Research Output 1988 2019

2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A multi-centre, single-arm, open-label study evaluating the safety and efficacy of fixed dose rituximab in patients with refractory, relapsed or chronic idiopathic thrombocytopenic purpura (R-ITP1000 study)

Tran, H. A., Brighton, T., Grigg, A. P., McRae, S., Dixon, J., Thurley, D., Gandhi, M. K., Truman, M., Marlton, P. & Catalano, J., 2014, In : British Journal of Haematology. 167, 2, p. 243 - 251 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Manchev, V. T., Hilpert, M., Berrou, E., Elaib, Z., Aouba, A., Boukour, S., Souquere, S., Pierron, G., Rameau, P., Andrews, R. K., Lanza, F., Bobe, R., Vainchenker, W. P., Rosa, J. P., Bryckaert, M. C., Debili, N., Favier, R. & Raslova, H., 2014, In : Blood. 124, 16, p. 2554 - 2563 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia

Awan, F. T., Hillmen, P., Hellmann, A., Robak, T., Hughes, S. G., Trone, D., Shannon, M., Flinn, I. W., Byrd, J. C. & LUCID trial investigators, 1 Nov 2014, In : British Journal of Haematology. 167, 4, p. 466-477 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Causes and clinical significance of prolonged activated partial thromboplastin times in thalassaemia major

McFadyen, J. D., Butler, J. A., Malan, E. & Tran, H. A., 2014, In : Annals of Hematology. 93, 5, p. 867 - 868 2 p.

Research output: Contribution to journalLetterOther

Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma

Pennings, G., Yong, A., Wong, C., Al-Tamimi, M., Gardiner, E. E., Andrews, R. K. & Kritharides, L., 2014, In : Platelets. 25, 8, p. 639 - 642 4 p.

Research output: Contribution to journalArticleResearchpeer-review

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Gitz, E., Pollitt, A. Y., Gitz-Francois, J. J., Alshehri, O., Mori, J., Montague, S., Nash, G. B., Douglas, M. R., Gardiner, E. E., Andrews, R. K., Buckley, C. D., Harrison, P. & Watson, S. P., 2014, In : Blood. 124, 14, p. 2262 - 2270 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Consensus guidelines for the use of empiric and diagnostic-driven antifungal treatment strategies in haematological malignancy, 2014

Morrissey, O., Gilroy, N., Macesic, N., Walker, P. A., Ananda-Rajah, M. R., May, M., Heath, C. H., Grigg, A. P., Bardy, P., Kwan, J., Kirsa, S. W., Slavin, M. A., Gottlieb, T. & Chen, S. C. A., 2014, In : Internal Medicine Journal. 44, 12, p. 1298 - 1314 17 p.

Research output: Contribution to journalArticleOther

Controlling pre-leukemic thymocyte self-renewal

Goossens, S. & Van Vlierberghe, P., 2014, In : PLoS Genetics. 10, 12, 3 p., e1004881.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells

Wenhao, N., Lim, J., Grumont, R. J., Gerondakis, S. D. & I-Hsin, S., 2014, In : Journal of Biological Chemistry. 289, 46, p. 31693 - 31707 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia

Saulep, D., Vincent, F., Le Page, M., Wei, A., Ting, S. B. N., Croce, C. M., Tam, C. & Mackay-Fisson, F., 2014, In : Leukemia. 28, 10, p. 2005 - 2015 11 p.

Research output: Contribution to journalArticleResearchpeer-review

DiagnoSTic assays for heparin-induced thrombocytopenia

Gardiner, E. E., Andrews, R. K. & Cuker, A. C., 2014, In : British Journal of Haematology. 166, 5, p. 631 - 633 3 p.

Research output: Contribution to journalArticleOther

Differential signaling by protease-activated receptors: implications for therapeutic targeting

Sidhu, T., French, S. & Hamilton, J. R., 2014, In : International Journal of Molecular Sciences. 15, 4, p. 6169 - 6183 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 1, p. 1 - 8 8 p., e170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Mithraprabhu, S., Kalff, A., Chow, A., Khong, T. T. F. & Spencer, A., 2014, In : Epigenetics. 9, 11, p. 1511 - 1520 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia (Blood Cancer Journal (2014) 4 (e237) DOI: 10.1038/bcj.2014.59)

Cummins, K. D., Jane, S. M., Ninkovic, S., Bazargan, A., Filshie, R. J. A., Sutrave, G., Hertzberg, M., Scott, A., Lane, S., Yannakou, C. K., Ritchie, P. D., D'Rozario, J., Black, J., Bavishi, K. & Wei, A., 1 Jan 2014, In : Blood Cancer Journal. 4, 9, e246.

Research output: Contribution to journalComment / DebateOtherpeer-review

Expression of Sprouty 1 protein (Spry1) is downregulated in human epithelial ovarian cancer and associated with clinicopathological features and patient outcome

Masoumi Moghaddam, S., Amini, A., Wei, A-Q. & Morris, D. L., 2014.

Research output: Contribution to conferencePosterOtherpeer-review

Growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine on mucin-expressing gastric cancer cell lines

Amini, A., Masoumi Moghaddam, S., Ehteda, A. & Morris, D. L., 2014.

Research output: Contribution to conferencePosterOtherpeer-review

Have all-trans retinoic acid and arsenic trioxide replaced all-trans retinoic acid and anthracyclines in APL as standard of care

Iland, H. J., Wei, A. & Seymour, J. F., 2014, In : Best Practice and Research in Clinical Haematology. 27, 1, p. 39 - 52 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Health economic impact of high-dose versus standard-dose cytarabine induction chemotherapy for acute myeloid leukaemia

Fedele, P., Avery, S., Patil, S., Spencer, A., Haas, M. & Wei, A., 2014, In : Internal Medicine Journal. 44, 8, p. 757 - 763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

Lamrani, L., Lacout, C., Ollivier, V., Denis, C. V., Gardiner, E. E., Ho Tin Noe, B., Vainchenker, W., Villeval, J-L. & Jandrot-Perrus, M., 2014, In : Blood. 124, 7, p. 1136 - 1145 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human fetal globin gene expression is regulated by LYA R

Ju, J., Wang, Y., Liu, R., Zhang, Y., Xu, Z., Wang, Y., Wu, Y., Liu, M., Cerruti, L., Zou, F., Ma, C., Fang, M., Tan, R., Jane, S. M. & Zhao, Q., 2 Sep 2014, In : Nucleic Acids Research. 42, 15, 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Identification and Analysis of Oncogenic Pathways in Deletion 20q Acute Myeloid Leukaemia.

Ku, M., Narayan, N., MacKinnon, R. N., Wall, M., Walkley, C., Purton, L. E., Cheng, H-C., Campbell, L. J. & Nandurkar, H. H., 2014, p. 5195.

Research output: Contribution to conferenceAbstractOtherpeer-review

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Denecker, G., Vandamme, N., Akay, O., Koludrovic, D., Taminau, J., Lemeire, K., Gheldof, A., Craene, B. D., Van Gele, M., Brochez, L., Udupi, G. M., Rafferty, M., Balint, B., Gallagher, W. M., Ghanem, G., Huylebroeck, D., Haigh, J. J., van den Oord, J., Larue, L., Davidson, I. & 2 othersMarine, J-C. & Berx, G., 2014, In : Cell Death and Differentiation. 21, 8, p. 1250 - 1261 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Incidence of venous thromboembolism in different ethnic groups: a regional direct comparison study

Liao, S., Woulfe, T., Hyder, S. W., Merriman, E. G., Simpson, D. E. & Chunilal, S., 2014, In : Journal of Thrombosis and Haemostasis. 12, 2, p. 214 - 219 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

Gardiner, E. E. & Medcalf, R. L., 2014, In : Journal of Thrombosis and Haemostasis. 12, 10, p. 1703 - 1705 3 p.

Research output: Contribution to journalArticleOther

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia

Hawkins, E., Oliaro, J., Ramsbottom, K. M., Ting, S. B. N., Sacirbegovic, F., Harvey, M., Kinwell, T., Ghysdael, J., Johnstone, R. W., Humbert, P. O. & Russell, S. M., 2014, In : PLoS ONE. 9, 1 (Art. No.: e87376), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Ghahremani, M. F., Radaelli, E., Haigh, K., Bartunkova, S., Haenebalcke, L., Marine, J-C., Goossens, S. & Haigh, J. J., 2014, In : Cell Cycle. 13, 9, p. 1501-1507 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Low-molecular-weight heparin biosimilars: Potential implications for clinical practice

Nandurkar, H. H., Chong, B. H., Salem, H. H., Gallus, A., Ferro, V. & McKinnon, R. A., 2014, In : Internal Medicine Journal. 44, 5, p. 497 - 500 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Lymphomania

Andrews, R. K. & Gardiner, E. E., 2014, In : Blood. 123, 20, p. 3057 - 3058 2 p.

Research output: Contribution to journalLetterOther

Mechanisms and potential molecular markers of early response to combination epigenetic therapy in patients with myeloid malignancies

Liu, H. B., Urbanavicius, D. B., Tan, P., Spencer, A. & Dear, A. E., 2014, In : International journal of oncology. 45, 4, p. 1742 - 1748 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular cloning and characterization of rhesus monkey platelet glycoprotein Ibalpha, a major ligand-binding subunit of GPIb-IX-V complex

Qiao, J. L., Shen, Y., Shi, M., Lu, Y. R., Cheng, J. & Chen, Y., 2014, In : Thrombosis Research. 133, 5, p. 817 - 825 9 p.

Research output: Contribution to journalArticleResearchpeer-review

N-Acetylcysteine for thrombotic thrombocytopenic purpura: Is a von Willebrand factor-inhibitory dose feasible in vivo?

Shortt, J., Opat, S. & Wood, E. M., 2014, In : Transfusion. 54, 9, p. 2362 - 2363 2 p.

Research output: Contribution to journalLetterOther

Neutrophil extracellular traps (NETs) and the role of platelets in infection

Andrews, R. K., Arthur, J. F. & Gardiner, E. E., 2014, In : Thrombosis and Haemostasis. 112, 4, p. 659 - 665 7 p.

Research output: Contribution to journalArticleResearchpeer-review

New oral anticoagulants: a practical guide on prescription, laboratory testing and peri-procedural/bleeding management

Tran, H. A., Joseph, J. E., Young, L., McRae, S., Curnow, J., Nandurkar, H., Wood, P. & McLintock, C. K., 2014, In : Internal Medicine Journal. 44, 6, p. 525 - 536 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NF-{kappa}B control of T cell development

Gerondakis, S. D., Fulford, T., Messina, N. L. & Grumont, R. J., 2014, In : Nature Immunology. 15, 1, p. 15 - 25 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimal approach for high-risk acute promyelocytic leukemia

Iland, H. J., Seymour, J. F. & Wei, A., 2014, In : Current Opinion in Hematology. 21, 2, p. 102 - 113 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Outcomes following second allogeneic haematopoietic transplants using fludarabine-melphalan conditioning

Bilmon, I., Nivison-Smith, I., Hertzberg, M. S., Ritchie, D., Greenwood, M. J., Spencer, A., Kennedy, G. A., Bryant, A. & Moore, J., 2014, In : Bone Marrow Transplantation. 49, 6, p. 852 - 853 2 p.

Research output: Contribution to journalLetterOther

Open Access

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase

Samson, A. L., Knaupp, A. S., Kass, I., Kleifeld, O., Marijanovic, E. M., Hughes, V. A., Lupton, C. J., Buckle, A. M., Bottomley, S. P. & Medcalf, R. L., 2014, In : Journal of Biological Chemistry. 289, 39, p. 26922 - 26936 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma sGPVI: Changing levels in human disease

Gardiner, E. E. & Andrews, R. K., 2014, In : Thrombosis Research. 133, 3, p. 306 - 307 2 p.

Research output: Contribution to journalLetterOther

Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?

Niego, B. & Medcalf, R. L., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1283 - 1296 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access

Platelet receptor expression and shedding: Glycoprotein Ib-IX-V and glycoprotein VI

Gardiner, E. E. & Andrews, R. K., 2014, In : Transfusion Medicine Reviews. 28, 2, p. 56 - 60 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymorphisms and interspecies differences of the activating and inhibitory Fc{gamma}RII of Macaca nemestrina influence the binding of human IgG subclasses

Trist, H., Tan, P., Wines, B. D., Ramsland, P. A., Orlowski, E., Stubbs, J., Gardiner, E. E., Pietersz, G. A., Kent, S. J., Stratov, I., Burton, D. & Hogarth, P. M., 2014, In : Journal of Immunology. 192, 2, p. 792 - 803 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-thrombotic syndrome: A potential cause of venous ulcer

Arumugaswamy, A. & Tran, H. A., 2014, In : Wound Practice & Research. 22, 2, p. 85 - 90 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Primary haemostasis: newer insights

Berndt, M. C., Metharom, P. & Andrews, R. K., 2014, In : Haemophilia. 20, S4, p. 15 - 22 8 p.

Research output: Contribution to journalArticleResearchpeer-review