Central Clinical School

Projects

Projects per year 2000 2028

• 15 Curtailed
• 28 Not started
• 533 Active
• 1148 Finished

Projects per year

Search results

• Active

  A Phase 3, randomized, double-blind, parallel-group, placebo controlled multicenter study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis.

  Glaspole, I. & Symons, K. M.

  7/06/19 → 1/12/22

  Project: Research

• Improved monitoring of Multiple Sclerosis (MS) using patient-derived and MRI scan information.

  Butzkueven, H.

  6/06/19 → 27/02/23

  Project: Research

• An open-label, multicenter, extension study to evaluate the safety and efficacy of Padsevonil as adjunctive treatment of focal-onset seizures in adult subjects with drug-resistant epilepsy.

  O'Brien, T., Perucca, P., D'Souza, W. J., Berkovic, S. F., Wijayath, M., Carney, P., Seneviratne, U., Reutens, D. C., Zentner, C., Frasca, J. & Nikpour, A.

  4/06/19 → 31/12/21

  Project: Research

• A Prospective, Single-arm, Multicenter Study to Evaluate the Safety and Performance of the Instylla Hydrogel Embolic System (HES) For Patients Requiring Vascular Embolization Alone or in the Pre-operative Setting for Treatment of Malignant and Benign Hypervascular Tumors, and Select Non-Traumatic End-Organ Infarct.

  Goh, G., Clements, W., Koukounaras, J. & Kavnoudias, H.

  3/06/19 → 31/12/24

  Project: Research

• Transforming pulmonary rehabilitation to reduce hospital admissions in COPD

  Holland, A., McDonald, C. F., Mahal, A. S., Lannin, N., Cox, N., Hepworth, G. & OʼHalloran, P. D.

  Department of Health (Australia)

  1/06/19 → 31/08/22

  Project: Research

• How to diagnose ataxia

  Szmulewicz, D.

  1/06/19 → 31/12/21

  Project: Research

• Bazedoxifene – A New Selective Estrogen Receptor Modulator Treatment for People with Schizophrenia

  Kulkarni, J., Gurvich, C., Thomas, N., Sundram, S., Hill, R. & Chu, S.

  1/06/19 → 31/05/22

  Project: Research

• Preferences and cost-effectiveness of case detection and management strategies for chlamydia control in Hong Kong

  Ong, J. & Wong, W. C. W.

  1/06/19 → 31/05/21

  Project: Research

• Identification and Forecasting of Seizure from EEG data recorded from rodents in Laboratory settings using QA/QC and Machine Learning Algorithms Stage 2

  O'Brien, T., Casillas-Espinosa, P. & Knight, K.

  Monash University – Internal Faculty Contribution

  1/06/19 → 30/05/21

  Project: Research

• Minimal genomics lab for AMR surveillance and diagnostics in provincial low-income settings.

  Okeke, I. & Holt, K.

  27/05/19 → 15/04/21

  Project: Research

• A phase 1a/1b multicenter, open-label, dose escalation, dose expansion study evaluating the safety, pharmacokinetics and activity of GDC-9545 alone or in combination with palbociclib and/or LHRH agonist in patients with locally advanced or metastatic estrogen receptor-positive breast cancer [GO39932].

  Richardson, G. & Baker, E.

  24/05/19 → 31/12/24

  Project: Research

• A phase 1b, multi-arm, open-label, study of HDM201 in combination with MBG453 or venetoclax in adult subjects with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS).

  Wei, A. & Kennedy, N.

  23/05/19 → 23/05/24

  Project: Research

• A Phase 3, Double-blind, Randomized, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Adults who Require Regular Red Blood Cell Transfusions Due to Beta -Thalassemia

  Kaplan, Z.

  20/05/19 → 19/05/24

  Project: Research

• ATLAS-OLE: An Open-label, Long-term Safety and Efficacy Study of Fitusiran in Patients with Hemophilia A or B, with or without Inhibitory Antibodies to Factor VIII or IX.

  Tran, H. & Kennedy, N.

  20/05/19 → 31/12/24

  Project: Research

• A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Durvalumab Monotherapy or in Combination with Bevacizumab as Adjuvant Therapy in Patients with Hepatocellular Carcinoma who are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (EMERALD-2).

  Roberts, S.

  17/05/19 → 31/05/23

  Project: Research

• A Cognitive-Mobility Stress Test To Detect MCI and Risk of Conversion to Dementia

  Callisaya, M.

  Dementia Australia Research Foundation Ltd

  1/05/19 → 1/05/21

  Project: Research

• Transforming the treatment landscape in elderly Acute Myeloid Leukaemia (AML)

  Wei, A., Bohlander, S. K., Reynolds, J. & Levis, M.

  1/05/19 → 31/12/22

  Project: Research

• Establishing the current state of teaching and knowledge of Interventional Radiology amongst Australian Medical students

  Clements, W. & Goh, G.

  1/05/19 → …

  Project: Research

• A Randomized, Controlled, Open-Label, Rater-Blinded, Phase 3b Study of the Efficacy, Safety, and Tolerability of 6-Week Extended Interval Dosing of Natalizumab (BG00002) in Subjects With Relapsing-Remitting Multiple Sclerosis Switching from Treatment with 4-Week Natalizumab Standard Interval Dosing (SID) in Relation to Continued SID Treatment.

  Van Der Walt, A.

  16/04/19 → 31/12/24

  Project: Research

• A Double-Blind, Randomized, Placebo-Controlled, Safety and Efficacy Study of ANAVEX2-73 in patients with Rett Syndrome.

  O'Brien, T.

  5/04/19 → 31/12/22

  Project: Research

• Clinical Study No. M15-563, An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP).

  Bertram, K. & Burn, K.

  3/04/19 → 30/04/24

  Project: Research

• A Phase 2, Open-label, Single-Arm Study of Pamiparib (BGB-290) for the Treatment of Patients with Metatstatic Castration-Resistant Prostate Cancer (mCRPC) with Homologous Recombination Deficiency (HRD).

  Voskoboynik, M. & Cross, N.

  3/04/19 → 30/04/24

  Project: Research

• Improving the health of older Australians at risk of dementia - The role of physical function and exercise

  Callisaya, M.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/04/19 → 30/09/21

  Project: Research

• Evaluating the effectiveness and safety of sodium selenate as a disease modifying treatment for patients with behavioural variant Frontotemporal Dementia (bvFTD)

  O'Brien, T., Malpas, C., Velakoulis, D., Brodtmann, A., Piguet, O., Kalincik, T., Walterfang, M., Ahmed, R., Bush, A. I. & Darby, D. G.

  Department of Health (Australia)

  1/04/19 → 31/03/24

  Project: Research

• EPO-TRAUMA: ErythroPOietin alfa to prevent mortality and reduce severe disability in critically ill TRAUMA patients: a multicentre, stratified, double blind, placebo randomised controlled trial. (The EPO-TRAUMA trial)

  French, C., Nichol, A., Bellomo, R., Cooper, J., Bailey, M., Higgins, L., McArthur, C., Hodgson, C., Gabbe, B., Duranteau, J., Presneill, J., Rosenfeld, J., Napolitano, L., Skrifvars, M., Reade, M. & Pettila, V.

  Department of Health (Australia)

  1/04/19 → 1/10/24

  Project: Research

• Novel Venetoclax Combinations To Improve Outcomes In Unfit Older Patients With Acute Myeloid Leukaemia

  Wei, A., Reynolds, J., Ritchie, D. S., Ananda-Rajah, M., Liew, D. & Ivey, A.

  1/04/19 → 31/03/24

  Project: Research

• A global prospective open access study to assess and optimize the monitoring of Multiple Sclerosis using smartphones (floodlight open study)

  Butzkueven, H. & Gresle, M.

  31/03/19 → 31/03/24

  Project: Research

• Tisagenlecleucel versus blinatumomab or inotuzumab for adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: A randomized, open-label, multicenter, phase III trial (OBERON).

  Wei, A. & Kennedy, N.

  28/03/19 → 31/12/24

  Project: Research

• A Multicenter, Open-label Phase 2 Study of Lenvatinib Plus Pembrolizumab in Previously Treated Subjects with Selected Solid Tumors (LEAP-005).

  Gill, S. & Cross, N.

  22/03/19 → 31/12/24

  Project: Research

• A Multi-Center, Observational Study in Males with Hemophilia A.

  Tran, H. & Kennedy, N.

  21/03/19 → 31/12/24

  Project: Research

• Stimulatrion Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients (SOLVE-CRT).

  Kaye, D.

  21/03/19 → 31/12/24

  Project: Research

• Integrated Management of Post Remission Leukaemia to Optimise longevity and Enhance Quality of Life

  Wei, A., Fleming, S. A. & Rady, K.

  14/03/19 → 30/05/22

  Project: Research

• A prospective, multi-national, non-interventional study in haemophilia A and B patients with or without inhibitors treated according to routine clinical treatment practice (explorer 6).

  Tran, H. & Kennedy, N.

  12/03/19 → 31/12/21

  Project: Research

• Brain glutamate imaging by ultra-high-field MRI for prediction of post-stroke epilepsy

  Kwan, P., O'Brien, T., Cloud, G., Hand, P., Yan, B., Nicolo, J. & Wright, D.

  11/03/19 → 8/03/21

  Project: Research

• Phase I, open label, non-randomised, non-comparative, multi-center study, evaluating S65487, a Bcl-2 inhibitor intravenously administered, in patients with Relapse or Refractory Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma or Chronic Lymphocytic Leukemia

  Spencer, A. & Kennedy, N.

  7/03/19 → 31/12/24

  Project: Research

• An Open-Label, Multicenter, Phase I/Ib Trial Evaluating the Safety, Efficacy, and Pharmacokinetics of Escalating Doses of mosunetuzumab (BTCT4465A) as a Single Agent and Combined with Atezolizumab in Patients with Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

  Fleming, S. A., Patil, S. & Kennedy, N.

  6/03/19 → 31/12/22

  Project: Research

• A Phase III, Double-Blind. Placebo-Controlled, Multicenter, Randomized Study of Pracinostat in Combination with Azacitidine in Patients > 18 Years with Newly Diagnosed Acute Myeloid Leukemia unfit for Standard Induction Chemotherapy.

  Wei, A. & Kennedy, N.

  4/03/19 → 31/10/23

  Project: Research

• Clinical and biological approaches to improving diagnostic confidence of Chronic Hypersensitivity Pneumonitis.

  Glaspole, I. & Barnes, H.

  4/03/19 → 3/03/22

  Project: Research

• A phase 1/1b study to evaluate the safety and tolerability of immunotherapy combinations in participants with breast or gynaecologic malignancies [AB928CSP0002].

  Richardson, G. & Baker, E.

  28/02/19 → 31/12/24

  Project: Research

• A phase 1/1b study to evaluate the safety and tolerability of immunotherapy combinations in participants with gastrointestinal malignancies [AB928CSP0003].

  Richardson, G. & Baker, E.

  28/02/19 → 31/12/24

  Project: Research

• A phase 1 study to evaluate the safety and tolerability of immunotherapy combinations in participants with advanced malignancies [AB928CSP0005].

  Richardson, G. & Baker, E.

  28/02/19 → 31/12/24

  Project: Research

• A Phase 1 First-in-Human Study of Bispecific Antibody TG-1801 in Subjects with B-Cell Lymphoma.

  Patil, S. & Kennedy, N.

  20/02/19 → 29/02/24

  Project: Research

• Combating adaptive resistance to tageted therapy in triple-negative breast cancer

  Nguyen, L., Swarbrick, A., Richardson, G., Loi, S. & Daly, R.

  15/02/19 → 14/02/23

  Project: Research

• Using next generation sequencing technology to improve the diagnosis of pancreatic cancer

  Croagh, D., Southey, M., Jenkins, B., Segelov, E., Rathi, V., Holt, B. A., Pilgrim, C., Bhutani, M. & Tagkalidis, P.

  Victorian Cancer Agency

  15/02/19 → 14/02/23

  Project: Research

• Real-time patient-reported outcomes measures (PROMs) in clinical practice – a novel approach to improving quality of care for patients with upper gastrointestinal cancer

  Zalcberg, J., Ioannou, L., Evans, S., King, M., Croagh, D., Pilgrim, C., Brown, W., White, K., Philip, J., Leong, T. & Earnest, A.

  15/02/19 → 14/02/23

  Project: Research

• A multicenter, single arm, study of daratumumab-lenalidomide-dexamethasone (DRd) for newly diagnosed transplant eligible multiple myeloma patients who fail bortezomib-based induction therapy.

  Spencer, A. & Kennedy, N.

  13/02/19 → 29/02/24

  Project: Research

• A Phase 3 Study Comparing Daratumumab, VELCADE (bortezomib), Lenalidomide, and Dexamethasone (D-VRd) vs VELCADE, Lenalidomide, and Dexamethasone (D-VRd) in Subjects with Previously Untreated Multiple Myeloma who are Eligible for High-Dose Therapy.

  Spencer, A. & Kennedy, N.

  13/02/19 → 29/02/24

  Project: Research

• Ways of Halting Antimicrobial resisTance In Fiji (WHAT-IF)

  Loftus, M. & Peleg, A.

  11/02/19 → 10/02/22

  Project: Research

• A Phase III, Randomized, Open-Label, Multi-Center, Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment Followed by Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer (NIAGARA).

  Voskoboynik, M. & Cross, N.

  6/02/19 → 31/12/24

  Project: Research

• MIDAS 2. A Phase III, Multicentre, Prospective, Randomised, Placebo-controlled, Double-blind, Parallel group, with an adaptive sample size re-estimation study in Stroke Survivors.

  Cloud, G. & Moore, A.

  1/02/19 → 31/12/22

  Project: Research