Research Output 1988 2019

2003

Survival of Vascularised Xenografts is Prolonged Using Donor Organs from Transgenic Mice Expressing Human Cd39.

Dwyer, K., Robson, S. C., Nandurkar, H. H., Mysore, T., Murray-Segal, L. J. & Cowan, P., 2003, p. 482.

Research output: Contribution to conferenceAbstractOtherpeer-review

Transgenic Mice Expressing Human Cd39 Prolong Survival Of Vascularised Xenografts

Dwyer, K., Robson, S. C., Nandurkar, H. H., Mysore, T. & Cowan, P., 2003, p. A68.

Research output: Contribution to conferenceAbstractOtherpeer-review

VEGF-A signaling in the glomerulus.

Eremina, V., Haigh, J., Nagy, A. & Quaggin, SE., 2003, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 14. p. 25A-25A

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

2002

Assessment of in vivo oxidative lipid metabolism following acute microcystin-LR-induced hepatotoxicity in rats.

Towner, R. A., Sturgeon, S. A. & Hore, K. E., 2002, In : Free Radical Research. 36, 1, p. 63 - 71 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteries.

Hamilton, J. R., Moffatt, J. D., Tatoulis, J. & Cocks, T. M., 2002, In : British Journal of Pharmacology. 136, p. 492 - 501 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling

Lawrenson, I. D., Wimmer-Kleikamp, S. H., Lock, P., Schoenwaelder, S. M., Down, M., Boyd, A. W., Alewood, P. F. & Lackmann, M., 2002, In : Journal of Cell Science. 115, 5, p. 1059 - 1072 14 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry)

Towner, R. A., Sturgeon, S. A., Khan, N., Hou, H. & Swartz, H. M., 2002, In : Chemico-Biological Interactions. 139, 3, p. 231 - 250 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Protection against thrombosis in mice lacking PAR3

Weiss, E. J., Hamilton, J. R., Lease, K. E. & Coughlin, S. R., 2002, In : Blood. 100, 9, p. 3240 - 3244 5 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA sustains integrin αIIbβ3 adhesion contacts under high shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 26 Apr 2002, In : Journal of Biological Chemistry. 277, 17, p. 14738-14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Specific monoclonal antibodies and human immunoglobulin E show that Hev b 5 is an abundant allergen in high protein powdered latex gloves

Sutherland, M. F., Drew, A., Rolland, J. M., Slater, J. E., Suphioglu, C. & O'Hehir, R. E., 4 May 2002, In : Clinical and Experimental Allergy. 32, 4, p. 583-589 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of VEGF-A in glomerular angiogenesis.

Eremina, V., Haigh, J., Nagy, A., Kikkawa, Y., Miner, JH. & Quaggin, SE., 2002, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 13. p. 100A-100A

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

2001

Dynamic aspects of platelet adhesion under flow

Dopheide, S. M., Yap, C. L. S. & Jackson, S., 2001, In : Clinical and Experimental Pharmacology and Physiology. 28, p. 355 - 363 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of vascular endothelial cell growth factor (VEGF) deletion on skin biology and mammary gland development and function

Rossiter, H., Barresi, C., Ban, J., Mayer, C., Rendl, M., Haigh, J., Wagner, EF. & Tschachler, E., 2001, JOURNAL OF INVESTIGATIVE DERMATOLOGY. Vol. 117. p. 1678-1678 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation

Pinter, E., Haigh, J., Nagy, A. & Madri, J. A., 2001, In : American Journal of Pathology. 158, 4, p. 1199-1206 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Lack of vascular endothelial cell growth factor (VEGF) in murine epidermal keratinocytes results in retardation of angiogenesis-dependent processes in the skin

Rossiter, H., Barresi, C., Ban, J., Mayer, C., Haigh, J., Wagner, E. & Tschachler, E., 2001, JOURNAL OF INVESTIGATIVE DERMATOLOGY. Vol. 117. p. 391-391 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

Novel alternatively spliced exon in the extracellular ligand-binding domain of the PACAP type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis

Daniel, P. B., Kieffer, T. J., Leech, C. A. & Habener, J. F., 2001, In : Journal of Molecular Biology. 276, 16, p. 12938* - 12944 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries

Hamilton, J. R., Moffatt, J. D., Frauman, A. G. & Cocks, T. M., 2001, In : Journal of Cardiovascular Pharmacology. 38, p. 108 - 119 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Short communication: Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation

Pinter, E., Haigh, J., Nagy, A. & Madri, J. A., 2001, In : American Journal of Pathology. 158, 4, p. 1199 1 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state

Haigh, J. J., Gerber, H-P., Ferrara, N. & Wagner, E. F., 2000, In : Development. 127, 7, p. 1445-1453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells

Hussain, M. A., Daniel, P. B. & Habener, J. F., 2000, In : Diabetes. 49, 10, p. 1681* - 1690 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis

Daniel, P. B., Rohrbach, L. & Habener, J. F., 2000, In : Endocrinology. 141, 11, p. 3923* - 3930 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Overexpression of a dominant negative CREB protein in HT-1080 cells selectively disrupts plasminogen activator inhibitor type 2 but not tissue-type plasminogen activator gene expression

Costa, M., Shen, Y. & Medcalf, R. L., 29 Sep 2000, In : FEBS Letters. 482, 1-2, p. 75-80 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pituitary adenylate cyclase activating polypeptide (PACAP) gene expression regulated by a testis-specific promoter in germ cells during spermatogenesis

Daniel, P. B. & Habener, J. F., 2000, In : Endocrinology. 141, 3, p. 1218* - 1227 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasminogen activator inhibitor type 2 (pai-2) inhibits apoptosis in vivo

Kwaan, H. C., Wang, J., Weiss, I., Medcalf, R. & Maurer, F., 1 Dec 2000, In : Blood. 96, 11 PART I, p. 44a 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton.

Jackson, S., Mistry, N. & Yuan, Y-P., 2000, In : Trends in Cardiovascular Medicine. 10, p. 192 - 197 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet gp ib/ix and integrin αiibβ3: studies in human platelets and transfected K562 and CHO cells

Jackson, S. P., Domagala, T., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Lanza, F. & Yap, C. L., 1 Dec 2000, In : Blood. 96, 11 PART I

Research output: Contribution to journalArticleResearchpeer-review

1999

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

Harling-McNabb, L., Deliyannis, G., Jackson, D. C., Gerondakis, S. D., Grigoriadis, G. & Brown, L. E., 1999, In : International Immunology. 11, 9, p. 1431 - 1439 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Enrichment of blood from ES cells in vitro

Perkins, A. C., 1998, In : Reproduction, Fertility and Development. 10

Research output: Contribution to journalArticleResearchpeer-review

IL-11, an'haematopoietic'regulator whose principal physiological function is in female fertility

Robb, L., Nandurkar, H. H. & Begley, C. G., 1998, p. 803.

Research output: Contribution to conferenceAbstractOtherpeer-review

Regulation of Hematopoiesis by Growth Factors: Contribution of Interleukin-11.

Nandurkar, H. H., 1998.

Research output: Contribution to conferenceAbstractOtherpeer-review

1997

Destabilising properties of the uuauuuauu element in the 3′ utr of plasminogen activator inhibitor type 2 (PAI-2) mRNA

Maurer, F., Tierney, M. & Medcalf, R. L., 1 Dec 1997, In : Fibrinolysis and Proteolysis. 11, SUPPL. 3, p. 3 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Identification of endothelial nuclear factors which recognise the cre-like element in the human t-pa gene promoter

Costa, M., Shen, Y., Maurer, F. & Medcalf, R., 1 Dec 1997, In : Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.

Research output: Contribution to journalArticleOtherpeer-review

1996

A retinoic acid/cAMP-responsive enhancer containing a cAMP responsive element is required for the activation of the mouse thrombomodulin-encoding gene in differentiating F9 cells

Niforas, P., Chu, M. D. & Bird, P., 17 Oct 1996, In : Gene. 176, 1-2, p. 139-147 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential binding of creb-1 and atf-2 to a cre-like element in the t-pa gene promoter correlates with the opposite regulation of t-Pa in ht-1080 and hela cells

Costa, M. & Medcalf, R. L., 1 Dec 1996, In : Fibrinolysis. 10, SUPPL. 3, 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression

Dear, A. E., Shen, Y., Rüegg, M. & Medcalf, R. L., 1 Jan 1996, In : European Journal of Biochemistry. 241, 1, p. 93-100 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pai-2 gene induction by tumour necrosis factor and phorbol ester requires transcriptional and posttranscriptional events

Maurer, F. & Medcalf, R. L., 1 Dec 1996, In : Fibrinolysis. 10, SUPPL. 3, p. 61 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

Gerondakis, S. D., Strasser, A., Metcalf, D., Grigoriadis, G., Scheerlinck, J-P. Y. & Grumont, R. J., 1996, In : Proceedings of the National Academy of Sciences. 93, 8, p. 3405 - 3409 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of tyrosine phosphorylation in the signalling of superoxide anion generation in platelet-activating-factor-stimulated peritoneal macrophages

Grigoriadis, G. & Stewart, A. G., 1996, In : Cellular Physiology and Biochemistry. 6, 5, p. 271 - 282 12 p.

Research output: Contribution to journalArticleResearchpeer-review