Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 518 Active
• 1140 Finished

Projects per year

Search results

• Active

  PP2A and tau – novel treatment targets in ischemic stroke and poststroke epilepsy

  Casillas-Espinosa, P. & Shultz, S.

  1/11/19 → 31/10/21

  Project: Research

• Centre for Research Excellence in Digestive Health

  Talley, N., Holtmann, G. J., Walker, M. M., Jones, M., Morrison, M., Keely, S., Gibson, P., Chan, S., Tack, J. & Coombes, J. S.

  1/11/19 → 31/10/24

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Subjects with Primary Sclerosing Cholangitis

  Roberts, S. & Lewis, P.

  30/10/19 → 31/12/21

  Project: Research

• A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)

  Moore, M., Singhal, N., Chin, V. T., Karikios, D., Houghton, B., Chan, M. M. K. & Hawkins, C.

  29/10/19 → 31/12/23

  Project: Research

• A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination therapy in Subjects with Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

  Wilson, J.

  28/10/19 → 31/12/24

  Project: Research

• A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients with Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation. Clinical study No. MGL-3196-11.

  Roberts, S.

  24/10/19 → 31/12/24

  Project: Research

• A Phase 2 Study of Cusatuzumab Plus Azacitidine in Patients with Newly Diagnosed Acute Myeloid Leukemia who are not Candidates for Intensive Chemotherapy.

  Wei, A. & Kennedy, N.

  22/10/19 → 31/12/24

  Project: Research

• A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-445 Combination Therapy in Subjects with Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes).

  Keating, D.

  21/10/19 → 31/12/25

  Project: Research

• Milrinone in Heart Failure with Preserved Ejection Fraction

  Mariani, J. & Dean, E.

  15/10/19 → 31/12/21

  Project: Research

• A Phase 1 Open-label, Multicenter study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of HBM4003 in Subjects with Advanced Solid Tumors.

  Haydon, A. & Hawkins, C.

  10/10/19 → 31/12/24

  Project: Research

• A multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of padsevonil as adjunctive treatment of focal-onset seizures in adult subjects with drug-resistant epilepsy.

  O'Brien, T., Kwan, P., D'Souza, W. J., Berkovic, S. F., Carney, P., Nikpour, A., Reutens, D. C. & Frasca, J.

  10/10/19 → 31/12/21

  Project: Research

• Machine learning for physiological monitoring and epilepsy diagnosis

  Nhu, D., Kuhlmann, L., Kwan, P., Gilligan, A. & Skouteris, H.

  Epworth Foundation (trading as Epworth HealthCare), Alfred Health

  9/10/19 → 8/10/22

  Project: Research

• Targeting Oxidant Dependent Pathways to Treat Skeletal Muscle Wasting in COPD

  Vlahos, R., Bozinovski, S. & Holland, A.

  7/10/19 → 31/12/21

  Project: Research

• Early HomeBase pulmonary rehabilitation after hospital in chronic obstructive pulmonary disease (COPD)

  Cox, N. & Holland, A.

  7/10/19 → 31/12/23

  Project: Research

• Establishing the best method for improving exercise capacity, symptoms and quality of life in IPF patients

  Corte, T. J., Knight, D., Laurent, G., Holland, A., Chambers, D. C., Moodley, Y. P., Walters, E. H., Westall, G., Glaspole, I. & Palmer, A. J.

  7/10/19 → 31/12/21

  Project: Research

• Strategy for rational combinations of therapeutics to target resistant human myeloma cell lines. Collaborative Agreement Celgene and Prof Andrew Spencer and Dr Tiffany Khong.

  Spencer, A., Khong, T. & Plowman, C.

  2/10/19 → 31/12/24

  Project: Research

• A Phase 3 Open-Label, Single-Arm Study to Evaluate The Efficacy and Safety of BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in Hemophilia A patients with Residual FVIII Levels < 1 IU/dL Receiving Prophylactic FVIII Infusions.

  Tran, H. & Kennedy, N.

  1/10/19 → 31/12/24

  Project: Research

• Phase 1b Open-label, Dose-Identification Study of XPro1595 in Patients with Mild to Moderate Alzheimer's Disease with Elevated high sensitivity C-reactive protein in Blood.

  O'Brien, T., Burn, K., Woodward, M. C., Lai, R., Clarnette, R., Brodtmann, A. & Nestor, P. J.

  25/09/19 → 31/08/22

  Project: Research

• A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination with Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants with Advanced Hepatocellular Carcinoma.

  Roberts, S., Lewis, P., George, J., Zekry, A., O'Beirne, J., Tse, E., McLachlan, S., Eastgate, M., Ananda, S. S. & Davison, S.

  24/09/19 → 30/09/23

  Project: Research

• A phase 2 study of venetoclax in combination with low-dose cytarabine in relapsing acute myeloid leukemia.

  Wei, A., Tiong, I. S., Reynolds, J. & Kennedy, N.

  22/09/19 → 31/12/24

  Project: Research

• Seizure Detection and Classification Using Eyelid Movements: A Video-EEG Monitoring Study (OPTALERT-0-001).

  O'Brien, T., Kwan, P. & Thomas, J.

  18/09/19 → 31/12/21

  Project: Research

• A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120101 Administered Intrathecally in Patients with Huntington's Disease.

  O'Brien, T., Bertram, K. & Burn, K.

  18/09/19 → 31/10/21

  Project: Research

• A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington's Disease.

  O'Brien, T., Bertram, K. & Burn, K.

  18/09/19 → 31/10/21

  Project: Research

• Extracting EMR data and improving data linkage for medical research

  Yasin, A., Aleti, A., Srikanth, V. & Skouteris, H.

  Peninsula Health

  16/09/19 → 15/09/22

  Project: Research

• A Phase Ib, open-label, multicentre study of oral LXH254 in combination with oral LTT462 in adult patients with advanced or metastatic KRAS or BRAF mutant Non-small Cell Lung Cancer.

  Haydon, A. & Hawkins, C.

  16/09/19 → 31/12/24

  Project: Research

• Evaluation of the Portico NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis.

  Walton, T.

  11/09/19 → 31/12/21

  Project: Research

• Analysis of Real-World Long-Term Effectiveness of Ocrelizumab in Primary Progressive MS Disease

  Butzkueven, H. & Hinson, E.

  11/09/19 → 30/11/23

  Project: Research

• A phase 1/2, open-label, multiple ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of AGEN2034 in subjects with metastatic or locally advanced solid tumors, with expansion to second line cervical cancer [C-700-001].

  Richardson, G. & Baker, E.

  10/09/19 → 31/12/24

  Project: Research

• Antibodies to Kappa myeloma antigen (KMA) and Lambda myeloma antigen (LMA) as Potential Therapeutics in Haematological Malignancies

  Spencer, A.

  9/09/19 → 9/03/21

  Project: Research

• A 12-week, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.

  Burgell, R. & Hogg, J.

  9/09/19 → 31/12/24

  Project: Research

• The International AML Platform Consortium (IAPC) trial.

  Wei, A. & Kennedy, N.

  5/09/19 → 31/12/24

  Project: Research

• A Phase 3, Randomized, Open-label Study of NKTR-214 Combined with Nivolumab Versus Nivolumab in Participants with Previously Untreated Unresectable or Metastatic Melanoma.

  Moore, M. & Hawkins, C.

  30/08/19 → 31/12/23

  Project: Research

• A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis.

  Sparrow, M.

  28/08/19 → 31/12/21

  Project: Research

• A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis.

  Sparrow, M.

  28/08/19 → 31/12/21

  Project: Research

• Phase II Study of Blinatumomab as Induction Therapy in Adolescent and Young Adult Acute Lymphoblastic Leukemia.

  Fleming, S. A. & Kennedy, N.

  27/08/19 → 31/12/23

  Project: Research

• A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combinations in myelofibrosis patients.

  Perkins, A. & Kennedy, N.

  23/08/19 → 31/12/24

  Project: Research

• A Phase 2, Open-label, Multicenter, Randomized Study of the Efficacy and Safety of R07198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma

  Haydon, A. & Hawkins, C.

  16/08/19 → 31/12/24

  Project: Research

• A Phase 3, Mutli-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia.

  Tran, H. & Kennedy, N.

  15/08/19 → 31/12/24

  Project: Research

• Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage-2 (The PATCH2 Study)

  Bernard, S., Mitra, B., Gruen, R. & Gantner, D.

  13/08/19 → 31/12/21

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants with High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630).

  Chipman, M., Hawkins, C. & Cross, N.

  12/08/19 → 31/12/24

  Project: Research

• A Phase 1/2 Open Label, Multi-Arm, Multicenter Study of MK-1308 in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors.

  Voskoboynik, M. & Hawkins, C.

  7/08/19 → 31/12/24

  Project: Research

• PACIFIC-Real World: First real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy.

  Moore, M. & Hawkins, C.

  7/08/19 → 31/12/24

  Project: Research

• An Open label, Multicentre, Phase I study of Ibrutinib, Rituximab, Valaciclovir and 3rd Party EBV specific T cells in Patients with immunosuppression related EBV-positive Brain and/or Systemic B cell lymphomas, that are relapsed/refractory or unsuitable for standard first-line treatments.

  Fleming, S. A. & Kennedy, N.

  7/08/19 → 31/12/24

  Project: Research

• Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae

  Macesic, N. & Peleg, A.

  1/08/19 → 31/03/21

  Project: Research

• A prospective, multicenter, observational, post-authorization safety study to evaluate the long term safety profile of LEMTRADA (alemtuzumab) treatment in patients with relapsing forms of multiple sclerosis (Post Authorization Safety Study (PASS) Protocol).

  Van Der Walt, A.

  31/07/19 → 31/12/24

  Project: Research

• How can electronic medical records be leveraged to explore value based care innovation in surgical care services?

  Hettiarachchi Senarath, G. M., McLoughlin, I., Srikanth, V. & Skouteris, H.

  Peninsula Health

  29/07/19 → 28/07/22

  Project: Research

• A phase 1, open-label, multi-center, non randomised, dose escalation study to evaluate the safety, tolerability and pharmacokinetic profile of XNW7201 in subjects with advanced solid tumors [XNW7201-1-02).

  Richardson, G. & Baker, E.

  22/07/19 → 31/12/24

  Project: Research

• Skyline Nu-Tech Donation to Dept of Diabetes.

  Cooper, M.

  22/07/19 → 31/12/24

  Project: Research

• A Phase Ib/II Study, Evaluating the Safety and Efficacy of Idasanutlin in Combination with Cytarabine and Daunorubicin in Patients Newly Diagnosed with Acute Myeloid Leukemia (AML) and the Safety and Efficacy of Idasanutlin in the Maintenance of First AML Complete Remission.

  Wei, A. & Kennedy, N.

  17/07/19 → 31/12/26

  Project: Research

• Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction.

  Cloud, G.

  15/07/19 → 31/12/21

  Project: Research