Central Clinical School

Projects

Projects per year

2000 2028

• 15 Curtailed
• 26 Not started
• 520 Active
• 1141 Finished

Projects per year

Search results

• Infections promote post-traumatic epilepsy and poor outcomes after traumatic brain injury

  Semple, B., O'Brien, T. & Li, J.

  United States Department of Defense (DoD)

  4/01/21 → 29/09/23

  Project: Research

• Improving Rehabilitation Outcomes through Self-Management: My Therapy

  Brusco, N., Morris, M. E., Hill, K., Taylor, N. F., Lee, A., Somerville, L., Lannin, N., Abdelmotaleb, R., Callaway, E., Kugler, H., Joy, A., Walpole, B., Boyd, L., Watterson, D. M., Raymond, M. J., Graco, M., Radia-George, C. & Sanfilippo, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/10/20 → 30/09/23

  Project: Research

• Frailty stratified, randomised controlled Bayesian adaptive trial of bortezomib versus lenalidomide in transplant-ineligible myeloma – the FRAIL-M study

  Spencer, A., McQuilten, Z., Wood, E., Reynolds, J., Quach, H., De Abreu Lourenco, R., King, M., Mollee, P. & Hubbard, R. E.

  Department of Health (Australia)

  3/01/19 → 30/09/23

  Project: Research

• A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination with Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants with Advanced Hepatocellular Carcinoma.

  Roberts, S., Lewis, P., George, J., Zekry, A., O'Beirne, J., Tse, E., McLachlan, S., Eastgate, M., Ananda, S. S. & Davison, S.

  24/09/19 → 30/09/23

  Project: Research

• SELExipag in inoperable or persistent/recurrent Chronic Thromboembolic pulmonary hypertension. A multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential, adaptive, Phase 3 study with open-label extension period to assess the efficacy and safety of selexipag as an add-on to standard of care therapy in subjects with inoperable or persistent/recurrent after surgical and /or interventional treatment Chronic Thromboembolic Pulmonary Hypertension.

  Whitford, H.

  29/09/20 → 30/09/23

  Project: Research

• TOP: TYSABRI Observational Program

  Van Der Walt, A.

  4/10/18 → 4/10/23

  Project: Research

• A Phase 1, 2-Part, Multicenter, Open-label, 3-Arm Study to Determine the effect of Enasidenib (CC-90007) on the Pharmacokinetics of Single Doses of Caffeine, Dextromethorphan, Flurbiprofen, Midazolam, Omeprazole, Digoxin, Rosuvastatin, and Pioglitazone in Subjects with Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring an Isocitrate Dehydrogenase 2 Mutation

  Wei, A. & Kennedy, N.

  12/10/18 → 12/10/23

  Project: Research

• Study of using Cyclophosphamide After Sibling-donor allogenic stem-cell Transplantation (CAST) in patients with acute leukaemia and Myelodysplasia: a randomised study comparing cyclosporin and methotrexate to cyclosporin and post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis.

  Curtis, D., Fleming, S. A., Patil, S. & Kennedy, N.

  23/10/18 → 23/10/23

  Project: Research

• CBTCT: NHMRC Centre of Research Excellence: Centre for Blood Transplant and Cell Therapy (CBTCT)

  Gottlieb, D., Tey, S., Ritchie, D. S. & Curtis, D.

  31/10/18 → 30/10/23

  Project: Research

• A Phase III, Double-Blind. Placebo-Controlled, Multicenter, Randomized Study of Pracinostat in Combination with Azacitidine in Patients > 18 Years with Newly Diagnosed Acute Myeloid Leukemia unfit for Standard Induction Chemotherapy.

  Wei, A. & Kennedy, N.

  4/03/19 → 31/10/23

  Project: Research

• Analysis of Real-World Long-Term Effectiveness of Ocrelizumab in Primary Progressive MS Disease

  Butzkueven, H. & Hinson, E.

  11/09/19 → 30/11/23

  Project: Research

• A 2-year prospective study to evaluate the onset of action of Mavenclad in subjects with highly active relapsing multiple sclerosis.

  Skibina, O. & O'Brien, T.

  5/12/18 → 5/12/23

  Project: Research

• Phase II Study of Blinatumomab as Induction Therapy in Adolescent and Young Adult Acute Lymphoblastic Leukemia.

  Fleming, S. A. & Kennedy, N.

  27/08/19 → 31/12/23

  Project: Research

• A phase 1/2, open-label, dose-escalation trial of GEN3013 in patients with relapsed, progressive or refractory b-cell lymphoma.

  Herbert, K. & Baker, E.

  1/09/20 → 31/12/23

  Project: Research

• Improving survival in myelofibrosis

  Perkins, A., Ross, D., Lane, S., Forsyth, C., Wei, A., Curtis, D., Shortt, J., Erber, W. N. & Stevenson, W. S.

  Department of Health (Australia)

  3/01/19 → 31/12/23

  Project: Research

• Cytosine methylation predicts diabetic nephropathy progression

  El-Osta, S., Groop, P., Khurana, I. & Maxwell, S. S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/23

  Project: Research

• Smart Targeted Nanoparticles for Diagnosis and Therapy

  Hagemeyer, C.

  1/01/19 → 31/12/23

  Project: Research

• Understanding how group 2 innate lymphoid cells in early-life regulate postnatal lung development and susceptibility

  Starkey, M.

  1/07/20 → 31/12/23

  Project: Research

• A randomised controlled trial of Focal Electrically Administered Seizure Therapy (FEAST) in patients with severe depression

  Loo, C., Martin, D., Fitzgerald, P., Dokos, S., Hadzi-Pavlovic, D., George, M., Bai, S. & Boonstra, T.

  1/01/19 → 31/12/23

  Project: Research

• Inhibition of the platelet thrombin receptor PAR4 to prevent thrombosis in coronary artery disease

  Hamilton, J. & Chen, V.

  1/01/20 → 31/12/23

  Project: Research

• A Double Blind, Placebo-controlled, Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Neuropathic Pain.

  Hutton, E.

  27/10/20 → 31/12/23

  Project: Research

• A Phase 3, Randomized, Open-label Study of NKTR-214 Combined with Nivolumab Versus Nivolumab in Participants with Previously Untreated Unresectable or Metastatic Melanoma.

  Moore, M. & Hawkins, C.

  30/08/19 → 31/12/23

  Project: Research

• A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)

  Moore, M., Singhal, N., Chin, V. T., Karikios, D., Houghton, B., Chan, M. M. K. & Hawkins, C.

  29/10/19 → 31/12/23

  Project: Research

• A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012).

  Roberts, S. & Lewis, P.

  5/06/20 → 31/12/23

  Project: Research

• A Two-part, 12-week, Double-blind, Randomised, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of Daily Administration of Tricaprilin as AC-SD-03 in Participants with Migraine.

  Hutton, E., Germaine, J., Sabet, A. & Mullen, S. A.

  17/09/20 → 31/12/23

  Project: Research

• Early HomeBase pulmonary rehabilitation after hospital in chronic obstructive pulmonary disease (COPD)

  Cox, N. & Holland, A.

  7/10/19 → 31/12/23

  Project: Research

• A Phase 1, Open-label, Multi-Center Dose Finding Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of ATG-017 Monotherapy in Patients with Advanced Solid Tumors and Hematological Malignancies.

  Voskoboynik, M., Tran, B., Gan, H. K. & Hawkins, C.

  23/07/20 → 31/12/23

  Project: Research

• A phase 1, open-label, dose escalation study of ADG116 in patients with advanced/metastatic solid tumors [ADG116-1003].

  Richardson, G. & Baker, E.

  24/09/20 → 31/12/23

  Project: Research

• A randomized, double-blind, placebo-controlled, parallel group, multicenter trial of CVL-865 as adjunctive therapy in adults with drug-resistant focal onset seizures (REALIZE TRIAL)

  O'Brien, T., Perucca, P., Nikpour, A., Wijayath, M., D'Souza, W. J., Reutens, D. C., Carney, P., Somerville, E. R. & Berkovic, S. F.

  5/06/20 → 31/12/23

  Project: Research

• RESOLUTE: A Multicenter, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab 100 mg in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils

  Dabscheck, E. & Hazard, A.

  30/06/20 → 31/12/23

  Project: Research

• CORE-VNS:Comprehensive Outcomes Registry in Subjects with Epilepsy Treated with Vagus Nerve Stimulation Therapy.

  O'Brien, T.

  24/09/18 → 31/12/23

  Project: Research

• An open-label, non-randomized, single-arm pilot study to evaluate the safety and efficacy of blood-brain barrier transient opening using NaviFUS System in patients with mild Alzheimer's Disease.

  O'Brien, T. & Burn, K.

  13/08/20 → 31/12/23

  Project: Research

• A Therapeutic Intervention, Open Label Study to Compare the Efficacy and Safety of Graded Exercise Compared to Passive Stretching in Subjects Who Have Sustained a Mild Traumatic Brain Injury

  O'Brien, T., Barlow, K., Levi, C. & Jankelowitz, S.

  5/05/20 → 31/12/23

  Project: Research

• Harnessing the microbiome to protect against chronic lung diseases

  Marsland, B.

  1/01/19 → 31/12/23

  Project: Research

• Early-life infections and the development of chronic disease

  Starkey, M.

  1/07/20 → 31/12/23

  Project: Research

• Klebsiella pneumoniae – a key driver in the global spread of antimicrobial resistance and a target for new approaches in diagnostics, surveillance and alternative therapeutics (KLEB-GAP).

  Sundsfjord, A., Hoyland Lohr, I., Samuelsen, O., Sunde, M., Lunestad, B. T., Brisse, S., Giske, C., Bengoechea, J., Holt, K. & Frantzen, C.

  30/06/19 → 31/12/23

  Project: Research

• A phase 1a/1b, open-label, dose-escalation and dose-expansion study of the anti-CTLA-4 monoclonal antibody CS1002 as monotherapy and in combination with anti-PD-1 monoclonal antibody CS1003 in subjects with advanced solid tumors

  Moore, M. & Hawkins, C.

  2/06/20 → 31/12/23

  Project: Research

• Self-regulated, glucose-responsive nanomaterials for smart insulin delivery

  Hagemeyer, C. & Cavalieri, F.

  1/01/20 → 31/12/23

  Project: Research

• Adjuvant Therapy with Pembrolizumab versus Placebo in Resected High-risk Stage II Melanoma: A Randomized, Double-blind Phase 3 Study.

  Haydon, A. & Cross, N.

  21/11/18 → 31/12/23

  Project: Research

• Harnessing tyrosine metabolism to combat respiratory diseases

  Marsland, B., Wypych, T. & Pattaroni, C.

  1/01/21 → 31/12/23

  Project: Research

• Sarah Kelly Jones Program

  De Castella, A. & Kulkarni, J.

  27/10/20 → 31/12/23

  Project: Research

• New models of gene regulation in diabetic complications

  El-Osta, S. & Khurana, I.

  1/01/19 → 31/12/23

  Project: Research

• An Open-Label Study To Evaluate The Long-Term Safety Of Daily Oral BCX7353 In Subjects With Type I and II Hereditary Angioedema.

  Zubrinich, C., Malinowski, L. & Thompson, K.

  27/07/18 → 31/12/23

  Project: Research

• A phase 1a/1b study of FPT155 in patients with advanced solid tumours [FPT155-001].

  Richardson, G. & Baker, E.

  10/12/18 → 31/12/23

  Project: Research

• RECAPs: Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS)

  Cadilhac, D., Lannin, N., Dewey, H., Kilkenny, M., Kneebone, I. I., Andrew, N., Drummond, A. & Cameron, J.

  1/01/19 → 31/12/23

  Project: Research

• Antiplatelet Removal and Hemocompatibility EventS with the HeartMate 3 Pump (ARIES HM3).

  Kaye, D. & Hayward, C.

  1/07/20 → 31/12/23

  Project: Research

• The STAREE Heart Study

  Hopper, I., Zoungas, S., Kaye, D., Reid, C., McNeil, J., Wang, B., Freedman, B., Marwick, T. H. & Tonkin, A.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/19 → 31/12/23

  Project: Research

• A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Ulcerative Colitis.

  Sparrow, M. & McKenzie, J.

  6/10/20 → 31/12/23

  Project: Research

• Preventing diabetic complications using anti-inflammatory peptides

  Tikellis, C. & Pickering, R.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/23

  Project: Research

• A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

  Sparrow, M. & McKenzie, J.

  21/05/20 → 31/12/23

  Project: Research