Research Output 1988 2019

2015

Global Coagulation Assays in the Normal Population: Female Gender, Older Age and East Asian Ethnicity Associated with Prothrombotic Parameters.

Ho, P., Lim, H. Y., Ng, C., Smith, C. L., Donnan, G. & Nandurkar, H. H., 2015, p. 4678.

Research output: Contribution to conferenceAbstractOtherpeer-review

Global regulator MorA affects virulence-associated protease secretion in Pseudomonas aeruginosa PAO1

Ravichandran, A., Ramachandran, M., Suriyanarayanan, T., Wong, C. C. & Swarup, S., 2015, In : PLoS ONE. 10, 4, p. 1 - 17 17 p., 0123805.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine on mucin-expressing gastrointestinal cancer cells in vitro and in vivo

Amini, A., Masoumi Moghaddam, S., Ehteda, A. & Morris, D. L., 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Grp78 injection ameliorates haemolytic uraemic syndrome (hus) phenotype in a suburb toxin induced mouse model.

Kamel, S., Freddi, S., Selan, C., Samudra, A. N., Sharma, A., Nandurkar, H. H. & Cowan, P., 2015, p. 75-76.

Research output: Contribution to conferenceAbstractOtherpeer-review

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su, E. J., Fredriksson, L. T., Kanzawa, M., Moore, S., Folestad, E., Stevenson, T. K., Nilsson, I., Sashindranath, M., Schielke, G. P., Warnock, M., Ragsdale, M., Mann, K. M., Lawrence, A-L. E., Medcalf, R. L., Eriksson, U., Murphy, G. G. & Lawrence, D. A., 2015, In : Frontiers in Cellular Neuroscience. 9, (Art. No: 385), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Impact of maintenance therapy on subsequent treatment in patients with newly diagnosed multiple myeloma: Use of “progression-free survival 2” as a clinical trial end-point

Dimopoulos, M. A., Petrucci, M. T., Foà, R., Catalano, J., Kropff, M., Terpos, E., Zhang, J., Grote, L., Jacques, C. & Palumbo, A., 5 Aug 2015, In : Haematologica: the hematology journal. 100, 8, p. e328-e330 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Rijal, S., Fleming, S., Cummings, N., Rynkiewicz, N., Ooms, L. M., Nguyen, N-Y. N., Teh, T-C., Avery, S., McManus, J., Papenfuss, A. T., McLean, C. A., Guthridge, M. A., Mitchell, C. A. & Wei, A., 30 Apr 2015, In : Blood. 125, 18, p. 2815-2824 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Intravascular leukocyte migration through platelet thrombi: directing leukocytes to sites of vascular injury

Ghasemzadeh, M. & Hosseini, E., 2015, In : Thrombosis and Haemostasis. 113, 6, p. 1224 - 1235 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo assessment of growth inhibitory and mucin depleting effects of bromelain and N-acetylcysteine in peritoneal carcinomatosis models

Amini, A., Masoumi Moghaddam, S. & Morris, D. L., 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Loss of c-REL but not NF-{kappa}B2 prevents autoimmune disease driven by FasL mutation

O'Reilly, L. A., Hughes, P. D., Lin, A., Waring, P. M., Siebenlist, U., Jain, R., Gray, D. H. D., Gerondakis, S. D. & Strasser, A., 2015, In : Cell Death and Differentiation. 22, 5, p. 767 - 778 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ib? in a patient with Bernard-Soulier syndrome

Qiao, J. L., Davis, A. K., Morel-Kopp, M-C., Ward, C., Gardiner, E. E. & Andrews, R. K., 2015, In : Annals of Hematology. 94, 12, p. 2069 - 2071 3 p.

Research output: Contribution to journalArticleOther

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression

Martin, A., Salvador, F., Moreno-Bueno, G., Floristan, A., Ruiz-Herguido, C., Cuevas, E. P., Morales, S., Santos, V., Csiszar, K., Dubus, P., Haigh, J. J., Bigas, A., Portillo, F. & Cano, A., 2015, In : EMBO Journal. 34, 8, p. 1090 - 1109 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Maintenance lenalidomide in combination with 5-azacitidine as post-remission therapy for acute myeloid leukaemia

Wei, A., Tan, P. T. G., Perruzza, S. N., Govindaraj, C., Fleming, S. A., McManus, J. F., Avery, S., Patil, S., Stevenson, W. C., Plebanski, M. & Spencer, A., 2015, In : British Journal of Haematology. 169, 2, p. 199 - 210 12 p.

Research output: Contribution to journalArticleResearchpeer-review

MDX-1097 induces antibody-dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide

Asvadi, P., Cuddihy, A. R., Dunn, R., Jiang, V., Wong, M. X., Jones, D. R., Khong, T. T. F. & Spencer, A., 2015, In : British Journal of Haematology. 169, 3, p. 333 - 343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methods for understanding shear induced thrombus growth

Pinar, I. P., Arthur, J., Andrews, R., Gardiner, E. E., Ryan, K. & Carberry, J. J., 1 Jan 2015, Ninth International Symposium on Turbulence and Shear Flow Phenomena (TSFP-9). Tavoularis, S. & Marusic, I. (eds.). Melbourne Vic Australia: University of Melbourne, p. 1-5 5 p. (9th International Symposium on Turbulence and Shear Flow Phenomena, TSFP 2015; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar, I., Arthur, J. F., Andrews, R. K., Gardiner, E. E., Ryan, K. & Carberry, J. J., 2015, In : PLoS ONE. 10, 12, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Monosomal karyotype predicts inferior survival independently of a complex karyotype in patients with myelodysplastic syndromes

McQuilten, Z., Sundararajan, V., Andrianopoulos, N., Curtis, D. J., Wood, E. M., Campbell, L. J. & Wall, M., 2015, In : Cancer. 121, 17, p. 2892 - 2899 8 p.

Research output: Contribution to journalArticleResearchpeer-review

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson, A. L., Ju, L., Kim, H. A., Zhang, S., Lee, J. A. A., Sturgeon, S. A., Sobey, C. G., Jackson, S. & Schoenwaelder, S. M., 2015, In : Scientific Reports. 5, (Art. No: 16171), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Müller glia are a major cellular source of survival signals for retinal neurons in diabetes

Fu, S., Dong, S., Zhu, M., Sherry, D. M., Wang, C., You, Z., Haigh, J. J. & Le, Y-Z., 2015, In : Diabetes. 64, 10, p. 3554-3563 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MYB elongation is regulated by the nucleic acid binding of NF?B p50 to the intronic stem-loop region

Pereira, L. A., Hugo, H. J., Malaterre, J., Xu, H., Sonza, S., Cures, A., Purcell, D. F. J., Ramsland, P. A., Gerondakis, S. D., Gonda, T. J. & Ramsay, R. G., 2015, In : PLoS ONE. 10, 4 (Art. No: e0122919), p. 1 - 25 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

Burkitt, M. D., Hanedi, A. F., Duckworth, C. A., Williams, J. M., Tang, J. M., O'Reilly, L. A., Putoczki, T. L., Gerondakis, S., Dimaline, R., Caamano, J. H. & Mark Pritchard, D., 1 Jul 2015, In : Journal of Pathology. 236, 3, p. 326-336 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Novel biological insights in T-cell acute lymphoblastic leukemia

Durinck, K., Goossens, S., Peirs, S., Wallaert, A., Loocke, W. V., Matthijssens, F., Pieters, T., Milani, G., Lammens, T., Rondou, P., Roy, N. V., Moerloose, B. D., Benoit, Y., Haigh, J., Speleman, F. P., Poppe, B. & Van Vlierberghe, P., 2015, In : Experimental Hematology. 43, 8, p. 625-639 15 p.

Research output: Contribution to journalArticleResearchpeer-review

NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation

Kim, K., Li, J., Tseng, A., Andrews, R. K. & Cho, J., 2015, In : Blood. 126, 16, p. 1952 - 1964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming quiescence by targeting p21 (Cdkn1a) sensitizes pre-leukemic stem cells to chemotherapy

Tremblay, C., Saw, J. M. Y., Chiu, S. K. & Curtis, D. J., 1 Sep 2015, p. S45. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Flierl, U., Nero, T. L., Lim, B., Arthur, J. F., Yao, Y., Jung, S. M., Gitz, E., Pollitt, A. Y., Zaldivia, M. T. K., Jandrot-Perrus, M., Schafer, A., Nieswandt, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 2015, In : Journal of Experimental Medicine. 212, 2, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelets are not just for clots

McFadyen, J. D. & Kaplan, Z., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 110 - 119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Horvay, K., Jarde, T., Casagranda, F., Perreau, V. M., Haigh, K., Nefzger, C. M., Akhtar, R., Gridley, T., Berx, G., Haigh, J. J., Barker, N., Polo, J. M., Hime, G. R. & Abud, H. E., 2015, In : EMBO Journal. 34, 10, p. 1319 - 1335 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer

Masoumi Moghaddam, S., Amini, A. & Morris, D. L., 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Ballantyne, L. L., Sin, Y. Y., Amand, T. S., Si, J., Goossens, S., Haenebalcke, L., Haigh, J. J., Kyriakopoulou, L. G., Schulze, A. J. & Funk, C. D., 2015, In : PLoS ONE. 10, 5 , 20 p., e0125967.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Synergistic inhibition of human gastric and colorectal cancers by Bromelain and N-acetylcysteine: An in vivo study

Amini, A., Masoumi Moghaddam, S., Ehteda, A., Liauw, W. S., Akhter, J., Pillai, K. & Morris, D. L., 1 Aug 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

van Helden, M. J., Goossens, S., Daussy, C., Mathieu, A-L., Faure, F., Marçais, A., Vandamme, N., Farla, N., Mayol, K., Viel, S., Degouve, S., Debien, E., Seuntjens, E., Conidi, A., Chaix, J., Mangeot, P., de Bernard, S., Buffat, L., Haigh, J. J., Huylebroeck, D. & 3 othersLambrecht, B. N., Berx, G. & Walzer, T., 2015, In : Journal of Experimental Medicine. 212, 12, p. 2015 - 2025 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The class II PI 3-kinase, PI3KC2{alpha}, links platelet internal membrane structure to shear-dependent adhesive function

Mountford, J. K., Petitjean, C., Kusuma Putra, H. W., McCafferty, J. A., Setiabakti, N. M., Lee, H., Tonnesen, L. L., McFadyen, J. D., Schoenwaelder, S. M., Eckly, A., Gachet, C., Ellis, S. L., Voss, A. K., Dickins, R. A., Hamilton, J. R. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 6535), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The dynamics of adult haematopoiesis in the bone and bone marrow environment

Ho, M. S. H., Medcalf, R. L., Livesey, S. A. & Traianedes, K., 2015, In : British Journal of Haematology. 170, 4, p. 472 - 486 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The fibrinolytic system-more than fibrinolysis?

Draxler, D. & Medcalf, R. L., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The platelet Fc receptor, FcgammaRIIa

Qiao, J. L., Al-Tamimi, M., Baker, R. I., Andrews, R. K. & Gardiner, E. E., 2015, In : Immunological Reviews. 268, 1, p. 241 - 252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The traumatic side of fibrinolysis

Medcalf, R. L., 2015, In : Blood. 125, 15, p. 2457 - 2458 2 p.

Research output: Contribution to journalLetterOther

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Ghasemzadeh, M., Schoenwaelder, S. M., Ruggeri, Z. M. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 7835), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb{alpha}

Carrim, N., Arthur, J. F., Hamilton, J. R., Gardiner, E. E., Andrews, R. K., Moran, N., Berndt, M. & Metharom, P., 2015, In : Redox Biology. 6, p. 640 - 647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

TOP2A knockdown resensitizes carfilzomib-resistant Hmcls to carfilzomib

Reale, A., Khong, T. T., Mithraprabhu, S., Savvidou, I., Ramachandran, M. & Spencer, A., Dec 2015, p. 4215. 1 p.

Research output: Contribution to conferenceAbstractOther

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Omilusik, K. D., Best, J. A., Yu, B., Goossens, S., Weidemann, A., Nguyen, J. V., Seuntjens, E., Stryjewska, A., Zweier, C., Roychoudhuri, R., Gattinoni, L., Bird, L. M., Higashi, Y., Kondoh, H., Huylebroeck, D., Haigh, J. J. & Goldrath, A. W., 26 Oct 2015, In : Journal of Experimental Medicine. 212, 12, p. 2027 - 2039 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect

Boyd, B. J., Galle, A., Daglas, M., Rosenfeld, J. V. & Medcalf, R., 2015, In : Journal of Drug Targeting. 23, 9, p. 847-853 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Treating pulmonary embolism in Pacific Asia with direct oral anticoagulants

Cohen, A., Jeyaindran, S., Kim, J. Y., Park, K., Sompradeekul, S., Tambunan, K. L., Tran, H. A., Tsai, I-C., Ward, C. & Wong, R., 2015, In : Thrombosis Research. 136, 2, p. 196 - 207 12 p.

Research output: Contribution to journalArticleResearchpeer-review

What drives "fibrinolysis"?

Medcalf, R. L., 2015, In : Hamostaseologie. 35, 4, p. 303-310 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Goossens, S., Radaelli, E., Blanchet, O., Durinck, K., Van der Meulen, J., Peirs, S., Taghon, T., Tremblay, C., Costa, M., Ghahremani, M. F., De Medts, J., Bartunkova, S., Haigh, K., Schwab, C., Farla, N., Pieters, T., Matthijssens, F., Roy, N. V., Best, J. A., Deswarte, K. & 24 othersBogaert, P., Carmichael, C., Rickard, A. S., Suryani, S., Bracken, L. S., Alserihi, R., Cante-Barrett, K., Haenebalcke, L., Clappier, E., Rondou, P., Slowicka, K., Huylebroeck, D., Goldrath, A. W., Janzen, V., McCormack, M., Lock, R. B., Curtis, D. J., Harrison, C., Berx, G., Speleman, F. P., Meijerink, J. P. P., Soulier, J., Van Vlierberghe, P. & Haigh, J. J., 2015, In : Nature Communications. 6, p. 1 - 12 12 p., 5794.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

ZEB2 drives immature t-cell lymphoblastic leukemia development via enhanced tumor initiating potential and increased IL-7 receptor signaling

Haigh, J. J. & Goossens, S., 2015, p. S106.

Research output: Contribution to conferenceAbstractOtherpeer-review

Zeb2 loss in adult mice results in a myeloproliferative disorder and is associated with altered JAK/STAT signaling pathway

Li, J., Riedt, T., Goossens, S., Guetgemann, I., Huylebroeck, D., Haigh, J., Brossart, P. & Janzen, V., Oct 2015, p. 228. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Open Access
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A multi-centre, single-arm, open-label study evaluating the safety and efficacy of fixed dose rituximab in patients with refractory, relapsed or chronic idiopathic thrombocytopenic purpura (R-ITP1000 study)

Tran, H. A., Brighton, T., Grigg, A. P., McRae, S., Dixon, J., Thurley, D., Gandhi, M. K., Truman, M., Marlton, P. & Catalano, J., 2014, In : British Journal of Haematology. 167, 2, p. 243 - 251 9 p.

Research output: Contribution to journalArticleResearchpeer-review