Research Output 1984 2019

2011

Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

Al-Tamimi, M., Grigoriadis, G., Tran, H., Paul, E., Servadei, P., Berndt, M., Gardiner, E. E. & Andrews, R. K., 2011, In : Blood. 117, 14, p. 3912 - 3920 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Collagen surfaces to measure thrombus formation under flow: Possibilities for standardization

Heemskerk, J., Sakariassen, K., Zwaginga, J. J., Brass, L., Jackson, S. P. & Farndale, R., 2011, In : Journal of Thrombosis and Haemostasis. 9, 4, p. 856 - 858 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Sashindranath, M., Samson, A., Downes, C. E., Crack, P., Lawrence, A. J., Li, Q-X., Ng, A. Q. P., Jones, N. C., Farrugia, J., Abdella, E., Vassalli, J-D., Madani, R. & Medcalf, R., 2011, In : Laboratory Investigation. 91, 7, p. 1079 - 1091 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Contribution of conserved lysine residues in the alpha{2}-antiplasmin C terminus to plasmin binding and inhibition

Lu, B. G. C., Sofian, T., Law, R. HP., Coughlin, P. B. & Horvath, A. J., 2011, In : Journal of Biological Chemistry. 286, 28, p. 24544 - 24552 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Corrigendum

Arthur, J. F., Shen, Y., Gardiner, E. E., Coleman, L., Murphy, D., Kenny, D., Andrews, R. K. & Berndt, M. C., Dec 2011, In : Journal of Thrombosis and Haemostasis. 9, 12, p. 2523 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

C-rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells

Grigoriadis, G., Vasanthakumar, A., Banerjee, A., Grumont, R. J., Overall, S., Gleeson, P. A., Shannon, M. & Gerondakis, S., 2011, In : PLoS ONE. 6, 10, 10 p., e26851.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Critical role of cRel subunit of NF-kB in sepsis survival

Courtine, E., Pene, F., Cagnard, N., Toubiana, J., Fitting, C., Brocheton, J., Rousseau, C., Gerondakis, S., Chiche, J-D., Ouaaz, F. & Mira, J-P., 2011, In : Infection and Immunity. 79, 5, p. 1848 - 1854 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-I?B pathway

Stankovic, S., Gugasyan, R., Kyparissoudis, K., Grumont, R., Banerjee, A., Tsichlis, P., Gerondakis, S. & Godfrey, D., 2011, In : Immunology and Cell Biology. 89, 2, p. 294 - 303 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

Straub, A., Krajewski, S., Hohmann, J. D., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y-P., Nandurkar, H., Jackson, S., Hickey, M. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 7, p. 1607 - 1616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Failure of eculizumab to correct paroxysmal cold hemoglobinuria

Gregory, G. P., Opat, S., Quach, H., Shortt, J. & Tran, H., Aug 2011, In : Annals of Hematology. 90, 8, p. 989-990 2 p.

Research output: Contribution to journalLetterOtherpeer-review

GPVI and GPIb alpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors

Hu, H., Armstrong, P., Khalil, E., Chen, Y-C., Straub, A., Li, M., Soosairajah, J., Hagemeyer, C., Bassler, N., Huang, D., Ahrens, I., Krippner, G., Gardiner, E. & Peter, K., 2011, In : PLoS ONE. 6, 4, 9 p., e19190.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIba-filamin interaction

Cranmer, S., Ashworth, K., Yao, Y., Berndt, M. C., Ruggeri, Z. M., Andrews, R. & Jackson, S., 2011, In : Blood. 117, 9, p. 2718 - 2727 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts

Sonderegger, S. E., Yap, J., Menkhorst, E., Weston, G., Stanton, P. G. & Dimitriadis, E., 2011, In : Human Reproduction. 26, 10, p. 2841 - 2849 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Methods to measure the kinetics of protease inhibition by serpins

Horvath, A. J., Lu, B. GC., Pike, R. N. & Bottomley, S. P., 2011, Methods in Enzymology, Volume 501: Serpin Structure and Evolution. Whisstock, J. C. & Bird, P. I. (eds.). USA: Academic Press, p. 223 - 235 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction

Liu, Y., Gao, X-M., Fang, L., Jennings, N., Su, Y., Xu, Q., Samson, A., Kiriazis, H., Wang, X-F., Shan, L., Sturgeon, S., Medcalf, R., Jackson, S., Dart, A. & Du, X-J., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 4, p. 834 - 841 8 p.

Research output: Contribution to journalArticleResearchpeer-review

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

Gough, S., Slape, C. & Aplan, P., 2011, In : Blood. 118, 24, p. 6247 - 6257 11 p.

Research output: Contribution to journalArticleOther

Occult Disseminated Malignancy Presenting as Microangiopathic Hemolytic Anemia

Grigoriadis, G., Teh, P. & Whitehead, S., Feb 2011, In : Therapeutic Apheresis and Dialysis. 15, 1, p. 114-115 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: A case study and review

Grigoriadis, G., Condon, J., Green, K., Anderson, M. A., Borosak, M. & Wood, E., 2011, In : Immunohematology. 27, 3, p. 83 - 88 6 p.

Research output: Contribution to journalArticleOther

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells

Wen, P., Osborne, S., Zanin, M., Low, P., Wang, H-T., Schoenwaelder, S., Jackson, S., Wedlich-Soldner, R., Vanhaesebroeck, B., Keating, D. & Meunier, F., 2011, In : Nature Communications. 2, 1, p. 491 - 502 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Plasminogen activation-based thrombolysis for ischaemic stroke: The diversity of targets may demand new approaches

Medcalf, R., 2011, In : Current Drug Targets. 12, 12, p. 1772 - 1781 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasminogen activator inhibitor type 2: still an enigmatic serpin but a model for gene regulation

Medcalf, R., 2011, Methods in Enzymology, Volume 499: Biology of Serpins. Whisstock, J. C. & Bird, P. I. (eds.). USA: Academic Press, p. 105 - 134 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Platelets - From function to dysfunction in essential thrombocythaemia

Andrews, R., Berndt, M. & Elalamy, I., 2011, In : European Oncology & Haematology. 7, 2, p. 125 - 131 7 p.

Research output: Contribution to journalArticleOther

PPAR(gamma)-independent thiazolidinedione-mediated inhibition of NUR77 expression in vascular endothelial cells

Hu, Y., Liu, H., Simpson, R. & Dear, A., 2011, In : Journal of Endocrinology. 208, 1, p. R1 - R7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Proliferation and bone marrow engraftment of AML blasts is dependent on β-catenin signalling. Br J Haematol. 2011 Jan;152(2):164-74

Siapati, EK. & Savvidou, I., 2011, In : British Journal of Haematology. 152, p. 164-174 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation

Tran, H., Collecutt, M., Whitehead, S. & Salem, H. H., 2011, In : Internal Medicine Journal. 41, 4, p. 337 - 343 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Reply to S.M. Sorscher et al

Henry, D. H., Costa, L., Goldwasser, F., Hirsh, V., Hungria, V., Prausova, J., Scagliotti, G. V., Sleeboom, H., Spencer, A., Vadhan-Raj, S., von Moos, R., Willenbacher, W., Wang, J., Jiang, Q-Z., Jun, S., Dansey, R. & Yeh, H., 1 Jul 2011, In : Journal of Clinical Oncology. 29, 19, p. 2736-2737 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Rivaroxaban and false positive lupus anticoagulant testing

Merriman, E., Kaplan, Z., Butler, J., Malan, E., Gan, E. & Tran, H., 2011, In : Thrombosis and Haemostasis. 105, 2, p. 385 - 386 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke

Al-Tamimi, M., Gardiner, E., Thom, J., Shen, Y., Cooper, M., Hankey, G., Berndt, M., Baker, R. & Andrews, R., 2011, In : Stroke. 42, 2, p. 498 - 500 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Westein, E., Jackson, S., Nesbitt, W. S. & Mitchell, A., 2011, In : Journal of Biomechanics. 44, 6, p. 1031 - 1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma

Khong, T. & Spencer, A., 2011, In : Molecular Cancer Therapeutics. 10, 10, p. 1909 - 1917 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The 78 kda glucose response protein (GRP78) is recruited to the surface of endothelium by interacting with thrombomodulin and it demonstrates antithrombotic activity.

Sharma, A. R., Zhang, X. M., Selan, C., Samudra, A. N., Murray-Segal, L. J., Salvaris, E. J., Michell, B., Kemp, B., Conway, E. D., YUAN, Y., Cowan, P. & Nandurkar, H. H., 2011, p. 775.

Research output: Contribution to conferenceAbstractOtherpeer-review

The anti-leukemic effect and molecular mechanisms of novel hydroxamate and benzamide histone deacetylase inhibitors with 5-aza-cytidine

Liu, H. B., Mayes, P. A., Perlmutter, P., McKendrick, J. & Dear, A. E., 2011, In : International journal of oncology. 38, 5, p. 1421 - 1425 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The catalytic class IA PI3K isoforms play divergent roles in breast cancer cell migration

De Laurentiis, A., Pardo, O., Palamidessi, A., Jackson, S., Schoenwaelder, S., Reichmann, E., Scita, G. & Arcaro, A., 2011, In : Cellular Signalling. 23, 3, p. 529 - 541 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The c-Rel transcription factor in development and disease

Gilmore, T. & Gerondakis, S., 2011, In : Genes & Cancer. 2, 7, p. 695 - 711 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The epigenomics revolution in myelodysplasia: A clinico-pathological perspective

Tan, P. T. & Wei, A. H., Oct 2011, In : Pathology. 43, 6, p. 536-546 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The maternal immune response to fetal platelet GPIbI? causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies

Li, C., Piran, S., Chen, P., Lang, S., Zarpellon, A., Jin, J. W., Zhu, G., Reheman, A., van der Wal, E., Simpson, E. K., Ni, R., Gross, P. L., Ware, J., Ruggeri, Z. M., Freedman, J. & Ni, H., 2011, In : Journal of Clinical Investigation. 121, 11, p. 4537 - 4547 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis

Chen, G., Hardy, K., Pagler, E., Ma, L., Lee, S., Gerondakis, S., Daley, S. & Shannon, M., 2011, In : Journal of Immunology. 187, 9, p. 4483 - 4491 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The prevalence of significant liver fibrosis and cirrhosis in haemophilia patients infected with hepatitis C using FibroScan

Kitson, M., Roberts, S., Kemp, W., Iser, D., Walsh, M., McCarthy, P., Street, A. & Tran, H., 2011, In : Haemophilia. 17, 2, p. 316 - 317 2 p.

Research output: Contribution to journalLetterOther

The role of platelets in atherothrombosis

Kaplan, Z. & Jackson, S., 2011, In : Hematology. 2011, 1, p. 51 - 61 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of the bone marrow microenvironment in multiple myeloma

Monaghan, K. & Spencer, A., 2011, In : European Journal of Clinical & Medical Oncology. 3, 2, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin

Niego, B., Samson, A., Petersen, K-U. & Medcalf, R., 2011, In : Brain Research. 1381, p. 38 - 51 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombotic thrombocytopenic purpura: Reducing the risk?

Berndt, M. & Andrews, R., 2011, In : European Journal of Clinical Investigation. 121, 2, p. 522 - 524 3 p.

Research output: Contribution to journalLetterOther

TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets

Arthur, J., Shen, Y., Gardiner, E., Coleman, L., Kenny, D., Andrews, R. & Berndt, M. C., 2011, In : Journal of Thrombosis and Haemostasis. 9, 1, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription factor AP-2alpha promotes EGF-dependent invasion of human trophoblast

Biadasiewicz, K., Sonderegger, S. E., Haslinger, P., Haider, S., Saleh, L., Fiala, C., Pollheimer, J. & Knofler, M., 2011, In : Endocrinology. 152, 4, p. 1458 - 1469 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

A GPIb-IX-V complex signaling environment

Gardiner, E., 2010, In : Journal of Thrombosis and Haemostasis. 8, 5, p. 1075 - 1076 2 p.

Research output: Contribution to journalLetterOther

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2010, In : Lab on a Chip. 10, 3, p. 291 - 302 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Arterial thrombosis: Going, gone!

Gardiner, E. & Berndt, M., 2010, In : Blood. 116, p. 2201 - 2202 2 p.

Research output: Contribution to journalLetterOther