Research Output 1988 2019

2018

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-Assembled Metal–Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Besford, Q. A., Ju, Y., Wang, T. Y., Yun, G., Cherepanov, P. V., Hagemeyer, C. E., Cavalieri, F. & Caruso, F., 27 Sep 2018, In : Small. 14, 39, 9 p., 1802342.

Research output: Contribution to journalArticleResearchpeer-review

Shear Containment of BDNF within Molecular Hydrogels Promotes Human Stem Cell Engraftment and Postinfarction Remodeling in Stroke

Nisbet, D. R., Wang, T. Y., Bruggeman, K. F., Niclis, J. C., Somaa, F. A., Penna, V., Hunt, C. P. J., Wang, Y., Kauhausen, J. A., Williams, R. J., Thompson, L. H. & Parish, C. L., 1 Sep 2018, In : Advanced Biosystems. 2, 9, 13 p., 1800113.

Research output: Contribution to journalArticleResearchpeer-review

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

Montague, S. J., Delierneux, C., Lecut, C., Layios, N., Dinsdale, R. J., Lee, C. S. M., Poulter, N. S., Andrews, R. K., Hampson, P., Wearn, C. M., Maes, N., Bishop, J., Bamford, A., Gardiner, C., Lee, W. M., Iqbal, T., Moiemen, N., Watson, S. P., Oury, C., Harrison, P. & 1 othersGardiner, E. E., 13 Feb 2018, In : Blood Advances. 2, 3, p. 240-251 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structure and function of the open canalicular system–the platelet’s specialized internal membrane network

Selvadurai, M. V. & Hamilton, J. R., 19 May 2018, In : Platelets. 29, 4, p. 319-325 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment

Flierl, U., Nero, T. L., Lim, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 1 Jan 2018, In : Journal of Thrombosis and Haemostasis. 16, 1, p. 181-185 5 p.

Research output: Contribution to journalLetterOtherpeer-review

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, I., Khong, T., Spencer, A. & Alt, K. M., Jul 2018, In : Archives of Medical Research. 6, 7, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Bain, C. R., Draxler, D. F., Taylor, R., Wallace, S., Gouldthorpe, O., Corcoran, T. B., Myles, P. S., L. Medcalf, R. & Bozaoglu, K., Aug 2018, In : Anaesthesia. 73, 8, p. 955-966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

Muscat, A. M., Wong, N. C., Drummond, K. J., Algar, E. M., Khasraw, M., Verhaak, R., Field, K., Rosenthal, M. A. & Ashley, D. M., 1 Jan 2018, In : Oncotarget. 9, 8, p. 7844-7858 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The role of autophagy in multiple myeloma disease progression

Savvidou, I., Chandrasekara, S. D., Khong, T. T. F. & Spencer, A., Jul 2018, In : Cancer Research. 78, 13 Supplement, 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Thrombin generation estimates the anticoagulation effect of direct oral anticoagulants with significant interindividual variability observed

Rigano, J., Ng, C., Nandurkar, H. H. & Ho, P., 1 Mar 2018, In : Blood Coagulation and Fibrinolysis. 29, 2, p. 148-154 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response

Mina, R., Petrucci, M. T., Corradini, P., Spada, S., Patriarca, F., Cerrato, C., De Paoli, L., Pescosta, N., Ria, R., Malfitano, A., Musto, P., Baldini, L., Guglielmelli, T., Gamberi, B., Mannina, D., Benevolo, G., Zambello, R., Falcone, A. P., Palumbo, A., Nagler, A. & 5 othersCalafiore, V., Hájek, R., Spencer, A., Boccadoro, M. & Bringhen, S., 1 Aug 2018, In : Clinical Lymphoma, Myeloma & Leukemia. 18, 8, p. 533-540 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding of the significance and health implications of asplenia in a cohort of patients with haemaglobinopathy: possible benefits of a spleen registry

Premawardena, C., Bowden, D., Kaplan, Z., Dendle, C. & Woolley, I. J., 2018, In : Hematology. 23, 8, p. 526-530 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Variable serologic and other phenotypes due to KLF1 mutations

Gillinder, K., Magor, G. & Perkins, A., 1 May 2018, In : Transfusion. 58, 5, p. 1324-1325 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature

Winkler, I. G., Barbier, V., Lowe, J., Tay, J., Magnani, J. L., Marlton, P., Mills, A., Perkins, A. C., Fiveash, C. E., Erbani, J. M. & Levesque, J. P., 28 Nov 2018, p. 4552. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Open Access
2017

A brief history of blood platelets: A personal view

Berndt, M. C., Metharom, P. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Gresele, P., Kleiman, N. S., Lopez, J. A. & Page, C. P. (eds.). Cham: Springer, p. 3-10 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Accelerating Early Drug Development: Come on Down Under

Wei, A., Jul 2017, In : Annals of Oncology. 28, 7, p. 1655-1657 3 p., mdx101.

Research output: Contribution to journalArticleOtherpeer-review

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair, A. P., Walker, P., Kalff, A., Bergin, K., Hocking, J., Avery, S., Curtis, D. J., Patil, S., Das, T., Klarica, D., Morgan, S., Muirhead, J., Gorniak, M. B., Reynolds, J. & Spencer, A., 1 Jun 2017, In : Bone Marrow Transplantation. 52, 6, p. 839-845 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler, D. F., Madondo, M. T., Hanafi, G., Plebanski, M. & Medcalf, R. L., 1 Apr 2017, In : Cytometry Part A. 91, 4, p. 336-350 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J., 1 Aug 2017, In : Disease Models and Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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An Evidence-Based Approach to Myeloma Bone Disease

Bingham, N., Reale, A. & Spencer, A., 1 Apr 2017, In : Current Hematologic Malignancy Reports. 12, 2, p. 109-118 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Brazilek, R. J., Tovar-Lopez, F. J., Wong, A. K. T., Tran, H., Davis, A. S., McFadyen, J. D., Kaplan, Z., Chunilal, S., Jackson, S. P., Nandurkar, H., Mitchell, A. & Nesbitt, W. S., 2017, In : Lab on a Chip. 17, 15, p. 2595-2608 14 p.

Research output: Contribution to journalArticleResearchpeer-review

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim, K., Li, J., Barazia, A., Tseng, A., Youn, S. W., Abbadessa, G., Yu, Y., Schwartz, B., Andrews, R. K., Gordeuk, V. R. & Cho, J., 2017, In : Haematologica: the hematology journal. 102, 2, p. 246-259 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: A pooled analysis

Gay, F., Oliva, S., Petrucci, M. T., Montefusco, V., Conticello, C., Musto, P., Catalano, L., Evangelista, A., Spada, S., Campbell, P., Ria, R., Salvini, M., Offidani, M., Carella, A-M., Omedé, P., Liberati, A. M., Troia, R., Cafro, A. M., Malfitano, A., Falcone, A. P. & 7 othersCaravita, T., Patriarca, F., Nagler, A., Spencer, A., Hajek, A. R., Palumbo, A. & Boccadoro, M., 1 Aug 2017, In : Leukemia. 31, 8, p. 1727-1734 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Basic mechanisms of platelet receptor shedding

Andrews, R. K. & Gardiner, E. E., 19 May 2017, In : Platelets. 28, 4, p. 319-324 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., Traunbauer, A. K., Sadovnik, I., Bauer, K., Valent, P., Bradner, J. E., Zuber, J., Shortt, J. & Johnstone, R. W., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2162-2174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia

Kantarjian, H. M., Stein, A., Gökbuget, N., Fielding, A. K., Schuh, A. C., Ribera, J. M., Wei, A., Dombret, H., Foà, R., Bassan, R., Arslan, Ö., Sanz, M. A., Bergeron, J., Demirkan, F., Lech-Maranda, E., Rambaldi, A., Thomas, X., Horst, H-A., Brüggemann, M., Klapper, W. & 6 othersWood, B. L., Fleishman, A., Nagorsen, D., Holland, C. J., Zimmerman, Z. & Topp, M. S., 2 Mar 2017, In : New England Journal of Medicine. 376, 9, p. 836-847 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Challenges and opportunities in protease-activated receptor drug development

Hamilton, J. R. & Trejo, J., 6 Jan 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 349-373 25 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Mithraprabhu, S., Khong, T., Ramachandran, M., Chow, A., Klarica, D., Mai, L., Walsh, S., Broemeling, D., Marziali, A., Wiggin, M., Hocking, J., Kalff, A., Durie, B. & Spencer, A., 1 Aug 2017, In : Leukemia. 31, 8, p. 1695-1705 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P. & Jung, S. M., 1 Mar 2017, In : Journal of Thrombosis and Haemostasis. 15, 3, p. 549-564 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski, M. T., Hu, Y., Roberts, K. G., Boer, J. M., McKenzie, M. D., Liu, G. J., Le Grice, O. D., Tremblay, C., Ghisi, M., Willson, T. A., Horstmann, M. A., Aifantis, I., Cimmino, L., Frietze, S., den Boer, M. L., Mullighan, C. G., Smyth, G. K. & Dickins, R. A., 6 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 773-791 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., van der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 othersJackson, S. P., 30 Aug 2017, In : Nature Communications. 8, 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Corrigendum to “KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study” [Leuk. Res. 50 (Nov) (2016) 123–131. PubMed PMID: 27736729](S0145212616301989)(10.1016/j.leukres.2016.09.012)

Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., Lewis, I. D., Rivera, G., Gratzinger, D., Fan, A. C., Felsher, D. W., Cortes, J. E., Watts, J. M., Yarranton, G. T., Walling, J. M. & Lancet, J. E., 1 Aug 2017, In : Leukemia Research. 59, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

CXCR4 in combination with immune check point inhibition in ovarian cancer mouse model demonstrates potential for novel therapeutic strategies

Masoumi Moghaddam, S., Starbuck, K., McGray, R., Francois, A., Odunsi, K. & Zsiros, E., Jul 2017.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Trevillyan, J. M., Gardiner, E. E., Andrews, R. K., Maisa, A., Hearps, A. C., Al-Tamimi, M., Crowe, S. M. & Hoy, J. F., 3 Apr 2017, In : Platelets. 28, 3, p. 301-304 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Development and validation of a high throughput whole blood thrombolysis plate assay

Bonnard, T., Law, L. S., Tennant, Z. & Hagemeyer, C. E., 1 Dec 2017, In : Scientific Reports. 7, 1, 10 p., 2346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury

Sashindranath, M., Dwyer, K. M., Dezfouli, S., Selan, C., Crikis, S., Lu, B., Yuan, Y., Hickey, M. J., Peter, K., Robson, S. C., Cowan, P. J. & Nandurkar, H. H., Jun 2017, In : Purinergic Signalling. 13, 2, p. 259-265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Döhner, H., Estey, E., Grimwade, D., Amadori, S., Appelbaum, F. R., Büchner, T., Dombret, H., Ebert, B. L., Fenaux, P., Larson, R. A., Levine, R. L., Lo-Coco, F., Naoe, T., Niederwieser, D., Ossenkoppele, G. J., Sanz, M. A., Sierra, J., Tallman, M. S., Tien, H. F., Wei, A. H. & 2 othersLöwenberg, B. & Bloomfield, C. D., 26 Jan 2017, In : Blood. 129, 4, p. 424-447 24 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Drugs targeting protease-activated receptor-4 improve the anti-thrombotic therapeutic window

French, S. L. & Hamilton, J. R., 1 Dec 2017, In : Annals of Translational Medicine. 5, 23, 5 p., 464.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation

Devos, M., Gilbert, B., Denecker, G., Leurs, K., Guire, C. M., Lemeire, K., Hochepied, T., Vuylsteke, M., Lambert, J., Van Den Broecke, C., Libbrecht, L., Haigh, J. J., Berx, G., Lippens, S., Vandenabeele, P. & Declercq, W., 1 Feb 2017, In : Journal of Investigative Dermatology. 137, 2, p. 494-505 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan, H., Lisman, T. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 113-114 2 p., 02414.

Research output: Contribution to journalArticleResearchpeer-review

Fibrinolysis: from blood to the brain

Medcalf, R. L., 1 Nov 2017, In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2089-2098 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Generation of an inducible mouse model to reversibly silence Stat3

Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.

Research output: Contribution to journalArticleResearchpeer-review

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M., Kats, L. & 6 othersGearhart, M. D., Bardwell, V. J., Dickins, R. A., Hannan, R. D., Papenfuss, A. T. & Johnstone, R. W., 6 Mar 2017, In : Nature Communications. 8, 14581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson, J. T., Shields, B. J., Shi, W., Di Rago, L., Metcalf, D., Nicola, N. A. & Mccormack, M. P., Aug 2017, In : Stem Cells. 35, 8, p. 1948-1957 10 p.

Research output: Contribution to journalArticleResearchpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review