Research Output 1988 2019

2017

Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes

Xiao, Z., Bonnard, T., Shakouri-Motlagh, A., Wylie, R. A. L., Collins, J., White, J., Heath, D. E., Hagemeyer, C. E. & Connal, L. A., 22 Aug 2017, In : Chemistry - A European Journal. 23, 47, p. 11294-11300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B. & Morgan, S., 2017, In : Annals of Hematology and Oncology. 4, 3, 1141.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Utility of CRISPR/Cas9 systems in hematology research

Lucas, D., O'Leary, H. A., Ebert, B. L., Cowan, C. A. & Tremblay, C. S., Oct 2017, In : Experimental Hematology. 54, p. 1-3 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Venous thromboembolism management in Northeast Melbourne: how does it compare to international guidelines and data?

Lim, H. Y., Chua, C. C., Tacey, M., Sleeman, M., Donnan, G., Nandurkar, H. & Ho, P., 1 Sep 2017, In : Internal Medicine Journal. 47, 9, p. 1034-1042 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Stryjewska, A., Dries, R., Pieters, T., Verstappen, G., Conidi, A., Coddens, K., Francis, A., Umans, L., van Ijcken, W. F. J., Berx, G., van Grunsven, L. A., Grosveld, F., Goossens, S., Haigh, J. J. & Huylebroeck, D., Mar 2017, In : Stem Cells. 35, 3, p. 611-625 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

β-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma

Savvidou, I., Khong, T., Cuddihy, A., McLean, C., Horrigan, S. & Spencer, A., 1 Sep 2017, In : Molecular Cancer Therapeutics. 16, 9, p. 1765-1778 14 p.

Research output: Contribution to journalArticleResearchpeer-review

‘Did He Who Made the Lamb Make Thee?’ New Developments in Treating the ‘Fearful Symmetry’ of Acute Myeloid Leukemia

Brumatti, G., Lalaoui, N., Wei, A. H. & Silke, J., 1 Mar 2017, In : Trends in Molecular Medicine. 23, 3, p. 264-281 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J. M., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., Van Der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 othersJackson, S. P., 27 Sep 2016, In : Nature Communications. 7, 17 p., 12862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D., Wang, H., Johnston, L., Daglas, M., Ates, R. C., Medcalf, R. L., Taylor, J. M. & Crack, P. J., 1 Jan 2016, In : eNeuro. 3, 1, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Abstract B39: PTP1B deficiency potentiate prostate cancer invasiveness by sensitizing Pten-null tumors to high-fat diet

Labbé, D. P., Uetani, N., Vinette, V., Aubry, I., Migon, E., Sirois, J., Haigh, J. J., Lessard, L., Bégin, L. R., Trotman, L. C., Paquet, M. & Tremblay, M. L., 2016, In : Molecular Cancer Research. 14, 1 Supplement, p. B39 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Smith, A. M., Dun, M. D., Lee, E. M., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A. S., Morris, J., Toop, H., Lock, R. B., Powell, J. A., Thomas, D., Guthridge, M. A., Moore, A., Ashman, L. K., Skelding, K. A., Enjeti, A. & Verrills, N. M., 2016, In : Oncotarget. 7, 30, p. 47465-47478 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets

Facey, A. D., Pinar, I., Arthur, J. F., Qiao, J. L., Jing, J., Mado, B., Carberry, J. J., Andrews, R. K. & Gardiner, E. E., 2016, In : Biochemistry. 55, 8, p. 1187 - 1194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-fibrinolytics

Draxler, D. F., Medcalf, R. L. & Gruen, R. L., 1 Jan 2016, Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B. & Moore, E. E. (eds.). Springer, p. 403-418 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

A Shear Micro-Gradient Microfluidic to Monitor Platelet Aggregation Dynamics in the Context of Von Willebrand Disease

Nandurkar, H., Nesbitt, W., Brazilek, R., Tovar-Lopez, F., Wong, A., Tran, H., Davis, A. & Mitchell, A., 2016, In : Blood. 128, 22, p. 3753-3753 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): And randomised, phase 3, open-label, multicentre study

Dimopoulos, M. A., Moreau, P., Palumbo, A., Joshua, D. E., Pour, L., Hájek, R., Facon, T., Ludwig, H., Oriol, A., Goldschmidt, H., Rosiñol, L., Straub, J., Suvorov, A., Araujo, C., Rimashevskaya, E., Pika, T., Gaidano, G., Weisel, K. C., Goranova-Marinova, V., Schwarer, A. & 11 othersMinuk, L., Masszi, T., Karamanesht, I., Offidani, M., Hungria, V., Spencer, A., Orlowski, R. Z., Gillenwater, H. H., Mohamed, N., Feng, S. & Chng, W. J., 1 Jan 2016, In : Lancet Oncology. 17, 1, p. 27-38 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability

Petitjean, C., Setiabakti, N. M., Mountford, J. K., Arthur, J. F., Ellis, S. L. & Hamilton, J. R., 2016, In : Platelets. 27, 5, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Lalaoui, N., Hänggi, K., Brumatti, G., Chau, D., Nguyen, N. Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 othersGugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W. L. & Silke, J., 12 Sep 2016, In : Cancer Cell. 30, 3, p. 499-500 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Daratumumab, bortezomib, and dexamethasone for multiple myeloma

Palumbo, A., Chanan-Khan, A., Weisel, K. C., Nooka, A. K., Masszi, T., Beksac, M., Spicka, I., Hungria, V., Munder, M., Mateos, M-V., Mark, T. M., Qi, M., Schecter, J., Amin, H., Qin, X., Deraedt, W., Ahmadi, T., Spencer, A. & Sonneveld, P., 25 Aug 2016, In : New England Journal of Medicine. 375, 8, p. 754-766 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia

Roboz, G. J., Montesinos, P., Selleslag, D., Wei, A., Jang, J. H., Falantes, J., Voso, M. T., Sayar, H., Porkka, K., Marlton, P., Almeida, A., Mohan, S., Ravandi, F., Garcia-Manero, G., Skikne, B. & Kantarjian, H. M., 1 Feb 2016, In : Future Oncology. 12, 3, p. 293-302 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Diagnosis and Management of Deep Vein Thrombosis and Pulmonary Embolism in Pregnancy

Bennett, A. & Chunilal, S., 1 Oct 2016, In : Seminars in Thrombosis and Hemostasis. 42, 7, p. 760-773 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Differentiation of human embryonic stem cells to HOXA + hemogenic vasculature that resembles the aorta-gonad-mesonephros

Ng, E., Azzola, L., Bruveris, F. F., Calvanese, V., Phipson, B., Vlahos, K., Hirst, C., Jokubaitis, V. J., Yu, Q. C., Maksimovic, J., Liebscher, S., Januar, V., Zhang, Z., Williams, B., Conscience, A., Durnall, J., Jackson, S., Costa, M., Elliott, D., Haylock, D. N. & 7 othersNilsson, S. K., Saffery, R., Schenke-Layland, K., Oshlack, A., Mikkola, H. K. A., Stanley, E. G. & Elefanty, A. G., 1 Nov 2016, In : Nature Biotechnology. 34, 11, p. 1168-1179 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Editorial: The role of the plasminogen activating system in neurobiology

Medcalf, R. L. & Lawrence, D. A., 4 Oct 2016, In : Frontiers in Cellular Neuroscience. 10, OCT2016, 3 p., 222.

Research output: Contribution to journalEditorialOtherpeer-review

Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies

Liu, H. B., Pattie, P., Chandrasekara, S., Spencer, A. & Dear, A. E., Sep 2016, In : Oncology Letters. 12, 3, p. 2175-2180 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetics in the biology and treatment of multiple myeloma

Spencer, A. & Mithraprabhu, S., 2016, In : European Oncology & Haematology. 12, 2, p. 96-102 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Evaluation of thromboelastography (teg) in patients with myeloproliferative neoplasm: platelet count> 600 (x109/L) associated with prothrombotic parameters

Smith, C., Hayes, L., Grigg, A., Nandurkar, H. & Ho, P., 2016. 1 p.

Research output: Contribution to conferenceAbstractOther

Evaluation of thromboelastography (teg) in patients with myeloproliferative neoplasm (mpn): platelet count> 600 associated with prothrombotic parameters.

Ng, C., Smith, C., Hayes, L., Grigg, L., Nandurkar, H. H. & Ho, P., 2016, p. S14.

Research output: Contribution to conferenceAbstractOtherpeer-review

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Forget about thrombosis: Platelets and Alzheimer's disease, yet another sticky situation

Mcfadyen, J. & Peter, K., 24 May 2016, In : Science Signaling. 9, 429, 3 p., fs9.

Research output: Contribution to journalArticleOtherpeer-review

GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives

Kao, T., Labonne, T., Niclis, J. C., Chaurasia, R., Lokmic, Z., Qian, E., Bruveris, F. F., Howden, S. E., Motazedian, A., Schiesser, J. V., Costa, M., Sourris, K., Ng, E., Anderson, D., Giudice, A., Farlie, P., Cheung, M. M. H., Lamande, S. R., Penington, A. J., Parish, C. L. & 5 othersThomson, L. H., Rafii, A., Elliott, D. A., Elefanty, A. G. & Stanley, E. G., 13 Sep 2016, In : Stem Cell Reports. 7, 3, p. 518-526 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Heavy menstrual bleeding and dysmenorrhea are improved by magentic resonance guided focused ultrasound surgery (mrgfus) of adenomyosis

Jayaram, R., Subbarayan, K., Mithraprabhu, S. & Govindarajan, M., May 2016, In : Fertility Research and Practice. 2, 7 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: Pivotal role of MCL1

Gong, J. N., Khong, T., Segal, D., Yao, Y., Riffkin, C. D., Garnier, J. M., Lin Khaw, S., Lessene, G., Spencer, A., Herold, M. J., Roberts, A. W. & Huang, D. C. S., 1 Jan 2016, In : Blood. 128, 14, p. 1834-1844 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler, M., Alt, K., Paterson, B. M., Kanellakis, P., Bobik, A., Donnelly, P. S., Hagemeyer, C. E. & Peter, K., 2 Dec 2016, In : Scientific Reports. 6, p. 1-10 10 p., 38161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking Par1 into the Par3 locus reveals Par1 expression is not tolerated in mouse platelets

French, S. L., Paramitha, A. C., Moon, M. J., Dickins, R. A. & Hamilton, J. R., 1 Oct 2016, In : PLoS ONE. 11, 10, 14 p., e0165565.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia

Ghisi, M., Kats, L., Masson, F., Li, J., Kratina, T., Vidacs, E., Gilan, O., Doyle, M. A., Newbold, A., Bolden, J. E., Fairfax, K. A., de Graaf, C. A., Firth, M., Zuber, J., Dickins, R. A., Corcoran, L. M., Dawson, M. A., Belz, G. T. & Johnstone, R. W., 11 Jul 2016, In : Cancer Cell. 30, 1, p. 59-74 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Idarucizumab: An anticoagulant reversal agent for dabigatran

Brown, A. F. T. & Nandurkar, H., 1 Nov 2016, In : Medicine Today. 17, 11, p. 63-65 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

Luis, T. C., Tremblay, C. S., Manz, M. G., North, T. E., King, K. Y. & Challen, G. A., 1 Oct 2016, In : Experimental Hematology. 44, 10, p. 908-912 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study

Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., Lewis, I. D., Rivera, G., Gratzinger, D., Fan, A. C., Felsher, D. W., Cortes, J. E., Watts, J. M., Yarranton, G. T., Walling, J. M. & Lancet, J. E., 1 Nov 2016, In : Leukemia Research. 50, p. 123-131 9 p.

Research output: Contribution to journalArticleResearchpeer-review

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Helsmoortel, H. H., Moerloose, B. D., Pieters, T., Ghazavi, F., Bresolin, S., Cavé, H., de Vries, A., de Haas, V., Flotho, C., Labarque, V., Niemeyer, C., De Paepe, P., Roy, N. V., Stary, J., van den Heuvel-Eibrink, M. M., Benoit, Y., Schulte, J., Steven, G., Berx, G., Haigh, J. J. & 3 othersSpeleman, F. P., Van Vlierberghe, P. & Lammens, T., Jun 2016, In : Haematologica: the hematology journal. 101, 6, p. e240 - e244 5 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access

Liquid biopsies for liquid tumors: Emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Hocking, J., Mithraprabhu, S., Kalff, A. & Spencer, A., 1 Jun 2016, In : Cancer Biology and Medicine. 13, 2, p. 215-225 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Liver-mediated shedding of platelet GPVI

Berndt, M. C. & Andrews, R. K., 11 Aug 2016, In : Blood. 128, 6, p. 751-752 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices

Muthiah, K., Connor, D., Ly, K., Gardiner, E. E., Andrews, R. K., Qiao, J., Rutgers, D., Robson, D., Low, J., Jarvis, S., MacDonald, P. B., Dhital, K., Jansz, P., Joseph, J. E. & Hayward, C. S., 1 Jun 2016, In : Journal of Heart and Lung Transplantation. 35, 6, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction

Ong, D. M., Aumann, H. A., Andrews, R. K., Gardiner, E. E., Rodgers, S. & Davis, A. K., 1 Jul 2016, In : Haemophilia. 22, 4, p. e345-e346

Research output: Contribution to journalLetterOtherpeer-review

Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients

Levin, N., Spencer, A., Harrison, S. J., Chauhan, D., Burrows, F. J., Anderson, K. C., Reich, S. D., Richardson, P. G. & Trikha, M., 1 Sep 2016, In : British Journal of Haematology. 174, 5, p. 711-720 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

Lukito, P., Wong, A., Jing, J., Arthur, J. F., Marasco, S. F., Murphy, D. A., Bergin, P. J., Shaw, J. A., Collecutt, M. F., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 11, p. 2253-2260 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Metalloproteolytic receptor shedding…platelets “acting their age”

Andrews, R. K. & Gardiner, E. E., 17 Aug 2016, In : Platelets. 27, 6, p. 512-518 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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