Research Output 1988 2019

2017

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N., Cameron, D. P., Hannan, K. M., Nguyen, N. Y. N., Fong, C. Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C. M., Diesch, J., Devlin, J. R., George, A. J., Sanij, E., Quin, J. E., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D. J., Harrison, S. J., Rozario, J. D. & 10 othersPowell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 25 May 2017, In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

KRAS-Mutated Myeloma Cells Exploit Autophagy and Macropinocytosis to Tolerate Glutamine-Deprived Conditions

Masoumi Moghaddam, S. & Spencer, A., Dec 2017, p. 1786.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Lenalidomide maintenance compared with placebo in responding elderly patients with diffuse large B-cell lymphoma treated with first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

Thieblemont, C., Tilly, H., Da Silva, M. G., Casasnovas, R. O., Fruchart, C., Morschhauser, F., Haioun, C., Lazarovici, J., Grosicka, A., Perrot, A., Trotman, J., Sebban, C., Caballero, D., Greil, R., Van Eygen, K., Cohen, A. M., Gonzalez, H., Bouabdallah, R., Oberic, L., Corront, B. & 10 othersChoufi, B., Lopez-Guillermo, A., Catalano, J., Van Hoof, A., Briere, J., Cabeçadas, J., Salles, G., Gaulard, P., Bosly, A. & Coiffier, B. B., 1 Aug 2017, In : Journal of Clinical Oncology. 35, 22, p. 2473-2481 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Ginn, S. L., Hallwirth, C. V., Liao, S. H. Y., Teber, E. T., Arthur, J. W., Wu, J., Lee, H. C., Tay, S. S., Hu, M., Reddel, R. R., McCormack, M. P., Thrasher, A. J., Cavazzana, M., Alexander, S. I. & Alexander, I. E., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial

Verstovsek, S., Mesa, R. A., Gotlib, J. R., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W. N., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Paquette, R. L., Raza, A., Jones, M., Kornacki, D., Sun, K. & 1 othersKantarjian, H. M., 22 Feb 2017, In : Journal of Hematology & Oncology. 10, 1, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J., Sep 2017, In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Low T-cell responses to mitogen stimulation predicts poor survival in recipients of allogeneic hematopoietic stem cell transplantation

Yong, M. K., Cameron, P. U., Slavin, M. A., Cheng, A. C., Orla Morrissey, C., Bergin, K., Spencer, A., Ritchie, D. & Lewin, S. R., 9 Nov 2017, In : Frontiers in Immunology. 8, NOV, 9 p., 1506.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic gatekeeper function of B-lymphoid transcription factors

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 othersRoss, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 23 Feb 2017, In : Nature. 542, 7642, p. 479-483 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Minute variation in murine ovarian cancer preclinical models significantly impact immunotherapy results obtained for clinical trial

Masoumi Moghaddam, S., McGray, R., Starbuck, K., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloma in the real world: What is really happening?

Bergin, K., McQuilten, Z., Moore, E., Wood, E. & Spencer, A., 1 Mar 2017, In : Clinical Lymphoma, Myeloma & Leukemia. 17, 3, p. 133-144.e1 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan, Y., Alwis, I., Wu, M. C. L., Kaplan, Z., Ashworth, K., Bark, D., Pham, A., McFadyen, J., Schoenwaelder, S. M., Josefsson, E. C., Kile, B. T. & Jackson, S. P., 27 Sep 2017, In : Science Translational Medicine. 9, 409, 14 p., eaam5861.

Research output: Contribution to journalArticleResearchpeer-review

Novel oral small molecule CXCR4 inhibitor improves activity of immune checkpoint blockade in ovarian cancer mouse model

Masoumi Moghaddam, S., Starbuck, K., McGray, R., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017, p. 956.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens, S., Peirs, S., Loocke, W. V., Wang, J., Takawy, M., Matthijssens, F., Sonderegger, S. E., Haigh, K., Nguyen, T., Vandamme, N., Costa, M., Carmichael, C., Van Nieuwerburgh, F., Deforce, D., Kleifeld, O., Curtis, D. J., Berx, G., Van Vlierberghe, P. & Haigh, J. J., 23 Feb 2017, In : Blood. 129, 8, p. 981-990 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Partial response after induction chemotherapy has clinical relevance in acute myeloid leukaemia

Fleming, S., Ong, D. M., Jackson, K., Avery, S., Mollee, P. N., Marlton, P., Kennedy, G. A. & Wei, A. H., Apr 2017, In : British Journal of Haematology. 177, 2, p. 328-330 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmin: A Modulator of Immune Function

Draxler, D. F., Sashindranath, M. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 143-153 11 p., 02353.

Research output: Contribution to journalArticleResearchpeer-review

Platelet adhesion

Gardiner, E. E. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Cham: Springer, p. 309-319 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Platelet-Derived Microvesicles in Cardiovascular Diseases

Zaldivia, M. T. K., McFadyen, J. D., Lim, B., Wang, X. & Peter, K., 21 Nov 2017, In : Frontiers in Cardiovascular Medicine. 4, 13 p., 74.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Platelet hyperreactivity in diabetes: Focus on GPVI signaling-are useful drugs already available?

Arthur, J. F., Jandeleit-Dahm, K. & Andrews, R. K., 1 Jan 2017, In : Diabetes. 66, 1, p. 7-13 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler, M., Wang, X., Lim, B., Leitner, E., Klingberg, F., Ching, V., Yao, Y., Huang, D., Gao, X. M., Kiriazis, H., Du, X. J., Haigh, J. J., Bobik, A., Hagemeyer, C. E., Ahrens, I. & Peter, K., 2017, In : Theranostics. 7, 13, p. 3192-3206 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., Grillo, I., Bakogianni, S., Ndiaye-Lobry, D., Martín, M. T., Guillamot, M., Banh, R. S., Xu, M., Figueroa, M. E., Dickins, R. A., Abdel-Wahab, O. & 4 othersPark, C. Y., Tsirigos, A., Neel, B. G. & Aifantis, I., 7 Sep 2017, In : Cell. 170, 6, p. 1079 - 1095.e20 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Restoring Cardiac Function After Myocardial Infarction by Targeting CD39 to Activated Platelets.

Ziegler, M., Hohmann, J., Searle, A., Abraham, M., Nandurkar, H. H., Wang, X. & Peter, K., 2017. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Retrospective evaluation of venous thromboembolism: Are all transient provoking events the same?

Chua, C. C., Lim, H. Y., Tacey, M., Nandurkar, H. & Ho, P., 1 Jul 2017, In : European Journal of Haematology. 99, 1, p. 18-26 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In : PLoS ONE. 12, 5, 21 p., e0177332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai, Y., Guo, J., Wang, T. Y., Ju, Y., Mitchell, A. J., Bonnard, T., Cui, J., Richardson, J. J., Hagemeyer, C. E., Alt, K. & Caruso, F., 23 Aug 2017, In : Advanced Healthcare Materials. 6, 16, 7 p., 1700467.

Research output: Contribution to journalArticleResearchpeer-review

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., May 2017, In : Journal of Thrombosis and Haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Significant age, race and gender differences in global coagulation assays parameters in the normal population

Ho, P., Ng, C., Rigano, J., Tacey, M., Smith, C., Donnan, G. & Nandurkar, H., 1 Jun 2017, In : Thrombosis Research. 154, p. 80-83 4 p.

Research output: Contribution to journalLetterResearchpeer-review

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis

Stack, J. R., Madigan, A., Helbert, L., Dunne, E., Gardiner, E. E., Andrews, R. K., Finan, R., Smyth, E., Kenny, D. & McCarthy, G. M., 1 Nov 2017, In : PLoS ONE. 12, 11, 8 p., e0188027.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Specification of neurotransmitter identity by Tal1 in thalamic nuclei

Lee, B., Lee, M., Song, S., Loi, L. D., Lam, D. T., Yoon, J., Baek, K., Curtis, D. J. & Jeong, Y., 1 Oct 2017, In : Developmental Dynamics. 246, 10, p. 749-758 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

Pieters, T., Haenebalcke, L., Bruneel, K., Vandamme, N., Hochepied, T., van Hengel, J., Wirth, D., Berx, G., Haigh, J. J., Van Roy, F. & Goossens, S., 27 Apr 2017, In : Journal of Visualized Experiments. 122, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted therapies for T-cell acute lymphoblastic leukaemia (T-ALL): what makes T-ALL TYK?

Curtis, D. J., 1 Apr 2017, In : British Journal of Haematology. 177, 2, p. 169-170 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Powell, J. A., Lewis, A. C., Zhu, W., Toubia, J., Pitman, M. R., Wallington-Beddoe, C. T., Moretti, P. A. B., Iarossi, D., Samaraweera, S. E., Cummings, N., Ramshaw, H. S., Thomas, D., Wei, A. H., Lopez, A. F., D'Andrea, R. J., Lewis, I. D. & Pitson, S. M., 9 Feb 2017, In : Blood. 129, 6, p. 771-782 12 p.

Research output: Contribution to journalArticleResearchpeer-review

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled, D., Grubman, A., Acevedo, K., Yang, S., Ke, Y. D., Moujalled, D. M., Duncan, C., Caragounis, A., Perera, N. D., Turner, B. J., Prudencio, M., Petrucelli, L., Blair, I., Ittner, L. M., Crouch, P. J., Liddell, J. R. & White, A. R., 1 May 2017, In : Human Molecular Genetics. 26, 9, p. 1732-1746 15 p., ddx093.

Research output: Contribution to journalArticleResearchpeer-review

The cutting edge of platelets

Andrews, R. K. & Gardiner, E. E., 19 May 2017, In : Platelets. 28, 4, p. 317-318 2 p.

Research output: Contribution to journalArticleOtherpeer-review

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Li, J., Riedt, T., Goossens, S., García, C. C., Szczepanski, S., Brandes, M., Pieters, T., Dobrosch, L., Gütgemann, I., Farla, N., Radaelli, E., Hulpiau, P., Mallela, N., Fröhlich, H., La Starza, R., Matteucci, C., Chen, T., Brossart, P., Mecucci, C., Huylebroeck, D. & 2 othersHaigh, J. J. & Janzen, V., 26 Jan 2017, In : Blood. 129, 4, p. 460-472 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The fibrinolysis inhibitor α2-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer

Paquet-Fifield, S., Roufail, S., Zhang, Y. F., Sofian, T., Byrne, D. J., Coughlin, P. B., Fox, S. B., Stacker, S. A. & Achen, M. G., 11 Jul 2017, In : Growth Factors. 35, 2-3, p. 61-75 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia

Fox, L. C., Cummins, K. D., Costello, B., Yeung, D., Cleary, R., Forsyth, C., Tatarczuch, M., Burbury, K., Motorna, O., Shortt, J., Fleming, S., McQuillan, A., Schwarer, A., Harrup, R., Holmes, A., Ratnasingam, S., Chan, K-L., Hsu, W-H., Ashraf, A., Putt, F. & 1 othersGrigg, A. P., 23 May 2017, In : Blood Advances. 1, 13, p. 802-811 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study

Tan, P., Tiong, I. S., Fleming, S., Pomilio, G., Cummings, N., Droogleever, M., McManus, J., Schwarer, A., Catalano, J., Patil, S., Avery, S., Spencer, A. & Wei, A., 2017, In : Oncotarget. 8, 32, p. 52269-52280 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Patients’ Perspective: Hematological Cancer Patients’ Experiences of Adverse Events as Part of Care

Bryant, J., Carey, M., Sanson-Fisher, R., Turon, H., Wei, A. & Kuss, B., 17 Mar 2017, (Accepted/In press) In : Journal of Patient Safety.

Research output: Contribution to journalArticleResearchpeer-review

The Snail Family in Normal and Malignant Haematopoiesis

Carmichael, C. L. & Haigh, J. J., 1 Feb 2017, In : Cells Tissues Organs. 203, 2, p. 82-98 17 p.

Research output: Contribution to journalArticleResearchpeer-review

To the editor: Venetoclax and obinutuzumab in chronic lymphocytic leukemia

Fischer, K., Al-Sawaf, O., Fink, A. M., Dixon, M., Bahlo, J., Warburton, S., Kipps, T. J., Weinkove, R., Robinson, S., Seiler, T., Opat, S., Owen, C. J., López, J., Humphrey, K., Humerickhouse, R., Tausch, E., Frenzel, L., Eichhorst, B., Wendtner, C. M., Stilgenbauer, S. & 7 othersLangerak, A. W., Van Dongen, J. J. M., Böttcher, S., Ritgen, M., Goede, V., Mobasher, M. & Hallek, M., 11 May 2017, In : Blood. 129, 19, p. 2702-2705 4 p.

Research output: Contribution to journalLetterOtherpeer-review

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

Fredriksson, L., Lawrence, D. A. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 154-168 15 p., 02355.

Research output: Contribution to journalArticleResearchpeer-review

Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes

Xiao, Z., Bonnard, T., Shakouri-Motlagh, A., Wylie, R. A. L., Collins, J., White, J., Heath, D. E., Hagemeyer, C. E. & Connal, L. A., 22 Aug 2017, In : Chemistry - A European Journal. 23, 47, p. 11294-11300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B. & Morgan, S., 2017, In : Annals of Hematology and Oncology. 4, 3, 1141.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Utility of CRISPR/Cas9 systems in hematology research

Lucas, D., O'Leary, H. A., Ebert, B. L., Cowan, C. A. & Tremblay, C. S., Oct 2017, In : Experimental Hematology. 54, p. 1-3 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Venous thromboembolism management in Northeast Melbourne: how does it compare to international guidelines and data?

Lim, H. Y., Chua, C. C., Tacey, M., Sleeman, M., Donnan, G., Nandurkar, H. & Ho, P., 1 Sep 2017, In : Internal Medicine Journal. 47, 9, p. 1034-1042 9 p.

Research output: Contribution to journalArticleResearchpeer-review