lung diseases

  Marsland, B.

  1/01/19 → 31/12/23

  Project: Research

• Molecular control of postnatal heart development

  Porrello, E. R., El-Osta, S., Delbridge, L. M. & Hudson, J.

  1/01/19 → 31/12/21

  Project: Research

• Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma

  Bourke, J., Royce, S., Bardin, P., Westall, G., Grainge, C., Oliver, B. G., Samuel, C. & Wadsworth, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/21

  Project: Research

• Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing

  Naderer, T., Shen, H., Peleg, A., Mackay, C., Ramm, G. & Dougan, G.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/21

  Project: Research

• Improving the safety and predictable efficacy of thrombolytic therapy in acute ischaemic stroke

  Medcalf, R., Boyd, B. & Cloud, G.

  1/01/19 → 31/12/22

  Project: Research

• Effect of clonal haematopoiesis and aspirin on outcomes in elderly: the ASPREE-HAEM study

  McQuilten, Z., Curtis, D., Wood, E., Wolfe, R., Lacaze, P., Sebra, R., Murphy, A. J., Riaz, M., McNeil, J., Woods, R. & Wong, N.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/21

  Project: Research

• MSPP: Multiple Sclerosis: Pregnancy and Prognosis

  Jokubaitis, V., Van Der Walt, A., Hellwig, K., McCombe, P. & Stankovich, J.

  1/01/19 → 31/12/22

  Project: Research

• A phase 3, open-label, randomised study to compare the efficacy and safety of luspatercept (Ace-536) versus epoetin alfa for the treatment of anaemia due to Ipss-R very low, low or intermediate risk myelodysplastic syndromes (MDS) in ESA naive subjects who require red blood cell transfusions [ACE-536-MDS-002]

  Kenealy, M. & Baker, E.

  20/12/18 → 31/12/24

  Project: Research

• ICAN: Immunoglobulin use and outcomes in Chronic lymphocytic leukaemia And Non-Hodgkin lymphoma – the ICAN study

  McQuilten, Z., Wood, E., Opat, S., Mulligan, S., Slavin, M., Crispin, P., Morrissey, O., Zalcberg, J., Teh, B. W., Waters, N., Rowsell, L., Crassini, K. & Wong, J.

  19/12/18 → 31/12/21

  Project: Research

• Next Generation of bespoke treatments: Artificial intelligence aiding in prognoses in treatment plans

  Law, M. & Seah, J.

  The Aftershock

  18/12/18 → 31/12/21

  Project: Research

• MS Reactor - Prospective clinic and home-based monitoring of cognition in relapsing remitting multiple sclerosis.

  Van Der Walt, A.

  17/12/18 → 30/11/22

  Project: Research

• A phase 1a/1b study of FPT155 in patients with advanced solid tumours [FPT155-001].

  Richardson, G. & Baker, E.

  10/12/18 → 31/12/23

  Project: Research

• A phase 1b/2 study of BMS-813160 in combination with chemotherapy or Nivolumab in patients with advanced solid tumors [CV202-103].

  Richardson, G. & Baker, E.

  10/12/18 → 31/12/24

  Project: Research

• A 2-year prospective study to evaluate the onset of action of Mavenclad in subjects with highly active relapsing multiple sclerosis.

  Skibina, O. & O'Brien, T.

  5/12/18 → 5/12/23

  Project: Research

• Long-term, prospective, multinational, parallel-cohort study monitoring safety in patients with MS newly started on fingolimod once daily or treated with another disease-modifying therapy.

  Van Der Walt, A. & Germaine, J.

  30/11/18 → 31/01/24

  Project: Research

• A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients with, or at high risk for, Cardiovascular Disease who are Statin Intolerant.

  Dart, A. & Sally, K.

  23/11/18 → 23/04/22

  Project: Research

• Adjuvant Therapy with Pembrolizumab versus Placebo in Resected High-risk Stage II Melanoma: A Randomized, Double-blind Phase 3 Study.

  Haydon, A. & Cross, N.

  21/11/18 → 31/12/23

  Project: Research

• A Phase III, Randomized, Double-blind, Placebo-Controlled, Multicenter study to Evaluate the Efficacy and Safety of Baloxavir Marboxil in Combination with Standard of Care Neuraminidase Inhibitor in Hospitalized Patients with Severe Influenza.

  Cheng, A. & Roney, J.

  15/11/18 → 15/05/21

  Project: Research

• Biomarkers of Brain Concussion

  Shultz, S., O'Brien, T., Kosofsky, B., Germaine, J., Smith, R., Fielding, J., Clough, M. & Wright, D.

  14/11/18 → 30/06/22

  Project: Research

• CBTCT: NHMRC Centre of Research Excellence: Centre for Blood Transplant and Cell Therapy (CBTCT)

  Gottlieb, D., Tey, S., Ritchie, D. S. & Curtis, D.

  31/10/18 → 30/10/23

  Project: Research

• Study of using Cyclophosphamide After Sibling-donor allogenic stem-cell Transplantation (CAST) in patients with acute leukaemia and Myelodysplasia: a randomised study comparing cyclosporin and methotrexate to cyclosporin and post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis.

  Curtis, D., Fleming, S. A., Patil, S. & Kennedy, N.

  23/10/18 → 23/10/23

  Project: Research

• An International Phase Ib multicentre study to characterize the safety and tolerability of intravenously administered S64315, a selective Mcl-1 inhibitor, in combination with orally administered venetoclax, a selective Bcl-2 inhibitor, in patients with Acute Myeloid Leukaemia (AML).

  Wei, A. & Kennedy, N.

  23/10/18 → 23/10/22

  Project: Research

• A Phase 1, 2-Part, Multicenter, Open-label, 3-Arm Study to Determine the effect of Enasidenib (CC-90007) on the Pharmacokinetics of Single Doses of Caffeine, Dextromethorphan, Flurbiprofen, Midazolam, Omeprazole, Digoxin, Rosuvastatin, and Pioglitazone in Subjects with Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring an Isocitrate Dehydrogenase 2 Mutation

  Wei, A. & Kennedy, N.

  12/10/18 → 12/10/23

  Project: Research

• MS Reactor - Prospective clinic and home-based monitoring of cognition in relapsing remitting multiple sclerosis.

  Van Der Walt, A. & Lechner-Scott, J.

  5/10/18 → 30/11/22

  Project: Research

• TOP: TYSABRI Observational Program

  Van Der Walt, A.

  4/10/18 → 4/10/23

  Project: Research

• MS Reactor - Prospective clinic and home-based monitoring of cognition in relapsing remitting multiple sclerosis.

  Van Der Walt, A.

  4/10/18 → 30/11/22

  Project: Research

• A Phase 2/3, Randomized, Double-blind, Placebo- and Active- controlled, Parallel-group, Multicenter Protocol to Evaluate the Efficacy and Safety of Guselkumab in Participants with Moderately to Severely Active Crohn's Disease (GALAXI).

  Sparrow, M. & Hogg, J.

  4/10/18 → 30/06/21

  Project: Research

• A Phase 3, multicentre, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL 112 in subjects with Acute Coronary Syndrome protocol #: CSL 112_3001 (the ApoA-1 Event ReducinG in Ischaemic Syndromes II (AEGIS-II) Study.

  Shaw, J.

  1/10/18 → 1/10/24

  Project: Research

• Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study. (DYNAMIC-RECTAL).

  Gill, S. & Cross, N.

  30/09/18 → 30/10/24

  Project: Research

• An exploratory study of venetoclax in combination with bortezomib-cyclophosphamide-dexamethasone (VCD) induction therapy in newly diagnosed transplant eligible (NDTE MM) multiple myeloma with proteomic correlative studies.

  Spencer, A., Kennedy, N., Mollee, P., Harrison, S. J., Quach, H. & Ho, P. J.

  27/09/18 → 27/09/23

  Project: Research

• A Phase 1 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects with Selected Relapsed or Refractory Hematological Malignancies.

  Wei, A. & Kennedy, N.

  27/09/18 → 27/09/23

  Project: Research

• CORE-VNS:Comprehensive Outcomes Registry in Subjects with Epilepsy Treated with Vagus Nerve Stimulation Therapy.

  O'Brien, T.

  24/09/18 → 31/12/23

  Project: Research

• A Phase 1 Trial of CEND-1 in Combination with Nabpaclitaxel and Gemcitabine in Metastatic Exocrine Pancreatic Cancer.

  Gill, S. & Cross, N.

  20/09/18 → 20/09/23

  Project: Research

• Phase II trial PD-L1/PD-1 blockade Avelumab (MSB0010718C) with Chemoradiotherapy for Locally Advanced Resectable T3b-4/N1-2 Rectal Cancer.

  Gill, S. & Cross, N.

  20/09/18 → 20/09/23

  Project: Research

• A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of BG00011 in Patients with Idiopathic Pulmonary Fibrosis.

  Glaspole, I. & Symons, K. M.

  13/09/18 → 31/07/22

  Project: Research

• Prospective clinic and home-based serial monitoring of cognition in relapsing-remitting multiple sclerosis.

  Van Der Walt, A. & Butzkueven, H.

  13/09/18 → 13/11/22

  Project: Research

• ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing

  Ong, J., Tucker, J. D. & Iwelunmor, J.

  1/09/18 → 31/08/24

  Project: Consultancy

• UPPRITE Trial - Universal Posaconazole Prophylaxis versus Pre-emptive Posaconazole Therapy for Fungal Infection Management Post-lung Transplantation.

  Morrissey, O. & Price, B.

  27/08/18 → 31/12/21

  Project: Research

• A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination therapy in Subjects with Cystic Fibrosis who are Homozygous or Heterozygous for the F508del Mutation.

  Keating, D.

  10/08/18 → 10/08/23

  Project: Research

• Open Label Clinical Trial to Study the Efficacy and Safety of the Combination Regimen of MK-5172 and MK-8742 +/- ribavirin (RBV) in the treatment of Hepatitis C G1 and 4, in patients either eligible for liver transplant (HCC) or curative therapy or non-eligible for curative therapy but clinically stable disease post local resection, embolization or ablative therapy: HATCHeT Study - HepATocellular Cancer Hcv Therapy Study.

  Kemp, W. & Mitchell, J.

  7/08/18 → 7/08/23

  Project: Research

• Thrombin Responsive Nanoparticles for Prophylaxis and Treatment of Acute Thrombosis

  Palazzolo, J. S. & Hagemeyer, C.

  6/08/18 → 5/02/22

  Project: Research

• An Open-Label Study To Evaluate The Long-Term Safety Of Daily Oral BCX7353 In Subjects With Type I and II Hereditary Angioedema.

  Zubrinich, C., Malinowski, L. & Thompson, K.

  27/07/18 → 31/12/23

  Project: Research

• Multiplex Active Ration Test for the Detection of Early Stage Ovarian Cancer

  Stephens, A. & Plebanski, M.

  1/07/18 → 30/06/21

  Project: Research

• CAST – A Randomised Phase 3 Trial of Cyclophosphamide after Sibling Allogeneic Haematopoietic Stem Cell Transplant

  Curtis, D., Hill, G. R., Gottlieb, D., Patil, S., Ritchie, D. S., King, M. & Morrissey, O.

  13/06/18 → 31/12/22

  Project: Research

• A registry-linked national platform trial to improve precision-based outcomes using novel therapies in acute myeloid leukaemia (AML)

  Wei, A., Dawson, M. A., Reynolds, J., Bohlander, S. K., Ivey, A., Ekert, P. G., Marlton, P. & Blombery, P. A.

  13/06/18 → 31/12/22

  Project: Research