Aust Ctr for Blood Diseases

Research Output 1984 2019

2016

Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking Par1 into the Par3 locus reveals Par1 expression is not tolerated in mouse platelets

French, S. L., Paramitha, A. C., Moon, M. J., Dickins, R. A. & Hamilton, J. R., 1 Oct 2016, In : PLoS ONE. 11, 10, 14 p., e0165565.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia

Ghisi, M., Kats, L., Masson, F., Li, J., Kratina, T., Vidacs, E., Gilan, O., Doyle, M. A., Newbold, A., Bolden, J. E., Fairfax, K. A., de Graaf, C. A., Firth, M., Zuber, J., Dickins, R. A., Corcoran, L. M., Dawson, M. A., Belz, G. T. & Johnstone, R. W., 11 Jul 2016, In : Cancer Cell. 30, 1, p. 59-74 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Idarucizumab: An anticoagulant reversal agent for dabigatran

Brown, A. F. T. & Nandurkar, H., 1 Nov 2016, In : Medicine Today. 17, 11, p. 63-65 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

Luis, T. C., Tremblay, C. S., Manz, M. G., North, T. E., King, K. Y. & Challen, G. A., 1 Oct 2016, In : Experimental Hematology. 44, 10, p. 908-912 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study

Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., Lewis, I. D., Rivera, G., Gratzinger, D., Fan, A. C., Felsher, D. W., Cortes, J. E., Watts, J. M., Yarranton, G. T., Walling, J. M. & Lancet, J. E., 1 Nov 2016, In : Leukemia Research. 50, p. 123-131 9 p.

Research output: Contribution to journalArticleResearchpeer-review

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Helsmoortel, H. H., Moerloose, B. D., Pieters, T., Ghazavi, F., Bresolin, S., Cavé, H., de Vries, A., de Haas, V., Flotho, C., Labarque, V., Niemeyer, C., De Paepe, P., Roy, N. V., Stary, J., van den Heuvel-Eibrink, M. M., Benoit, Y., Schulte, J., Steven, G., Berx, G., Haigh, J. J. & 3 others, Speleman, F. P., Van Vlierberghe, P. & Lammens, T., Jun 2016, In : Haematologica: the hematology journal. 101, 6, p. e240 - e244 5 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access

Liquid biopsies for liquid tumors: Emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Hocking, J., Mithraprabhu, S., Kalff, A. & Spencer, A., 1 Jun 2016, In : Cancer Biology and Medicine. 13, 2, p. 215-225 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Liver-mediated shedding of platelet GPVI

Berndt, M. C. & Andrews, R. K., 11 Aug 2016, In : Blood. 128, 6, p. 751-752 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices

Muthiah, K., Connor, D., Ly, K., Gardiner, E. E., Andrews, R. K., Qiao, J., Rutgers, D., Robson, D., Low, J., Jarvis, S., MacDonald, P. B., Dhital, K., Jansz, P., Joseph, J. E. & Hayward, C. S., 1 Jun 2016, In : Journal of Heart and Lung Transplantation. 35, 6, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction

Ong, D. M., Aumann, H. A., Andrews, R. K., Gardiner, E. E., Rodgers, S. & Davis, A. K., 1 Jul 2016, In : Haemophilia. 22, 4, p. e345-e346

Research output: Contribution to journalLetterOtherpeer-review

Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients

Levin, N., Spencer, A., Harrison, S. J., Chauhan, D., Burrows, F. J., Anderson, K. C., Reich, S. D., Richardson, P. G. & Trikha, M., 1 Sep 2016, In : British Journal of Haematology. 174, 5, p. 711-720 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

Lukito, P., Wong, A., Jing, J., Arthur, J. F., Marasco, S. F., Murphy, D. A., Bergin, P. J., Shaw, J. A., Collecutt, M. F., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 11, p. 2253-2260 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Metalloproteolytic receptor shedding…platelets “acting their age”

Andrews, R. K. & Gardiner, E. E., 17 Aug 2016, In : Platelets. 27, 6, p. 512-518 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modeling metazoan apoptotic pathways in yeast

Bloomer, D. T., Kitevska, T., Brand, I. L., Jabbour, A. M., Nguyen, H. & Hawkins, C. J., 2016, Programmed Cell Death: Methods and Protocols. Puthalakath, H. & Hawkins, C. J. (eds.). New York NY USA: Humana Press, p. 161 - 183 23 p. (Methods in Molecular Biology; vol. 1419).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging

Heidt, T., Ehrismann, S., Hovener, J. B., Neudorfer, I., Hilgendorf, I., Reisert, M., Hagemeyer, C. E., Zirlik, A., Reinohl, J. O., Bode, C., Peter, K., von Elverfeldt, D. & Von Zur Muhlen, C., 2016, In : Scientific Reports. 6, 9 p., 25044.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: The SPHInX study protocol

Calderone, A., Stevens, W., Prior, D., Nandurkar, H., Gabbay, E., Proudman, S. M., Williams, T., Celermajer, D., Sahhar, J., Wong, P. K. K., Thakkar, V., Dwyer, N., Wrobel, J., Chin, W., Liew, D., Staples, M., Buchbinder, R. & Nikpour, M., 1 Dec 2016, In : BMJ Open. 6, 12, 12 p., e011028.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

p120 catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Pieters, T., Goossens, S., Haenebalcke, L., Andries, V., Stryjewska, A., De Rycke, R., Lemeire, K., Hochepied, T., Huylebroeck, D., Berx, G., Stemmler, M. P., Wirth, D., Haigh, J. J., van Hengel, J. & van Roy, F., 2016, In : PLoS Genetics. 12, 8, 28 p., e1006243.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

Szabo, R., Samson, A. L., Lawrence, D. A., Medcalf, R. L. & Bugge, T. H., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1618-1628 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In : Biology Open. 6, 11, 12 p., 160098.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Plasminogen and stroke: more is better

Medcalf, R. L., 1 Sep 2016, In : Journal of Thrombosis and Haemostasis. 14, 9, p. 1819-1821 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Platelet and erythrocyte sources of S1P are redundant for vascular development and homeostasis, but both rendered essential after plasma S1P depletion in anaphylactic shock

Gazit, S. L., Mariko, B., Therond, P., Decouture, B., Xiong, Y., Couty, L., Bonnin, P., Baudrie, V., Le Gall, S. M., Dizier, B., Zoghdani, N., Ransinan, J., Hamilton, J. R., Gaussem, P., Tharaux, P. L., Chun, J., Coughlin, S. R., Bachelot-Loza, C., Hla, T., Ho-Tin-Noé, B. & 1 others, Camerer, E., 30 Sep 2016, In : Circulation Research. 119, 8, p. 110-126 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymer capsules for plaque-targeted in vivo delivery

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 21 Sep 2016, In : Advanced Materials. 28, 35, p. 7703-7707 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymer capsules for plaque-targeted in vivo delivery (Adv. Mater, (2016), 28, (7703-7707), 10.1002/adma.201601754): Erratum

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 28 Sep 2016, In : Advanced Materials. 28, 36, p. 7820 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Protease-activated receptor 4: From structure to function and back again

French, S. L. & Hamilton, J. R., 2016, In : British Journal of Pharmacology. 173, 20, p. 2952 - 2965 14 p.

Research output: Contribution to journalArticleOtherpeer-review

PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers

Labbé, D. P., Uetani, N., Vinette, V., Lessard, L., Aubry, I., Migon, E., Sirois, J., Haigh, J. J., Bégin, L. R., Trotman, L. C., Paquet, M. & Tremblay, M. L., 2016, In : Cancer Research. 76, 11, p. 3130-3135 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

Pang, S. H. M., Minnich, M., Gangatirkar, P., Zheng, Z., Ebert, A., Song, G., Dickins, R. A., Corcoran, L. M., Mullighan, C. G., Busslinger, M., Huntington, N. D., Nutt, S. L. & Carotta, S., 2016, In : Leukemia. 30, 6, p. 1375-1387 13 p.

Research output: Contribution to journalArticleResearchpeer-review

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis, A., Slape, C. I., Failla, L. M., Saw, J. M. Y., Tremblay, C., Powell, D. R., Rossello, F. J., Wei, A., Strasser, A. & Curtis, D. J., 2016, In : Cell Death and Differentiation. 23, 6, p. 1049 - 1059 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Retrospective review on isolated distal deep vein thrombosis (IDDVT) - A benign entity or not?

Ho, P., Lim, H. Y., Chua, C. C., Sleeman, M., Tacey, M., Donnan, G. & Nandurkar, H., 2016, In : Thrombosis Research. 142, p. 11 - 16 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Roar: A Phase Ib Trial of Oral Azacitidine (CC-486) in Combination with Lenalidomide and Dexamethasone (Rd) for Patients with Relapsed and/or Refractory (R/R) Multiple Myeloma Who Have Failed a Prior Lenalidomide-Containing Regimen

Kalff, A., Reed, K., Khong, T. T., Mithraprabhu, S., Ramachandran, M., Reynolds, J., Bergin, K., Thakurta, A., Wang, M., Spencer, A., Guzman, R., Cuoto, S. & Ren, Y., 2 Dec 2016, In : Blood. 128, 22, 1 p., 2121.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Sprouty

Masoumi Moghaddam, S. & Amini, A., 2016, Encyclopedia of Signaling Molecules. Choi, S. (ed.). 2nd ed. Springer, p. 1 - 7 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hanggi, K., Brumatti, G., Chau, D., Nguyen, N-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W-L. & Silke, J., 2016, In : Cancer Cell. 29, 2, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ten years of cerebral venous thrombosis: Male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events

Lim, H. Y., Ng, C., Donnan, G., Nandurkar, H. & Ho, P., 2016, In : Journal of Thrombosis and Thrombolysis. 42, 3, p. 423 - 431 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

Saulep-Easton, D., Vincent, F. B., Quah, P. S., Wei, A., Ting, S. B., Croce, C. M., Tam, C. & Mackay, F., 2016, In : Leukemia. 30, 1, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti, G., Ma, C., Lalaoui, N., Nguyen, N. Y., Navarro, M., Tanzer, M. C., Richmond, J., Ghisi, M., Salmon, J. M., Silke, N., Pomilio, G., Glaser, S. P., de Valle, E., Gugasyan, R., Gurthridge, M. A., Condon, S. M., Johnstone, R. W., Lock, R., Salvesen, G. S., Wei, A. & 3 others, Vaux, D. L., Ekert, P. G. & Silke, J., 18 May 2016, In : Science Translational Medicine. 8, 339, 339ra69.

Research output: Contribution to journalArticleResearchpeer-review

The influence of differentially expressed tissue-type plasminogen activator in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Dahl, L. C. M., Nasa, Z., Chung, J., Niego, B., Tarlac, V., Ho, K. C. H., Galle, A. A., Petratos, S., Alderuccio, F. P. & Medcalf, R. L., 18 Jul 2016, In : PLoS ONE. 11, 7, 22 p., e0158653.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Maragno, A. L., Le Toumelin-Braizat, G., Chanrion, M., Kelly, G. L., Gong, J. N., Moujalled, D. M., Bruno, A., Csekei, M., Paczal, A., Szabo, Z. B., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G. & 2 others, Pomilio, G. & Wei, A. H., 2016, In : Nature. 538, 7626, p. 477-482 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Scott, C. L., Soen, B., Martens, L., Skrypek, N., Saelens, W., Taminau, J., Blancke, G., Van Isterdael, G., Huylebroeck, D., Haigh, J., Saeys, Y., Guilliams, M., Lambrecht, B. N. & Berx, G., 2016, In : Journal of Experimental Medicine. 213, 6, p. 897-911 15 p.

Research output: Contribution to journalArticleResearchpeer-review

TOP2A a New Predictive Marker of Response to Carfilzomib in Multiple Myeloma

Reale, A., Khong, T., Mithraprabhu, S., Reynolds, J., Ramachandran, M., Savvidou, I., Bergin, K., Hocking, J. & Spencer, A., 2 Dec 2016, In : Blood. 128, 22, 1 p., 4461.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

ε-globin expression is regulated by SUV4-20h1

Wang, Y., Rank, G., Li, Z., Wang, Y., Ju, J., Nuber, A., Wu, Y., Liu, M., Nie, M., Huang, F., Cerruti, L., Ma, C., Tan, R., Schotta, G., Jane, S. M., Zeng, C. K. & Zhao, Q., 30 Apr 2016, In : Haematologica: the hematology journal. 101, 5, p. e168-e172

Research output: Contribution to journalLetterResearchpeer-review

Open Access
2015

14-3-3{zeta} coordinates adipogenesis of visceral fat

Lim, G., Albrecht, T., Piske, M., Sarai, K., Lee, J. T. C., Ramshaw, H. S., Sinha, S., Guthridge, M. A., Acker-Palmer, A., Lopez, A. F., Clee, S. M., Nislow, C. & Johnson, J. D., 2015, In : Nature Communications. 6, (Art. No: 7671), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sanchez Guiu, I. M., Martinez-Martinez, I., Martinez, C., Navarro-Fernandez, J., Garcia-Candel, F., Ferrer-Marin, F., Vicente, V., Watson, S. P., Andrews, R. K., Gardiner, E. E., Lozano, M. L. & Rivera, J., 2015, In : Thrombosis and Haemostasis. 114, 2, p. 313 - 324 12 p.

Research output: Contribution to journalArticleResearchpeer-review

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Van Overbeke, W., Wongsantichon, J., Everaert, I., Verhelle, A., Zwaenepoel, O., Loonchanta, A., Burtnick, L. D., De Ganck, A., Hochepied, T., Haigh, J. J., Cuvelier, C., Derave, W., Robinson, R. C. & Gettemans, J., 2015, In : Human Molecular Genetics. 24, 9, p. 2492 - 2507 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel role for the EMT regulator, snai1, in hematopoiesis and leukemia

Carmichael, C., Goossens, S., Kile, B. & Haigh, J. J., 2015, p. S56. 1 p.

Research output: Contribution to conferencePosterOtherpeer-review