Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 518 Active
• 1140 Finished

Projects per year

Search results

• Active

  An open label phase Ib dose finding study of BI 836880 in combination with BI 754091 to characterize safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer and in other solid tumors.

  Voskoboynik, M., Richardson, G. E. & Hawkins, C.

  1/07/20 → 31/12/22

  Project: Research

• Developing Treatments for Vitiligo and Melanoma

  Shackleton, M.

  1/07/20 → 30/06/25

  Project: Research

• Understanding how group 2 innate lymphoid cells in early-life regulate postnatal lung development and susceptibility

  Starkey, M.

  1/07/20 → 31/12/23

  Project: Research

• Early-life infections and the development of chronic disease

  Starkey, M.

  1/07/20 → 31/12/23

  Project: Research

• Antiplatelet Removal and Hemocompatibility EventS with the HeartMate 3 Pump (ARIES HM3).

  Kaye, D. & Hayward, C.

  1/07/20 → 31/12/23

  Project: Research

• Development of Small Molecules to Promote Remyelination in Multiple Sclerosis

  Petratos, S., Baell, J. & Hawkey, L.

  1/07/20 → 30/06/21

  Project: Research

• An open label Phase 1B dose finding study of BI 836880 in combination with BI 754091 to characterise safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in patients with locally advanced or metastatic non-squamous non-small cell lung cancer and in other solid tumours.

  Richardson, G. & Baker, E.

  1/07/20 → 31/12/22

  Project: Research

• Developing Treatments for Vitiligo and Melanoma

  Shackleton, M.

  Vitiligo Association of Australia

  1/07/20 → 30/06/25

  Project: Research

• Monash University's Global COVIDIAB Registry

  Zimmet, P.

  30/06/20 → 31/01/25

  Project: Research

• RESOLUTE: A Multicenter, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab 100 mg in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils

  Dabscheck, E. & Hazard, A.

  30/06/20 → 31/12/23

  Project: Research

• Single Particle Elemental Analysis – Imaging Mass Cytometer Facility

  Ellis, A., Bush, A., Mitchell, A., Corbett, A., Reichman, S., Ball, A., Fox, K., Nugegoda, D., Paz Ferreiro, J., Cook, P., Hagemeyer, C., Teo, B. M., Yu, A., Brinkworth, C. & Gray, D.

  25/06/20 → 24/06/21

  Project: Research

• A confirmatory, prospective, open-label, multi-centre phase 3 study to evaluate diagnostic performance of 89 Zirconium-labelled girentuximab (89Zr-TLX250) to non-invasively detect clear cell renal cell carcinoma (ccRCC) by positron emission tomography/CT (PET/CT) imaging in patients with indeterminate renal masses [Zr-TLX250-003] [ZIRCON].

  Frydenberg, M., Baker, E. & Thompson, K.

  25/06/20 → 31/12/21

  Project: Research

• LCSRIF: Live Cell Super Resolution Imaging Facility

  Caruso, F., Porter, C., Pouton, C., Johnston, A., Yeo, L., Cavalieri, F., Yarovsky, I., Kent, S., Cortez-Jugo, C., O'Brien-Simpson, N. M., Hinde, E., Yeo, L., Ellis, S. L. & Wise, A.

  25/06/20 → 24/06/21

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Pamrevlumab in Subjects with Idiopathic Pulmonary Fibrosis (IPF)

  Glaspole, I. & Symons, K. M.

  23/06/20 → 31/12/22

  Project: Research

• A Phase 3 Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL) Once-Daily in Participants with HIV-1 Virologically Suppressed on Bictegravir / Emtricitabine / Tenofovir / Alafenamide (BIC/FTC/TAF)

  McMahon, J. & Roney, J.

  21/06/20 → 31/12/22

  Project: Research

• A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 via an Implantable Pump and a Cranial Port and Double Lumen Catheter (ICVRX) in Subjects with Focal Seizures, with Temporal Lobe Onset with or without Secondary Generalization

  O'Brien, T. & Germaine, J.

  17/06/20 → 31/12/22

  Project: Research

• The biological underpinnings of Motoric Cognitive Risk Syndrome: a mult-center study

  Verghese, J., Srikanth, V. & Callisaya, M.

  15/06/20 → 31/03/21

  Project: Research

• Clinician-level quality of care reports- dealing with the complex issue of outliers

  Kirkman, M., Evans, S., Heathcote, P., Fisher, J., Millar, J., Mark, S., Currow, D., Frydenberg, M. & Khadra, M. H.

  12/06/20 → 11/06/22

  Project: Research

• A Phase 3, Randomized, Clinical Study in HIV-1 Infected Heavily Treatment-Experienced Participants Evaluating the Antiretroviral Activity of Blinded Islatravir (ISL), Doravirine (DOR), and Doravirine/Islatravir (DOR/ISL), Each Compared to Placebo, and the Antiretroviral Activity, Safety, and Tolerability of Open-Label DOR/ISL.

  McMahon, J. & Roney, J. J.

  11/06/20 → 4/02/22

  Project: Research

• A randomized, double-blind, placebo-controlled, parallel group, multicenter trial of CVL-865 as adjunctive therapy in adults with drug-resistant focal onset seizures (REALIZE TRIAL)

  O'Brien, T., Perucca, P., Nikpour, A., Wijayath, M., D'Souza, W. J., Reutens, D. C., Carney, P., Somerville, E. R. & Berkovic, S. F.

  5/06/20 → 31/12/23

  Project: Research

• A Phase 3 Randomized, Active-Controlled, Open-Label Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL) Once-Daily in Participants with HIV-1 Virologically Suppressed on Antiretroviral Therapy

  Schmidt, T. & Silvers, J.

  5/06/20 → 31/12/22

  Project: Research

• A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012).

  Roberts, S. & Lewis, P.

  5/06/20 → 31/12/23

  Project: Research

• Improving compliance with VLCD by reducing halitosis

  Burton, P. & Brown, W.

  Myerton Australia Pty Ltd

  4/06/20 → 3/06/21

  Project: Research

• An open label Phase 1B dose finding study of BI 836880 in combination with BI 754091 to characterise safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in patients with locally advanced or metastatic non-squamous non-small cell lung cancer and in other solid tumours.

  Richardson, G. & Baker, E.

  3/06/20 → 31/12/22

  Project: Research

• A phase 1a/1b, open-label, dose-escalation and dose-expansion study of the anti-CTLA-4 monoclonal antibody CS1002 as monotherapy and in combination with anti-PD-1 monoclonal antibody CS1003 in subjects with advanced solid tumors

  Moore, M. & Hawkins, C.

  2/06/20 → 31/12/23

  Project: Research

• Epidemiological modelling to deliver better care for Australian patients with myeloma

  McQuilten, Z., Petrie, D., Spencer, A., Wood, E., Harris, A. & Fanning, L.

  1/06/20 → 31/05/23

  Project: Research

• Autoimmune Encephalitis - a rare and debilitating neurological illness affecting the Australian population. A study of the Australian Autoimmune Encephalitis Consortium.

  Monif, M., Butzkueven, H., Reddel, S. W., Kalincik, T., Tarlinton, D., Seneviratne, U., Kulkarni, J., Buzzard, K. & Taylor, B. V. M.

  1/06/20 → 31/05/24

  Project: Research

• Discovering new drugs for epilepsy using personalised medicine

  Kwan, P., Rollo, B., Langmead, C., Ayers, K. L. & Harris, A.

  1/06/20 → 31/05/22

  Project: Research

• Development of a digital health platform and care management support program for improving secondary prevention for patients after stroke or transient ischaemic attack.

  Cadilhac, D., Cameron, J., Silvera, D., Varnfield, M. & Lannin, N.

  CSIRO Commonwealth Scientific and Industrial Research Organisation (Australia)

  1/06/20 → 31/05/21

  Project: Research

• Sodium Selenate as a Disease Modifying Treatment for Progressive Supranuclear Palsy (Sodium Selenate for PSP)

  O'Brien, T., Bertram, K., Vivash, L., Evans, A., Kimber, T. E., O'Sullivan, J. D., Malpas, C., Fielding, J., Velakoulis, D. & Law, M.

  1/06/20 → 31/05/25

  Project: Research

• LOLIPOP: The Long-term Outcomes of Lidocaine Infusions for persistent PostOperative Pain in patients undergoing breast surgery (LOLIPOP) Trial

  Corcoran, T., Myles, P., Toner, A., Saunders, C., Forbes, A., Peyton, P., Leslie, K., Schug, S., Story, D. A. & Scott, D.

  1/06/20 → 31/05/25

  Project: Research

• Inhaled oligonucleotides to generate a decoy receptor for the SARS Coronarvirus-2

  Thomas, M., Wilton, S., McAuley, J. & Pickering, R.

  1/06/20 → 28/02/21

  Project: Research

• Creating an evidence base for clinical care: A randomized controlled study examining the efficacy of the low FODMAP diet for the relief of gastrointestinal symptoms in endometriosis.

  Muir, J., Burgell, R., Varney, J., Moore, J., Morrison, M. & Fisher, J.

  1/06/20 → 31/05/25

  Project: Research

• Reducing the burden of chronic kidney disease in the indigenous population - the PROPHECY CKD study

  Cooper, M., Morey, K., Zimmet, P., Mentha, R., Jandeleit-Dahm, K., El-Osta, S., McDonald, S. P. & Khurana, I.

  1/06/20 → 31/05/23

  Project: Research

• Novel inhibitors of SARS coronaviruses targeting ACE2

  Drummer, H., Widdop, R., Aguilar, M., Shehabi, Y., Del Borgo, M., Coulibaly, F., McMahon, J., Kulkarni, K., Lambert, P. & McIntosh, M.

  1/06/20 → 28/02/21

  Project: Research

• Measuring adherence to best practice guidelines for the management of ovarian cancer in Australia to determine the extent to which variation in care influences clinical and patient-reported outcomes

  Zalcberg, J., Rome, R., Antony, J., Schofield, P., Brand, A., Richardson, G., Farrell, R., Evans, S., Hegarty, S. & Earnest, A.

  Department of Health (Australia)

  1/06/20 → 31/05/25

  Project: Research

• Make your selfie healthy

  Sharp, G.

  28/05/20 → 30/06/21

  Project: Research

• A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

  Sparrow, M. & McKenzie, J.

  21/05/20 → 31/12/23

  Project: Research

• The Australian and New Zealand Multiple Sclerosis and Neuroimmunology COVID-19 virus data registry

  Van Der Walt, A., Broadley, S. & Mason, D.

  Multiple Sclerosis Research Australia

  18/05/20 → 21/05/21

  Project: Research

• Open-label Phase 2 study of Ladiratuzumab Vedotin (LV) for unresectable locally advanced or metastatic solid tumors [SGNLVA-005]

  Richardson, G. & Baker, E.

  13/05/20 → 31/12/21

  Project: Research

• A Phase 2a, Randomized, Open-Label Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Patients with Non-Transfusion Dependent β-Thalassemia Intermedia

  Kaplan, Z.

  5/05/20 → 4/05/25

  Project: Research

• A Therapeutic Intervention, Open Label Study to Compare the Efficacy and Safety of Graded Exercise Compared to Passive Stretching in Subjects Who Have Sustained a Mild Traumatic Brain Injury

  O'Brien, T., Barlow, K., Levi, C. & Jankelowitz, S.

  5/05/20 → 31/12/23

  Project: Research

• Effects of Poor Sleep on Alzheimer’s Disease Pathogenesis: Extending the Glymphatic Flow Hypothesis

  Pase, M., Lim, Y. Y., Naughton, M. & Buckley, R.

  National Health and Medical Research Council (NHMRC) (Australia)

  4/05/20 → 31/12/24

  Project: Research

• A randomized, double-blind, dose-ranging, placebo-controlled Phase 2a evaluation of the safety, tolerability and pharmacokinetics of PLN-74809 in participants with idiopathic pulmonary fibrosis.

  Glaspole, I., Thien, F. & Symons, K. M.

  1/05/20 → 31/12/21

  Project: Research

• Seizure Detection Using Electrocardiogram Recordings and Kaoskey TRIO Software Study (KAOSKEY-K-001).

  O'Brien, T. & Thomas, J.

  1/05/20 → 31/12/21

  Project: Research

• First Seizures: Patient Reported Outcome Measures

  Ademi Delaney, Z., Foster, E., Kwan, P., Chen, B., O'Brien, T., Liew, D. & Zomer, E.

  30/04/20 → 30/03/24

  Project: Research

• Deriving actionable strategies to enhance cancer immunotherapy response

  Andrews, M.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/04/20 → 31/12/21

  Project: Research

• Formyl Peptide Receptor Agonist as Novel Therapy for Hypertension

  Qin, C. H., Jackson, K. L. & Ritchie, R.

  1/04/20 → 31/03/22

  Project: Research

• MRI Cervical muscles in chronic migraine and cervical dystonia

  Hutton, E. & Zhang, L.

  Brain Foundation

  1/04/20 → 31/03/21

  Project: Research

• Role of histone methyltransferase EZH2 in diabetes associated atherosclerosis

  Khan, W.

  1/04/20 → 31/03/22

  Project: Research