Research Output 1984 2019

2015

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Flierl, U., Nero, T. L., Lim, B., Arthur, J. F., Yao, Y., Jung, S. M., Gitz, E., Pollitt, A. Y., Zaldivia, M. T. K., Jandrot-Perrus, M., Schafer, A., Nieswandt, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 2015, In : Journal of Experimental Medicine. 212, 2, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelets are not just for clots

McFadyen, J. D. & Kaplan, Z., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 110 - 119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Horvay, K., Jarde, T., Casagranda, F., Perreau, V. M., Haigh, K., Nefzger, C. M., Akhtar, R., Gridley, T., Berx, G., Haigh, J. J., Barker, N., Polo, J. M., Hime, G. R. & Abud, H. E., 2015, In : EMBO Journal. 34, 10, p. 1319 - 1335 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer

Masoumi Moghaddam, S., Amini, A. & Morris, D. L., 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Ballantyne, L. L., Sin, Y. Y., Amand, T. S., Si, J., Goossens, S., Haenebalcke, L., Haigh, J. J., Kyriakopoulou, L. G., Schulze, A. J. & Funk, C. D., 2015, In : PLoS ONE. 10, 5 , 20 p., e0125967.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Synergistic inhibition of human gastric and colorectal cancers by Bromelain and N-acetylcysteine: An in vivo study

Amini, A., Masoumi Moghaddam, S., Ehteda, A., Liauw, W. S., Akhter, J., Pillai, K. & Morris, D. L., 1 Aug 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

van Helden, M. J., Goossens, S., Daussy, C., Mathieu, A-L., Faure, F., Marçais, A., Vandamme, N., Farla, N., Mayol, K., Viel, S., Degouve, S., Debien, E., Seuntjens, E., Conidi, A., Chaix, J., Mangeot, P., de Bernard, S., Buffat, L., Haigh, J. J., Huylebroeck, D. & 3 others, Lambrecht, B. N., Berx, G. & Walzer, T., 2015, In : Journal of Experimental Medicine. 212, 12, p. 2015 - 2025 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The class II PI 3-kinase, PI3KC2{alpha}, links platelet internal membrane structure to shear-dependent adhesive function

Mountford, J. K., Petitjean, C., Kusuma Putra, H. W., McCafferty, J. A., Setiabakti, N. M., Lee, H., Tonnesen, L. L., McFadyen, J. D., Schoenwaelder, S. M., Eckly, A., Gachet, C., Ellis, S. L., Voss, A. K., Dickins, R. A., Hamilton, J. R. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 6535), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The dynamics of adult haematopoiesis in the bone and bone marrow environment

Ho, M. S. H., Medcalf, R. L., Livesey, S. A. & Traianedes, K., 2015, In : British Journal of Haematology. 170, 4, p. 472 - 486 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The fibrinolytic system-more than fibrinolysis?

Draxler, D. & Medcalf, R. L., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The platelet Fc receptor, FcgammaRIIa

Qiao, J. L., Al-Tamimi, M., Baker, R. I., Andrews, R. K. & Gardiner, E. E., 2015, In : Immunological Reviews. 268, 1, p. 241 - 252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The traumatic side of fibrinolysis

Medcalf, R. L., 2015, In : Blood. 125, 15, p. 2457 - 2458 2 p.

Research output: Contribution to journalLetterOther

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Ghasemzadeh, M., Schoenwaelder, S. M., Ruggeri, Z. M. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 7835), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb{alpha}

Carrim, N., Arthur, J. F., Hamilton, J. R., Gardiner, E. E., Andrews, R. K., Moran, N., Berndt, M. & Metharom, P., 2015, In : Redox Biology. 6, p. 640 - 647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

TOP2A knockdown resensitizes carfilzomib-resistant Hmcls to carfilzomib

Reale, A., Khong, T. T., Mithraprabhu, S., Savvidou, I., Ramachandran, M. & Spencer, A., Dec 2015, p. 4215. 1 p.

Research output: Contribution to conferenceAbstractOther

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Omilusik, K. D., Best, J. A., Yu, B., Goossens, S., Weidemann, A., Nguyen, J. V., Seuntjens, E., Stryjewska, A., Zweier, C., Roychoudhuri, R., Gattinoni, L., Bird, L. M., Higashi, Y., Kondoh, H., Huylebroeck, D., Haigh, J. J. & Goldrath, A. W., 26 Oct 2015, In : Journal of Experimental Medicine. 212, 12, p. 2027 - 2039 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect

Boyd, B. J., Galle, A., Daglas, M., Rosenfeld, J. V. & Medcalf, R., 2015, In : Journal of Drug Targeting. 23, 9, p. 847-853 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Treating pulmonary embolism in Pacific Asia with direct oral anticoagulants

Cohen, A., Jeyaindran, S., Kim, J. Y., Park, K., Sompradeekul, S., Tambunan, K. L., Tran, H. A., Tsai, I-C., Ward, C. & Wong, R., 2015, In : Thrombosis Research. 136, 2, p. 196 - 207 12 p.

Research output: Contribution to journalArticleResearchpeer-review

What drives "fibrinolysis"?

Medcalf, R. L., 2015, In : Hamostaseologie. 35, 4, p. 303-310 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Goossens, S., Radaelli, E., Blanchet, O., Durinck, K., Van der Meulen, J., Peirs, S., Taghon, T., Tremblay, C., Costa, M., Ghahremani, M. F., De Medts, J., Bartunkova, S., Haigh, K., Schwab, C., Farla, N., Pieters, T., Matthijssens, F., Roy, N. V., Best, J. A., Deswarte, K. & 24 others, Bogaert, P., Carmichael, C., Rickard, A. S., Suryani, S., Bracken, L. S., Alserihi, R., Cante-Barrett, K., Haenebalcke, L., Clappier, E., Rondou, P., Slowicka, K., Huylebroeck, D., Goldrath, A. W., Janzen, V., McCormack, M., Lock, R. B., Curtis, D. J., Harrison, C., Berx, G., Speleman, F. P., Meijerink, J. P. P., Soulier, J., Van Vlierberghe, P. & Haigh, J. J., 2015, In : Nature Communications. 6, p. 1 - 12 12 p., 5794.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

ZEB2 drives immature t-cell lymphoblastic leukemia development via enhanced tumor initiating potential and increased IL-7 receptor signaling

Haigh, J. J. & Goossens, S., 2015, p. S106.

Research output: Contribution to conferenceAbstractOtherpeer-review

Zeb2 loss in adult mice results in a myeloproliferative disorder and is associated with altered JAK/STAT signaling pathway

Li, J., Riedt, T., Goossens, S., Guetgemann, I., Huylebroeck, D., Haigh, J., Brossart, P. & Janzen, V., Oct 2015, p. 228. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Open Access
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A multi-centre, single-arm, open-label study evaluating the safety and efficacy of fixed dose rituximab in patients with refractory, relapsed or chronic idiopathic thrombocytopenic purpura (R-ITP1000 study)

Tran, H. A., Brighton, T., Grigg, A. P., McRae, S., Dixon, J., Thurley, D., Gandhi, M. K., Truman, M., Marlton, P. & Catalano, J., 2014, In : British Journal of Haematology. 167, 2, p. 243 - 251 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Manchev, V. T., Hilpert, M., Berrou, E., Elaib, Z., Aouba, A., Boukour, S., Souquere, S., Pierron, G., Rameau, P., Andrews, R. K., Lanza, F., Bobe, R., Vainchenker, W. P., Rosa, J. P., Bryckaert, M. C., Debili, N., Favier, R. & Raslova, H., 2014, In : Blood. 124, 16, p. 2554 - 2563 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia

Awan, F. T., Hillmen, P., Hellmann, A., Robak, T., Hughes, S. G., Trone, D., Shannon, M., Flinn, I. W., Byrd, J. C. & LUCID trial investigators, 1 Nov 2014, In : British Journal of Haematology. 167, 4, p. 466-477 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Bromelain and N-acetylcysteine induce cytotoxic effects and reduce the expression of mucin in mucin-producing carcinoma cell lines of gastrointestinal origin

Amini, A., Masoumi Moghaddam, S. & Morris, D. L., 2014.

Research output: Contribution to conferencePosterOtherpeer-review

Causes and clinical significance of prolonged activated partial thromboplastin times in thalassaemia major

McFadyen, J. D., Butler, J. A., Malan, E. & Tran, H. A., 2014, In : Annals of Hematology. 93, 5, p. 867 - 868 2 p.

Research output: Contribution to journalLetterOther

Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma

Pennings, G., Yong, A., Wong, C., Al-Tamimi, M., Gardiner, E. E., Andrews, R. K. & Kritharides, L., 2014, In : Platelets. 25, 8, p. 639 - 642 4 p.

Research output: Contribution to journalArticleResearchpeer-review

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Gitz, E., Pollitt, A. Y., Gitz-Francois, J. J., Alshehri, O., Mori, J., Montague, S., Nash, G. B., Douglas, M. R., Gardiner, E. E., Andrews, R. K., Buckley, C. D., Harrison, P. & Watson, S. P., 2014, In : Blood. 124, 14, p. 2262 - 2270 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Consensus guidelines for the use of empiric and diagnostic-driven antifungal treatment strategies in haematological malignancy, 2014

Morrissey, O., Gilroy, N., Macesic, N., Walker, P. A., Ananda-Rajah, M. R., May, M., Heath, C. H., Grigg, A. P., Bardy, P., Kwan, J., Kirsa, S. W., Slavin, M. A., Gottlieb, T. & Chen, S. C. A., 2014, In : Internal Medicine Journal. 44, 12, p. 1298 - 1314 17 p.

Research output: Contribution to journalArticleOther

Controlling pre-leukemic thymocyte self-renewal

Goossens, S. & Van Vlierberghe, P., 2014, In : PLoS Genetics. 10, 12, 3 p., e1004881.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells

Wenhao, N., Lim, J., Grumont, R. J., Gerondakis, S. D. & I-Hsin, S., 2014, In : Journal of Biological Chemistry. 289, 46, p. 31693 - 31707 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia

Saulep, D., Vincent, F., Le Page, M., Wei, A., Ting, S. B. N., Croce, C. M., Tam, C. & Mackay-Fisson, F., 2014, In : Leukemia. 28, 10, p. 2005 - 2015 11 p.

Research output: Contribution to journalArticleResearchpeer-review

DiagnoSTic assays for heparin-induced thrombocytopenia

Gardiner, E. E., Andrews, R. K. & Cuker, A. C., 2014, In : British Journal of Haematology. 166, 5, p. 631 - 633 3 p.

Research output: Contribution to journalArticleOther

Differential signaling by protease-activated receptors: implications for therapeutic targeting

Sidhu, T., French, S. & Hamilton, J. R., 2014, In : International Journal of Molecular Sciences. 15, 4, p. 6169 - 6183 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 1, p. 1 - 8 8 p., e170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Mithraprabhu, S., Kalff, A., Chow, A., Khong, T. T. F. & Spencer, A., 2014, In : Epigenetics. 9, 11, p. 1511 - 1520 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia (Blood Cancer Journal (2014) 4 (e237) DOI: 10.1038/bcj.2014.59)

Cummins, K. D., Jane, S. M., Ninkovic, S., Bazargan, A., Filshie, R. J. A., Sutrave, G., Hertzberg, M., Scott, A., Lane, S., Yannakou, C. K., Ritchie, P. D., D'Rozario, J., Black, J., Bavishi, K. & Wei, A., 1 Jan 2014, In : Blood Cancer Journal. 4, 9, e246.

Research output: Contribution to journalComment / DebateOtherpeer-review

Expression of Sprouty 1 protein (Spry1) is downregulated in human epithelial ovarian cancer and associated with clinicopathological features and patient outcome

Masoumi Moghaddam, S., Amini, A., Wei, A-Q. & Morris, D. L., 2014.

Research output: Contribution to conferencePosterOtherpeer-review

Growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine on mucin-expressing gastric cancer cell lines

Amini, A., Masoumi Moghaddam, S., Ehteda, A. & Morris, D. L., 2014.

Research output: Contribution to conferencePosterOtherpeer-review

Have all-trans retinoic acid and arsenic trioxide replaced all-trans retinoic acid and anthracyclines in APL as standard of care

Iland, H. J., Wei, A. & Seymour, J. F., 2014, In : Best Practice and Research in Clinical Haematology. 27, 1, p. 39 - 52 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Health economic impact of high-dose versus standard-dose cytarabine induction chemotherapy for acute myeloid leukaemia

Fedele, P., Avery, S., Patil, S., Spencer, A., Haas, M. & Wei, A., 2014, In : Internal Medicine Journal. 44, 8, p. 757 - 763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

Lamrani, L., Lacout, C., Ollivier, V., Denis, C. V., Gardiner, E. E., Ho Tin Noe, B., Vainchenker, W., Villeval, J-L. & Jandrot-Perrus, M., 2014, In : Blood. 124, 7, p. 1136 - 1145 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human fetal globin gene expression is regulated by LYA R

Ju, J., Wang, Y., Liu, R., Zhang, Y., Xu, Z., Wang, Y., Wu, Y., Liu, M., Cerruti, L., Zou, F., Ma, C., Fang, M., Tan, R., Jane, S. M. & Zhao, Q., 2 Sep 2014, In : Nucleic Acids Research. 42, 15, 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Identification and Analysis of Oncogenic Pathways in Deletion 20q Acute Myeloid Leukaemia.

Ku, M., Narayan, N., MacKinnon, R. N., Wall, M., Walkley, C., Purton, L. E., Cheng, H-C., Campbell, L. J. & Nandurkar, H. H., 2014, p. 5195.

Research output: Contribution to conferenceAbstractOtherpeer-review