Research Output 1984 2019

2017

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., van der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 30 Aug 2017, In : Nature Communications. 8, 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Corrigendum to “KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study” [Leuk. Res. 50 (Nov) (2016) 123–131. PubMed PMID: 27736729](S0145212616301989)(10.1016/j.leukres.2016.09.012)

Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., Lewis, I. D., Rivera, G., Gratzinger, D., Fan, A. C., Felsher, D. W., Cortes, J. E., Watts, J. M., Yarranton, G. T., Walling, J. M. & Lancet, J. E., 1 Aug 2017, In : Leukemia Research. 59, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

CXCR4 in combination with immune check point inhibition in ovarian cancer mouse model demonstrates potential for novel therapeutic strategies

Masoumi Moghaddam, S., Starbuck, K., McGray, R., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Cytomegalovirus Reactivation Is Associated with Increased Risk of Late-Onset Invasive Fungal Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Study in the Current Era of Viral Load Monitoring

Yong, M. K., Ananda-Rajah, M., Cameron, P. U., Morrissey, O. C., Spencer, A., Ritchie, D., Cheng, A. C., Lewin, S. R. & Slavin, M., Nov 2017, In : Biology of Blood and Marrow Transplantation. 23, 11, p. 1961-1967 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Trevillyan, J. M., Gardiner, E. E., Andrews, R. K., Maisa, A., Hearps, A. C., Al-Tamimi, M., Crowe, S. M. & Hoy, J. F., 3 Apr 2017, In : Platelets. 28, 3, p. 301-304 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Development and validation of a high throughput whole blood thrombolysis plate assay

Bonnard, T., Law, L. S., Tennant, Z. & Hagemeyer, C. E., 1 Dec 2017, In : Scientific Reports. 7, 1, 10 p., 2346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury

Sashindranath, M., Dwyer, K. M., Dezfouli, S., Selan, C., Crikis, S., Lu, B., Yuan, Y., Hickey, M. J., Peter, K., Robson, S. C., Cowan, P. J. & Nandurkar, H. H., Jun 2017, In : Purinergic Signalling. 13, 2, p. 259-265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Döhner, H., Estey, E., Grimwade, D., Amadori, S., Appelbaum, F. R., Büchner, T., Dombret, H., Ebert, B. L., Fenaux, P., Larson, R. A., Levine, R. L., Lo-Coco, F., Naoe, T., Niederwieser, D., Ossenkoppele, G. J., Sanz, M. A., Sierra, J., Tallman, M. S., Tien, H. F., Wei, A. H. & 2 others, Löwenberg, B. & Bloomfield, C. D., 26 Jan 2017, In : Blood. 129, 4, p. 424-447 24 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Drugs targeting protease-activated receptor-4 improve the anti-thrombotic therapeutic window

French, S. L. & Hamilton, J. R., 1 Dec 2017, In : Annals of Translational Medicine. 5, 23, 5 p., 464.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation

Devos, M., Gilbert, B., Denecker, G., Leurs, K., Guire, C. M., Lemeire, K., Hochepied, T., Vuylsteke, M., Lambert, J., Van Den Broecke, C., Libbrecht, L., Haigh, J. J., Berx, G., Lippens, S., Vandenabeele, P. & Declercq, W., 1 Feb 2017, In : Journal of Investigative Dermatology. 137, 2, p. 494-505 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan, H., Lisman, T. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 113-114 2 p., 02414.

Research output: Contribution to journalArticleResearchpeer-review

Fibrinolysis: from blood to the brain

Medcalf, R. L., 1 Nov 2017, In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2089-2098 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Generation of an inducible mouse model to reversibly silence Stat3

Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.

Research output: Contribution to journalArticleResearchpeer-review

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M., Kats, L. & 6 others, Gearhart, M. D., Bardwell, V. J., Dickins, R. A., Hannan, R. D., Papenfuss, A. T. & Johnstone, R. W., 6 Mar 2017, In : Nature Communications. 8, 14581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson, J. T., Shields, B. J., Shi, W., Di Rago, L., Metcalf, D., Nicola, N. A. & Mccormack, M. P., Aug 2017, In : Stem Cells. 35, 8, p. 1948-1957 10 p.

Research output: Contribution to journalArticleResearchpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review

High rates of potentially infectious exposures between immunocompromised patients and their companion animals: an unmet need for education

Gurry, G. A., Campion, V., Premawardena, C., Woolley, I., Shortt, J., Bowden, D. K., Kaplan, Z. & Dendle, C., 1 Mar 2017, In : Internal Medicine Journal. 47, 3, p. 333-335 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

Bradstock, K. F., Link, E., Di Iulio, J., Szer, J., Marlton, P., Wei, A., Enno, A., Schwarer, A., Lewis, I. D., Rozario, J. D., Coyle, L., Cull, G., Campbell, P., Leahy, M. F., Hahn, U. H., Cannell, P., Tiley, C., Lowenthal, R. M., Moore, J. & Cartwright, K., 20 May 2017, In : Journal of Clinical Oncology. 35, 15, p. 1678 - 1685 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of Acetylation, Immune Cell Alterations and Gene Signature As Dynamic Biomarkers of Response to Panobinostat Treatment in Multiple Myeloma Patients

Mithraprabhu, S., Savvidou, I., Ramachandran, M., Kalff, A., Khong, T. T., Reed, K., Reynolds, J. & Spencer, A., 7 Dec 2017, In : Blood. 130, Suppl 1, 1 p., 1823.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation

Yong, M. K., Cameron, P. U., Slavin, M., Morrissey, C. O., Bergin, K., Spencer, A., Ritchie, D., Cheng, A. C., Samri, A., Carcelain, G., Autran, B. & Lewin, S. R., 1 Jun 2017, In : Journal of Infectious Diseases. 215, 11, p. 1684-1694 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green, T. N., Hamilton, J. R., Morel-Kopp, M. C., Zheng, Z., Chen, T. Y. T., Hearn, J. I., Sun, P. P., Flanagan, J. U., Young, D., Barber, P. A., During, M. J., Ward, C. M. & Kalev-Zylinska, M. L., 2017, In : Platelets. 28, 8, p. 799-811 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N., Cameron, D. P., Hannan, K. M., Nguyen, N. Y. N., Fong, C. Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C. M., Diesch, J., Devlin, J. R., George, A. J., Sanij, E., Quin, J. E., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D. J., Harrison, S. J., Rozario, J. D. & 10 others, Powell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 25 May 2017, In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

KRAS-Mutated Myeloma Cells Exploit Autophagy and Macropinocytosis to Tolerate Glutamine-Deprived Conditions

Masoumi Moghaddam, S. & Spencer, A., Dec 2017, p. 1786.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Lenalidomide maintenance compared with placebo in responding elderly patients with diffuse large B-cell lymphoma treated with first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

Thieblemont, C., Tilly, H., Da Silva, M. G., Casasnovas, R. O., Fruchart, C., Morschhauser, F., Haioun, C., Lazarovici, J., Grosicka, A., Perrot, A., Trotman, J., Sebban, C., Caballero, D., Greil, R., Van Eygen, K., Cohen, A. M., Gonzalez, H., Bouabdallah, R., Oberic, L., Corront, B. & 10 others, Choufi, B., Lopez-Guillermo, A., Catalano, J., Van Hoof, A., Briere, J., Cabeçadas, J., Salles, G., Gaulard, P., Bosly, A. & Coiffier, B. B., 1 Aug 2017, In : Journal of Clinical Oncology. 35, 22, p. 2473-2481 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Ginn, S. L., Hallwirth, C. V., Liao, S. H. Y., Teber, E. T., Arthur, J. W., Wu, J., Lee, H. C., Tay, S. S., Hu, M., Reddel, R. R., McCormack, M. P., Thrasher, A. J., Cavazzana, M., Alexander, S. I. & Alexander, I. E., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial

Verstovsek, S., Mesa, R. A., Gotlib, J. R., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W. N., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Paquette, R. L., Raza, A., Jones, M., Kornacki, D., Sun, K. & 1 others, Kantarjian, H. M., 22 Feb 2017, In : Journal of Hematology & Oncology. 10, 1, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J., Sep 2017, In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Low T-cell responses to mitogen stimulation predicts poor survival in recipients of allogeneic hematopoietic stem cell transplantation

Yong, M. K., Cameron, P. U., Slavin, M. A., Cheng, A. C., Orla Morrissey, C., Bergin, K., Spencer, A., Ritchie, D. & Lewin, S. R., 9 Nov 2017, In : Frontiers in Immunology. 8, NOV, 9 p., 1506.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic gatekeeper function of B-lymphoid transcription factors

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 others, Ross, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 23 Feb 2017, In : Nature. 542, 7642, p. 479-483 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Minute variation in murine ovarian cancer preclinical models significantly impact immunotherapy results obtained for clinical trial

Masoumi Moghaddam, S., McGray, R., Starbuck, K., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloma in the real world: What is really happening?

Bergin, K., McQuilten, Z., Moore, E., Wood, E. & Spencer, A., 1 Mar 2017, In : Clinical Lymphoma, Myeloma & Leukemia. 17, 3, p. 133-144.e1 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan, Y., Alwis, I., Wu, M. C. L., Kaplan, Z., Ashworth, K., Bark, D., Pham, A., McFadyen, J., Schoenwaelder, S. M., Josefsson, E. C., Kile, B. T. & Jackson, S. P., 27 Sep 2017, In : Science Translational Medicine. 9, 409, 14 p., eaam5861.

Research output: Contribution to journalArticleResearchpeer-review

Novel oral small molecule CXCR4 inhibitor improves activity of immune checkpoint blockade in ovarian cancer mouse model

Masoumi Moghaddam, S., Starbuck, K., McGray, R., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017, p. 956.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens, S., Peirs, S., Loocke, W. V., Wang, J., Takawy, M., Matthijssens, F., Sonderegger, S. E., Haigh, K., Nguyen, T., Vandamme, N., Costa, M., Carmichael, C., Van Nieuwerburgh, F., Deforce, D., Kleifeld, O., Curtis, D. J., Berx, G., Van Vlierberghe, P. & Haigh, J. J., 23 Feb 2017, In : Blood. 129, 8, p. 981-990 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Partial response after induction chemotherapy has clinical relevance in acute myeloid leukaemia

Fleming, S., Ong, D. M., Jackson, K., Avery, S., Mollee, P. N., Marlton, P., Kennedy, G. A. & Wei, A. H., Apr 2017, In : British Journal of Haematology. 177, 2, p. 328-330 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmin: A Modulator of Immune Function

Draxler, D. F., Sashindranath, M. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 143-153 11 p., 02353.

Research output: Contribution to journalArticleResearchpeer-review

Platelet adhesion

Gardiner, E. E. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Cham: Springer, p. 309-319 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Platelet-Derived Microvesicles in Cardiovascular Diseases

Zaldivia, M. T. K., McFadyen, J. D., Lim, B., Wang, X. & Peter, K., 21 Nov 2017, In : Frontiers in Cardiovascular Medicine. 4, 13 p., 74.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Platelet hyperreactivity in diabetes: Focus on GPVI signaling-are useful drugs already available?

Arthur, J. F., Jandeleit-Dahm, K. & Andrews, R. K., 1 Jan 2017, In : Diabetes. 66, 1, p. 7-13 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler, M., Wang, X., Lim, B., Leitner, E., Klingberg, F., Ching, V., Yao, Y., Huang, D., Gao, X. M., Kiriazis, H., Du, X. J., Haigh, J. J., Bobik, A., Hagemeyer, C. E., Ahrens, I. & Peter, K., 2017, In : Theranostics. 7, 13, p. 3192-3206 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., Grillo, I., Bakogianni, S., Ndiaye-Lobry, D., Martín, M. T., Guillamot, M., Banh, R. S., Xu, M., Figueroa, M. E., Dickins, R. A., Abdel-Wahab, O. & 4 others, Park, C. Y., Tsirigos, A., Neel, B. G. & Aifantis, I., 7 Sep 2017, In : Cell. 170, 6, p. 1079 - 1095.e20 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Restoring Cardiac Function After Myocardial Infarction by Targeting CD39 to Activated Platelets.

Ziegler, M., Hohmann, J., Searle, A., Abraham, M., Nandurkar, H. H., Wang, X. & Peter, K., 2017. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Retrospective evaluation of venous thromboembolism: Are all transient provoking events the same?

Chua, C. C., Lim, H. Y., Tacey, M., Nandurkar, H. & Ho, P., 1 Jul 2017, In : European Journal of Haematology. 99, 1, p. 18-26 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In : PLoS ONE. 12, 5, 21 p., e0177332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai, Y., Guo, J., Wang, T. Y., Ju, Y., Mitchell, A. J., Bonnard, T., Cui, J., Richardson, J. J., Hagemeyer, C. E., Alt, K. & Caruso, F., 23 Aug 2017, In : Advanced Healthcare Materials. 6, 16, 7 p., 1700467.

Research output: Contribution to journalArticleResearchpeer-review

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., May 2017, In : Journal of Thrombosis and Haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleResearchpeer-review