Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 518 Active
• 1140 Finished

Projects per year

Search results

• Active

  Improvement First Seizure Assessment and Management

  O'Brien, T., Perucca, P., Liew, D., Ademi Delaney, Z. & Carney, P.

  Monash University – Internal University Contribution, Epilepsy Foundation

  1/12/20 → 31/12/22

  Project: Research

• Gut Lung Axis in Cystic Fibrosis (GLAX-CF)

  Frayman, K. & Marsland, B.

  1/11/20 → 31/10/21

  Project: Research

• A Randomized, Double-Blind, Double-Dummy, Active-Controlled Study Comparing the Efficacy, Safety and Tolerability of ABBV-951 to Oral Carbidopa/Levodopa in Advanced Parkinson's Disease Patients.

  Bertram, K. & Burn, K.

  1/11/20 → 30/11/22

  Project: Research

• Sarah Kelly Jones Program

  De Castella, A. & Kulkarni, J.

  27/10/20 → 31/12/23

  Project: Research

• A Double Blind, Placebo-controlled, Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Neuropathic Pain.

  Hutton, E.

  27/10/20 → 31/12/23

  Project: Research

• Testing of the effect of E2730 treatment on multimodality in-vivo biomarkers of GABAergic function in healthy rats and preclinical chronic epilepsy models

  O'Brien, T., Kwan, P., Ali, I., Casillas-Espinosa, P., Jones, N., Jupp, B., Vivash, L., Wright, D., Mychasiuk, R. & Major, B.

  Eisai Inc. USA

  22/10/20 → 21/10/21

  Project: Research

• A Phase 1b Study of ZN-c3 in Combination with Chemotherapy in Patients with Platinum-Resistant Ovarian, Peritoneal or Fallopian Tube Cancer.

  Richardson, G. & Baker, E.

  22/10/20 → 31/12/22

  Project: Research

• An Open-Label, Multi-Center, Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420 as a Single Agent in Hematologic and Molecular Relapsed/Refractory Acute Myeloid Leukaemia.

  Wei, A., Bajel, A. & Kennedy, N.

  20/10/20 → 31/12/25

  Project: Research

• An Open-label Extension of Study M15-736 to Evaluate the Safety and Tolerability of 24-hour Daily Exposure of ABBV-951 in Subjects with Advanced Parkinson's Disease.

  Bertram, K. & Burn, K.

  20/10/20 → 31/12/24

  Project: Research

• Randomized Multicenter, Parallel-Group Study to Evaluate the Safety and Effectiveness of the Instylla Hydrogel Embolic System (HES) Compared with Standard of Care Transcatheter Arterial Embolization (TAE) / Transcatheter Arterial Chemoembolization (cTACE) for Vascular Occlusion of Hypervascular Tumors, a Pivotal Study.

  Goh, G., Kavnoudias, H. & Goodwin, M.

  20/10/20 → 31/12/24

  Project: Research

• An Open Label, Multi-Center, Dose Escalation/Expansion, Phase 1 Study of IMU- 201 (PD1-Vaxx), a B-Cell Immunotherapy, in Adults with Non-Small Cell Lung Cancer [IMU201-101].

  Richardson, G. & Baker, E.

  14/10/20 → 31/12/22

  Project: Research

• A Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination with Ruxolitinib Versus Best Available Therapy in Subjects with Relapsed/Refractory Myelofibrosis (TRANSFORM-2).

  Perkins, A., Kennedy, N., Hamad, N. & Chuah, H.

  12/10/20 → 31/12/25

  Project: Research

• An Open-Label Study in Adolescent and Adult Severe (Coagulation Factor Activity <1%) Hemophilia A or B Patients With or Without Inhibitors Comparing Standard Treatment to PF-06741086 Prophylaxis.

  Tran, H. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Ulcerative Colitis.

  Sparrow, M. & McKenzie, J.

  6/10/20 → 31/12/23

  Project: Research

• A Phase I/II, Open-Label, Multicentre 2-Part Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 as Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory Acute Myeloid Leukaemia Patients Not Eligible for Intensive Induction Therapy.

  Wei, A. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• Phase I/II, international, multicentre, open-label, non-randomised, non-comparative, study evaluating the safety, tolerability and clinical activity of intravenously administered S64315, a selective Mcl-1 inhibitor, in combination with azacitidine in patients with acute myeloid leukaemia (AML).

  Wei, A. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• An open-label extension of Study M15-741 to evaluate the safety and tolerability of 24-hour daily exposure of continuous subcutaneous infusion of ABBV-951 in subjects with Parkinson's disease.

  Bertram, K., Fung, V. S. C., Hayes, M., Stell, R., Kimber, T. E. & Bonke, V.

  6/10/20 → 31/12/25

  Project: Research

• A Phase II, 6-week, multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel group trial with a quetiapine arm to evaluate the efficacy, tolerability and safety of oral BI 1358894 in patients with Major Depressive Disorder with inadequate response to antidepressants.

  Chen, L. Y. & De Castella, A.

  6/10/20 → 31/12/24

  Project: Research

• Improving Rehabilitation Outcomes through Self-Management: My Therapy

  Brusco, N., Morris, M. E., Hill, K., Taylor, N. F., Lee, A., Somerville, L., Lannin, N., Abdelmotaleb, R., Callaway, E., Kugler, H., Joy, A., Walpole, B., Boyd, L., Watterson, D. M., Raymond, M. J., Graco, M., Radia-George, C. & Sanfilippo, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/10/20 → 30/09/23

  Project: Research

• SELExipag in inoperable or persistent/recurrent Chronic Thromboembolic pulmonary hypertension. A multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential, adaptive, Phase 3 study with open-label extension period to assess the efficacy and safety of selexipag as an add-on to standard of care therapy in subjects with inoperable or persistent/recurrent after surgical and /or interventional treatment Chronic Thromboembolic Pulmonary Hypertension.

  Whitford, H.

  29/09/20 → 30/09/23

  Project: Research

• A phase 1, open-label, dose escalation study of ADG116 in patients with advanced/metastatic solid tumors [ADG116-1003].

  Richardson, G. & Baker, E.

  24/09/20 → 31/12/23

  Project: Research

• A Multicenter, Open-Label, Randomized Phase III Study to Evaluate the Efficacy and Safety of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (B-Vd) Compared with the Combination of Daratumumab, Bortezomib and Dexamethasone (D-Vd) in Participants with Relapsed/Refractory Multiple Myeloma – DREAMM 7.

  Spencer, A. & Kennedy, N.

  22/09/20 → 31/12/25

  Project: Research

• ENZA-p: A randomised phase II trial using PSMA as a therapeutic agent and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide.

  Voskoboynik, M. & Hawkins, C.

  22/09/20 → 31/12/25

  Project: Research

• TTRACK - Prevalence and characteristics of transthyretin amyloidosis in patients with left ventricular hypertrophy of unknown etiology.

  Hare, J. & Downes, R.

  21/09/20 → 31/12/21

  Project: Research

• A Phase III, Open Label, Randomized Study to Evaluate the Efficacy and Safety of Single Agent Belantamab Mafodotin Compared to Pomalidomide plus Lowdose Dexamethasone (pom/dex) in Participants with Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 3).

  Spencer, A. & Kennedy, N.

  17/09/20 → 31/12/25

  Project: Research

• Feasibility study of the HighLife 28mm trans-septal trans-catheter mitral valve in patients with moderate-severe or severe mitral regurgitation and at high surgical risk.

  Walton, T.

  17/09/20 → 31/12/22

  Project: Research

• A Two-part, 12-week, Double-blind, Randomised, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of Daily Administration of Tricaprilin as AC-SD-03 in Participants with Migraine.

  Hutton, E., Germaine, J., Sabet, A. & Mullen, S. A.

  17/09/20 → 31/12/23

  Project: Research

• A Double-Blind, Randomised, Placebo-Controlled, Phase II Study of the Efficacy and Safety of LAU-7B in the Treatment of Cystic Fibrosis in Adults.

  Kotsimbos, T. & deSilva, C.

  16/09/20 → 31/12/22

  Project: Research

• A randomised, double-blind, placebo-controlled parallel group study in IPF patients over 12 weeks evaluating efficacy, safety and tolerability of BI 1015550 taken orally.

  Glaspole, I. & Symons, K. M.

  15/09/20 → 31/12/22

  Project: Research

• Unlocking the secrets of metabolic variation in a highly diverse bacterium

  Wyres, K., Holt, K., Monk, J. & Brisse, S.

  9/09/20 → 8/09/23

  Project: Research

• To test the pre-clinical efficacy of a food ingredient on mitochondrial function and kidney injury in experimental diabetes

  Coughlan, M.

  7/09/20 → 19/04/21

  Project: Research

• Enabling Klebsiella pneumoniae genomic surveillance and sero-epidemiology

  Holt, K. & Wyres, K.

  7/09/20 → 30/09/21

  Project: Research

• COVIDIAB Registry - Collecting data of COVID-19 complications in relations to Diabetes

  Zimmet, P.

  1/09/20 → 30/09/25

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington's Disease.

  O'Brien, T. & Burn, K.

  1/09/20 → 30/04/23

  Project: Research

• ENHANCE: A Randomized, Double-blind, Multicenter Study Comparing Magrolimab in Combination with Azacitidine versus Azacitidine Plus Placebo in Treatment-naïve Patients with Higher Risk Myelodysplastic Syndrome.

  Wei, A., Kennedy, N., Fong, C. Y., Kenealy, M., D'Rozario, J., Forsyth, C. J., Shortt, J., Hertzberg, M. S., Bajel, A. & Kwan, J.

  1/09/20 → 31/12/25

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120101 in Patients with Huntington's Disease.

  O'Brien, T. & Burn, K.

  1/09/20 → 30/04/23

  Project: Research

• A phase 1/2, open-label, dose-escalation trial of GEN3013 in patients with relapsed, progressive or refractory b-cell lymphoma.

  Herbert, K. & Baker, E.

  1/09/20 → 31/12/23

  Project: Research

• A preclinical evaluation to identify novel drug combinations that will improve clinical outcomes in patients treated with AZA + Venetoclax

  Wei, A. & Brown, F.

  27/08/20 → 26/08/22

  Project: Research

• A phase 1, open label, multi-center, dose escalation clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of CN1 in patients with advanced solid tumors or B-cell lymphoma [CN1-101].

  Richardson, G. & Baker, E.

  27/08/20 → 31/12/22

  Project: Research

• In vitro study of biofilm formation on new HVAD driveline

  Qu, Y., McGiffin, D., Peleg, A. & Thissen, H.

  27/08/20 → 27/08/21

  Project: Research

• MCIS: Characterising Mild Cognitive Impairment using multimodal biomarkers.

  O'Brien, T. & Vivash, L.

  17/08/20 → 31/12/21

  Project: Research

• A Phase 2a, Multicenter, Single-Blind, Placebo-Controlled, Multiple Cohort Study Evaluating ABI-H2158-Containing Regimens in Chronic Hepatitis B Infection.

  Roberts, S. & Mitchell, J. L.

  15/08/20 → 15/08/22

  Project: Research

• An open-label, non-randomized, single-arm pilot study to evaluate the safety and efficacy of blood-brain barrier transient opening using NaviFUS System in patients with mild Alzheimer's Disease.

  O'Brien, T. & Burn, K.

  13/08/20 → 31/12/23

  Project: Research

• A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing Selpercatinib to Physicians Choice of Cabozantinib or Vandetanib in Patients with Progressive, Advanced, Kinase Inhibitor Naive, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531).

  Topliss, D. & Davids, F.

  11/08/20 → 3/03/23

  Project: Research

• A Prospective, Non-Randomized Single-Arm Pilot Study to Assess the Safety and Effectiveness of Instylla HES For Transcatheter Embolization of Arterial Bleeds.

  Goh, G. & Kavnoudias, H.

  30/07/20 → 28/02/22

  Project: Research

• A phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with melanoma brain metastases.

  Haydon, A. & Hawkins, C.

  29/07/20 → 28/02/25

  Project: Research

• A Study to Evaluate the Feasibility and Safety of the Millipede Transcatheter Annuloplasty Ring System in Patients with Functional Mitral Regurgitation (Millipede Feasibility Study).

  Walton, T. & Holland, S.

  29/07/20 → 31/12/26

  Project: Research

• A Phase 1, Open-label, Multi-Center Dose Finding Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of ATG-017 Monotherapy in Patients with Advanced Solid Tumors and Hematological Malignancies.

  Voskoboynik, M., Tran, B., Gan, H. K. & Hawkins, C.

  23/07/20 → 31/12/23

  Project: Research

• Polarization of immune cells by novel compounds

  Ali, I., Jones, N., Monif, M. & Semple, B.

  13/07/20 → 12/09/21

  Project: Research

• Understanding how group 2 innate lymphoid cells in early life regulate postnatal lung development and susceptibility to chronic respiratory diseases

  Starkey, M.

  1/07/20 → 31/12/22

  Project: Research