Research Output 1988 2019

2016

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modeling metazoan apoptotic pathways in yeast

Bloomer, D. T., Kitevska, T., Brand, I. L., Jabbour, A. M., Nguyen, H. & Hawkins, C. J., 2016, Programmed Cell Death: Methods and Protocols. Puthalakath, H. & Hawkins, C. J. (eds.). New York NY USA: Humana Press, p. 161 - 183 23 p. (Methods in Molecular Biology; vol. 1419).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging

Heidt, T., Ehrismann, S., Hovener, J. B., Neudorfer, I., Hilgendorf, I., Reisert, M., Hagemeyer, C. E., Zirlik, A., Reinohl, J. O., Bode, C., Peter, K., von Elverfeldt, D. & Von Zur Muhlen, C., 2016, In : Scientific Reports. 6, 9 p., 25044.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: The SPHInX study protocol

Calderone, A., Stevens, W., Prior, D., Nandurkar, H., Gabbay, E., Proudman, S. M., Williams, T., Celermajer, D., Sahhar, J., Wong, P. K. K., Thakkar, V., Dwyer, N., Wrobel, J., Chin, W., Liew, D., Staples, M., Buchbinder, R. & Nikpour, M., 1 Dec 2016, In : BMJ Open. 6, 12, 12 p., e011028.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

p120 catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Pieters, T., Goossens, S., Haenebalcke, L., Andries, V., Stryjewska, A., De Rycke, R., Lemeire, K., Hochepied, T., Huylebroeck, D., Berx, G., Stemmler, M. P., Wirth, D., Haigh, J. J., van Hengel, J. & van Roy, F., 2016, In : PLoS Genetics. 12, 8, 28 p., e1006243.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

Szabo, R., Samson, A. L., Lawrence, D. A., Medcalf, R. L. & Bugge, T. H., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1618-1628 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In : Biology Open. 6, 11, 12 p., 160098.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Plasminogen and stroke: more is better

Medcalf, R. L., 1 Sep 2016, In : Journal of Thrombosis and Haemostasis. 14, 9, p. 1819-1821 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Platelet and erythrocyte sources of S1P are redundant for vascular development and homeostasis, but both rendered essential after plasma S1P depletion in anaphylactic shock

Gazit, S. L., Mariko, B., Therond, P., Decouture, B., Xiong, Y., Couty, L., Bonnin, P., Baudrie, V., Le Gall, S. M., Dizier, B., Zoghdani, N., Ransinan, J., Hamilton, J. R., Gaussem, P., Tharaux, P. L., Chun, J., Coughlin, S. R., Bachelot-Loza, C., Hla, T., Ho-Tin-Noé, B. & 1 othersCamerer, E., 30 Sep 2016, In : Circulation Research. 119, 8, p. 110-126 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymer capsules for plaque-targeted in vivo delivery

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 21 Sep 2016, In : Advanced Materials. 28, 35, p. 7703-7707 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymer capsules for plaque-targeted in vivo delivery (Adv. Mater, (2016), 28, (7703-7707), 10.1002/adma.201601754): Erratum

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 28 Sep 2016, In : Advanced Materials. 28, 36, p. 7820 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Protease-activated receptor 4: From structure to function and back again

French, S. L. & Hamilton, J. R., 2016, In : British Journal of Pharmacology. 173, 20, p. 2952 - 2965 14 p.

Research output: Contribution to journalArticleOtherpeer-review

PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers

Labbé, D. P., Uetani, N., Vinette, V., Lessard, L., Aubry, I., Migon, E., Sirois, J., Haigh, J. J., Bégin, L. R., Trotman, L. C., Paquet, M. & Tremblay, M. L., 2016, In : Cancer Research. 76, 11, p. 3130-3135 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

Pang, S. H. M., Minnich, M., Gangatirkar, P., Zheng, Z., Ebert, A., Song, G., Dickins, R. A., Corcoran, L. M., Mullighan, C. G., Busslinger, M., Huntington, N. D., Nutt, S. L. & Carotta, S., 2016, In : Leukemia. 30, 6, p. 1375-1387 13 p.

Research output: Contribution to journalArticleResearchpeer-review

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis, A., Slape, C. I., Failla, L. M., Saw, J. M. Y., Tremblay, C., Powell, D. R., Rossello, F. J., Wei, A., Strasser, A. & Curtis, D. J., 2016, In : Cell Death and Differentiation. 23, 6, p. 1049 - 1059 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Retrospective review on isolated distal deep vein thrombosis (IDDVT) - A benign entity or not?

Ho, P., Lim, H. Y., Chua, C. C., Sleeman, M., Tacey, M., Donnan, G. & Nandurkar, H., 2016, In : Thrombosis Research. 142, p. 11 - 16 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Sprouty

Masoumi Moghaddam, S. & Amini, A., 2016, Encyclopedia of Signaling Molecules. Choi, S. (ed.). 2nd ed. Springer, p. 1 - 7 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hanggi, K., Brumatti, G., Chau, D., Nguyen, N-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 othersGugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W-L. & Silke, J., 2016, In : Cancer Cell. 29, 2, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ten years of cerebral venous thrombosis: Male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events

Lim, H. Y., Ng, C., Donnan, G., Nandurkar, H. & Ho, P., 2016, In : Journal of Thrombosis and Thrombolysis. 42, 3, p. 423 - 431 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

Saulep-Easton, D., Vincent, F. B., Quah, P. S., Wei, A., Ting, S. B., Croce, C. M., Tam, C. & Mackay, F., 2016, In : Leukemia. 30, 1, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti, G., Ma, C., Lalaoui, N., Nguyen, N. Y., Navarro, M., Tanzer, M. C., Richmond, J., Ghisi, M., Salmon, J. M., Silke, N., Pomilio, G., Glaser, S. P., de Valle, E., Gugasyan, R., Gurthridge, M. A., Condon, S. M., Johnstone, R. W., Lock, R., Salvesen, G. S., Wei, A. & 3 othersVaux, D. L., Ekert, P. G. & Silke, J., 18 May 2016, In : Science Translational Medicine. 8, 339, 339ra69.

Research output: Contribution to journalArticleResearchpeer-review

The influence of differentially expressed tissue-type plasminogen activator in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Dahl, L. C. M., Nasa, Z., Chung, J., Niego, B., Tarlac, V., Ho, K. C. H., Galle, A. A., Petratos, S., Alderuccio, F. P. & Medcalf, R. L., 18 Jul 2016, In : PLoS ONE. 11, 7, 22 p., e0158653.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Maragno, A. L., Le Toumelin-Braizat, G., Chanrion, M., Kelly, G. L., Gong, J. N., Moujalled, D. M., Bruno, A., Csekei, M., Paczal, A., Szabo, Z. B., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G. & 2 othersPomilio, G. & Wei, A. H., 2016, In : Nature. 538, 7626, p. 477-482 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Scott, C. L., Soen, B., Martens, L., Skrypek, N., Saelens, W., Taminau, J., Blancke, G., Van Isterdael, G., Huylebroeck, D., Haigh, J., Saeys, Y., Guilliams, M., Lambrecht, B. N. & Berx, G., 2016, In : Journal of Experimental Medicine. 213, 6, p. 897-911 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

ε-globin expression is regulated by SUV4-20h1

Wang, Y., Rank, G., Li, Z., Wang, Y., Ju, J., Nuber, A., Wu, Y., Liu, M., Nie, M., Huang, F., Cerruti, L., Ma, C., Tan, R., Schotta, G., Jane, S. M., Zeng, C. K. & Zhao, Q., 30 Apr 2016, In : Haematologica: the hematology journal. 101, 5, p. e168-e172

Research output: Contribution to journalLetterResearchpeer-review

Open Access
2015

14-3-3{zeta} coordinates adipogenesis of visceral fat

Lim, G., Albrecht, T., Piske, M., Sarai, K., Lee, J. T. C., Ramshaw, H. S., Sinha, S., Guthridge, M. A., Acker-Palmer, A., Lopez, A. F., Clee, S. M., Nislow, C. & Johnson, J. D., 2015, In : Nature Communications. 6, (Art. No: 7671), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sanchez Guiu, I. M., Martinez-Martinez, I., Martinez, C., Navarro-Fernandez, J., Garcia-Candel, F., Ferrer-Marin, F., Vicente, V., Watson, S. P., Andrews, R. K., Gardiner, E. E., Lozano, M. L. & Rivera, J., 2015, In : Thrombosis and Haemostasis. 114, 2, p. 313 - 324 12 p.

Research output: Contribution to journalArticleResearchpeer-review

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Van Overbeke, W., Wongsantichon, J., Everaert, I., Verhelle, A., Zwaenepoel, O., Loonchanta, A., Burtnick, L. D., De Ganck, A., Hochepied, T., Haigh, J. J., Cuvelier, C., Derave, W., Robinson, R. C. & Gettemans, J., 2015, In : Human Molecular Genetics. 24, 9, p. 2492 - 2507 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel role for the EMT regulator, snai1, in hematopoiesis and leukemia

Carmichael, C., Goossens, S., Kile, B. & Haigh, J. J., 2015, p. S56. 1 p.

Research output: Contribution to conferencePosterOtherpeer-review

Apixaban and patient management following stroke/tia: A consensus guide

Levi, C. R., Campbell, B. C. V., Lindley, R. I., Nandurkar, H. H., Parsons, M. W. & Hankey, G., 2015, p. 83.

Research output: Contribution to conferencePosterOtherpeer-review

Approval of the first protease-activated receptor antagonist: rationale, development, significance, and considerations of a novel anti-platelet agent

French, S., Arthur, J. F., Tran, H. A. & Hamilton, J. R., 2015, In : Blood Reviews. 29, 3, p. 179 - 189 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A rare case of IGH/MYC and IGH/BCL2 double hit primary plasma cell leukemia

Kalff, A., Khong, T., Wall, M., Gorniak, M., Mithraprabhu, S., Campbell, L. J. & Spencer, A., 2015, In : Haematologica: the hematology journal. 100, 2, p. e60-e62 3 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access

Asymmetric cell division during T cell development controls downstream fate

Pham, K., Shimoni, R., Ludford-Menting, M. J., Hawkins, E., Ramsbottom, K. M., Oliaro, J., Izon, D. J., Ting, S. B. N., Reynolds, J. B., Lythe, G., Molina-Paris, C., Melichar, H. J., Robey, E., Humbert, P. O., Gu, M. & Russell, S. M., 2015, In : Journal of Cell Biology. 210, 6, p. 933 - 950 18 p.

Research output: Contribution to journalArticleResearchpeer-review

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

Lee, E. F., Takiguchi, M., Pettikiriarachchi, A., Evangelista, M., Huang, D. C. S., Dickins, R. A. & Fairlie, W. D., 12 Mar 2015, In : Cell Death and Disease. 6, 3 p., e1679.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells: significance of combination therapy

Amini, A., Masoumi Moghaddam, S. & Morris, D. L., 2015.

Research output: Contribution to conferencePosterOtherpeer-review

Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: A randomised, multicentre, phase 3 trial

Gay, F., Oliva, S., Petrucci, M. T., Conticello, C., Catalano, L., Corradini, P., Siniscalchi, A., Magarotto, V., Pour, L., Carella, A-M., Malfitano, A., Petrò, D., Evangelista, A., Spada, S., Pescosta, N., Omedè, P., Campbell, P., Liberati, A. M., Offidani, M., Ria, R. & 6 othersPulini, S., Patriarca, F., Hajek, R., Spencer, A., Boccadoro, M. & Palumbo, A., 2015, In : Lancet Oncology. 16, 16, p. 1617-1629 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Class II but not second class - prospects for the development of class II PI3K inhibitors

Mountford, S. J., Zheng, Z., Sundaram, K., Jennings, I., Hamilton, J. R. & Thompson, P., 2015, In : A C S Medicinal Chemistry Letters. 6, 1, p. 3 - 6 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation

Pham, T., Patil, S., Fleming, S. A., Avery, S., Walker, P. A., Wei, A., Curtis, D. J., Stuart, G., Klarica, D., O'Brien, M., Morris, K., Das, T. P., Bollard, G. M., Muirhead, J., Coutsouvelis, J. & Spencer, A., 2015, In : Transfusion. 55, 11, p. 2709 - 2713 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of intermittent and continuous extracorporeal treatments for the enhanced elimination of dabigatran

Bouchard, J., Ghannoum, M., Bernier-Jean, A., Williamson, D. R., Kershaw, G., Weatherburn, C., Eris, J. M., Tran, H. A., Patel, J. P. & Roberts, D. M., 2015, In : Clinical Toxicology. 53, 3, p. 156 - 163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Current state and novel approaches of antiplatelet therapy

Metharom, P., Berndt, M. C., Baker, R. I. & Andrews, R. K., 2015, In : Arteriosclerosis, Thrombosis and Vascular Biology. 35, 6, p. 1327 - 1338 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytokine Receptors and Their Ligands

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F. & Parker, M. W., 1 Jan 2015, Encyclopedia of Cell Biology: Functional Cell Biology. Bradshaw, R. A. & Stahl, P. D. (eds.). Waltham MA USA: Elsevier, Vol. 3. p. 22-36 15 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Dendritic cell-mediated phagocytosis but not immune activation is enhanced by plasmin

Borg, R., Samson, A. L., Au, A. E-L., Scholzen, A., Fuchsberger, M., Kong, Y. Y., Freeman, R., Mifsud, N. A., Plebanski, M. & Medcalf, R. L., 2015, In : PLoS ONE. 10, 7 , 19 p., e0131216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J., Segal, D., Nero, T. L., Parker, M. W., Wan, S. S., de Silva, M., Guthridge, M. A., Wei, A. & Burns, C. J., 2015, In : Bioorganic & Medicinal Chemistry. 23, 19 (Art. No: 12539), p. 6280 - 6296 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Disseminated Enteroviral Infection Associated with Obinutuzumab

Dendle, C., Gilbertson, M., Korman, T., Golder, V., Morand, E. F. & Opat, S., 2015, In : Emerging infectious diseases. 21, 9, p. 1661 - 1663 3 p.

Research output: Contribution to journalArticleOther

Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Combariza, M. E., Yu, X., Nesbitt, W., Tovar-Lopez, F., Rabus, D. G. & Mitchell, A., 1 Jan 2015, Micro+Nano Materials, Devices, and Systems. Palomba, S. & Eggleton, B. J. (eds.). Bellingham WA USA: SPIE, 10 p. 96681U. (Proceedings of SPIE; vol. 9668).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Editorial: ADAMs control inflammation from afar

Andrews, R. K. & Gardiner, E. E., 2015, In : Journal of leukocyte biology. 97, 3, p. 437 - 438 2 p.

Research output: Contribution to journalLetterOther

Effects of abacavir administration on structural and functional markers of platelet activation

Trevillyan, J. M., Arthur, J. F., Jing, J., Andrews, R. K., Gardiner, E. E. & Hoy, J. F., 2015, In : AIDS. 29, 17, p. 2309 - 2313 5 p.

Research output: Contribution to journalArticleResearchpeer-review