Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 520 Active
• 1141 Finished

Projects per year

Search results

• Integrating genomic and artificial intelligence approaches to combat antimicrobial resistance

  Macesic, N.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• A translational framework for discovering novel solutions for drug resistance in acute myeloid leukaemia

  Brown, F.

  1/01/20 → 31/12/24

  Project: Research

• Cardiac MRI in the evaluation of cardiovascular disease – enhancing mechanistic understanding and diagnostic certainty to drive new paradigms of care.

  Taylor, A.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• Manipulating antibody production to maximise memory in vaccine responses

  Quast, I.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/24

  Project: Research

• Gene editing to cure sickle cell disease

  Perkins, A.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/24

  Project: Research

• Optimising the control and management of sexually transmitted infections through research and innovation

  Fairley, C.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• A Phase 3 Open-Label, Single-Arm Study to Evaluate The Efficacy and Safety of BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in Hemophilia A patients with Residual FVIII Levels < 1 IU/dL Receiving Prophylactic FVIII Infusions.

  Tran, H. & Kennedy, N.

  1/10/19 → 31/12/24

  Project: Research

• A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combinations in myelofibrosis patients.

  Perkins, A. & Kennedy, N.

  23/08/19 → 31/12/24

  Project: Research

• A Multi-Center, Observational Study in Males with Hemophilia A.

  Tran, H. & Kennedy, N.

  21/03/19 → 31/12/24

  Project: Research

• PACIFIC-Real World: First real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy.

  Moore, M. & Hawkins, C.

  7/08/19 → 31/12/24

  Project: Research

• Randomized Multicenter, Parallel-Group Study to Evaluate the Safety and Effectiveness of the Instylla Hydrogel Embolic System (HES) Compared with Standard of Care Transcatheter Arterial Embolization (TAE) / Transcatheter Arterial Chemoembolization (cTACE) for Vascular Occlusion of Hypervascular Tumors, a Pivotal Study.

  Goh, G., Kavnoudias, H. & Goodwin, M.

  20/10/20 → 31/12/24

  Project: Research

• Reducing the burden of diabetic complications

  Cooper, M.

  1/01/20 → 31/12/24

  Project: Research

• A 12-week, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis.

  Burgell, R. & Hogg, J.

  9/09/19 → 31/12/24

  Project: Research

• A Phase II, 6-week, multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel group trial with a quetiapine arm to evaluate the efficacy, tolerability and safety of oral BI 1358894 in patients with Major Depressive Disorder with inadequate response to antidepressants.

  Chen, L. Y. & De Castella, A.

  6/10/20 → 31/12/24

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants with High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630).

  Chipman, M., Hawkins, C. & Cross, N.

  12/08/19 → 31/12/24

  Project: Research

• Innovating Women's Mental Health

  Kulkarni, J.

  1/01/20 → 31/12/24

  Project: Research

• Tisagenlecleucel versus blinatumomab or inotuzumab for adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: A randomized, open-label, multicenter, phase III trial (OBERON).

  Wei, A. & Kennedy, N.

  28/03/19 → 31/12/24

  Project: Research

• The International AML Platform Consortium (IAPC) trial.

  Wei, A. & Kennedy, N.

  5/09/19 → 31/12/24

  Project: Research

• Preclinical activity of Aplidin in multiple myeloma

  Spencer, A. & Plowman, C.

  8/07/19 → 31/12/24

  Project: Research

• Next Generation Imaging Biomarkers for Mild Traumatic Brain Injury

  Wright, D.

  1/01/20 → 31/12/24

  Project: Research

• A clone-specific risk framework for Klebsiella pneumoniae transmission and AMR

  Wyres, K.

  1/01/20 → 31/12/24

  Project: Research

• Strategy for rational combinations of therapeutics to target resistant human myeloma cell lines. Collaborative Agreement Celgene and Prof Andrew Spencer and Dr Tiffany Khong.

  Spencer, A., Khong, T. & Plowman, C.

  2/10/19 → 31/12/24

  Project: Research

• A phase 2 study of venetoclax in combination with low-dose cytarabine in relapsing acute myeloid leukemia.

  Wei, A., Tiong, I. S., Reynolds, J. & Kennedy, N.

  22/09/19 → 31/12/24

  Project: Research

• A phase 1/1b study to evaluate the safety and tolerability of immunotherapy combinations in participants with breast or gynaecologic malignancies [AB928CSP0002].

  Richardson, G. & Baker, E.

  28/02/19 → 31/12/24

  Project: Research

• A Prospective, Single-arm, Multicenter Study to Evaluate the Safety and Performance of the Instylla Hydrogel Embolic System (HES) For Patients Requiring Vascular Embolization Alone or in the Pre-operative Setting for Treatment of Malignant and Benign Hypervascular Tumors, and Select Non-Traumatic End-Organ Infarct.

  Goh, G., Clements, W., Koukounaras, J. & Kavnoudias, H.

  3/06/19 → 31/12/24

  Project: Research

• Stimulatrion Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients (SOLVE-CRT).

  Kaye, D.

  21/03/19 → 31/12/24

  Project: Research

• A Phase 3, Mutli-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia.

  Tran, H. & Kennedy, N.

  15/08/19 → 31/12/24

  Project: Research

• Therapeutic targeting of interleukin-22 for severe pediatric urinary tract infection and associated renal complications

  Starkey, M. & Deshpande, A. V.

  1/01/21 → 31/12/24

  Project: Research

• A Randomized, Controlled, Open-Label, Rater-Blinded, Phase 3b Study of the Efficacy, Safety, and Tolerability of 6-Week Extended Interval Dosing of Natalizumab (BG00002) in Subjects With Relapsing-Remitting Multiple Sclerosis Switching from Treatment with 4-Week Natalizumab Standard Interval Dosing (SID) in Relation to Continued SID Treatment.

  Van Der Walt, A.

  16/04/19 → 31/12/24

  Project: Research

• ATLAS-OLE: An Open-label, Long-term Safety and Efficacy Study of Fitusiran in Patients with Hemophilia A or B, with or without Inhibitory Antibodies to Factor VIII or IX.

  Tran, H. & Kennedy, N.

  20/05/19 → 31/12/24

  Project: Research

• A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination therapy in Subjects with Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

  Wilson, J.

  28/10/19 → 31/12/24

  Project: Research

• A Prospective Non-Interventional Study of Bleeding Episodes, Factor VIII Infusions, and Patient-Reported Outcomes in Individuals with Severe Hemophilia A.

  Tran, H. & Kennedy, N.

  10/01/19 → 31/12/24

  Project: Research

• An Open-label Extension of Study M15-736 to Evaluate the Safety and Tolerability of 24-hour Daily Exposure of ABBV-951 in Subjects with Advanced Parkinson's Disease.

  Bertram, K. & Burn, K.

  20/10/20 → 31/12/24

  Project: Research

• A Phase 2, Open-label, Multicenter, Randomized Study of the Efficacy and Safety of R07198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma

  Haydon, A. & Hawkins, C.

  16/08/19 → 31/12/24

  Project: Research

• A Phase 1 Open-label, Multicenter study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of HBM4003 in Subjects with Advanced Solid Tumors.

  Haydon, A. & Hawkins, C.

  10/10/19 → 31/12/24

  Project: Research

• Phase 2 Study of Talimogene Laherparepvec in Combination with Pembrolizumab in Subjects with Unresectable/Metastatic Stage IIIB-IVM1d Melanoma Who Have Progressed on Prior Anti PD-1 Based Therapy

  Haydon, A. & Hawkins, C.

  12/12/19 → 31/12/24

  Project: Research

• A Phase I, open-label, multicenter, study of WVT078 in subjects with relapsed and/or refractory multiple myeloma

  Spencer, A. & Kennedy, N.

  6/11/19 → 31/12/24

  Project: Research

• Skyline Nu-Tech Donation to Dept of Diabetes.

  Cooper, M.

  22/07/19 → 31/12/24

  Project: Research

• A Phase 1/2 Open Label, Multi-Arm, Multicenter Study of MK-1308 in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors.

  Voskoboynik, M. & Hawkins, C.

  7/08/19 → 31/12/24

  Project: Research

• Virulence Associated small RNAs in Acinetobacter baumannii

  Peleg, A., Boyce, J., Vogel, J. & Short, F.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/24

  Project: Research

• A Multicenter, Open-label Phase 2 Study of Lenvatinib Plus Pembrolizumab in Previously Treated Subjects with Selected Solid Tumors (LEAP-005).

  Gill, S. & Cross, N.

  22/03/19 → 31/12/24

  Project: Research

• A Phase 1, Dose Escalation Study of Flotetuzumab, a CD123 x CD3 DART Protein, Combined with MGA012, an Anti-PD-1 Antibody, in Patients with Relapsed or Refractory Acute Myeloid Leukemia.

  Wei, A. & Kennedy, N.

  9/07/19 → 31/12/24

  Project: Research

• A multidisciplinary approach to understanding the transmission dynamics and the control of sexually transmitted infections

  Chow, E.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• Improving treatment and control of drug resistant and refractory sexually transmitted infections

  Bradshaw, C.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• A phase 1/2, open-label, multiple ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of AGEN2034 in subjects with metastatic or locally advanced solid tumors, with expansion to second line cervical cancer [C-700-001].

  Richardson, G. & Baker, E.

  10/09/19 → 31/12/24

  Project: Research

• A phase 1b/2 study of BMS-813160 in combination with chemotherapy or Nivolumab in patients with advanced solid tumors [CV202-103].

  Richardson, G. & Baker, E.

  10/12/18 → 31/12/24

  Project: Research

• A phase 1 study to evaluate the safety and tolerability of immunotherapy combinations in participants with advanced malignancies [AB928CSP0005].

  Richardson, G. & Baker, E.

  28/02/19 → 31/12/24

  Project: Research

• A new approach to disinvestment: Application to falls prevention mobilisation alarms

  Haines, T., Shorr, R., Botti, M. A., Brusco, N., O'Brien, L., Redley, B., Bowles, K., Hutchinson, A. M., Mitchell, D. F., Hunter, P., Boyd, L., Jellett, J., Raymond, M., Webb-St Mart, M. & Steen, K.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/24

  Project: Research

• Monash University's Global COVIDIAB Registry

  Zimmet, P.

  30/06/20 → 31/01/25

  Project: Research

• A phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with melanoma brain metastases.

  Haydon, A. & Hawkins, C.

  29/07/20 → 28/02/25

  Project: Research