Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 520 Active
• 1141 Finished

Projects per year

Search results

• A Phase 2a, Randomized, Open-Label Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Patients with Non-Transfusion Dependent β-Thalassemia Intermedia

  Kaplan, Z.

  5/05/20 → 4/05/25

  Project: Research

• Creating an evidence base for clinical care: A randomized controlled study examining the efficacy of the low FODMAP diet for the relief of gastrointestinal symptoms in endometriosis.

  Muir, J., Burgell, R., Varney, J., Moore, J., Morrison, M. & Fisher, J.

  1/06/20 → 31/05/25

  Project: Research

• Sodium Selenate as a Disease Modifying Treatment for Progressive Supranuclear Palsy (Sodium Selenate for PSP)

  O'Brien, T., Bertram, K., Vivash, L., Evans, A., Kimber, T. E., O'Sullivan, J. D., Malpas, C., Fielding, J., Velakoulis, D. & Law, M.

  1/06/20 → 31/05/25

  Project: Research

• Measuring adherence to best practice guidelines for the management of ovarian cancer in Australia to determine the extent to which variation in care influences clinical and patient-reported outcomes

  Zalcberg, J., Rome, R., Antony, J., Schofield, P., Brand, A., Richardson, G., Farrell, R., Evans, S., Hegarty, S. & Earnest, A.

  Department of Health (Australia)

  1/06/20 → 31/05/25

  Project: Research

• LOLIPOP: The Long-term Outcomes of Lidocaine Infusions for persistent PostOperative Pain in patients undergoing breast surgery (LOLIPOP) Trial

  Corcoran, T., Myles, P., Toner, A., Saunders, C., Forbes, A., Peyton, P., Leslie, K., Schug, S., Story, D. A. & Scott, D.

  1/06/20 → 31/05/25

  Project: Research

• Developing Treatments for Vitiligo and Melanoma

  Shackleton, M.

  Vitiligo Association of Australia

  1/07/20 → 30/06/25

  Project: Research

• Developing Treatments for Vitiligo and Melanoma

  Shackleton, M.

  1/07/20 → 30/06/25

  Project: Research

• COVIDIAB Registry - Collecting data of COVID-19 complications in relations to Diabetes

  Zimmet, P.

  1/09/20 → 30/09/25

  Project: Research

• The Meydan Family Foundation Diabetes Complications Research Hub

  Cooper, M., Jane, S. & Mitchell, C.

  31/12/16 → 31/12/25

  Project: Research

• The role of a low emulsifier diet to treat Crohn's disease

  Halmos, E.

  1/01/21 → 31/12/25

  Project: Research

• Gene-transfer, open-label, dose escalation study of SPK-8011 [adeno-associated viral vector with B-domain-deleted human factor VIII gene] in individuals with haemophilia A

  Tran, H. & Kennedy, N.

  14/02/20 → 31/12/25

  Project: Research

• Screening/Observational Protocol to Determine Patient Eligibility for Inclusion in AAV Gene Therapy Clinical Trials (ECLIPSE)

  Tran, H. & Kennedy, N.

  20/02/20 → 31/12/25

  Project: Research

• An Open-Label, Phase 2a/2b Study of KRT-232 in Subjects With Primary Myelofibrosis (PMF), Post–Polycythemia Vera MF (Post-PV-MF), Or Post–Essential Thrombocythemia MF(Post–ET-MF) Who Have Failed Prior Treatment with a JAK Inhibitor (KRT-232-101)

  Perkins, A. & Kennedy, N.

  20/01/20 → 31/12/25

  Project: Research

• A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (C-935788-058).

  Tran, H. & Kennedy, N.

  31/03/20 → 31/12/25

  Project: Research

• A Two-Part, Randomized, Open-label, Multicenter, Phase 2a/2b Study of the Efficacy, Safety, and Pharmacokinetics of KRT-232 Compared to Ruxolitinib in Patients with Phlebotomy-Dependent Polycythemia Vera (KRT-232-102)

  Perkins, A., Burbury, K. L. & Kennedy, N.

  20/01/20 → 31/12/25

  Project: Research

• Optimising patient & health system outcomes in chronic respiratory disease

  Holland, A.

  1/01/21 → 31/12/25

  Project: Research

• A Phase 1, Open-label, Multiple-Ascending Dose Study of the Safety and Tolerability of T3011 in Advanced Cutaneous or Subcutaneous Malignancies

  Haydon, A. & Hawkins, C.

  20/01/20 → 31/12/25

  Project: Research

• A Multicenter, Open-Label, Randomized Phase III Study to Evaluate the Efficacy and Safety of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (B-Vd) Compared with the Combination of Daratumumab, Bortezomib and Dexamethasone (D-Vd) in Participants with Relapsed/Refractory Multiple Myeloma – DREAMM 7.

  Spencer, A. & Kennedy, N.

  22/09/20 → 31/12/25

  Project: Research

• A 46-week, Double-blind, Placebo-controlled, Phase 3 Study with a 6-week Randomized-withdrawal Period to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.

  Burgell, R. & McKenzie, J.

  26/03/20 → 31/12/25

  Project: Research

• A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-445 Combination Therapy in Subjects with Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes).

  Keating, D.

  21/10/19 → 31/12/25

  Project: Research

• Leaving no one behind: community-driven approaches to eliminate HIV in Australia

  Ong, J.

  1/01/21 → 31/12/25

  Project: Research

• A Phase 1b/III study of Ipatasertib plus Palbociclib and Fulvestrant versus placebo plus Palbociclib and Fulvestrant in hormone receptor positive and Her2 negative locally advanced unresectable or metastatic breast cancer [Ipatunity150] [CO41012]

  Antill, Y., Baker, E. & Thompson, K.

  13/02/20 → 31/12/25

  Project: Research

• Revolutionising Multiple Sclerosis Care and trials through e-health

  Butzkueven, H.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/25

  Project: Research

• A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Clinical Outcomes, Antiviral Activity, Safety, Tolerability, Pharmacokinetics, and Pharmacokinetics/Pharmacodynamics of JNJ-53718678 in Adult and Adolescent Hematopoietic Stem Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Upper Respiratory Tract (FREESIA)

  Kliman, D., Kennedy, N. & Thompson, K.

  15/01/20 → 31/12/25

  Project: Research

• A Phase 1b, Multi-center, Randomized, Double blind, Placebo-controlled Study to Investigate the Efficacy, Safety and Pharmacokinetics of CSL312 in the Prevention of Peripherally Inserted Central Catheter (PICC)-associated Thrombosis in Subjects with Cancer

  Tran, H., Chunilal, S., Casey, J., Sanmugarajah, J. & Kennedy, N.

  10/02/20 → 31/12/25

  Project: Research

• A Phase 2 Open-Label Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination with Ruxolitinib in Subjects with Myelofibrosis

  Perkins, A.

  6/03/20 → 31/12/25

  Project: Research

• A Phase 3, multicenter, open-label, randomized study to evaluate the efficacy and safety of Fedratinib compared to best available therapy in subjects with DIPSS-Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and previously treated with ruxolitinib (The FREEDOM 2 trial)

  Perkins, A. & Kennedy, N.

  16/12/19 → 31/12/25

  Project: Research

• An Open-Label Study in Adolescent and Adult Severe (Coagulation Factor Activity <1%) Hemophilia A or B Patients With or Without Inhibitors Comparing Standard Treatment to PF-06741086 Prophylaxis.

  Tran, H. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• Efficacy and Safety of Concizumab prophylaxis in patients with haemophilia A or B with inhibitors (Explorer7).

  Tran, H. & Kennedy, N.

  20/01/20 → 31/12/25

  Project: Research

• A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy with Nivolumab versus Placebo after Complete Resection of Stage IIB/C Melanoma.

  Haydon, A. & Hawkins, C.

  12/02/20 → 31/12/25

  Project: Research

• CERPASS: A Randomized, Controlled, Open-Label, Phase 2 Study of Cemiplimab as a Single Agent and in Combination with RP1 in Patients with Advanced Cutaneous Squamous Cell Carcinoma.

  Haydon, A. & Hawkins, C.

  12/12/19 → 31/12/25

  Project: Research

• An open-label, multi-center, long-term extension study of Zanubrutinib (BGB-3111) in patients with B-cell malignancies

  Kenealy, M. & Baker, E.

  13/02/20 → 31/12/25

  Project: Research

• CARTITUDE-4: A Phase 3 Randomized Study Comparing JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) Therapy Directed Against BCMA, versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Subjects with Relapsed and Lenalidomide-Refractory Multiple Myeloma

  Spencer, A. & Kennedy, N.

  18/03/20 → 31/12/25

  Project: Research

• A Phase III, Open Label, Randomized Study to Evaluate the Efficacy and Safety of Single Agent Belantamab Mafodotin Compared to Pomalidomide plus Lowdose Dexamethasone (pom/dex) in Participants with Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 3).

  Spencer, A. & Kennedy, N.

  17/09/20 → 31/12/25

  Project: Research

• ENZA-p: A randomised phase II trial using PSMA as a therapeutic agent and prognostic indicator in men with metastatic castration-resistant prostate cancer treated with enzalutamide.

  Voskoboynik, M. & Hawkins, C.

  22/09/20 → 31/12/25

  Project: Research

• ENHANCE: A Randomized, Double-blind, Multicenter Study Comparing Magrolimab in Combination with Azacitidine versus Azacitidine Plus Placebo in Treatment-naïve Patients with Higher Risk Myelodysplastic Syndrome.

  Wei, A., Kennedy, N., Fong, C. Y., Kenealy, M., D'Rozario, J., Forsyth, C. J., Shortt, J., Hertzberg, M. S., Bajel, A. & Kwan, J.

  1/09/20 → 31/12/25

  Project: Research

• A Randomized, Double-Blind, Phase 3 Study to Evaluate the Activity of Momelotinib (MMB) versus Danazol (DAN) in Symptomatic, Anemic Subjects with Primary Myelofibrosis (PMF), Post-Polycythemia Vera (PV) Myelofibrosis, or Post Essential Thrombocythemia (ET) Myelofibrosis who were Previously Treated with JAK Inhibitor Therapy

  Perkins, A., Leahy, M. F., Ross, D., Prasad, R. & Kennedy, N.

  5/02/20 → 31/12/25

  Project: Research

• Brain stimulation therapeutics for mental health disorders: from concept to clinical application

  Fitzgerald, P.

  1/01/21 → 31/12/25

  Project: Research

• Efficacy and Safety of Concizumab prophylaxis in patients with haemophilia A or B without inhibitors (Explorer8)

  Tran, H. & Kennedy, N.

  20/01/20 → 31/12/25

  Project: Research

• A Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination with Ruxolitinib Versus Best Available Therapy in Subjects with Relapsed/Refractory Myelofibrosis (TRANSFORM-2).

  Perkins, A., Kennedy, N., Hamad, N. & Chuah, H.

  12/10/20 → 31/12/25

  Project: Research

• A Phase 4, Open-Label, Randomized Study of Two Inotuzumab Ozogamicin Dose Levels in Adult Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic leukemia Eligible for Hematopoietic Stem Cell Transplantation and Who Have Risk Factor(s) for Veno-Occlusive Disease.

  Fleming, S. A. & Kennedy, N.

  9/07/19 → 31/12/25

  Project: Research

• Multi-dimensional monitoring of cognition and cerebellar function to prospectively define disease progression in multiple sclerosis

  Van Der Walt, A.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/25

  Project: Research

• A Phase I/II, Open-Label, Multicentre 2-Part Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 as Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory Acute Myeloid Leukaemia Patients Not Eligible for Intensive Induction Therapy.

  Wei, A. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• An Open-Label, Multi-Center, Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420 as a Single Agent in Hematologic and Molecular Relapsed/Refractory Acute Myeloid Leukaemia.

  Wei, A., Bajel, A. & Kennedy, N.

  20/10/20 → 31/12/25

  Project: Research

• Phase I/II, international, multicentre, open-label, non-randomised, non-comparative, study evaluating the safety, tolerability and clinical activity of intravenously administered S64315, a selective Mcl-1 inhibitor, in combination with azacitidine in patients with acute myeloid leukaemia (AML).

  Wei, A. & Kennedy, N.

  6/10/20 → 31/12/25

  Project: Research

• An open-label extension of Study M15-741 to evaluate the safety and tolerability of 24-hour daily exposure of continuous subcutaneous infusion of ABBV-951 in subjects with Parkinson's disease.

  Bertram, K., Fung, V. S. C., Hayes, M., Stell, R., Kimber, T. E. & Bonke, V.

  6/10/20 → 31/12/25

  Project: Research

• Quantifying myocardial inflammation in acute rheumatic fever and rheumatic heart disease

  O'Brien, J. & Taylor, A.

  23/03/20 → 22/03/26

  Project: Research

• Collaboration on Roche Managed Primary Data Collection NIS and RWD Analytics Activities

  Butzkueven, H. & Van Der Walt, A.

  Hoffmann-La Roche Switzerland

  6/12/19 → 1/12/26

  Project: Research

• A Phase Ib/II Study, Evaluating the Safety and Efficacy of Idasanutlin in Combination with Cytarabine and Daunorubicin in Patients Newly Diagnosed with Acute Myeloid Leukemia (AML) and the Safety and Efficacy of Idasanutlin in the Maintenance of First AML Complete Remission.

  Wei, A. & Kennedy, N.

  17/07/19 → 31/12/26

  Project: Research

• A Study to Evaluate the Feasibility and Safety of the Millipede Transcatheter Annuloplasty Ring System in Patients with Functional Mitral Regurgitation (Millipede Feasibility Study).

  Walton, T. & Holland, S.

  29/07/20 → 31/12/26

  Project: Research