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2020

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Nik, S. H. M., Dong, Y., Zhou, X. F., Manucat-Tan, N. B., Ludington, A., Adelson, D. L., Pederson, S. & Lardelli, M., 24 Jan 2020, In : PLoS ONE. 15, 1, 36 p., e0227258.

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A collection of genetic mouse lines and related tools for inducible and reversible intersectional mis-expression

Ahmadzadeh, E., Bayin, N. S., Qu, X., Singh, A., Madisen, L., Stephen, D., Zeng, H., Joyner, A. L. & Rosello-Diez, A., 28 May 2020, In : Development. 147, 10, 12 p., 186650.

Research output: Contribution to journalArticleResearchpeer-review

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture

Grubman, A., Vandekolk, T. H., Schröder, J., Sun, G., Hatwell-Humble, J., Chan, J., Oksanen, M., Lehtonen, S., Hunt, C., Koistinaho, J. E., Nilsson, S. K., Haynes, J. M., Pouton, C. W. & Polo, J. M., 9 Jun 2020, In : Stem Cell Reports. 14, 6, p. 1018-1032 15 p.

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Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Oikari, L. E., Pandit, R., Stewart, R., Cuní-López, C., Quek, H., Sutharsan, R., Rantanen, L. M., Oksanen, M., Lehtonen, S., de Boer, C. M., Polo, J. M., Götz, J., Koistinaho, J. & White, A. R., 12 May 2020, In : Stem Cell Reports. 14, 5, p. 924-939 16 p.

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Bioinspired polynorepinephrine nanoparticles as an efficient vehicle for enhanced drug delivery

Lu, Z., Douek, A. M., Rozario, A. M., Tabor, R. F., Kaslin, J., Follink, B. & Teo, B. M., 1 Jan 2020, In : Journal of Materials Chemistry B. 8, 5, p. 961-968 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Ataluren on dystrophin mutations

Berger, J., Li, M., Berger, S., Meilak, M., Rientjes, J. & Currie, P. D., Jun 2020, In : Journal of Cellular and Molecular Medicine. 24, 12, p. 6680-6689 10 p.

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Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes

Wang, Y., Lim, R. & Nie, G., 15 Jan 2020, In : Placenta. 90, p. 71-81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling

Julier, Z., Karami, R., Nayer, B., Lu, Y-Z., Park, A. J., Maruyama, K., Kuhn, G. A., Müller, R., Akira, S. & Martino, M. M., 12 Jun 2020, In : Science Advances. 6, 24, 13 p., eaba7602.

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Extensive Connectivity Between the Medial Pulvinar and the Cortex Revealed in the Marmoset Monkey

Homman-Ludiye, J., Mundinano, I. C., Kwan, W. C. & Bourne, J. A., Mar 2020, In : Cerebral Cortex. 30, 3, p. 1797-1812 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Frontline Science: Dynamic cellular and subcellular features of migrating leukocytes revealed by in vivo lattice lightsheet microscopy

Manley, H. R., Potter, D. L., Heddleston, J. M., Chew, T-L., Keightley, M. C. & Lieschke, G. J., 23 Apr 2020, (Accepted/In press) In : Journal of leukocyte biology. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones

Serlidaki, D., van Waarde, M. A. W. H., Rohland, L., Wentink, A. S., Dekker, S. L., Kamphuis, M. J., Boertien, J. M., Brunsting, J. F., Nillegoda, N. B., Bukau, B., Mayer, M. P., Kampinga, H. H. & Bergink, S., 22 May 2020, In : The Journal of Biological Chemistry. 295, 21, p. 7301-7316 16 p.

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Gas-Generating, pH-Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast-Enhanced Ultrasound Imaging

Vidallon, M. L. P., Douek, A. M., Quek, A., McLiesh, H., Kaslin, J., Tabor, R. F., Bishop, A. I. & Teo, B. M., Feb 2020, In : Particle and Particle Systems Characterization. 37, 2, 8 p., 1900471.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing

Mochizuki, M., Güç, E., Park, A. J., Julier, Z., Briquez, P. S., Kuhn, G. A., Müller, R., Swartz, M. A., Hubbell, J. A. & Martino, M. M., Apr 2020, In : Nature Biomedical Engineering. 4, 4, p. 463-475 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Ooi, L., Dottori, M., Cook, A. L., Engel, M., Gautam, V., Grubman, A., Hernández, D., King, A. E., Maksour, S., Targa Dias Anastacio, H., Balez, R., Pébay, A., Pouton, C., Valenzuela, M., White, A. & Williamson, R., 13 Apr 2020, (Accepted/In press) In : Neuroscientist. 17 p.

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Insights into Gonadal Sex Differentiation Provided by Single-Cell Transcriptomics in the Chicken Embryo

Estermann, M. A., Williams, S., Hirst, C. E., Roly, Z. Y., Serralbo, O., Adhikari, D., Powell, D., Major, A. T. & Smith, C. A., 7 Apr 2020, In : Cell Reports. 31, 1, 19 p., 107491.

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Modelling lyssavirus infections in human stem cell-derived neural cultures

Sundaramoorthy, V., Godde, N., Farr, R. J., Green, D., Haynes, J. M., Bingham, J., O’Brien, C. M. & Dearnley, M., 25 Mar 2020, In : Viruses. 12, 4, 24 p., 359.

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Neurogenesis in the inner ear: The zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood

Schwarzer, S., Asokan, N., Bludau, O., Chae, J., Kuscha, V., Kaslin, J. & Hans, S., Apr 2020, In : Development (Cambridge). 147, 7, 17 p., 176750.

Research output: Contribution to journalArticleResearchpeer-review

Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb

Delgado, I., Lopez-Delgado, A. C., Rosello Diez, A., Giovinazzo, G., Cadenas, V., Fernandez-de-Manuel, L., Sanchez-Cabo, F., Anderson, M. J., Lewandoski, M. & Torres, M., 3 Jun 2020, In : Science Advances. 6, 23, 9 p., eaaz0742.

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Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Li, J., Sun, Y. B. Y., Chen, W., Fan, J., Li, S., Qu, X., Chen, Q., Chen, R., Zhu, D., Zhang, J., Wu, Z., Chi, H., Crawford, S., Oorschot, V., Puelles, V. G., Kerr, P. G., Ren, Y., Nilsson, S. K., Christian, M., Tang, H. & 4 others, Chen, W., Bertram, J. F., Nikolic-Paterson, D. J. & Yu, X., 5 Feb 2020, In : EMBO Reports. 21, 2, 20 p., e48781.

Research output: Contribution to journalArticleResearchpeer-review

SOX3 promotes generation of committed spermatogonia in postnatal mouse testes

McAninch, D., Mäkelä, J-A., La, H. M., Hughes, J. N., Lovell-Badge, R., Hobbs, R. M. & Thomas, P. Q., 21 Apr 2020, In : Scientific Reports. 10, 1, 13 p., 6751.

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Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury

Kim, H. A., Semple, B. D., Dill, L. K., Pham, L., Dworkin, S., Zhang, S. R., Lim, R., Sobey, C. G. & McDonald, S. J., May 2020, In : Brain, Behavior, and Immunity. 5, 8 p., 100072.

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Transgenesis and web resources in Quail

Serralbo, O., Salgado, D., Véron, N., Cooper, C., Dejardin, M. J., Doran, T., Gros, J. & Marcelle, C., 27 May 2020, In : eLife. 9, 16 p., e56312.

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1 Citation (Scopus)

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Chew, S., Lampinen, R., Saveleva, L., Korhonen, P., Mikhailov, N., Grubman, A., Polo, J. M., Wilson, T., Komppula, M., Rönkkö, T., Gu, C., Mackay-Sim, A., Malm, T., White, A. R., Jalava, P. & Kanninen, K. M., 1 Jun 2020, In : Particle and Fibre Toxicology. 17, 1, 15 p., 18.

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2019

Additives migrating from 3D-printed plastic induce developmental toxicity and neuro-behavioural alterations in early life zebrafish (Danio rerio)

Walpitagama, M., Carve, M., Douek, A. M., Trestrail, C., Bai, Y., Kaslin, J. & Wlodkowic, D., 1 Aug 2019, In : Aquatic Toxicology. 213, 11 p., 105227.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization

Coughlan, E., Garside, V. C., Wong, S. F. L., Liang, H., Kraus, D., Karmakar, K., Maheshwari, U., Rijli, F. M., Bourne, J. & McGlinn, E., 19 Nov 2019, In : Cell Reports. 29, 8, p. 2408-2421 14 p.

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A modular millifluidic homeostatic imaging plate for imaging of larval zebrafish

Friedrich, T., Douek, A. M., Vandestadt, C., Wlodkowic, D. & Kaslin, J., 31 Jan 2019, In : Zebrafish. 16, 1, p. 37-46 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., Xing, Y. L., Emery, B. & Cappai, R., Mar 2019, In : GLIA. 67, 3, p. 525-538 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation

Jiang, J-H., Bhuiyan, M. S., Shen, H-H., Cameron, D. R., Rupasinghe, T. W. T., Wu, C. M., Le Brun, A. P., Kostoulias, X., Domene, C., Fulcher, A. J., McConville, M. J., Howden, B. P., Lieschke, G. J. & Peleg, A. Y., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3722-3727 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., Pflueger, J., Lister, R., Rackham, O. J. L., Petretto, E. & Polo, J. M., Dec 2019, In : Nature Neuroscience. 22, 12, p. 2087-2097 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Li, A., Wilson, S., Fitzpatrick, I., Barabadi, M., Chan, S. T., Krause, M., Kusuma, G. D., James, D. & Lim, R., 12 Dec 2019, In : Journal of Visualized Experiments. 2019, 154, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A

Hall, T., Wood, A., Ehrlich, O. V., Li, M., Sonntag, C., Cole, N. J., Huttner, I. G., Sztal, T. & Currie, P., 1 Dec 2019, In : npj Regenerative Medicine. 4, 1, 13 p., 21.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K. M., Polo, J. M., Meyer-Hermann, M., Victora, G. D. & Vinuesa, C. G., 20 Aug 2019, In : Immunity. 51, 2, p. 337-350 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Jiang, M., Fan, J., Qu, X., Li, S., Nilsson, S. K., Sun, Y. B. Y., Chen, Y., Yu, D., Liu, D., Liu, B-C., Tang, M., Chen, W., Ren, Y., Nikolic-Paterson, D. J., Jiang, X., Li, J. & Yu, X., 9 Aug 2019, In : Frontiers in Pharmacology. 10, 17 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Culturing and measuring fetal and newborn murine long bones

Uribe, V. & Rosello Diez, A., 1 Apr 2019, In : Journal of Visualized Experiments. 2019, 146, e59509.

Research output: Contribution to journalArticleOtherpeer-review

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A. L., La, H. M., Rossello, F., Anko, M-L., Fuller-Pace, F. V. & Hobbs, R., 1 Dec 2019, In : Nature Communications. 10, 1, 21 p., 2278.

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4 Citations (Scopus)

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2019, In : Oncogene. 38, 10, p. 1661-1675 15 p.

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1 Citation (Scopus)

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

Skvortsova, K., Masle-Farquhar, E., Luu, P. L., Song, J. Z., Qu, W., Zotenko, E., Gould, C. M., Du, Q., Peters, T. J., Colino-Sanguino, Y., Pidsley, R., Nair, S. S., Khoury, A., Smith, G. C., Miosge, L. A., Reed, J. H., Kench, J. G., Rubin, M. A., Horvath, L., Bogdanovic, O. & 5 others, Lim, S. M., Polo, J. M., Goodnow, C. C., Stirzaker, C. & Clark, S. J., 11 Feb 2019, In : Cancer Cell. 35, 2, p. 297-314 18 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Effect of storage duration on cytokine stability in human serum and plasma

Vincent, F. B., Nim, H. T., Lee, J. P. W., Morand, E. F. & Harris, J., Jan 2019, In : Cytokine. 113, p. 453-457 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions

Tichy, A-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M. & Janovjak, H., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3046-3055 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Fluorescently labeled TracrRNA improves work flow and facilitates successful genome editing in zebrafish

Hamimi, M., Khabooshan, M., Castillo, H. A. & Kaslin, J., 31 Jan 2019, In : Zebrafish. 16, 1, p. 135-137 3 p.

Research output: Contribution to journalArticleOtherpeer-review

High glucose levels affect retinal patterning during zebrafish embryogenesis

Singh, A., Castillo, H. A., Brown, J., Kaslin, J., Dwyer, K. M. & Gibert, Y., 11 Mar 2019, In : Scientific Reports. 9, 1, 13 p., 4121.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells

Nakanishi, M., Mitchell, R. R., Benoit, Y. D., Orlando, L., Reid, J. C., Shimada, K., Davidson, K. C., Shapovalova, Z., Collins, T. J., Nagy, A. & Bhatia, M., 2 May 2019, In : Cell. 177, 4, p. 910-924 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Alberts, N., Mathangasinghe, Y. & Nillegoda, N. B., 2 Sep 2019, In : Journal of Visualized Experiments. 151

Research output: Contribution to journalArticleOtherpeer-review

Isolation of synaptic vesicles from genetically engineered cultured neurons

McKenzie, C., Spanova, M., Johnson, A., Kainrath, S., Zheden, V., Sitte, H. H. & Janovjak, H., 15 Jan 2019, In : Journal of Neuroscience Methods. 312, p. 114-121 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

Čapek, D., Smutny, M., Tichy, A-M., Morri, M., Janovjak, H. & Heisenberg, C. P., 16 Jan 2019, In : eLife. 8, 24 p., e42093.

Research output: Contribution to journalArticleResearchpeer-review

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Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B. & Costa, M. W., Feb 2019, In : Molecular Metabolism. 20, p. 102-114 13 p.

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2 Citations (Scopus)

Midbrain tectal stem cells display diverse regenerative capacities in zebrafish

Lindsey, B. W., Aitken, G. E., Tang, J. K., Khabooshan, M., Douek, A. M., Vandestadt, C. & Kaslin, J., 14 Mar 2019, In : Scientific Reports. 9, 1, 20 p., 4420.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling β-Peptide Hydrogel

Motamed, S., Del Borgo, M. P., Zhou, K., Kulkarni, K., Crack, P. J., Merson, T. D., Aguilar, M-I., Finkelstein, D. I. & Forsythe, J. S., 8 Nov 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 12 p., 315.

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2 Citations (Scopus)

More than blindsight: Case report of a child with extraordinary visual capacity following perinatal bilateral occipital lobe injury

Mundinano, I-C., Chen, J., de Souza, M., Sarossy, M. G., Joanisse, M. F., Goodale, M. A. & Bourne, J. A., May 2019, In : Neuropsychologia. 128, p. 178-186 9 p.

Research output: Contribution to journalArticleOtherpeer-review

13 Citations (Scopus)